ZA9810468B - Heterocyclic compounds for inhibition of gastric acid secretion processes for their preparation and pharmaceutical compositions thereof - Google Patents

Heterocyclic compounds for inhibition of gastric acid secretion processes for their preparation and pharmaceutical compositions thereof

Info

Publication number
ZA9810468B
ZA9810468B ZA9810468A ZA9810468A ZA9810468B ZA 9810468 B ZA9810468 B ZA 9810468B ZA 9810468 A ZA9810468 A ZA 9810468A ZA 9810468 A ZA9810468 A ZA 9810468A ZA 9810468 B ZA9810468 B ZA 9810468B
Authority
ZA
South Africa
Prior art keywords
inhibition
preparation
pharmaceutical compositions
heterocyclic compounds
gastric acid
Prior art date
Application number
ZA9810468A
Other languages
English (en)
Inventor
Kosrat Amin
Mikael Dahlstroem
Peter Nordberg
Ingemar Starke
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of ZA9810468B publication Critical patent/ZA9810468B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA9810468A 1997-11-28 1998-11-16 Heterocyclic compounds for inhibition of gastric acid secretion processes for their preparation and pharmaceutical compositions thereof ZA9810468B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9704404A SE9704404D0 (sv) 1997-11-28 1997-11-28 New compounds

Publications (1)

Publication Number Publication Date
ZA9810468B true ZA9810468B (en) 1999-05-21

Family

ID=20409181

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9810468A ZA9810468B (en) 1997-11-28 1998-11-16 Heterocyclic compounds for inhibition of gastric acid secretion processes for their preparation and pharmaceutical compositions thereof

Country Status (33)

Country Link
US (1) US6518270B1 (es)
EP (1) EP1042324B1 (es)
JP (1) JP2001525322A (es)
KR (1) KR20010032559A (es)
CN (1) CN1142933C (es)
AR (1) AR016972A1 (es)
AT (1) ATE233263T1 (es)
AU (1) AU752187C (es)
BR (1) BR9814755A (es)
CA (1) CA2311798A1 (es)
CZ (1) CZ292349B6 (es)
DE (1) DE69811735T2 (es)
DK (1) DK1042324T3 (es)
EE (1) EE04060B1 (es)
ES (1) ES2191356T3 (es)
HK (1) HK1030216A1 (es)
HU (1) HUP0100601A3 (es)
ID (1) ID24730A (es)
IL (1) IL136145A0 (es)
IS (1) IS5486A (es)
MY (1) MY121032A (es)
NO (1) NO315704B1 (es)
NZ (1) NZ504355A (es)
PL (1) PL340920A1 (es)
PT (1) PT1042324E (es)
RU (1) RU2241000C2 (es)
SE (1) SE9704404D0 (es)
SK (1) SK283904B6 (es)
TR (1) TR200001530T2 (es)
TW (1) TW515798B (es)
UA (1) UA70932C2 (es)
WO (1) WO1999028322A1 (es)
ZA (1) ZA9810468B (es)

