ZA977474B - 6-O-substituted ketolides having antibacterial activity. - Google Patents

6-O-substituted ketolides having antibacterial activity.

Info

Publication number
ZA977474B
ZA977474B ZA9707474A ZA977474A ZA977474B ZA 977474 B ZA977474 B ZA 977474B ZA 9707474 A ZA9707474 A ZA 9707474A ZA 977474 A ZA977474 A ZA 977474A ZA 977474 B ZA977474 B ZA 977474B
Authority
ZA
South Africa
Prior art keywords
antibacterial activity
substituted ketolides
ketolides
substituted
antibacterial
Prior art date
Application number
ZA9707474A
Other languages
English (en)
Inventor
Yat Sun Or
Zhenkun Ma
Richard F Clark
Daniel T Chu
Jacob J Plattner
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of ZA977474B publication Critical patent/ZA977474B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08Hetero rings containing eight or more ring members, e.g. erythromycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
ZA9707474A 1996-09-04 1997-08-20 6-O-substituted ketolides having antibacterial activity. ZA977474B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70777696A 1996-09-04 1996-09-04

Publications (1)

Publication Number Publication Date
ZA977474B true ZA977474B (en) 1998-03-23

Family

ID=24843126

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9707474A ZA977474B (en) 1996-09-04 1997-08-20 6-O-substituted ketolides having antibacterial activity.

Country Status (12)

Country Link
US (1) US5866549A (xx)
JP (8) JP5107201B2 (xx)
AR (1) AR008164A1 (xx)
CO (1) CO4910135A1 (xx)
CZ (4) CZ303474B6 (xx)
GT (1) GT199700099A (xx)
IL (4) IL199743A (xx)
RO (4) RO123573B1 (xx)
TW (1) TW458980B (xx)
UA (1) UA51730C2 (xx)
YU (1) YU11699A (xx)
ZA (1) ZA977474B (xx)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100523679B1 (ko) * 1996-09-04 2005-10-26 아보트 러보러터리즈 항균 활성을 지닌 6-o-치환된 케톨라이드
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
US6124269A (en) * 1997-10-29 2000-09-26 Abbott Laboratories 2-Halo-6-O-substituted ketolide derivatives
AU5995299A (en) * 1998-11-03 2000-05-22 Pfizer Products Inc. Novel macrolide antibiotics
ID30233A (id) 1999-01-27 2001-11-15 Pfizer Prod Inc Antibiotika ketolida
CZ20013223A3 (cs) * 1999-03-15 2002-01-16 Abbott Laboratories 6-0-Substituované makrolidy mající antibakteriální aktivitu
US6939861B2 (en) * 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
ATE340183T1 (de) 1999-04-16 2006-10-15 Kosan Biosciences Inc Antiinfektiöse makrolidderivate
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
WO2000062783A2 (en) * 1999-04-16 2000-10-26 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
HUP0201516A3 (en) * 1999-05-24 2003-03-28 Pfizer Prod Inc 13-methyl-erythromycin derivatives, process for their preparation and pharmaceutical compositions containing them
US6420535B1 (en) * 1999-06-07 2002-07-16 Abbott Laboratories 6-O-carbamate ketolide derivatives
AU5871000A (en) * 1999-06-11 2001-01-02 Paul G. Abrams High dose radionuclide complexes for bone marrow suppression
US6417366B2 (en) * 1999-06-24 2002-07-09 Abbott Laboratories Preparation of quinoline-substituted carbonate and carbamate derivatives
US6437106B1 (en) 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
US6569836B2 (en) 1999-12-02 2003-05-27 Abbott Laboratories 6-O-alkyl-2-nor-2-substituted ketolide derivatives
US6946446B2 (en) 2000-02-24 2005-09-20 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
US6605707B1 (en) 2000-03-23 2003-08-12 Abbott Laboratories Process for the preparation of 6-O-propargyl erythromycin derivatives
US6638908B1 (en) * 2000-08-09 2003-10-28 Yale University Crystals of the large ribosomal subunit
US6947844B2 (en) * 2000-08-09 2005-09-20 Yale University Modulators of ribosomal function and identification thereof
US6472372B1 (en) * 2000-12-06 2002-10-29 Ortho-Mcneil Pharmaceuticals, Inc. 6-O-Carbamoyl ketolide antibacterials
US6455680B1 (en) 2000-12-21 2002-09-24 Abbott Laboratories Methods utilizing aryl thioimines in synthesis of erythromycin derivatives
WO2002062398A2 (en) 2001-01-08 2002-08-15 Neorx Corporation Radioactively labelled conjugates of phosphonates
TWI246515B (en) 2001-05-30 2006-01-01 Abbott Lab An arylation method for the functionalization of O-allyl erythromycin derivatives
US6756359B2 (en) 2001-07-03 2004-06-29 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
US6952650B2 (en) 2001-08-03 2005-10-04 Yale University Modulators of ribosomal function and identification thereof
IL151012A0 (en) 2001-08-03 2003-02-12 Ribosomes Structure And Protei Ribosomes structure and protein synthesis inhibitors
JP2005503416A (ja) 2001-09-17 2005-02-03 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 6−o−カルバメート−11,12−ラクト−ケトライド抗菌剤
US6670331B2 (en) * 2001-12-04 2003-12-30 Enanta Pharmaceuticals, Inc. 11-O-substituted ketolide derivatives
BR0214748A (pt) 2001-12-05 2004-11-23 Ortho Mcneil Pharm Inc Derivados 6-oacil-cetolidas de eritromicina, úteis como antibacterianos
AU2002364552A1 (en) 2001-12-13 2003-06-30 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
WO2003068792A1 (fr) * 2002-02-13 2003-08-21 Taisho Pharmaceutical Co.,Ltd. Procede de fabrication d'un derive d'erythromycine 'a'
US20030162729A1 (en) * 2002-02-13 2003-08-28 Zhenkun Ma Macrolides with activity against methicillin-resistant staphylococcus aureus
CA2484087A1 (en) * 2002-04-30 2003-11-13 Abbott Laboratories Antibacterial compounds with improved pharmacokinetic profiles
US6992069B2 (en) * 2002-04-30 2006-01-31 Yu-Gui Gu Tricyclic macrolide antibacterial compounds
US20050267054A1 (en) * 2002-04-30 2005-12-01 Clark Richard F Antibacterial compounds with improved pharmacokinetic profiles
DE60326710D1 (de) * 2002-04-30 2009-04-30 Abbott Lab Trizyklische antibakterielle makrolidderivate
US20040033970A1 (en) * 2002-04-30 2004-02-19 Clark Richard F. Antibacterial compounds with improved pharmacokinetic profiles
US7135573B2 (en) * 2002-05-13 2006-11-14 Enanta Pharmaceuticals, Inc. Processes for the preparation of O-(6-Pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine
US6878691B2 (en) * 2002-05-13 2005-04-12 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US7064110B2 (en) * 2002-05-13 2006-06-20 Enanta Pharmaceuticals, Inc. 6-11 bicycle ketolide derivatives
CN1659178A (zh) * 2002-05-13 2005-08-24 英安塔制药有限公司 6、11二环红霉素衍生物
US6841664B2 (en) * 2002-07-25 2005-01-11 Enanra Pharmaceuticals, Inc. 6,11-4-carbon bridged ketolides
US6764998B1 (en) 2003-06-18 2004-07-20 Enanta Pharmaceuticals, Inc. 6,11-4C-bicyclic 9a-azalide derivatives
US6753318B1 (en) 2002-07-25 2004-06-22 Enanta Pharmaceuticals, Inc. 6,11-4-carbon bridged erythromycin derivatives
WO2003097659A1 (en) * 2002-05-13 2003-11-27 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US7910558B2 (en) * 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
WO2005070918A1 (en) * 2002-05-13 2005-08-04 Enanta Pharmaceuticals, Inc. Process for the preparation of t-11 bicyclic erythromycin derivatives
US7273853B2 (en) * 2002-05-13 2007-09-25 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
AU2003234650A1 (en) 2002-05-31 2003-12-19 Janssen Pharmaceutica N.V. 3-descladinosyl-6-o-carbamoyl and 6-o-carbonoyl macrolide antibacterial agents
US7091196B2 (en) * 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
JP2006523229A (ja) * 2003-03-05 2006-10-12 リブ−エックス ファーマシューティカルズ,インコーポレイテッド 二官能性複素環式化合物ならびにその製造および使用方法
US6645941B1 (en) 2003-03-26 2003-11-11 Enanta Pharmaceuticals, Inc. 6,11-3C-bicyclic 9a-azalide derivatives
US7163924B2 (en) * 2003-04-25 2007-01-16 Chiron Corporation Ketolide derivatives
US7332476B2 (en) * 2003-04-25 2008-02-19 Novartis Ag Pyridyl substituted ketolide antibiotics
US6716820B1 (en) * 2003-06-05 2004-04-06 Enanta Pharmaceuticals, Inc. 6-O-substituted bicyclic macrolides
US6790835B1 (en) 2003-06-05 2004-09-14 Enanta Pharmaceuticals, Inc. Bicyclic macrolide derivatives
US20040254126A1 (en) * 2003-06-05 2004-12-16 Yao-Ling Qiu 11-12 Bicyclic erythromycin derivatives
US6774115B1 (en) 2003-06-05 2004-08-10 Enanta Pharmaceuticals, Inc. 6-O-substituted bicyclic ketolides
US6765016B1 (en) 2003-06-05 2004-07-20 Enanta Pharmaceuticals, Inc. Bicyclic ketolide derivatives
US7439268B2 (en) * 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
US20050049210A1 (en) * 2003-08-27 2005-03-03 Idexx Laboratories, Inc. Methods for the controlled delivery of pharmacologically active compounds
US7276487B2 (en) * 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
US20070149463A1 (en) * 2003-10-30 2007-06-28 Oyelere Adegboyega K Bifunctional macrolide heterocyclic compounds and methods of making and using the same
EP1699808A1 (en) * 2003-11-18 2006-09-13 Rib-X Pharmaceuticals, Inc. Bifunctional macrolide heterocyclic compounds and methods of making and using the same
US7414030B2 (en) * 2004-01-07 2008-08-19 Enanta Pharmaceuticals, Inc. 6-11 Bicyclic erythromycin derivatives
WO2005070113A2 (en) * 2004-01-09 2005-08-04 Enanta Pharmaceuticals, Inc. 9n-substituted 6-11 bicyclic erythromycin derivatives
EP1723159B1 (en) 2004-02-27 2019-06-12 Melinta Therapeutics, Inc. Macrocyclic compounds and methods of making and using the same
BRPI0513903A (pt) * 2004-07-28 2008-05-20 Ranbaxy Lab Ltd derivados de cetolìdeos úteis como agentes antimicrobianos, seus processos de preparação e composições farmacêuticas compreendendo os mesmos
EP1807439A2 (en) * 2004-10-25 2007-07-18 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
US7229972B2 (en) * 2004-12-07 2007-06-12 Enanta Pharmaceuticals, Inc. 3,6-Bicyclolides
US7419962B2 (en) * 2004-12-07 2008-09-02 Enanta Pharmaceuticals, Inc. 3,6-bicyclolides
WO2006065721A2 (en) * 2004-12-13 2006-06-22 Enanta Pharmaceuticals, Inc. 11, 12-lactone bicyclolides
TW200635600A (en) * 2004-12-13 2006-10-16 Enanta Pharm Inc Tetracyclic bicyclolides
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
US20090005325A1 (en) * 2005-11-23 2009-01-01 Biswajit Bas Ketolide Derivatives as Antibacterial Agents
EP1960413A2 (en) * 2005-11-23 2008-08-27 Ranbaxy Laboratories Limited Macrolides derivatives as antibacterial agents
US7595300B2 (en) * 2005-12-13 2009-09-29 Kosan Biosciences Incorporated 7-quinolyl ketolide antibacterial agents
JP5015016B2 (ja) * 2006-02-07 2012-08-29 大正製薬株式会社 10a−アザライド化合物
US8354383B2 (en) * 2007-09-17 2013-01-15 Enanta Pharmaceuticals, Inc. 6,11-bridged biaryl macrolides
US8273720B2 (en) * 2007-09-17 2012-09-25 Enanta Pharmaceuticals, Inc. 6,11-bicyclolides: bridged biaryl macrolide derivatives
CN101855219B (zh) * 2007-09-17 2014-06-25 英安塔制药有限公司 6,11-桥联的联芳大环内酯类
US7550625B2 (en) * 2007-10-19 2009-06-23 Idexx Laboratories Esters of florfenicol
TW200946109A (en) * 2008-05-09 2009-11-16 Enanta Pharm Inc Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides
AR085286A1 (es) 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
IL293115A (en) * 2019-12-02 2022-07-01 Aliquantumrx Inc Salts and polymorphs of cethromycin for the treatment of disease Salts and polymorphs of cethromycin

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2526951B2 (ja) * 1986-12-17 1996-08-21 大正製薬株式会社 エリスロマイシンa誘導体およびその製造方法
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
US5350839A (en) * 1990-10-15 1994-09-27 Taisho Pharmaceutical Co., Ltd. 2'-position modified compound of erythromycin or its derivative
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of the history of erythromycin
FR2669337B1 (fr) * 1990-11-21 1995-03-24 Roussel Uclaf Nouveaux derives descladinosyles de l'erythromycine, leur procede de preparation et leur application comme medicaments.
KR0166096B1 (ko) * 1990-11-28 1999-01-15 우에하라 아키라 6-0-메틸에리쓰로마이신 a 유도체
WO1993013663A1 (en) * 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
US5523399A (en) * 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
CA2093303C (en) * 1992-04-09 1998-11-24 Abraham Araya Aluminosilicates
JP3259429B2 (ja) * 1992-04-22 2002-02-25 大正製薬株式会社 5−o−デソサミニルエリスロノライドa誘導体
ATE135707T1 (de) * 1992-04-22 1996-04-15 Taisho Pharmaceutical Co Ltd 5-0-desosaminylerythronolid a derivate
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2738571B1 (fr) * 1995-09-11 1997-10-17 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-0-methyl- erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
PT876388E (pt) * 1995-11-08 2004-07-30 Abbott Lab Derivados de eritromicina triciclica
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
KR100523679B1 (ko) * 1996-09-04 2005-10-26 아보트 러보러터리즈 항균 활성을 지닌 6-o-치환된 케톨라이드

Also Published As

Publication number Publication date
RO123591B1 (ro) 2014-03-28
RO123529B1 (ro) 2013-04-30
CZ303474B6 (cs) 2012-10-03
IL199746A (en) 2010-11-30
JP2009084282A (ja) 2009-04-23
AR008164A1 (es) 1999-12-09
GT199700099A (es) 1999-02-24
CO4910135A1 (es) 2000-04-24
IL199743A (en) 2010-11-30
YU11699A (sh) 2001-07-10
US5866549A (en) 1999-02-02
JP2009073840A (ja) 2009-04-09
JP4981846B2 (ja) 2012-07-25
JP5107303B2 (ja) 2012-12-26
JP5222913B2 (ja) 2013-06-26
IL199745A (en) 2010-11-30
RO123371B1 (ro) 2011-11-30
JP2009221214A (ja) 2009-10-01
TW458980B (en) 2001-10-11
IL199744A (en) 2010-11-30
RO123573B1 (ro) 2013-11-29
JP2009263370A (ja) 2009-11-12
CZ303581B6 (cs) 2012-12-19
CZ303573B6 (cs) 2012-12-12
UA51730C2 (uk) 2002-12-16
JP2011016808A (ja) 2011-01-27
JP4981776B2 (ja) 2012-07-25
JP5107201B2 (ja) 2012-12-26
CZ303382B6 (cs) 2012-08-22
JP2015038095A (ja) 2015-02-26
JP2013047243A (ja) 2013-03-07
JP2009062378A (ja) 2009-03-26

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