ZA932642B - Indole derivatives - Google Patents

Indole derivatives

Info

Publication number
ZA932642B
ZA932642B ZA932642A ZA932642A ZA932642B ZA 932642 B ZA932642 B ZA 932642B ZA 932642 A ZA932642 A ZA 932642A ZA 932642 A ZA932642 A ZA 932642A ZA 932642 B ZA932642 B ZA 932642B
Authority
ZA
South Africa
Prior art keywords
indole derivatives
indole
derivatives
Prior art date
Application number
ZA932642A
Other languages
English (en)
Inventor
Alfredo Cugola
Giovanni Gavirghi
Simone Giacobbe
Original Assignee
Glaxo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Spa filed Critical Glaxo Spa
Publication of ZA932642B publication Critical patent/ZA932642B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
ZA932642A 1992-04-16 1993-04-14 Indole derivatives ZA932642B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929208492A GB9208492D0 (en) 1992-04-16 1992-04-16 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
ZA932642B true ZA932642B (en) 1994-01-10

Family

ID=10714220

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA932642A ZA932642B (en) 1992-04-16 1993-04-14 Indole derivatives

Country Status (41)

Country Link
US (4) US5374648A (pm)
EP (1) EP0568136A1 (pm)
JP (2) JPH07505407A (pm)
KR (1) KR100264114B1 (pm)
CN (1) CN1042331C (pm)
AP (1) AP480A (pm)
AT (1) AT403917B (pm)
AU (1) AU666927B2 (pm)
BE (1) BE1006343A5 (pm)
BG (1) BG62136B1 (pm)
BR (1) BR1100323A (pm)
CA (3) CA2094075A1 (pm)
CH (1) CH685630A5 (pm)
CY (1) CY2038B1 (pm)
CZ (1) CZ285799B6 (pm)
DK (1) DK169890B1 (pm)
ES (1) ES2105924B1 (pm)
FI (1) FI106198B (pm)
FR (1) FR2690919B1 (pm)
GB (2) GB9208492D0 (pm)
GE (1) GEP19991704B (pm)
GR (1) GR1001619B (pm)
HK (1) HK95797A (pm)
HU (2) HU217964B (pm)
IL (1) IL105412A (pm)
IS (1) IS3994A (pm)
IT (1) IT1265325B1 (pm)
LU (1) LU88248A1 (pm)
MX (1) MX9302195A (pm)
MY (1) MY112232A (pm)
NO (1) NO301879B1 (pm)
NZ (1) NZ247413A (pm)
OA (1) OA10103A (pm)
PL (1) PL176451B1 (pm)
RO (1) RO113242B1 (pm)
RU (1) RU2129544C1 (pm)
SE (1) SE504336C2 (pm)
SK (1) SK281941B6 (pm)
TW (1) TW224457B (pm)
WO (1) WO1993021153A1 (pm)
ZA (1) ZA932642B (pm)

