AR002703A1 - Procedimiento para la preparación de un preparado de flavanolignano y composición en forma de dosificación unitaria oral sólida.. - Google Patents

Procedimiento para la preparación de un preparado de flavanolignano y composición en forma de dosificación unitaria oral sólida..

Info

Publication number
AR002703A1
AR002703A1 ARP960101065A AR10106596A AR002703A1 AR 002703 A1 AR002703 A1 AR 002703A1 AR P960101065 A ARP960101065 A AR P960101065A AR 10106596 A AR10106596 A AR 10106596A AR 002703 A1 AR002703 A1 AR 002703A1
Authority
AR
Argentina
Prior art keywords
preparation
flavanolignan
clear solution
heating
procedure
Prior art date
Application number
ARP960101065A
Other languages
English (en)
Original Assignee
Madaus Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Madaus Gmbh filed Critical Madaus Gmbh
Publication of AR002703A1 publication Critical patent/AR002703A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Procedimiento para la elaboración de un preparado de flavanolignano con una liberación mejorada en comparación con la del flavanolignano puro,caracterizado por el hecho de que se prepara (a) una solución alcoholicoacuosa de substancias vehicularesf armacéuticamente aceptables y agentes humectantes,suspendiendo en esta solución un flavanolignano calentando la mezcla obtenida hasta la temperatura de ebullición para formar una solución clara, o (b) sesuspende un flavanolignano y un agentehumect ante en alcohol, calentando la suspensión obtenida con agitación hasta la formación de una solución clara,adicionando esta última con una solución acuosa de substancias vehiculares farmacéuticamente aceptables, calentando la mezclaobtenida bajo agitaciónhasta estar en presencia de una solución clara, y de que a continuación se concentra la solución clara obtenida según (a) o (b) para la formación de unco-precipitado, el que se filtra, secándose el co-precipitadooriginado bajo vacío.
ARP960101065A 1995-01-18 1996-01-18 Procedimiento para la preparación de un preparado de flavanolignano y composición en forma de dosificación unitaria oral sólida.. AR002703A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19501266A DE19501266A1 (de) 1995-01-18 1995-01-18 Verfahren zur Herstellung von Flavano-Lignan-Zubereitungen mit verbesserter Freisetzung und Resorbierbarkeit danach erhältliche Zubereitungen und deren Verwendung zur Herstellung von Arzneimitteln

Publications (1)

Publication Number Publication Date
AR002703A1 true AR002703A1 (es) 1998-04-29

Family

ID=7751686

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960101065A AR002703A1 (es) 1995-01-18 1996-01-18 Procedimiento para la preparación de un preparado de flavanolignano y composición en forma de dosificación unitaria oral sólida..

Country Status (16)

Country Link
US (2) US5906991A (es)
EP (1) EP0722719B1 (es)
JP (1) JP2812909B2 (es)
KR (1) KR100198012B1 (es)
CN (1) CN1079674C (es)
AR (1) AR002703A1 (es)
AT (1) ATE303134T1 (es)
BR (1) BR9600145A (es)
CA (1) CA2167570C (es)
CZ (1) CZ283405B6 (es)
DE (2) DE19501266A1 (es)
ES (1) ES2248802T3 (es)
HU (1) HU225657B1 (es)
PL (1) PL188128B1 (es)
RU (1) RU2157225C2 (es)
TW (1) TW358028B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19814014A1 (de) 1997-12-19 1999-09-30 Krewel Meuselbach Gmbh Arzneipflanzentrockenextrakte
DE19915178A1 (de) 1999-04-03 2000-10-05 Univ Mainz Johannes Gutenberg Hepatitis C Virus Zellkultursystem
US7175855B1 (en) 1999-05-27 2007-02-13 Pfizer Inc. Ziprasidone suspension
WO2001054673A1 (en) * 2000-01-31 2001-08-02 The University Of British Columbia Method for preparing and administering medicinal plant material
KR100385366B1 (ko) * 2001-03-05 2003-05-27 부광약품 주식회사 생체이용율을 개선한 실리마린 제제 조성물
CZ292832B6 (cs) * 2001-08-30 2003-12-17 Ivax Pharmaceuticals S.R.O. Způsob přípravy silymarinu se zvýšenou rozpustností
GB2432788C (en) 2004-07-07 2018-06-27 Integria Healthcare Australia Pty Ltd An echinacea formulation
CN101164537B (zh) * 2006-10-16 2010-08-25 江苏大学 高效口服水飞蓟宾缓释制剂及其制备方法
FR2907680B1 (fr) * 2006-10-27 2012-12-28 Scras Utilisation therapeutique d'au moins une neurotoxine botulique dans le traitement de la douleur induite par au moins un agent anti-cancereux
DE102008039271A1 (de) 2007-12-23 2009-06-25 Euromed Sa Neuer Mariendistelextrakt, Verfahren zur Herstellung und Verwendung
CZ2008407A3 (cs) 2008-06-26 2009-08-26 Agra Group, A. S. Vodorozpustný prípravek na bázi flavanonol lignanu a zpusob jeho prípravy
CN101429107B (zh) * 2008-11-18 2013-03-20 云南民族大学 一种木脂素类化合物及其制备方法、鉴定方法和应用
PT2430017T (pt) 2009-05-14 2016-10-12 Madaus Gmbh Método para a preparação de silibinina amorfa
EP2742954A1 (en) * 2012-12-17 2014-06-18 INDENA S.p.A. "Silymarin aqueous formulation"
KR101878599B1 (ko) * 2017-03-28 2018-07-13 전북대학교산학협력단 메틸설포닐메테인과 만니톨의 흡수촉진 및 고미감소를 위한 공침조성물과 이의 제조방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5238085A (en) * 1975-09-19 1977-03-24 Toyobo Co Ltd Method of producing arabinogalactanase
GB1554662A (en) * 1976-05-05 1979-10-24 Inverni Della Beffa Spa Polyhydroxyphenylchromanones
DE3537656A1 (de) * 1984-11-22 1986-05-22 Dr. Madaus GmbH & Co, 5000 Köln Verfahren zur herstellung von isosilybinfreiem silibinin und arzneimittel, enthaltend silibinin
IT1215291B (it) * 1985-07-17 1990-01-31 Inverni Della Beffa Spa Complessi di flavanolignani con fosfolipidi, loro preparazione e relative composizioni farmaceutiche.
IT1187687B (it) * 1985-07-17 1987-12-23 Inverni Della Beffa Spa Composizioni farmaceutiche contenenti come principi attivi flavanolignani e fosfolipidi
IT1245761B (it) * 1991-01-30 1994-10-14 Alfa Wassermann Spa Formulazioni farmaceutiche contenenti glicosaminoglicani assorbibili per via orale.
EP0577143B1 (de) * 1992-07-03 1999-01-27 ALFATEC-PHARMA GmbH Feste und flüssige Lösungen von Flavonoiden
DE4401646A1 (de) * 1994-01-21 1995-07-27 Krewel Werke Gmbh Optimal freisetzende Kava-Extrakte

