DE69529056T2 - Pyrrolopyridazin-derivate - Google Patents

Pyrrolopyridazin-derivate

Info

Publication number
DE69529056T2
DE69529056T2 DE69529056T DE69529056T DE69529056T2 DE 69529056 T2 DE69529056 T2 DE 69529056T2 DE 69529056 T DE69529056 T DE 69529056T DE 69529056 T DE69529056 T DE 69529056T DE 69529056 T2 DE69529056 T2 DE 69529056T2
Authority
DE
Germany
Prior art keywords
group
alkyl group
aryl
halogeno
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69529056T
Other languages
English (en)
Other versions
DE69529056D1 (de
Inventor
Tomio Kimura
Yoshimi Fujihara
Nobuhiko Shibakawa
Hiroshi Fujiwara
Etsuro Itoh
Keiji Matsunobu
Keiichi Tabata
Hiroshi Yasuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Ube Corp
Original Assignee
Sankyo Co Ltd
Ube Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd, Ube Industries Ltd filed Critical Sankyo Co Ltd
Publication of DE69529056D1 publication Critical patent/DE69529056D1/de
Application granted granted Critical
Publication of DE69529056T2 publication Critical patent/DE69529056T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
DE69529056T 1994-01-19 1995-01-18 Pyrrolopyridazin-derivate Expired - Fee Related DE69529056T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP398894 1994-01-19
PCT/JP1995/000038 WO1995019980A1 (fr) 1994-01-19 1995-01-18 Derive de pyrrolopyridazine

Publications (2)

Publication Number Publication Date
DE69529056D1 DE69529056D1 (de) 2003-01-16
DE69529056T2 true DE69529056T2 (de) 2003-11-13

Family

ID=11572411

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69529056T Expired - Fee Related DE69529056T2 (de) 1994-01-19 1995-01-18 Pyrrolopyridazin-derivate

Country Status (19)

Country Link
US (1) US6063782A (de)
EP (1) EP0742218B1 (de)
KR (1) KR100361199B1 (de)
CN (1) CN1044811C (de)
AT (1) ATE229020T1 (de)
AU (1) AU680998B2 (de)
CZ (1) CZ283216B6 (de)
DE (1) DE69529056T2 (de)
DK (1) DK0742218T3 (de)
ES (1) ES2185693T3 (de)
FI (1) FI112488B (de)
HK (1) HK1015609A1 (de)
HU (1) HU225920B1 (de)
MX (1) MX9602850A (de)
NO (1) NO307300B1 (de)
NZ (1) NZ278675A (de)
PT (1) PT742218E (de)
RU (1) RU2146257C1 (de)
WO (1) WO1995019980A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6316429B1 (en) * 1997-05-07 2001-11-13 Sugen, Inc. Bicyclic protein kinase inhibitors
SE9704404D0 (sv) * 1997-11-28 1997-11-28 Astra Ab New compounds
DE19836698A1 (de) * 1998-08-13 2000-02-17 Bayer Ag Verfahren zur Herstellung von fluorierten Benzylalkoholen und -aldehyden
TWI287014B (en) * 1999-06-15 2007-09-21 Sankyo Co Optically active pyrrolopyridazine compound
CA2399380A1 (en) 2000-02-10 2001-08-16 Sankyo Company, Limited Pyrrolopyridazine compound
FR2849025B1 (fr) * 2002-12-20 2005-10-14 Rhodia Chimie Sa Esters d'allyle substitue par un groupe difluoromethylene, leur procede de synthese et leur utilisation
JP2003119140A (ja) * 2001-08-08 2003-04-23 Sankyo Co Ltd ピロロピリダジン化合物を含有する医薬
BR0213586A (pt) * 2001-09-27 2004-10-26 Monsanto Technology Llc Composições fungicidas e suas aplicações em agricultura
TW200420293A (en) * 2002-09-25 2004-10-16 Sankyo Co Pharmaceutical compositions for the reduction of gastric acid concentration in blood
AU2003266621A1 (en) * 2002-09-25 2004-04-19 Sankyo Company, Limited Medicinal composition for treatment for or prevention of visceral pain
EP1611901B1 (de) * 2003-03-13 2013-07-10 Eisai R&D Management Co., Ltd. Mittel zur Prävention oder Heilung von Zähneknirschen
CA2579127C (en) * 2004-09-03 2011-08-02 Yuhan Corporation Pyrrolo[3,2-b]pyridine derivatives and processes for the preparation thereof
DK1784402T3 (da) * 2004-09-03 2011-11-14 Yuhan Corp Pyrrolo[3,2-c]pyridinderivater samt fremgangsmåder til deres fremstilling
ATE466013T1 (de) * 2004-09-03 2010-05-15 Yuhan Corp Pyrroloä3,2-cüpyridinderivate und verfahren zu deren herstellung
KR101137168B1 (ko) * 2005-03-09 2012-04-19 주식회사유한양행 피롤로［２,３-ｄ］피리다진 유도체 및 그의 제조방법
AU2007205452B2 (en) * 2006-01-16 2012-04-12 Ube Industries, Ltd. Pyrrolopyridazinone compound
CN101003537A (zh) * 2006-01-17 2007-07-25 上海恒瑞医药有限公司 吡咯并哒嗪类衍生物及其制备方法和用途
SG182662A1 (en) 2010-01-28 2012-08-30 Harvard College Compositions and methods for enhancing proteasome activity
WO2012154967A1 (en) 2011-05-12 2012-11-15 Proteostasis Therapeutics, Inc. Proteostasis regulators
WO2014116228A1 (en) 2013-01-25 2014-07-31 President And Fellows Of Harvard College Usp14 inhibitors for treating or preventing viral infections
WO2015073528A1 (en) 2013-11-12 2015-05-21 Proteostasis Therapeutics, Inc. Proteasome activity enhancing compounds
JP6764866B2 (ja) * 2015-01-13 2020-10-07 ビブレオン バイオサイエンシーズ，エルエルシー Ｃａ２＋放出活性化Ｃａ２＋（ＣＲＡＣ）チャネルのモジュレーターおよびその薬学的使用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8901430D0 (en) * 1989-01-23 1989-03-15 Smithkline Beckman Intercredit Compounds
WO1991017164A1 (de) * 1990-04-27 1991-11-14 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue pyridazine
US5068332A (en) * 1990-10-12 1991-11-26 American Home Products Corporation Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors
WO1992006979A1 (de) * 1990-10-15 1992-04-30 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue diazine
DK0609328T3 (da) * 1991-10-25 1999-10-25 Byk Gulden Lomberg Chem Fab Pyrrolo-pyridaziner med gastro-intestinal beskyttelsesvirkning

