AP1192A - Solubilized sertraline compositions. - Google Patents
Solubilized sertraline compositions. Download PDFInfo
- Publication number
- AP1192A AP1192A APAP/P/1998/001280A AP9801280A AP1192A AP 1192 A AP1192 A AP 1192A AP 9801280 A AP9801280 A AP 9801280A AP 1192 A AP1192 A AP 1192A
- Authority
- AP
- ARIPO
- Prior art keywords
- composition
- sertraline
- matter
- solubilizing agent
- acid
- Prior art date
Links
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 title claims abstract description 133
- 229960002073 sertraline Drugs 0.000 title claims abstract description 126
- 239000000203 mixture Substances 0.000 title claims abstract description 75
- 239000002904 solvent Substances 0.000 claims abstract description 85
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims abstract description 31
- 239000002552 dosage form Substances 0.000 claims description 49
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 31
- 150000007524 organic acids Chemical class 0.000 claims description 31
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 29
- GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical compound CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 claims description 29
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 26
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 26
- 150000003839 salts Chemical class 0.000 claims description 26
- 238000012360 testing method Methods 0.000 claims description 23
- 125000005456 glyceride group Chemical group 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 18
- 229940093915 gynecological organic acid Drugs 0.000 claims description 16
- 235000005985 organic acids Nutrition 0.000 claims description 16
- 229920001223 polyethylene glycol Polymers 0.000 claims description 16
- 238000013270 controlled release Methods 0.000 claims description 14
- 239000011780 sodium chloride Substances 0.000 claims description 14
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 13
- 230000003381 solubilizing effect Effects 0.000 claims description 13
- 235000010323 ascorbic acid Nutrition 0.000 claims description 12
- -1 organic acid salts Chemical class 0.000 claims description 12
- ARIWANIATODDMH-UHFFFAOYSA-N rac-1-monolauroylglycerol Chemical compound CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 claims description 12
- 239000011668 ascorbic acid Substances 0.000 claims description 11
- 235000015165 citric acid Nutrition 0.000 claims description 11
- 239000002202 Polyethylene glycol Substances 0.000 claims description 10
- 229960005070 ascorbic acid Drugs 0.000 claims description 10
- CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 10
- 150000002334 glycols Chemical class 0.000 claims description 10
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims description 10
- 229960005261 aspartic acid Drugs 0.000 claims description 9
- 235000003704 aspartic acid Nutrition 0.000 claims description 9
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 238000001727 in vivo Methods 0.000 claims description 9
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 8
- 235000010216 calcium carbonate Nutrition 0.000 claims description 8
- 230000000052 comparative effect Effects 0.000 claims description 8
- 230000036961 partial effect Effects 0.000 claims description 8
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 7
- 229960002989 glutamic acid Drugs 0.000 claims description 7
- 229940087068 glyceryl caprylate Drugs 0.000 claims description 7
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 claims description 6
- 239000001639 calcium acetate Substances 0.000 claims description 6
- 235000011092 calcium acetate Nutrition 0.000 claims description 6
- 229960005147 calcium acetate Drugs 0.000 claims description 6
- 229960003563 calcium carbonate Drugs 0.000 claims description 6
- 150000002148 esters Chemical class 0.000 claims description 6
- 235000013922 glutamic acid Nutrition 0.000 claims description 6
- 239000004220 glutamic acid Substances 0.000 claims description 6
- 229940068939 glyceryl monolaurate Drugs 0.000 claims description 6
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 5
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 5
- 229920001451 polypropylene glycol Polymers 0.000 claims description 5
- 229920000136 polysorbate Polymers 0.000 claims description 5
- 150000005846 sugar alcohols Polymers 0.000 claims description 5
- 150000005323 carbonate salts Chemical class 0.000 claims description 4
- 229960004106 citric acid Drugs 0.000 claims description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 4
- 239000000783 alginic acid Substances 0.000 claims 4
- 235000010443 alginic acid Nutrition 0.000 claims 4
- 229920000615 alginic acid Polymers 0.000 claims 4
- 229960001126 alginic acid Drugs 0.000 claims 4
- 150000004781 alginic acids Chemical group 0.000 claims 4
- 239000008159 sesame oil Substances 0.000 claims 4
- 235000011803 sesame oil Nutrition 0.000 claims 4
- 239000001509 sodium citrate Substances 0.000 claims 4
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 4
- 235000011083 sodium citrates Nutrition 0.000 claims 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 4
- 235000019483 Peanut oil Nutrition 0.000 claims 3
- 239000000312 peanut oil Substances 0.000 claims 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 239000003921 oil Substances 0.000 claims 1
- 235000019198 oils Nutrition 0.000 claims 1
- 239000000243 solution Substances 0.000 description 41
- 239000000546 pharmaceutical excipient Substances 0.000 description 33
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 24
- 239000011248 coating agent Substances 0.000 description 18
- 238000000576 coating method Methods 0.000 description 18
- 229940079593 drug Drugs 0.000 description 14
- 239000003814 drug Substances 0.000 description 14
- 238000009472 formulation Methods 0.000 description 14
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 13
- 239000008101 lactose Substances 0.000 description 13
- 239000002253 acid Substances 0.000 description 11
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 10
- 238000004090 dissolution Methods 0.000 description 9
- 239000000499 gel Substances 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 150000007513 acids Chemical class 0.000 description 8
- 239000011575 calcium Substances 0.000 description 8
- 238000001879 gelation Methods 0.000 description 8
- 238000013268 sustained release Methods 0.000 description 8
- 239000012730 sustained-release form Substances 0.000 description 8
- 230000008901 benefit Effects 0.000 description 7
- 239000012528 membrane Substances 0.000 description 7
- 230000003204 osmotic effect Effects 0.000 description 7
- 239000012085 test solution Substances 0.000 description 7
- GLQPTZAAUROJMO-UHFFFAOYSA-N 4-(3,4-dimethoxyphenyl)benzaldehyde Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC=C(C=O)C=C1 GLQPTZAAUROJMO-UHFFFAOYSA-N 0.000 description 6
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 6
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 238000000338 in vitro Methods 0.000 description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- 239000011159 matrix material Substances 0.000 description 6
- 229960003660 sertraline hydrochloride Drugs 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 5
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 5
- 229930091371 Fructose Natural products 0.000 description 5
- 239000005715 Fructose Substances 0.000 description 5
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 5
- 239000002775 capsule Substances 0.000 description 5
- 239000001087 glyceryl triacetate Substances 0.000 description 5
- 235000013773 glyceryl triacetate Nutrition 0.000 description 5
- 230000007246 mechanism Effects 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 239000002244 precipitate Substances 0.000 description 5
- 230000002829 reductive effect Effects 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 229960002622 triacetin Drugs 0.000 description 5
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 4
- CIWBSHSKHKDKBQ-DUZGATOHSA-N D-araboascorbic acid Natural products OC[C@@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-DUZGATOHSA-N 0.000 description 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 4
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 4
- 229920001400 block copolymer Polymers 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 230000003111 delayed effect Effects 0.000 description 4
- 235000010350 erythorbic acid Nutrition 0.000 description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N hexanedioic acid Natural products OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 4
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- 150000003904 phospholipids Chemical class 0.000 description 4
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- GTZCVFVGUGFEME-UHFFFAOYSA-N trans-aconitic acid Natural products OC(=O)CC(C(O)=O)=CC(O)=O GTZCVFVGUGFEME-UHFFFAOYSA-N 0.000 description 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 4
- 239000001124 (E)-prop-1-ene-1,2,3-tricarboxylic acid Substances 0.000 description 3
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 3
- CTXGTHVAWRBISV-UHFFFAOYSA-N 2-hydroxyethyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCO CTXGTHVAWRBISV-UHFFFAOYSA-N 0.000 description 3
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 3
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- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 3
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- KGUHOFWIXKIURA-VQXBOQCVSA-N [(2r,3s,4s,5r,6r)-6-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl dodecanoate Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](COC(=O)CCCCCCCCCCC)O[C@@H]1O[C@@]1(CO)[C@@H](O)[C@H](O)[C@@H](CO)O1 KGUHOFWIXKIURA-VQXBOQCVSA-N 0.000 description 2
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5141397P | 1997-07-01 | 1997-07-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AP9801280A0 AP9801280A0 (en) | 1998-06-30 |
| AP1192A true AP1192A (en) | 2003-07-23 |
Family
ID=21971159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| APAP/P/1998/001280A AP1192A (en) | 1997-07-01 | 1998-06-25 | Solubilized sertraline compositions. |
Country Status (34)
| Country | Link |
|---|---|
| EP (1) | EP0999829A1 (es) |
| JP (1) | JP2000514100A (es) |
| KR (1) | KR100366373B1 (es) |
| CN (1) | CN1261794A (es) |
| AP (1) | AP1192A (es) |
| AR (3) | AR015917A1 (es) |
| AU (1) | AU742535B2 (es) |
| BG (1) | BG103918A (es) |
| BR (1) | BR9810739A (es) |
| CA (1) | CA2290974C (es) |
| CO (1) | CO4940495A1 (es) |
| DZ (1) | DZ2548A1 (es) |
| EA (1) | EA002481B1 (es) |
| HN (1) | HN1998000102A (es) |
| HR (1) | HRP980377A2 (es) |
| HU (1) | HUP0002236A3 (es) |
| ID (1) | ID23429A (es) |
| IL (1) | IL133076A (es) |
| IS (1) | IS5260A (es) |
| MA (1) | MA24587A1 (es) |
| NO (1) | NO996520L (es) |
| OA (1) | OA11243A (es) |
| PA (1) | PA8454301A1 (es) |
| PE (1) | PE97199A1 (es) |
| PL (1) | PL337804A1 (es) |
| SK (1) | SK181099A3 (es) |
| TN (1) | TNSN98124A1 (es) |
| TR (1) | TR199903297T2 (es) |
| TW (1) | TW550087B (es) |
| UA (1) | UA67741C2 (es) |
| UY (1) | UY25071A1 (es) |
| WO (1) | WO1999001120A1 (es) |
| YU (1) | YU68299A (es) |
| ZA (1) | ZA985708B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DZ3227A1 (fr) | 1999-12-23 | 2001-07-05 | Pfizer Prod Inc | Compositions pharmaceutiques fournissant des concentrations de medicaments ameliorees |
| US20030086972A1 (en) * | 2000-08-09 | 2003-05-08 | Appel Leah E. | Hydrogel-driven drug dosage form |
