AR002703A1 - Procedimiento para la preparación de un preparado de flavanolignano y composición en forma de dosificación unitaria oral sólida.. - Google Patents
Procedimiento para la preparación de un preparado de flavanolignano y composición en forma de dosificación unitaria oral sólida..Info
- Publication number
- AR002703A1 AR002703A1 ARP960101065A AR10106596A AR002703A1 AR 002703 A1 AR002703 A1 AR 002703A1 AR P960101065 A ARP960101065 A AR P960101065A AR 10106596 A AR10106596 A AR 10106596A AR 002703 A1 AR002703 A1 AR 002703A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- flavanolignan
- clear solution
- heating
- procedure
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Procedimiento para la elaboración de un preparado de flavanolignano con una liberación mejorada en comparación con la del flavanolignano puro,caracterizado por el hecho de que se prepara (a) una solución alcoholicoacuosa de substancias vehicularesf armacéuticamente aceptables y agentes humectantes,suspendiendo en esta solución un flavanolignano calentando la mezcla obtenida hasta la temperatura de ebullición para formar una solución clara, o (b) sesuspende un flavanolignano y un agentehumect ante en alcohol, calentando la suspensión obtenida con agitación hasta la formación de una solución clara,adicionando esta última con una solución acuosa de substancias vehiculares farmacéuticamente aceptables, calentando la mezclaobtenida bajo agitaciónhasta estar en presencia de una solución clara, y de que a continuación se concentra la solución clara obtenida según (a) o (b) para la formación de unco-precipitado, el que se filtra, secándose el co-precipitadooriginado bajo vacío.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19501266A DE19501266A1 (de) | 1995-01-18 | 1995-01-18 | Verfahren zur Herstellung von Flavano-Lignan-Zubereitungen mit verbesserter Freisetzung und Resorbierbarkeit danach erhältliche Zubereitungen und deren Verwendung zur Herstellung von Arzneimitteln |
Publications (1)
Publication Number | Publication Date |
---|---|
AR002703A1 true AR002703A1 (es) | 1998-04-29 |
Family
ID=7751686
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP960101065A AR002703A1 (es) | 1995-01-18 | 1996-01-18 | Procedimiento para la preparación de un preparado de flavanolignano y composición en forma de dosificación unitaria oral sólida.. |
Country Status (16)
Country | Link |
---|---|
US (2) | US5906991A (es) |
EP (1) | EP0722719B1 (es) |
JP (1) | JP2812909B2 (es) |
KR (1) | KR100198012B1 (es) |
CN (1) | CN1079674C (es) |
AR (1) | AR002703A1 (es) |
AT (1) | ATE303134T1 (es) |
BR (1) | BR9600145A (es) |
CA (1) | CA2167570C (es) |
CZ (1) | CZ283405B6 (es) |
DE (2) | DE19501266A1 (es) |
ES (1) | ES2248802T3 (es) |
HU (1) | HU225657B1 (es) |
PL (1) | PL188128B1 (es) |
RU (1) | RU2157225C2 (es) |
TW (1) | TW358028B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19814014A1 (de) | 1997-12-19 | 1999-09-30 | Krewel Meuselbach Gmbh | Arzneipflanzentrockenextrakte |
DE19915178A1 (de) | 1999-04-03 | 2000-10-05 | Univ Mainz Johannes Gutenberg | Hepatitis C Virus Zellkultursystem |
US7175855B1 (en) | 1999-05-27 | 2007-02-13 | Pfizer Inc. | Ziprasidone suspension |
WO2001054673A1 (en) * | 2000-01-31 | 2001-08-02 | The University Of British Columbia | Method for preparing and administering medicinal plant material |
KR100385366B1 (ko) * | 2001-03-05 | 2003-05-27 | 부광약품 주식회사 | 생체이용율을 개선한 실리마린 제제 조성물 |
CZ292832B6 (cs) * | 2001-08-30 | 2003-12-17 | Ivax Pharmaceuticals S.R.O. | Způsob přípravy silymarinu se zvýšenou rozpustností |
GB2432788C (en) | 2004-07-07 | 2018-06-27 | Integria Healthcare Australia Pty Ltd | An echinacea formulation |
CN101164537B (zh) * | 2006-10-16 | 2010-08-25 | 江苏大学 | 高效口服水飞蓟宾缓释制剂及其制备方法 |
FR2907680B1 (fr) * | 2006-10-27 | 2012-12-28 | Scras | Utilisation therapeutique d'au moins une neurotoxine botulique dans le traitement de la douleur induite par au moins un agent anti-cancereux |
DE102008039271A1 (de) | 2007-12-23 | 2009-06-25 | Euromed Sa | Neuer Mariendistelextrakt, Verfahren zur Herstellung und Verwendung |
