AP118A - Prodrugs of antiflammatory 3-acyl-2-oxindole-1-carboxamides - Google Patents

Prodrugs of antiflammatory 3-acyl-2-oxindole-1-carboxamides Download PDF

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Publication number
AP118A
AP118A APAP/P/1989/000141A AP8900141A AP118A AP 118 A AP118 A AP 118A AP 8900141 A AP8900141 A AP 8900141A AP 118 A AP118 A AP 118A
Authority
AP
ARIPO
Prior art keywords
compound
carbon atoms
calcd
recrystallization
yield
Prior art date
Application number
APAP/P/1989/000141A
Other languages
English (en)
Other versions
AP8900141A0 (en
Inventor
Thomas C Crawford
Lawrence Alan Reiter
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AP8900141A0 publication Critical patent/AP8900141A0/xx
Application granted granted Critical
Publication of AP118A publication Critical patent/AP118A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
APAP/P/1989/000141A 1988-10-18 1989-10-16 Prodrugs of antiflammatory 3-acyl-2-oxindole-1-carboxamides AP118A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1988/003658 WO1990004393A1 (en) 1988-10-18 1988-10-18 Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides

Publications (2)

Publication Number Publication Date
AP8900141A0 AP8900141A0 (en) 1989-10-31
AP118A true AP118A (en) 1991-02-22

Family

ID=22208957

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1989/000141A AP118A (en) 1988-10-18 1989-10-16 Prodrugs of antiflammatory 3-acyl-2-oxindole-1-carboxamides

Country Status (33)

Country Link
US (1) US5118703A (de)
JP (1) JPH07597B2 (de)
KR (1) KR910007237B1 (de)
CN (1) CN1022241C (de)
AP (1) AP118A (de)
AR (1) AR246519A1 (de)
AT (1) ATE125794T1 (de)
AU (1) AU606819B2 (de)
BG (1) BG50834A3 (de)
CA (1) CA1339558C (de)
CZ (1) CZ278983B6 (de)
DD (1) DD285604A5 (de)
DK (1) DK514989A (de)
EG (1) EG19887A (de)
FI (1) FI95253C (de)
HU (1) HU208421B (de)
IE (1) IE66586B1 (de)
IL (1) IL91960A (de)
IS (1) IS1598B (de)
MA (1) MA21657A1 (de)
MX (1) MX18021A (de)
MY (1) MY104238A (de)
NO (1) NO178027C (de)
NZ (1) NZ231044A (de)
OA (1) OA09140A (de)
PH (1) PH27554A (de)
PL (2) PL162316B1 (de)
PT (1) PT92000B (de)
RO (1) RO109195B1 (de)
RU (1) RU2036905C1 (de)
SK (1) SK278175B6 (de)
WO (1) WO1990004393A1 (de)
YU (1) YU48070B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5059693A (en) * 1989-10-06 1991-10-22 Pfizer Inc. Process for making 3-aroyl-2-oxindole-1-carboxamides
WO1994012505A1 (en) * 1992-11-23 1994-06-09 Pfizer Inc. Regioselective synthesis of 4-chloro-2-thiophenecarboxylic acid
US5270331A (en) * 1993-01-26 1993-12-14 Pfizer, Inc. Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides
CA2155664C (en) * 1993-02-09 1999-06-15 Ralph P. Robinson Oxindole 1-[n-(alkoxycarbonyl)]carboxamides and 1-(n-carboxamido)carboxamides as antiinflammatory agents
US5449788A (en) * 1994-01-28 1995-09-12 Catalytica, Inc. Process for preparing 2-oxindole-1-carboxamides
CN1094819C (zh) * 1997-04-30 2002-11-27 大兴株式会社 环状坯料之制造装置
EP0984012A3 (de) * 1998-08-31 2001-01-10 Pfizer Products Inc. Stickstoffmonoxid freisetzende Oxindol-Prodrugs mit analgetischen und entzündungshemmenden Eigenschaften
JP2003512396A (ja) * 1999-10-26 2003-04-02 ザ・ユニバーシティ・オブ・テキサス・サウスウエスタン・メディカル・センター インドリン化合物を投与することを含む脱毛症の処置方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE558210A (de) * 1956-06-08
US3564009A (en) * 1966-01-13 1971-02-16 Sumitomo Chemical Co Process for producing 1-acylindole derivatives
BE756447A (fr) * 1969-10-15 1971-03-22 Pfizer Oxindolecarboxamides
US3923996A (en) * 1972-07-31 1975-12-02 Sandoz Ag 3-Substituted-oxindoles in compositions and methods of treating obesity
IE53102B1 (en) * 1981-05-12 1988-06-22 Ici Plc Pharmaceutical spiro-succinimide derivatives
DE3268971D1 (en) * 1981-10-06 1986-03-20 Ici Plc Biochemical process
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
US4752609A (en) * 1985-06-20 1988-06-21 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
UA25898A1 (uk) * 1987-02-02 1999-02-26 Пфайзер Інк. Спосіб одержаhhя кристалічhої hатрієвої солі 5-хлор-3-(2-теhоїл)-2-оксііhдол-1-карбоксаміду
DE68923673T2 (de) * 1988-10-18 1996-01-18 Pfizer Prodrogen von antiinflammatorischen 3-Acyl-2-oxindol-1-carboxamiden.
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives
US5059693A (en) * 1989-10-06 1991-10-22 Pfizer Inc. Process for making 3-aroyl-2-oxindole-1-carboxamides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Chem. Ber. 109 (2) pp.723-739, (1976). *
Chemical Abstracts, Vol. 110, 1989, 18555r; *