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JP4803935B2 (ja) * 1999-10-08 2011-10-26 アフィニアム・ファーマシューティカルズ・インコーポレイテッド Ｆａｂｉ阻害剤
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IL164703A0 (en) 2002-04-19 2005-12-18 Cellular Genomics Inc ImidazoÄ1,2-AÜpyrazin-8-ylamines method of making and method of use thereof
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TW200420293A (en) * 2002-09-25 2004-10-16 Sankyo Co Pharmaceutical compositions for the reduction of gastric acid concentration in blood
ES2518316T3 (es) 2002-12-06 2014-11-05 Debiopharm International Sa Compuestos heterocíclicos, métodos de fabricación de los mismos y su uso en terapia
US7160885B2 (en) 2003-02-10 2007-01-09 Cgi Pharmaceuticals, Inc. Certain 6, 8-(heteroaryl or aryl) disubstituted imidazo[1,2-a]pyrazines as modulators of Hsp90 complex activity
AR043002A1 (es) * 2003-02-18 2005-07-13 Altana Pharma Ag Imidazopirazinas 6-substituidos
WO2004082586A2 (en) * 2003-03-17 2004-09-30 Affinium Pharmaceuticals, Inc. Phamaceutical compositions comprising inhibitors of fab i and further antibiotics
WO2005014599A1 (en) 2003-06-04 2005-02-17 Cellular Genomics, Inc. Imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of bruton’s tyrosine kinase by such compounds
WO2005005429A1 (en) 2003-06-30 2005-01-20 Cellular Genomics, Inc. Certain heterocyclic substituted imidazo[1,2-a]pyrazin-8-ylamines and methods of inhibition of bruton’s tyrosine kinase by such compounds
WO2005019220A2 (en) 2003-08-11 2005-03-03 Cellular Genomics Inc. Substituted imidazo[1,2-a]pyrazines as modulators of kinase activity
EP1682133A1 (en) 2003-11-03 2006-07-26 AstraZeneca AB Imidazo 1,2-a pyridine derivatives for the treatment of silent gastro-esophageal reflux
PT1828167E (pt) * 2004-06-04 2014-10-08 Debiopharm Int Sa Derivados de acrilamida como agentes antibióticos
EP1787991B2 (en) 2004-07-28 2020-06-24 Takeda Pharmaceutical Company Limited PYRROLO[2,3-c]PYRIDINE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE
EP1776361A1 (en) * 2004-08-02 2007-04-25 Altana Pharma AG 5-substituted 1h-pyrroloý3,2-b¨pyridines
ATE533765T1 (de) 2004-09-03 2011-12-15 Yuhan Corp Pyrroloä2,3-cüpyridinderivate und verfahren für deren herstellung
BRPI0514843A (pt) * 2004-09-03 2008-06-24 Yuhan Corp derivados de pirrolo[3,2-c] piridina e processos para a preparação dos mesmos
WO2006025715A1 (en) * 2004-09-03 2006-03-09 Yuhan Corporation Pyrrolo[3,2-c]pyridine derivatives and processes for the preparation thereof
JP4989478B2 (ja) * 2004-09-03 2012-08-01 ユーハン・コーポレイション ピロロ［３，２−ｂ］ピリジン誘導体及びその製造方法
WO2007024294A2 (en) 2005-05-03 2007-03-01 Cgi Pharmaceuticals, Inc. Certain substituted ureas, as modulators of kinase activity
EP1928237A4 (en) 2005-09-02 2011-03-09 Abbott Lab NEW HETEROCYCLES BASED ON IMIDAZO
KR20080075027A (ko) * 2005-12-05 2008-08-13 아피늄 파마슈티컬스, 인크. Ｆａｂｉ 억제제 및 항박테리아제로서의헤테로시클릴아크릴아미드 화합물
EP2029605A1 (en) * 2006-06-06 2009-03-04 Schering Corporation Imidazopyrazines as protein kinase inhibitors
WO2008009122A1 (en) 2006-07-20 2008-01-24 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as fab i inhibitors
EP3255045A1 (en) 2007-02-16 2017-12-13 Debiopharm International SA Salts, prodrugs and polymorphs of fab i inhibitors
WO2009102468A1 (en) 2008-02-13 2009-08-20 Cgi Pharmaceuticals, Inc. 6-aryl-imidaz0[l, 2-a] pyrazine derivatives, method of making, and method of use thereof
CN104059073B (zh) 2008-12-08 2017-04-12 吉利德康涅狄格公司 咪唑并哌嗪syk抑制剂
CN104744476B (zh) 2008-12-08 2017-04-12 吉利德康涅狄格公司 咪唑并吡嗪syk抑制剂
US8450321B2 (en) 2008-12-08 2013-05-28 Gilead Connecticut, Inc. 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
KR101717809B1 (ko) 2010-03-11 2017-03-17 질레드 코네티컷 인코포레이티드 이미다조피리딘 ｓｙｋ 억제제
LT2861608T (lt) 2012-06-19 2019-07-10 Debiopharm International Sa (e)-n-metil-n-((3-metilbenzofuran-2-il)metil)-3-(7-okso-5,6,7,8-tetrahidro-1,8-nafthidrin-3-il)akrilamido provaisto dariniai
SI3027171T1 (sl) 2013-07-30 2020-08-31 Gilead Connecticut, Inc. Formulacija inhibitorjev SYK
ES2822285T3 (es) 2013-07-30 2021-04-30 Kronos Bio Inc Polimorfo de inhibidores de SYK
KR20180002888A (ko) 2013-12-04 2018-01-08 길리애드 사이언시즈, 인코포레이티드 암을 치료하는 방법
GB201321738D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
UY35898A (es) 2013-12-23 2015-07-31 Gilead Sciences Inc ?compuestos inhibidores de syk y composiciones que los comprenden?.
BR112016028641A2 (pt) 2014-07-14 2017-08-22 Gilead Sciences Inc ?método para tratar câncer?
HUE052140T2 (hu) 2016-02-26 2021-04-28 Debiopharm Int Sa Diabéteszes lábfertõzések kezelésére szolgáló gyógyszer
CA3073871A1 (en) 2017-08-25 2019-02-28 Gilead Sciences, Inc. Polymorphs of syk inhibitors
CN113950479A (zh) 2019-02-22 2022-01-18 克洛诺斯生物股份有限公司 作为syk抑制剂的缩合吡嗪的固体形式