CZ2008407A3 (cs) | 2008-06-26 | 2009-08-26 | Agra Group, A. S. | Vodorozpustný prípravek na bázi flavanonol lignanu a zpusob jeho prípravy |
CN101429107B (zh) * | 2008-11-18 | 2013-03-20 | 云南民族大学 | 一种木脂素类化合物及其制备方法、鉴定方法和应用 |
PT2430017T (pt) | 2009-05-14 | 2016-10-12 | Madaus Gmbh | Método para a preparação de silibinina amorfa |
EP2742954A1 (en) * | 2012-12-17 | 2014-06-18 | INDENA S.p.A. | "Silymarin aqueous formulation" |
KR101878599B1 (ko) * | 2017-03-28 | 2018-07-13 | 전북대학교산학협력단 | 메틸설포닐메테인과 만니톨의 흡수촉진 및 고미감소를 위한 공침조성물과 이의 제조방법 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5238085A (en) * | 1975-09-19 | 1977-03-24 | Toyobo Co Ltd | Method of producing arabinogalactanase |
GB1554662A (en) * | 1976-05-05 | 1979-10-24 | Inverni Della Beffa Spa | Polyhydroxyphenylchromanones |
DE3537656A1 (de) * | 1984-11-22 | 1986-05-22 | Dr. Madaus GmbH & Co, 5000 Köln | Verfahren zur herstellung von isosilybinfreiem silibinin und arzneimittel, enthaltend silibinin |
IT1215291B (it) * | 1985-07-17 | 1990-01-31 | Inverni Della Beffa Spa | Complessi di flavanolignani con fosfolipidi, loro preparazione e relative composizioni farmaceutiche. |
IT1187687B (it) * | 1985-07-17 | 1987-12-23 | Inverni Della Beffa Spa | Composizioni farmaceutiche contenenti come principi attivi flavanolignani e fosfolipidi |
IT1245761B (it) * | 1991-01-30 | 1994-10-14 | Alfa Wassermann Spa | Formulazioni farmaceutiche contenenti glicosaminoglicani assorbibili per via orale. |
EP0577143B1 (de) * | 1992-07-03 | 1999-01-27 | ALFATEC-PHARMA GmbH | Feste und flüssige Lösungen von Flavonoiden |
DE4401646A1 (de) * | 1994-01-21 | 1995-07-27 | Krewel Werke Gmbh | Optimal freisetzende Kava-Extrakte |
-
1995
- 1995-01-18 DE DE19501266A patent/DE19501266A1/de not_active Ceased
-
1996
- 1996-01-16 ES ES96100528T patent/ES2248802T3/es not_active Expired - Lifetime
- 1996-01-16 EP EP96100528A patent/EP0722719B1/de not_active Expired - Lifetime
- 1996-01-16 DE DE59611266T patent/DE59611266D1/de not_active Expired - Lifetime
- 1996-01-16 AT AT96100528T patent/ATE303134T1/de active
- 1996-01-17 CN CN96104331A patent/CN1079674C/zh not_active Expired - Lifetime
- 1996-01-17 RU RU96100835/14A patent/RU2157225C2/ru active IP Right Revival
- 1996-01-17 PL PL96312350A patent/PL188128B1/pl unknown
- 1996-01-17 CZ CZ96142A patent/CZ283405B6/cs not_active IP Right Cessation
- 1996-01-17 KR KR1019960000777A patent/KR100198012B1/ko not_active IP Right Cessation
- 1996-01-17 HU HU9600099A patent/HU225657B1/hu unknown
- 1996-01-18 BR BR9600145A patent/BR9600145A/pt not_active Application Discontinuation
- 1996-01-18 CA CA002167570A patent/CA2167570C/en not_active Expired - Fee Related
- 1996-01-18 JP JP8006581A patent/JP2812909B2/ja not_active Expired - Fee Related
- 1996-01-18 AR ARP960101065A patent/AR002703A1/es active IP Right Grant
- 1996-01-19 TW TW085100637A patent/TW358028B/zh not_active IP Right Cessation
-
1997
- 1997-11-24 US US08/976,771 patent/US5906991A/en not_active Expired - Lifetime
-
1999
- 1999-02-10 US US09/247,612 patent/US6020384A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
KR960028916A (ko) | 1996-08-17 |
JPH08231409A (ja) | 1996-09-10 |
US6020384A (en) | 2000-02-01 |
EP0722719B1 (de) | 2005-08-31 |
HUP9600099A3 (en) | 1998-04-28 |
CN1144677A (zh) | 1997-03-12 |
TW358028B (en) | 1999-05-11 |
ATE303134T1 (de) | 2005-09-15 |
HU225657B1 (en) | 2007-05-29 |
PL312350A1 (en) | 1996-07-22 |
JP2812909B2 (ja) | 1998-10-22 |
US5906991A (en) | 1999-05-25 |
RU2157225C2 (ru) | 2000-10-10 |
CZ283405B6 (cs) | 1998-04-15 |
HUP9600099A2 (en) | 1997-05-28 |
DE19501266A1 (de) | 1996-07-25 |
BR9600145A (pt) | 1998-01-06 |
DE59611266D1 (de) | 2005-10-06 |
CA2167570C (en) | 1999-03-16 |
KR100198012B1 (ko) | 1999-06-15 |
CA2167570A1 (en) | 1996-07-19 |
PL188128B1 (pl) | 2004-12-31 |
CZ14296A3 (en) | 1996-08-14 |
ES2248802T3 (es) | 2006-03-16 |
CN1079674C (zh) | 2002-02-27 |
HU9600099D0 (en) | 1996-03-28 |
EP0722719A1 (de) | 1996-07-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration |