ATE318825T1 - Herstellung von cephalosporin - Google Patents

Herstellung von cephalosporin

Info

Publication number
ATE318825T1
ATE318825T1 AT01997475T AT01997475T ATE318825T1 AT E318825 T1 ATE318825 T1 AT E318825T1 AT 01997475 T AT01997475 T AT 01997475T AT 01997475 T AT01997475 T AT 01997475T AT E318825 T1 ATE318825 T1 AT E318825T1
Authority
AT
Austria
Prior art keywords
cephalosporin
production
formula
sodium salt
preparing ceftiofur
Prior art date
Application number
AT01997475T
Other languages
English (en)
Inventor
Andres Berger
Martin Decristorforo
Johannes Ludescher
Herbert Schleich
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Application granted granted Critical
Publication of ATE318825T1 publication Critical patent/ATE318825T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT01997475T 2000-11-22 2001-11-20 Herstellung von cephalosporin ATE318825T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25270700P 2000-11-22 2000-11-22

Publications (1)

Publication Number Publication Date
ATE318825T1 true ATE318825T1 (de) 2006-03-15

Family

ID=22957174

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01997475T ATE318825T1 (de) 2000-11-22 2001-11-20 Herstellung von cephalosporin

Country Status (11)

Country Link
US (1) US6504026B2 (de)
EP (1) EP1343790B1 (de)
JP (1) JP4319835B2 (de)
KR (1) KR100870885B1 (de)
AT (1) ATE318825T1 (de)
AU (1) AU2002219127A1 (de)
CA (1) CA2427199C (de)
DE (1) DE60117620T2 (de)
ES (1) ES2258569T3 (de)
TW (1) TWI246513B (de)
WO (1) WO2002042266A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555679B2 (en) 2001-10-03 2003-04-29 Orchid Chemicals & Pharmaceuticals Ltd. Method for preparation of ceftiofur sodium from its hydrohalide salts
EP1556388B1 (de) * 2002-10-29 2007-09-19 Lupin Limited Verfahren zur herstellung von ceftiofur
JP2009511563A (ja) * 2005-10-12 2009-03-19 オーキッド ケミカルズ アンド ファーマシューティカルズ リミテッド セファロスポリン抗生物質の結晶性ナトリウム塩
US8470809B2 (en) * 2005-10-12 2013-06-25 Orchid Chemicals & Pharmaceuticals Limited Crystalline sodium salt of cephalosporin antibiotic
WO2010020871A2 (en) * 2008-08-22 2010-02-25 Orchid Chemicals & Pharmaceuticals Limited Crystalline sodium salt of cephalosporin antibiotic
KR101699539B1 (ko) * 2015-12-30 2017-02-13 (주)솔레이어 나노 여과 모듈 및 이를 이용한 농축 방법
CN115772179A (zh) * 2022-12-09 2023-03-10 山东鑫泉医药有限公司 头孢噻呋钠的重结晶方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902683A (en) * 1984-10-25 1990-02-20 The Upjohn Company Crystalline cephalosporin hydrohalide salts
US4937330A (en) * 1985-08-12 1990-06-26 The Upjohn Company Conversion of cephalosporin hydrohalide salt to alkali metal salt
US4877782A (en) * 1988-02-16 1989-10-31 The Upjohn Company Zinc ceftiofur complexes
IL95561A0 (en) 1990-09-02 1991-06-30 Weizmann Kiryat Membrane Prod Method for the purification and concentration of biologically active materials
JP2919112B2 (ja) * 1991-05-13 1999-07-12 武田薬品工業株式会社 セファロスポリン注射剤およびその製造法
TW293821B (en) 1993-09-27 1996-12-21 Ind Tech Res Inst Process for preparing alkali salts of cephalosporin C
US5491259A (en) 1994-09-13 1996-02-13 The Dow Chemical Company Process to produce aminocarboxylic acids containing low residual salt
ES2105988B1 (es) 1996-03-15 1998-07-01 Antibioticos Sa Procedimiento para purificar 7-sustituido-amino-desacetoxi-cefalosporinas mediante el empleo de membranas de filtracion.
IT1283641B1 (it) 1996-07-30 1998-04-23 Ribbon Srl Procedimento per la preparazione di cefalosporine
DE69909077T2 (de) 1998-04-14 2004-05-06 Dsm Ip Assets B.V. Membranfiltration
DE19839209A1 (de) 1998-08-28 2000-03-02 Fraunhofer Ges Forschung Verfahren zur Gewinnung von festen Stoffen aus Lösungen
KR100355115B1 (ko) * 1999-01-14 2002-11-22 주식회사 엘지씨아이 세프티오퍼 합성에 유용한 중간체 및 이를 이용한 세프티오퍼의 제조 방법
JP3737642B2 (ja) * 1999-01-18 2006-01-18 武田薬品工業株式会社 セファロスポリン注射剤およびその製造法
US6458949B1 (en) * 2000-08-14 2002-10-01 Aurobindo Pharma Limited Ceftiofur, its intermediate and a process for the preparation of the same

Also Published As

Publication number Publication date
WO2002042266A3 (en) 2002-08-15
KR20030070014A (ko) 2003-08-27
AU2002219127A1 (en) 2002-06-03
DE60117620T2 (de) 2006-10-12
KR100870885B1 (ko) 2008-11-28
US6504026B2 (en) 2003-01-07
DE60117620D1 (de) 2006-04-27
ES2258569T3 (es) 2006-09-01
JP2004514667A (ja) 2004-05-20
WO2002042266A2 (en) 2002-05-30
CA2427199A1 (en) 2002-05-30
TWI246513B (en) 2006-01-01
EP1343790A2 (de) 2003-09-17
EP1343790B1 (de) 2006-03-01
US20020082248A1 (en) 2002-06-27
JP4319835B2 (ja) 2009-08-26
CA2427199C (en) 2009-02-10

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