ZA985016B - C-4"-substituted macrolide derivatives. - Google Patents

C-4"-substituted macrolide derivatives.

Info

Publication number
ZA985016B
ZA985016B ZA9805016A ZA985016A ZA985016B ZA 985016 B ZA985016 B ZA 985016B ZA 9805016 A ZA9805016 A ZA 9805016A ZA 985016 A ZA985016 A ZA 985016A ZA 985016 B ZA985016 B ZA 985016B
Authority
ZA
South Africa
Prior art keywords
macrolide derivatives
substituted macrolide
substituted
derivatives
macrolide
Prior art date
Application number
ZA9805016A
Other languages
English (en)
Inventor
Brian Scott Bronk
Takushi Kaneko
Michael Anthony Letavic
Hengmiao Cheng
Edward Alan Glazer
Bingwei Vera Yang
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of ZA985016B publication Critical patent/ZA985016B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA9805016A 1997-06-11 1998-06-10 C-4"-substituted macrolide derivatives. ZA985016B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4998097P 1997-06-11 1997-06-11

Publications (1)

Publication Number Publication Date
ZA985016B true ZA985016B (en) 1999-12-10

Family

ID=21962765

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9805016A ZA985016B (en) 1997-06-11 1998-06-10 C-4"-substituted macrolide derivatives.

Country Status (40)

Country Link
EP (1) EP0988309B1 (sk)
JP (1) JP3262806B2 (sk)
KR (1) KR100369959B1 (sk)
CN (1) CN1145636C (sk)
AP (1) AP1189A (sk)
AR (1) AR013085A1 (sk)
AT (1) ATE310742T1 (sk)
AU (1) AU745006C (sk)
BG (1) BG64357B1 (sk)
BR (1) BR9810097A (sk)
CA (1) CA2293397C (sk)
CO (1) CO4950584A1 (sk)
DE (1) DE69832486T2 (sk)
DZ (1) DZ2515A1 (sk)
EA (1) EA002440B1 (sk)
ES (1) ES2251081T3 (sk)
GT (1) GT199800075A (sk)
HK (1) HK1025974A1 (sk)
HN (1) HN1998000074A (sk)
HR (1) HRP980315A2 (sk)
HU (1) HUP0004076A3 (sk)
ID (1) ID24530A (sk)
IL (1) IL132808A (sk)
IS (1) IS1979B (sk)
MA (1) MA24563A1 (sk)
MY (1) MY133027A (sk)
NO (1) NO315560B1 (sk)
NZ (1) NZ500652A (sk)
OA (1) OA11226A (sk)
PA (1) PA8452001A1 (sk)
PE (1) PE79999A1 (sk)
PL (1) PL337497A1 (sk)
SK (1) SK168299A3 (sk)
TN (1) TNSN98084A1 (sk)
TW (2) TWI224106B (sk)
UA (1) UA70298A (sk)
UY (1) UY25041A1 (sk)
WO (1) WO1998056801A1 (sk)
YU (1) YU62999A (sk)
ZA (1) ZA985016B (sk)

Families Citing this family (37)