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US5519048A (en) * 1993-05-27 1996-05-21 Merrell Pharmaceuticals Inc. 3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof
ES2103590T3 (es) * 1993-05-27 1997-09-16 Merrell Pharma Inc Derivados del acido 3-(indol-3-il) propenoico utilizables como antagonistas nmda.
GB9319243D0 (en) * 1993-09-17 1993-11-03 Glaxo Spa Heterocyclic compounds
GB9321221D0 (en) * 1993-10-14 1993-12-01 Glaxo Spa Heterocyclic compounds
TW280819B (pm) * 1993-11-17 1996-07-11 Sumitomo Pharma
US5563157B1 (en) 1994-10-31 1999-02-02 Hoecst Marion Roussel Inc Heterocycle substituted propenoic acid derivatives and pharmaceutical compositions thereof
GB9502695D0 (en) * 1995-02-11 1995-03-29 Glaxo Spa Pharmaceutical composition
GB9504361D0 (en) * 1995-03-04 1995-04-26 Glaxo Spa Heterocyclic compounds
AU4416197A (en) * 1996-09-17 1998-04-14 Regents Of The University Of California, The Positive ampa receptor modulation to enhance brain neurotrophic factor expression
BR9712144A (pt) * 1996-09-30 1999-08-31 Hoechst Marion Roussel Inc Novos antagonistas de nmda (d- aspartato de n-metila).
US5922752A (en) * 1997-06-11 1999-07-13 Hoechst Marion Roussell, Inc. NMDA (n-methyl-d-aspartate) antagonists
KR100440553B1 (ko) * 1998-03-26 2004-07-15 후지사와 야꾸힝 고교 가부시키가이샤 서방성 제제
NZ523812A (en) * 2000-07-31 2004-07-30 Dainippon Pharmaceutical Co Medicaments containing 2-aryl-8-oxodihydropurine derivatives as the active ingredient for treating dementia, dsmnesia, learning deficit and higher brain dysfunction
US20030162825A1 (en) * 2001-11-09 2003-08-28 Sepracor Inc. D-amino acid oxidase inhibitors for learning and memory
US7582657B2 (en) * 2001-12-10 2009-09-01 Amgen Inc. Vanilloid receptor ligands and their use in treatments
PA8579701A1 (es) * 2002-08-23 2005-05-24 Pfizer Prod Inc Profarmaco inhibidor de beta-lactamasa
DE10306202A1 (de) 2003-02-13 2004-08-26 Grünenthal GmbH Arzneimittel enthaltend substituierte 2-Aryl-Aminoessigsäure-Verbindungen und/oder substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen
WO2004108733A1 (en) * 2003-06-05 2004-12-16 Pfizer Products Inc. Beta-lactamase inhibitor prodrug
RU2247563C1 (ru) * 2003-06-16 2005-03-10 Пятигорская государственная фармацевтическая академия Способ получения твердой лекарственной формы, содержащей глюкозамина гидрохлорид
WO2005051919A1 (en) * 2003-11-26 2005-06-09 Pfizer Products Inc. Aminopyrazole derivatives as gsk-3 inhibitors
US7488747B2 (en) * 2003-12-29 2009-02-10 Sepracor Inc. Pyrrole and pyrazole DAAO inhibitors
RU2281755C2 (ru) * 2004-04-19 2006-08-20 Пятигорская государственная фармацевтическая академия Композиция - лекарственная форма противоартрозного средства глюкозамина гидрохлорида для ректального применения
US20060002999A1 (en) * 2004-06-17 2006-01-05 Forest Laboratories, Inc. Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane
US20080293726A1 (en) 2005-07-06 2008-11-27 Sepracor Inc. Combinations of Eszopiclone and Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-N-Methyl-1-Napthalenamine or Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Napthalenamine, and Methods of Treatment of Menopause and Mood, Anxiety, and Cognitive Disorders
RU2430913C2 (ru) * 2006-01-06 2011-10-10 Сепракор Инк. Циклоалкиламины в качестве ингибиторов повторного поглощения моноамина
CN104276955A (zh) * 2006-01-06 2015-01-14 赛诺维信制药公司 基于四氢萘酮的单胺再摄取抑制剂
PT2816024T (pt) 2006-03-31 2017-10-20 Sunovion Pharmaceuticals Inc Aminas quirais
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US7884124B2 (en) * 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US20080082066A1 (en) * 2006-10-02 2008-04-03 Weyerhaeuser Co. Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
EP1942104A1 (en) 2006-12-20 2008-07-09 sanofi-aventis Heteroarylcyclopropanecarboxamides and their use as pharmaceuticals
WO2008089453A2 (en) 2007-01-18 2008-07-24 Sepracor Inc. Inhibitors of d-amino acid oxidase
US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
NZ580429A (en) 2007-05-31 2012-04-27 Sepracor Inc Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
US20090247644A1 (en) * 2008-03-28 2009-10-01 Forest Laboratories Holdings Limited Memantine formulations
US20100120740A1 (en) * 2008-08-07 2010-05-13 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
EA201101307A1 (ru) 2009-03-10 2012-03-30 Сантен Фармасьютикал Ко., Лтд. Профилактические или терапевтические средства для расстройств зрительного нерва, содержащие производные 4,6-дихлор-1н-индол-2-карбоновой кислоты или их соли в качестве активных ингредиентов
US20110034434A1 (en) * 2009-08-07 2011-02-10 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US9737531B2 (en) 2012-07-12 2017-08-22 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
USRE49340E1 (en) 2014-04-30 2022-12-20 Yufeng Jane Tseng Use of known compounds as D-amino acid oxidase inhibitors
KR20240042153A (ko) 2016-09-14 2024-04-01 위펑 제인 쳉 D-아미노산 옥시다제 (daao) 저해제로서 신규한 치환된 벤즈이미다졸 유도체
WO2018229744A1 (en) 2017-06-12 2018-12-20 Glytech Llc. Treatment of depression with nmda antagonists and d2/5ht2a or selective 5ht2a antagonists
CN112707874A (zh) * 2020-12-29 2021-04-27 广东中科药物研究有限公司 一种抗病毒化合物及其制备方法

