ZA957548B - Benzoylguanidines substituted by heterocyclic n-oxide process for their preparation their use as a medicament or diagnostic agent medicament containing them and intermediate products for their preparation - Google Patents

Benzoylguanidines substituted by heterocyclic n-oxide process for their preparation their use as a medicament or diagnostic agent medicament containing them and intermediate products for their preparation

Info

Publication number
ZA957548B
ZA957548B ZA957548A ZA957548A ZA957548B ZA 957548 B ZA957548 B ZA 957548B ZA 957548 A ZA957548 A ZA 957548A ZA 957548 A ZA957548 A ZA 957548A ZA 957548 B ZA957548 B ZA 957548B
Authority
ZA
South Africa
Prior art keywords
alkyl
preparation
opt
medicament
ome
Prior art date
Application number
ZA957548A
Other languages
English (en)
Inventor
Heinz-Werner Kleemann
Hans-Jochen Lang
Jan-Robert Schwark
Andreas Weichert
Wolfgang Scholz
Udo Albus
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA957548B publication Critical patent/ZA957548B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • C07D215/60—N-oxides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Surgery (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
ZA957548A 1994-09-09 1995-09-08 Benzoylguanidines substituted by heterocyclic n-oxide process for their preparation their use as a medicament or diagnostic agent medicament containing them and intermediate products for their preparation ZA957548B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4432106A DE4432106A1 (de) 1994-09-09 1994-09-09 Mit Heterocyclen-N-Oxid-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum, sie enthaltendes Medikament sowie Zwischenprodukte zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
ZA957548B true ZA957548B (en) 1996-04-17

Family

ID=6527788

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA957548A ZA957548B (en) 1994-09-09 1995-09-08 Benzoylguanidines substituted by heterocyclic n-oxide process for their preparation their use as a medicament or diagnostic agent medicament containing them and intermediate products for their preparation

Country Status (22)

Country Link
US (1) US5641792A (cs)
EP (1) EP0700904B1 (cs)
JP (1) JP4113262B2 (cs)
KR (1) KR960010619A (cs)
CN (1) CN1119643A (cs)
AT (1) ATE210121T1 (cs)
AU (1) AU695342B2 (cs)
CA (1) CA2157855C (cs)
CZ (1) CZ291188B6 (cs)
DE (2) DE4432106A1 (cs)
DK (1) DK0700904T3 (cs)
ES (1) ES2168324T3 (cs)
FI (1) FI954190A7 (cs)
HU (1) HU219976B (cs)
IL (1) IL115196A (cs)
NO (1) NO305202B1 (cs)
NZ (1) NZ272946A (cs)
PL (1) PL310346A1 (cs)
PT (1) PT700904E (cs)
RU (1) RU2160727C2 (cs)
SI (1) SI9500280B (cs)
ZA (1) ZA957548B (cs)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0765867A1 (de) * 1995-09-27 1997-04-02 Hoechst Aktiengesellschaft Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Antiarrhytmika oder Diagnostikum sowie sie enthaltendes Medikament
DE19540995A1 (de) * 1995-11-03 1997-05-07 Hoechst Ag Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19542306A1 (de) * 1995-11-14 1997-05-15 Hoechst Ag Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
PL316439A1 (en) * 1995-11-20 1997-05-26 Hoechst Ag Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such
DE19546736A1 (de) * 1995-12-14 1997-06-19 Hoechst Ag Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate
DE19621319A1 (de) * 1996-05-28 1997-12-04 Hoechst Ag Bis-ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19737224A1 (de) 1997-08-27 1999-03-18 Hoechst Marion Roussel De Gmbh Pharmazeutisches Kombinationspräparat aus einem Inhibitor des Natrium-Wasserstoff-Austauschers und einem Arzneimittel zur Behandlung von Herz-Kreislauferkrankungen
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
US6455554B1 (en) 1999-06-07 2002-09-24 Targacept, Inc. Oxopyridinyl pharmaceutical compositions and methods for use
EP1534278A4 (en) * 2002-08-01 2006-09-06 Nitromed Inc NITROSED PROTONATE PUMP INHIBITORS, COMPOSITIONS AND USE METHOD
CN101056842A (zh) * 2004-11-16 2007-10-17 默克公司 治疗中风的(2r)－2－丙基辛酸前药