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EP1779853A3 (en) * 1997-09-10 2010-01-27 Merial Ltd. 9a-azalides as veterinary antimicrobial agents
US6339063B1 (en) 1997-09-10 2002-01-15 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
JP2001515865A (ja) * 1997-09-10 2001-09-25 メルク エンド カムパニー インコーポレーテッド 家畜抗菌剤としての９ａ−アザライド
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
CA2349338C (en) 1998-11-03 2005-12-06 Pfizer Products Inc. Novel macrolide antibiotics
CA2411293A1 (en) * 1999-01-28 2000-07-28 Pfizer Products Inc. Novel azalides and methods of making same
JP2003507487A (ja) * 1999-08-24 2003-02-25 アボット・ラボラトリーズ 抗菌活性を有する９ａ−アザライド類
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
MXPA02007305A (es) 2000-01-27 2002-11-29 Pfizer Prod Inc Composiciones antiboticas de azalida.
JP4104463B2 (ja) * 2001-04-27 2008-06-18 ファイザー・プロダクツ・インク ４’’−置換された−９−デオキソ−９ａ−アザ−９ａ−ホモエリスロマイシン誘導体を製造するための方法
JP2003040782A (ja) * 2001-05-31 2003-02-13 Pfizer Prod Inc アザリド抗生物質組成物
CN100577681C (zh) 2002-07-08 2010-01-06 葛兰素伊斯特拉齐瓦基森塔萨格勒布公司 用于治疗炎性疾病和病症的新化合物、组合物和方法
ES2325495T3 (es) 2002-07-08 2009-09-07 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Moleculas hibridas de macrolidos con moleculas anti-inflamatorias esteroideas y no esteroideas.
CA2489398A1 (en) * 2002-07-08 2004-01-15 Pliva-Istrazivacki Institut D.O.O. Novel nonsteroidal anti-inflammatory substances, compositions and methods for their use
TW200420573A (en) 2002-09-26 2004-10-16 Rib X Pharmaceuticals Inc Bifunctional heterocyclic compounds and methods of making and using same
CA2529817C (en) * 2003-03-10 2013-02-12 Optimer Pharmaceuticals, Inc. Novel antibacterial agents
US7276487B2 (en) 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
JP5383037B2 (ja) 2004-02-27 2014-01-08 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 大環状化合物およびそれらを製造し使用する方法
US8293715B2 (en) 2007-08-06 2012-10-23 Taisho Pharmaceutical Co., Ltd. 10a-Azalide compound crosslinked at 10a- and 12-positions
CN101917850B (zh) 2007-10-25 2016-01-13 森普拉制药公司 大环内酯类抗菌剂的制备方法
WO2009139181A1 (ja) 2008-05-15 2009-11-19 大正製薬株式会社 ４員環構造を有する１０ａ－アザライド化合物
WO2010048599A1 (en) 2008-10-24 2010-04-29 Cempra Pharmaceuticals, Inc. Methods for treating gastrointestinal diseases
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
WO2012038372A1 (en) * 2010-09-20 2012-03-29 Novartis Ag Novel process for the preparation of 9-deoxo-9a-aza- 9a-homoerythromycin a modified in the c-4'' of the cladinose ring by an epoxide group
AR085286A1 (es) * 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
SG11201405895UA (en) 2012-03-27 2014-10-30 Cempra Pharmaceuticals Inc Parenteral formulations for administering macrolide antibiotics
JP5857008B2 (ja) * 2012-08-20 2016-02-10 大正製薬株式会社 Ｃ−４”位置換マクロライド誘導体を含有する医薬
US9982005B2 (en) 2013-04-04 2018-05-29 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
CN105669798B (zh) * 2013-08-23 2019-07-26 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN103965273B (zh) * 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物
AR102810A1 (es) 2014-08-18 2017-03-29 Taisho Pharmaceutical Co Ltd Derivado de macrólido sustituido en la posición c-4
WO2016057798A1 (en) 2014-10-08 2016-04-14 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
CN107530365A (zh) 2015-03-25 2018-01-02 哈佛大学的校长及成员们 具有修饰的脱氧糖胺糖的大环内酯及其用途
CN108003207B (zh) 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE445223B (sv) * 1977-02-04 1986-06-09 Pfizer Sett att framstella 4"-amino-erytomylin-a-derivat
US4150220A (en) * 1977-02-04 1979-04-17 Pfizer Inc. Semi-synthetic 4"-erythromycin A derivatives
YU43006B (en) * 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
GR80277B (en) * 1983-09-06 1985-01-04 Pfizer Azahomoerythromycin b derivatives and intermediates therefor
US4512982A (en) * 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
US5412982A (en) * 1994-03-10 1995-05-09 Potts; James K. Windsock support

Also Published As

Publication number Publication date
ES2251081T3 (es) 2006-04-16
JP3262806B2 (ja) 2002-03-04
AP9801254A0 (en) 1998-06-30
NO996107D0 (no) 1999-12-10
UA70298C2 (uk) 2004-10-15
UY25041A1 (es) 2000-09-29
DE69832486T2 (de) 2006-07-27
HN1998000074A (es) 1999-01-08
IL132808A (en) 2004-08-31
EA199901014A1 (ru) 2000-06-26
UA70298A (uk) 2004-10-15
HK1025974A1 (en) 2000-12-01
NO996107L (no) 2000-02-10
CN1259955A (zh) 2000-07-12
NO315560B1 (no) 2003-09-22
GT199800075A (es) 1999-11-30
EP0988309A1 (en) 2000-03-29
SK168299A3 (en) 2000-09-12
OA11226A (en) 2003-07-16
AP1189A (en) 2003-07-16
CA2293397C (en) 2004-08-31
ID24530A (id) 2000-07-20
EP0988309B1 (en) 2005-11-23
NZ500652A (en) 2001-10-26
HRP980315A2 (en) 1999-04-30
IS5250A (is) 1999-11-16
AU745006B2 (en) 2002-03-07
BG64357B1 (bg) 2004-11-30
HUP0004076A3 (en) 2003-05-28
MY133027A (en) 2007-10-31
MA24563A1 (fr) 1998-12-31
BR9810097A (pt) 2000-08-08
JP2000514097A (ja) 2000-10-24
TWI224106B (en) 2004-11-21
KR20010013633A (ko) 2001-02-26
WO1998056801A1 (en) 1998-12-17
DZ2515A1 (fr) 2003-02-01
EA002440B1 (ru) 2002-04-25
CO4950584A1 (es) 2000-09-01
TW200418871A (en) 2004-10-01
PL337497A1 (en) 2000-08-28
HUP0004076A2 (hu) 2001-04-28
PE79999A1 (es) 1999-08-25
DE69832486D1 (de) 2005-12-29
IS1979B (is) 2005-01-14
AU745006C (en) 2006-02-23
AR013085A1 (es) 2000-12-13
CN1145636C (zh) 2004-04-14
TNSN98084A1 (fr) 2005-03-15
PA8452001A1 (es) 2000-05-24
YU62999A (sh) 2002-10-18
CA2293397A1 (en) 1998-12-17
IL132808A0 (en) 2001-03-19
ATE310742T1 (de) 2005-12-15
AU7228198A (en) 1998-12-30
KR100369959B1 (ko) 2003-02-12
BG103969A (en) 2000-07-31

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