Family Cites Families (7)

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US3010971A (en) * 1960-08-04 1961-11-28 Smith Kline French Lab Cyclopropylamine derivatives and processes for their preparation
DK500285A (da) * 1984-11-02 1986-05-03 Glaxo Group Ltd Cephalosporinantibiotika
US4960786A (en) * 1989-04-24 1990-10-02 Merrell Dow Pharmaceuticals Inc. Excitatory amino acid antagonists
PT93943A (pt) * 1989-05-05 1991-02-08 Searle & Co Processo para a preparacao de composicoes contendo compostos indole-2-carboxilato para tratamento de perturbacoes do snc
ATE136295T1 (de) * 1990-07-16 1996-04-15 Merrell Dow Pharma Exzitatorische aminosäureantagonisten
US5284862A (en) * 1991-03-18 1994-02-08 Warner-Lambert Company Derivatives of 2-carboxyindoles having pharmaceutical activity
US5145845A (en) * 1991-05-14 1992-09-08 Warner-Lambert Co. Substituted 2-carboxylindoles having pharmaceutical activity

Also Published As

Publication number Publication date
RU94045915A (ru) 1996-09-10
HU9402975D0 (en) 1995-02-28
NZ247413A (en) 1995-12-21
CH685630A5 (fr) 1995-08-31
CA2094076A1 (en) 1993-10-17
CZ285799B6 (cs) 1999-11-17
FI944800L (fi) 1994-10-12
SK124194A3 (en) 1995-05-10
DK169890B1 (da) 1995-03-27
GB2266091A (en) 1993-10-20
US5374649A (en) 1994-12-20
DK43193D0 (da) 1993-04-15
AU666927B2 (en) 1996-02-29
SK281941B6 (sk) 2001-09-11
IL105412A (en) 1998-02-22
CY2038B1 (en) 1998-04-30
RO113242B1 (ro) 1998-05-29
SE9301241L (sv) 1993-10-17
NO943913L (no) 1994-12-14
JPH0649027A (ja) 1994-02-22
SE504336C2 (sv) 1997-01-13
GB9208492D0 (en) 1992-06-03
CA2094073A1 (en) 1993-10-17
IL105412A0 (en) 1993-08-18
FI106198B (fi) 2000-12-15
EP0568136A1 (en) 1993-11-03
WO1993021153A1 (en) 1993-10-28
IS3994A (is) 1993-10-17
MY112232A (en) 2001-05-31
NO943913D0 (no) 1994-10-14
BG99111A (bg) 1995-05-31
ATA75293A (de) 1997-11-15
BG62136B1 (bg) 1999-03-31
MX9302195A (es) 1994-03-31
FI944800A0 (fi) 1994-10-12
AT403917B (de) 1998-06-25
LU88248A1 (fr) 1994-03-01
HUT70526A (en) 1995-10-30
GEP19991704B (en) 1999-08-05
AP480A (en) 1996-03-22
AU3692393A (en) 1993-10-21
US5374648A (en) 1994-12-20
CN1042331C (zh) 1999-03-03
CA2094075A1 (en) 1993-10-17
HU211826A9 (en) 1995-12-28
GB2266091B (en) 1995-08-09
ES2105924A1 (es) 1997-10-16
ITRM930236A0 (it) 1993-04-15
BR1100323A (pt) 2000-06-27
US5510367A (en) 1996-04-23
GR1001619B (el) 1994-07-29
KR100264114B1 (ko) 2000-11-01
FR2690919B1 (fr) 1995-05-05
OA10103A (en) 1996-12-18
CN1085212A (zh) 1994-04-13
SE9301241D0 (sv) 1993-04-15
NO301879B1 (no) 1997-12-22
PL176451B1 (pl) 1999-05-31
CZ254394A3 (en) 1995-07-12
JPH07505407A (ja) 1995-06-15
DK43193A (da) 1993-10-17
ITRM930236A1 (it) 1994-10-15
RU2129544C1 (ru) 1999-04-27
GB9307808D0 (en) 1993-06-02
HU217964B (hu) 2000-05-28
ES2105924B1 (es) 1998-07-01
HK95797A (en) 1997-08-08
BE1006343A5 (fr) 1994-07-26
AP9300524A0 (en) 1993-04-30
FR2690919A1 (fr) 1993-11-12
IT1265325B1 (it) 1996-10-31
US5373018A (en) 1994-12-13
TW224457B (pm) 1994-06-01

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