Also Published As

Publication number Publication date
KR960028916A (ko) 1996-08-17
JPH08231409A (ja) 1996-09-10
US6020384A (en) 2000-02-01
EP0722719B1 (de) 2005-08-31
HUP9600099A3 (en) 1998-04-28
CN1144677A (zh) 1997-03-12
TW358028B (en) 1999-05-11
ATE303134T1 (de) 2005-09-15
HU225657B1 (en) 2007-05-29
PL312350A1 (en) 1996-07-22
JP2812909B2 (ja) 1998-10-22
US5906991A (en) 1999-05-25
RU2157225C2 (ru) 2000-10-10
CZ283405B6 (cs) 1998-04-15
HUP9600099A2 (en) 1997-05-28
DE19501266A1 (de) 1996-07-25
BR9600145A (pt) 1998-01-06
DE59611266D1 (de) 2005-10-06
CA2167570C (en) 1999-03-16
KR100198012B1 (ko) 1999-06-15
CA2167570A1 (en) 1996-07-19
PL188128B1 (pl) 2004-12-31
CZ14296A3 (en) 1996-08-14
ES2248802T3 (es) 2006-03-16
CN1079674C (zh) 2002-02-27
HU9600099D0 (en) 1996-03-28
EP0722719A1 (de) 1996-07-24

Similar Documents

Publication Publication Date Title
AR002703A1 (es) Procedimiento para la preparación de un preparado de flavanolignano y composición en forma de dosificación unitaria oral sólida..
PT76107A (en) Process for preparing new 6-substituted-s-triazolo <3,4-a>phthalazine derivatives and of pharmaceutical compositions containing the same
FR2368270A1 (fr) Comprime destine au nettoyage des protheses dentaires ou d'autres appareils semblables, et procede de preparation de ce comprime
IT1255729B (it) Derivati di s-triazina come agenti fotostabilizzanti
ES491224A0 (es) Procedimiento para la preparacion de anilidas de acidos 4- amino-2-ureido-(o-tioureido)-pirimidin-5-carboxilicos
SG46307A1 (en) New pyrazine derivatives the preparation and use thereof
PT76495A (en) Process for preparing new imidazolphenyl-tetrahydropyridazines
IL78691A (en) Quinolylglycinamide derivatives,their preparation and pharmaceutical compositions containing them
PE78799A1 (es) Sal de hemisulfato del (1s,4r)-cis-4-[2-amino-6-(ciclopropilamino)-9h-purin-9-il]-2-ciclopenten-1-metanol
EP0114788A3 (en) Aqueous composition containing polymaleic acid, surfactants and complexing agents as well as its preparation and use as assistant in the pretreatment of cellulose containing fibrous materials
AU4812485A (en) 1h-indol-3-yl containing 1,3-dimethyl-1h-purine-2,6-diones
BR9508629A (pt) Composto solvato e hidrato do mesmo processos para o tratamento ou profilaxia de uma infecção viral num ser humano e para a preparação do composto uso de um composto e formulação farmacêutica
PT81109B (en) Process for preparing 7-<2-(dialkilamino)-ethyl>-4-hidroxy-1,3--benzimidazol-2-ones
ZA836663B (en) Isoquinoline derivatives,a process for their preparation,pharmaceutical formulations based on these compounds and the use thereof
KR100884685B1 (ko) 신속 방출 활성 물질을 함유하는 초순도 플루다라 경구제제
PT84399B (en) Process for the preparation of pharmaceutical compositions containing sodium 2-(2,6-dichloroanilino) phenylacetate
ES2036174T3 (es) Un procedimiento para la preparacion de una combinacion broncodilatadora de prazosin-pirbuterol.
ES2047540T3 (es) Compuesto farmaceutico y procedimiento para su preparacion.
ES516694A0 (es) Procedimiento de preparacion de derivados de la 4-fenil quinazolina.
ZA874470B (en) New tetrahydrobenzothiazoles,and the preparation and use thereof
EP0086453A3 (en) Thiazaspiro derivatives, process for their preparation and pharmaceutical composition
ZA876995B (en) Derivatives of indole,their preparation process,their use in combatting parasites and the compositions containing them
ZA807789B (en) Piperidine derivatives,their preparation,and pharmaceutical formulations containing these compounds
ES525464A0 (es) Procedimiento para la preparacion de esteres piridincarboxilicos de dipamina y de sus derivados n-alquilicos.
IL96372A0 (en) Imidazoquinoxaline compounds,their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
FG Grant, registration