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE271903C (cs) *
US3780027A (en) 1970-04-29 1973-12-18 Merck & Co Inc Anthranilic acid derivatives
DE2258276C3 (de) * 1972-11-28 1981-08-13 Bayer Ag, 5090 Leverkusen Triazolyl-stilbene, sowie deren Herstellung und Verwendung als optische Aufheller
US3931181A (en) * 1973-07-27 1976-01-06 Hoffmann-La Roche Inc. 2,4-Diamino-5-benzylpyrimidines
JPS59510B2 (ja) * 1973-11-22 1984-01-07 塩野義製薬株式会社 ピリジンユウドウタイ ノ セイゾウホウ
US4373024A (en) 1980-12-02 1983-02-08 Phillips Petroleum Company Apparatus useful for foam breaking
US4617307A (en) * 1984-06-20 1986-10-14 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors
DD271903A1 (de) * 1988-05-17 1989-09-20 Univ Halle Wittenberg Verfahren zur herstellung stabiler, 2-unsubstituierter imidazol-3-oxide
US4959377A (en) * 1989-06-29 1990-09-25 Hoechst-Roussel Pharmaceuticals Inc. Phenoxypyridinamine compounds which are use as a dermatological composition
DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
US5212182A (en) * 1990-10-03 1993-05-18 American Home Products Corpooration Substituted quinolinyl- and naphthalenylbenzamides or benzylamines and related compounds useful as analgesics
CZ284456B6 (cs) * 1992-02-15 1998-12-16 Hoechst Aktiengesellschaft Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
EP0556674B1 (de) * 1992-02-15 1996-06-19 Hoechst Aktiengesellschaft 3,5-Substituierte Benzoylguanidine, mit antiarrythmischer Wirkung und inhibierender Wirkung auf die Proliferationen von Zellen
TW250479B (cs) * 1992-12-15 1995-07-01 Hoechst Ag
TW250477B (cs) * 1992-12-15 1995-07-01 Hoechst Ag
DE59306029D1 (de) * 1992-12-16 1997-05-07 Hoechst Ag 3,5-Substituierte Aminobenzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
EP0612723B1 (de) * 1993-02-20 1997-08-27 Hoechst Aktiengesellschaft Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, als Inhibitoren des zellulären Na+/H+-Austauschs oder als Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
CZ231595A3 (en) 1996-04-17
FI954190L (fi) 1996-03-10
DE4432106A1 (de) 1996-03-14
SI9500280A (en) 1996-04-30
NZ272946A (en) 1996-12-20
US5641792A (en) 1997-06-24
JP4113262B2 (ja) 2008-07-09
RU2160727C2 (ru) 2000-12-20
IL115196A0 (en) 1995-12-31
NO953555D0 (no) 1995-09-08
HU9502634D0 (en) 1995-11-28
DE59509899D1 (de) 2002-01-17
CN1119643A (zh) 1996-04-03
ES2168324T3 (es) 2002-06-16
JPH0892215A (ja) 1996-04-09
AU3050495A (en) 1996-03-21
IL115196A (en) 2003-01-12
HUT72630A (en) 1996-05-28
NO305202B1 (no) 1999-04-19
SI9500280B (en) 2001-12-31
HU219976B (hu) 2001-10-28
EP0700904B1 (de) 2001-12-05
KR960010619A (ko) 1996-04-20
FI954190A0 (fi) 1995-09-07
PT700904E (pt) 2002-05-31
ATE210121T1 (de) 2001-12-15
FI954190A7 (fi) 1996-03-10
NO953555L (no) 1996-03-11
CA2157855C (en) 2009-04-21
AU695342B2 (en) 1998-08-13
DK0700904T3 (da) 2002-03-18
CA2157855A1 (en) 1996-03-10
PL310346A1 (en) 1996-03-18
EP0700904A1 (de) 1996-03-13
CZ291188B6 (cs) 2003-01-15

Similar Documents

Publication Publication Date Title
ZA957548B (en) Benzoylguanidines substituted by heterocyclic n-oxide process for their preparation their use as a medicament or diagnostic agent medicament containing them and intermediate products for their preparation
PL316440A1 (en) Novel sulphonimidoamides, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent a such
YU69991A (sh) Derivati piridina
GR3030365T3 (en) Substituted benzoylguanidines, a process for their preparation, their use as drug or diagnostic agents as well as medicaments containing them
GB1106040A (en) Novel benzdiaz[1,4]epine derivatives and a process for the manufacture thereof
HUT63828A (en) Process for producing pleuromutilin complexes
ES8604981A1 (es) Un procedimiento para preparar derivados de acido griseolico
CH676202A5 (cs)
EP0003150B1 (en) Stabilized aqueous parenteral antibiotic compositions and a process for their preparation
IL99898A0 (en) 7-acyl-3-substituted carbamoyloxy cephem compounds,their preparation and antibacterial compositions containing them
HUT58110A (en) New compound
Blair et al. The effect of actinomycin, clavacin, and tyrothricin on staphylococcal toxin
JPH06700B2 (ja) 安定な水性液剤
GB1065617A (en) Nitrofuran derivatives
GB1274553A (en) Hydroxyalkylene-substituted benzoxazines and benzothiazines
ES366561A1 (es) Un procedimiento para la preparacion de un compuesto selec-cionado del grupo de esteres benzoato de 4-pirazolidinoles 1,2-disustituidos.