| MXPA03001771A (es) | 2000-08-30 | 2003-06-04 | Pfizer Prod Inc | Formulaciones de liberacion sostenida para secretagogos de hormona del crecimiento. |
| US20040191207A1 (en) * | 2003-03-31 | 2004-09-30 | Lipari John M. | Alpha-hydroxy acid ester drug delivery compositions and methods of use |
| CN101631593B (zh) * | 2007-03-12 | 2014-08-13 | 帝斯曼知识产权资产管理有限公司 | 化妆品组合物 |
| BR112012003592B8 (pt) | 2009-08-19 | 2021-05-25 | Eisai R&D Man Co Ltd | composição farmacêutica contendo derivado de quinolina |
| US20130035344A1 (en) * | 2009-12-29 | 2013-02-07 | Kowa Co., Ltd. | Pharmaceutical composition for oral administration |
| JPWO2011081117A1 (ja) * | 2009-12-29 | 2013-05-09 | 興和株式会社 | 経口投与用固形医薬組成物 |
| CN109908354A (zh) * | 2017-12-12 | 2019-06-21 | 万特制药(海南)有限公司 | 盐酸舍曲林口服浓缩液及其制备工艺 |
| CN114894736B (zh) * | 2022-05-20 | 2025-03-21 | 中化地质矿山总局地质研究院 | 一种氯化物型卤水中硝酸根的测定方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0415612A2 (en) * | 1989-08-30 | 1991-03-06 | Pfizer Inc. | Use of sertraline for the treatment of chemical dependencies |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4803076A (en) * | 1986-09-04 | 1989-02-07 | Pfizer Inc. | Controlled release device for an active substance |
| ZA97976B (en) * | 1996-04-05 | 1997-08-18 | Alza Corp | Uniform drug delivery theraphy. |
-
1998
- 1998-06-15 BR BR9810739-9A patent/BR9810739A/pt not_active Application Discontinuation
- 1998-06-15 ID IDW991701A patent/ID23429A/id unknown
- 1998-06-15 SK SK1810-99A patent/SK181099A3/sk unknown
- 1998-06-15 EA EA199900962A patent/EA002481B1/ru unknown
- 1998-06-15 TR TR1999/03297T patent/TR199903297T2/xx unknown
- 1998-06-15 WO PCT/IB1998/000933 patent/WO1999001120A1/en not_active Ceased
- 1998-06-15 IL IL13307698A patent/IL133076A/xx not_active IP Right Cessation
- 1998-06-15 YU YU68299A patent/YU68299A/sh unknown
- 1998-06-15 CN CN98806763A patent/CN1261794A/zh active Pending
- 1998-06-15 CA CA002290974A patent/CA2290974C/en not_active Expired - Fee Related
- 1998-06-15 JP JP11506774A patent/JP2000514100A/ja active Pending
- 1998-06-15 PL PL98337804A patent/PL337804A1/xx unknown
- 1998-06-15 KR KR10-1999-7011361A patent/KR100366373B1/ko not_active Expired - Fee Related
- 1998-06-15 AU AU75448/98A patent/AU742535B2/en not_active Ceased
- 1998-06-15 HU HU0002236A patent/HUP0002236A3/hu unknown
- 1998-06-15 UA UA99116391A patent/UA67741C2/uk unknown
- 1998-06-15 EP EP98923019A patent/EP0999829A1/en not_active Withdrawn
- 1998-06-25 AP APAP/P/1998/001280A patent/AP1192A/en active
- 1998-06-25 TW TW087110267A patent/TW550087B/zh active
- 1998-06-26 PE PE1998000573A patent/PE97199A1/es not_active Application Discontinuation
- 1998-06-29 UY UY25071A patent/UY25071A1/es not_active IP Right Cessation
- 1998-06-29 AR ARP980103146A patent/AR015917A1/es not_active Application Discontinuation
- 1998-06-29 PA PA19988454301A patent/PA8454301A1/es unknown
- 1998-06-30 MA MA25146A patent/MA24587A1/fr unknown
- 1998-06-30 ZA ZA9805708A patent/ZA985708B/xx unknown
- 1998-06-30 TN TNTNSN98124A patent/TNSN98124A1/fr unknown
- 1998-06-30 DZ DZ980158A patent/DZ2548A1/xx active
- 1998-07-01 HN HN1998000102A patent/HN1998000102A/es unknown
- 1998-07-01 CO CO98037137A patent/CO4940495A1/es unknown
- 1998-07-01 HR HR60/051,413A patent/HRP980377A2/hr not_active Application Discontinuation
-
1999
- 1999-11-19 IS IS5260A patent/IS5260A/is unknown
- 1999-11-23 BG BG103918A patent/BG103918A/xx unknown
- 1999-12-21 OA OA9900301A patent/OA11243A/en unknown
- 1999-12-28 NO NO996520A patent/NO996520L/no not_active Application Discontinuation
-
2003
- 2003-06-19 AR ARP030102179A patent/AR040279A2/es unknown
- 2003-06-19 AR ARP030102180A patent/AR040280A2/es unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0415612A2 (en) * | 1989-08-30 | 1991-03-06 | Pfizer Inc. | Use of sertraline for the treatment of chemical dependencies |
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