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US4507294A (en) * 1982-03-08 1985-03-26 Schering Corp. Imidazo[1,2-a]pyrazines
DE3269604D1 (en) * 1981-06-26 1986-04-10 Schering Corp Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
US4725601A (en) * 1985-06-04 1988-02-16 Fujisawa Pharmaceutical Co., Ltd. Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers
WO1991017164A1 (de) * 1990-04-27 1991-11-14 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue pyridazine
US5041442A (en) * 1990-07-31 1991-08-20 Syntex (U.S.A.) Inc. Pyrrolo(1,2-a)pyrazines as inhibitors of gastric acid secretion
WO1992006979A1 (de) * 1990-10-15 1992-04-30 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue diazine
DK0609328T3 (da) * 1991-10-25 1999-10-25 Byk Gulden Lomberg Chem Fab Pyrrolo-pyridaziner med gastro-intestinal beskyttelsesvirkning
DE69529056T2 (de) 1994-01-19 2003-11-13 Sankyo Co Pyrrolopyridazin-derivate
SE9602286D0 (sv) 1996-06-10 1996-06-10 Astra Ab New compounds
SE9700661D0 (sv) 1997-02-25 1997-02-25 Astra Ab New compounds
SE9704404D0 (sv) 1997-11-28 1997-11-28 Astra Ab New compounds

Also Published As

Publication number Publication date
ID24730A (id) 2000-08-03
CZ20001947A3 (cs) 2000-11-15
HUP0100601A2 (hu) 2001-09-28
UA70932C2 (uk) 2004-11-15
CZ292349B6 (cs) 2003-09-17
KR20010032559A (ko) 2001-04-25
PL340920A1 (en) 2001-03-12
US6518270B1 (en) 2003-02-11
HUP0100601A3 (en) 2002-10-28
IS5486A (is) 2000-05-10
EE200000315A (et) 2001-10-15
JP2001525322A (ja) 2001-12-11
DK1042324T3 (da) 2003-05-05
SK283904B6 (sk) 2004-04-06
BR9814755A (pt) 2000-10-03
DE69811735T2 (de) 2003-12-18
TW515798B (en) 2003-01-01
NO315704B1 (no) 2003-10-13
SK6742000A3 (en) 2001-03-12
TR200001530T2 (tr) 2000-11-21
ES2191356T3 (es) 2003-09-01
CN1142933C (zh) 2004-03-24
EP1042324B1 (en) 2003-02-26
DE69811735D1 (de) 2003-04-03
EE04060B1 (et) 2003-06-16
PT1042324E (pt) 2003-06-30
HK1030216A1 (en) 2001-04-27
NO20002721L (no) 2000-07-28
EP1042324A1 (en) 2000-10-11
SE9704404D0 (sv) 1997-11-28
AU1356599A (en) 1999-06-16
IL136145A0 (en) 2001-05-20
MY121032A (en) 2005-12-30
AU752187C (en) 2003-09-18
RU2241000C2 (ru) 2004-11-27
WO1999028322A1 (en) 1999-06-10
NO20002721D0 (no) 2000-05-26
CN1284078A (zh) 2001-02-14
NZ504355A (en) 2001-12-21
AR016972A1 (es) 2001-08-01
CA2311798A1 (en) 1999-06-10
ATE233263T1 (de) 2003-03-15
AU752187B2 (en) 2002-09-12

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