Also Published As

Publication number Publication date
RU2146257C1 (ru) 2000-03-10
DE69529056D1 (de) 2003-01-16
FI112488B (fi) 2003-12-15
WO1995019980A1 (fr) 1995-07-27
CZ208496A3 (en) 1996-12-11
ES2185693T3 (es) 2003-05-01
EP0742218A1 (de) 1996-11-13
AU680998B2 (en) 1997-08-14
AU1465795A (en) 1995-08-08
NZ278675A (en) 1997-07-27
DK0742218T3 (da) 2003-01-13
EP0742218B1 (de) 2002-12-04
NO962998D0 (no) 1996-07-18
ATE229020T1 (de) 2002-12-15
MX9602850A (es) 1997-06-28
HUT77998A (hu) 1999-04-28
US6063782A (en) 2000-05-16
HU9601967D0 (en) 1996-09-30
HK1015609A1 (en) 1999-10-15
CN1044811C (zh) 1999-08-25
HU225920B1 (en) 2008-01-28
EP0742218A4 (de) 1997-07-09
NO307300B1 (no) 2000-03-13
CN1143964A (zh) 1997-02-26
NO962998L (no) 1996-09-17
PT742218E (pt) 2003-02-28
CZ283216B6 (cs) 1998-02-18
FI962892A (fi) 1996-09-16
FI962892A0 (fi) 1996-07-18
KR100361199B1 (ko) 2003-04-16

Similar Documents

Publication Publication Date Title
DE69529056D1 (de) Pyrrolopyridazin-derivate
ATE311358T1 (de) Immunoregulierende verbindungen, deren derivate und ihre verwendung
DK0683773T3 (da) Hypolopidæmiske kondenserede 1,4-thiazepiner
DE69418704T2 (de) Anthranilsäure derivate
NO20014925D0 (no) Farmasöytiske forbindelser
WO2001003685A3 (en) Novel prodrugs for antimicrobial amidines
DE69623497T2 (de) 1-methylcarbapenem-derivate
EP0808839A4 (de) Epoxysuccinamid-derivate oder deren salze und medikamente die diese enthalten
DK0974589T3 (da) Benzimidazolderivater og farmaceutiske acceptable salte deraf
TW244336B (de)
DK0485219T3 (da) Lægemidler til forebyggelse og behandling af kredsløbsorgansygdomme indeholdende spiro-3-heteroazolidinforbindelser
HRP990130B1 (en) HALOGEN DERIVATIVES 9a-N-(N'-ARYLCARBAMOYL)- AND 9a-N-(N'-ARYLTHIOCARBAMOYL)-9-DEOXO-9a-AZA-9a OF HOMOERYTHROMYCIN A
AP2003002831A0 (en) Derivatives of etoposide and analogs, and pharmaceutical compositions containing them
CA2181553A1 (en) Pyrrolopyridazine derivatives
EP1197211A4 (de) Wirkstoffe zur vorbeugung und behandlung von krebs

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee