PE78799A1 - Sal de hemisulfato del (1s,4r)-cis-4-[2-amino-6-(ciclopropilamino)-9h-purin-9-il]-2-ciclopenten-1-metanol - Google Patents

Sal de hemisulfato del (1s,4r)-cis-4-[2-amino-6-(ciclopropilamino)-9h-purin-9-il]-2-ciclopenten-1-metanol

Info

Publication number
PE78799A1
PE78799A1 PE1998000374A PE00037498A PE78799A1 PE 78799 A1 PE78799 A1 PE 78799A1 PE 1998000374 A PE1998000374 A PE 1998000374A PE 00037498 A PE00037498 A PE 00037498A PE 78799 A1 PE78799 A1 PE 78799A1
Authority
PE
Peru
Prior art keywords
purin
cis
methanol
amino
ciclopropilamino
Prior art date
Application number
PE1998000374A
Other languages
English (en)
Inventor
Couper Brodie Alastair
Francis Jones Martin
Frederick Seager John
John Wallis Christopher
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10812407&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE78799(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE78799A1 publication Critical patent/PE78799A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Abstract

SE REFIERE AL HEMISULFATO DE (1S,4R)-CIS-4-[2-AMINO-6-(CICLOPROPILAMINO)-9H-PURIN-9-IL]-2-CICLOPENTEN-1-METANOL, O SU SOLVATO O HIDRATO. LA SAL DE HEMISULFATO FORMA UN POLVO QUE FLUYE LIBREMENTE, NO SE AGLOMERA Y ES VERTIDO Y COMPACTADO FACILMENTE; SIENDO MAS SOLUBLE EN AGUA QUE LA SAL DE SUCCINATO DEL COMPUESTO. TAMBIEN SE REFIERE AL PROCEDIMIENTO PARA LA PREPARACION QUE COMPRENDE LA MEZCLA DEL ACIDO SULFURICO Y DEL (1S, 4R)-CIS-4-[2-AMINO-6-(CICLOPROPILAMINO)-9H-PURIN-9-IL]-2-CICLOPENTEN-1-METANOL EN UNA PROPORCION DE 1:2. EL COMPUESTO PUEDE SER UTIL PARA EL TRATAMIENTO DE UNA INFECCION VIRAL PROVOCADA POR VIH O VIRUS DE LA HEPATITIS (VHB)
PE1998000374A 1997-05-17 1998-05-14 Sal de hemisulfato del (1s,4r)-cis-4-[2-amino-6-(ciclopropilamino)-9h-purin-9-il]-2-ciclopenten-1-metanol PE78799A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9709945.1A GB9709945D0 (en) 1997-05-17 1997-05-17 A novel salt

Publications (1)

Publication Number Publication Date
PE78799A1 true PE78799A1 (es) 1999-08-31

Family

ID=10812407

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000374A PE78799A1 (es) 1997-05-17 1998-05-14 Sal de hemisulfato del (1s,4r)-cis-4-[2-amino-6-(ciclopropilamino)-9h-purin-9-il]-2-ciclopenten-1-metanol

Country Status (51)

Country Link
US (1) US6294540B1 (es)
EP (1) EP0983271B1 (es)
JP (2) JP3150711B2 (es)
KR (1) KR100521292B1 (es)
CN (2) CN1150194C (es)
AP (1) AP2009A (es)
AR (2) AR015668A1 (es)
AT (1) ATE259811T1 (es)
AU (1) AU739953B2 (es)
BG (1) BG64390B1 (es)
BR (1) BRPI9809126B8 (es)
CA (1) CA2289753C (es)
CO (1) CO4940435A1 (es)
DE (1) DE69821758T2 (es)
DK (1) DK0983271T3 (es)
DZ (1) DZ2493A1 (es)
EA (1) EA001809B1 (es)
EE (1) EE03924B1 (es)
EG (1) EG23836A (es)
ES (1) ES2214712T3 (es)
GB (3) GB9709945D0 (es)
GE (1) GEP20022680B (es)
HK (1) HK1024236A1 (es)
HN (1) HN1998000071A (es)
HR (1) HRP980265B1 (es)
HU (1) HU226563B1 (es)
ID (1) ID24910A (es)
IL (2) IL132793A0 (es)
IS (1) IS2207B (es)
JO (1) JO2032B1 (es)
MA (1) MA26498A1 (es)
MY (1) MY120151A (es)
NO (1) NO324731B1 (es)
NZ (2) NZ510622A (es)
OA (1) OA11304A (es)
PA (1) PA8451301A1 (es)
PE (1) PE78799A1 (es)
PL (1) PL189527B1 (es)
PT (1) PT983271E (es)
RS (1) RS49655B (es)
SA (1) SA98190179B1 (es)
SI (1) SI0983271T1 (es)
SK (1) SK285159B6 (es)
SV (1) SV1998000057A (es)
TN (1) TNSN98065A1 (es)
TR (1) TR199902810T2 (es)
TW (1) TW480259B (es)
UA (1) UA56231C2 (es)
UY (1) UY25004A1 (es)
WO (1) WO1998052949A1 (es)
ZA (2) ZA984085B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9802472D0 (en) * 1998-02-06 1998-04-01 Glaxo Group Ltd Pharmaceutical compositions
HU226998B1 (en) * 2000-11-23 2010-04-28 Richter Gedeon Nyrt Desloratadine hemisulphate, process for the preparation thereof and pharmaceutical compositions containing the same
GB0320738D0 (en) 2003-09-04 2003-10-08 Glaxo Group Ltd Novel process
CA2662586A1 (en) * 2006-09-28 2008-04-03 Esteve Quimica, S.A. Process for the preparation of abacavir
EP1905772A1 (en) 2006-09-28 2008-04-02 Esteve Quimica, S.A. Process for the preparation of abacavir
EP2085397A1 (en) 2008-01-21 2009-08-05 Esteve Quimica, S.A. Crystalline form of abacavir
EP2218721A1 (en) * 2009-02-11 2010-08-18 LEK Pharmaceuticals d.d. Novel salts of sitagliptin
EP2305680A3 (en) 2009-09-30 2011-05-18 Aurobindo Pharma Limited Novel salts of (1S,4R)-cis-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol
UA105556C2 (uk) 2010-01-27 2014-05-26 Віів Гелскер Компані Комбінація сполук, що містить інгібітори віл інтегрази з іншими терапевтичними агентами
WO2012137227A2 (en) 2011-04-08 2012-10-11 Laurus Labs Private Limited Solid forms of antiretroviral compounds, process for the preparation and their pharmaceutical composition thereof
WO2014133085A1 (ja) 2013-02-27 2014-09-04 国立大学法人京都大学 がんの予防または治療用医薬組成物
CN104788451A (zh) * 2014-01-21 2015-07-22 浙江九洲药业股份有限公司 一种阿巴卡韦的制备方法
CN105315280A (zh) * 2014-06-06 2016-02-10 上海迪赛诺化学制药有限公司 一种阿巴卡韦结晶体及其制备方法
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY104575A (en) * 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
GB9417249D0 (en) * 1994-08-26 1994-10-19 Wellcome Found A novel salt
MY115461A (en) * 1995-03-30 2003-06-30 Wellcome Found Synergistic combinations of zidovudine, 1592u89 and 3tc
TR199802703T2 (xx) 1996-06-25 1999-03-22 Glaxo Group Limited HIV tedavisinde Vx478, Zidov�din, ve/veya 1592U89 i�eren kombinasyonlar�n kullan�m�.

Also Published As

Publication number Publication date
CA2289753A1 (en) 1998-11-26
GB9926839D0 (en) 2000-01-12
HU226563B1 (en) 2009-04-28
EP0983271B1 (en) 2004-02-18
IL132793A0 (en) 2001-03-19
MY120151A (en) 2005-09-30
AR015668A1 (es) 2001-05-16
GB2348202B (en) 2001-08-08
SI0983271T1 (en) 2004-06-30
HRP980265A2 (en) 1999-02-28
EA199900944A1 (ru) 2000-06-26
CN100408580C (zh) 2008-08-06
JP2000514096A (ja) 2000-10-24
ATE259811T1 (de) 2004-03-15
GB2340491A (en) 2000-02-23
SK285159B6 (sk) 2006-07-07
EE9900537A (et) 2000-06-15
CO4940435A1 (es) 2000-07-24
TR199902810T2 (xx) 2000-02-21
IL132793A (en) 2006-10-31
GB0010222D0 (en) 2000-06-14
DZ2493A1 (fr) 2004-06-20
GB2348202A (en) 2000-09-27
KR100521292B1 (ko) 2005-10-17
DK0983271T3 (da) 2004-05-10
SV1998000057A (es) 1999-03-02
BRPI9809126B8 (pt) 2021-07-06
YU59599A (es) 2002-08-12
AP2009A (en) 2009-06-26
CA2289753C (en) 2007-01-23
EP0983271A1 (en) 2000-03-08
UA56231C2 (uk) 2003-05-15
HN1998000071A (es) 1999-03-19
AU7765598A (en) 1998-12-11
WO1998052949A1 (en) 1998-11-26
BRPI9809126B1 (pt) 2018-02-06
OA11304A (en) 2003-10-22
EG23836A (en) 2007-10-02
BG103959A (en) 2000-12-29
HUP0002754A3 (en) 2003-01-28
PL189527B1 (pl) 2005-08-31
CN1515572A (zh) 2004-07-28
SK156199A3 (en) 2000-07-11
HK1024236A1 (en) 2000-10-05
BR9809126A (pt) 2000-08-01
CN1150194C (zh) 2004-05-19
NO995622L (no) 2000-01-14
RS49655B (sr) 2007-09-21
ZA984083B (en) 1999-11-15
MA26498A1 (fr) 2004-12-20
NZ510622A (en) 2002-04-26
JP3150711B2 (ja) 2001-03-26
EE03924B1 (et) 2002-12-16
PL336888A1 (en) 2000-07-17
PT983271E (pt) 2004-07-30
ZA984085B (en) 2000-01-26
KR20010012623A (ko) 2001-02-26
BG64390B1 (bg) 2004-12-30
AP9901688A0 (en) 1999-12-31
CN1263529A (zh) 2000-08-16
DE69821758D1 (de) 2004-03-25
AU739953B2 (en) 2001-10-25
ID24910A (id) 2000-08-31
ES2214712T3 (es) 2004-09-16
JP2000327679A (ja) 2000-11-28
IS5246A (is) 1999-11-11
AR059120A2 (es) 2008-03-12
NO995622D0 (no) 1999-11-16
SA98190179B1 (ar) 2006-08-15
HUP0002754A2 (hu) 2001-06-28
NZ500865A (en) 2001-04-27
TNSN98065A1 (fr) 2005-03-15
DE69821758T2 (de) 2005-01-13
PA8451301A1 (es) 2000-05-24
GB9709945D0 (en) 1997-07-09
GEP20022680B (en) 2002-04-25
US6294540B1 (en) 2001-09-25
UY25004A1 (es) 2000-10-31
GB2340491B (en) 2000-10-18
EA001809B1 (ru) 2001-08-27
IS2207B (is) 2007-02-15
NO324731B1 (no) 2007-12-03
JO2032B1 (en) 1999-05-15
TW480259B (en) 2002-03-21
HRP980265B1 (en) 2004-10-31

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