Also Published As

Publication number Publication date
IL91960A (en) 1994-04-12
ATE125794T1 (de) 1995-08-15
EG19887A (en) 1996-03-31
NO178027C (no) 1996-01-10
AP8900141A0 (en) 1989-10-31
NO178027B (no) 1995-10-02
NZ231044A (en) 1990-12-21
OA09140A (fr) 1991-10-31
SK590689A3 (en) 1996-03-06
CZ278983B6 (en) 1994-11-16
CZ590689A3 (en) 1994-04-13
KR910007237B1 (ko) 1991-09-24
SK278175B6 (en) 1996-03-06
JPH02149559A (ja) 1990-06-08
HUT58052A (en) 1992-01-28
FI911855A0 (fi) 1991-04-17
IL91960A0 (en) 1990-07-12
CA1339558C (en) 1997-11-25
RU2036905C1 (ru) 1995-06-09
MA21657A1 (fr) 1990-07-01
CN1041938A (zh) 1990-05-09
US5118703A (en) 1992-06-02
WO1990004393A1 (en) 1990-05-03
FI95253C (fi) 1996-01-10
YU48070B (sh) 1997-01-08
DD285604A5 (de) 1990-12-19
IS3509A7 (is) 1990-04-19
DK514989A (da) 1990-04-19
YU200589A (en) 1991-02-28
AU606819B2 (en) 1991-02-14
AU4295689A (en) 1990-04-26
MY104238A (en) 1994-02-28
PT92000A (pt) 1990-04-30
IE66586B1 (en) 1996-01-24
RO109195B1 (ro) 1994-12-30
PL162316B1 (pl) 1993-09-30
NO911512L (no) 1991-06-12
NO911512D0 (no) 1991-04-17
FI95253B (fi) 1995-09-29
AR246519A1 (es) 1994-08-31
JPH07597B2 (ja) 1995-01-11
DK514989D0 (da) 1989-10-17
CN1022241C (zh) 1993-09-29
KR900006285A (ko) 1990-05-07
IE893332L (en) 1990-04-18
HU886740D0 (en) 1991-07-29
PT92000B (pt) 1995-06-30
BG50834A3 (en) 1992-11-16
IS1598B (is) 1996-05-20
PH27554A (en) 1993-08-18
PL163112B1 (pl) 1994-02-28
HU208421B (en) 1993-10-28
MX18021A (es) 1993-11-01

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