ZA929650B - 20-methyl-substituted vitamin D derivatives. - Google Patents
20-methyl-substituted vitamin D derivatives.Info
- Publication number
- ZA929650B ZA929650B ZA929650A ZA929650A ZA929650B ZA 929650 B ZA929650 B ZA 929650B ZA 929650 A ZA929650 A ZA 929650A ZA 929650 A ZA929650 A ZA 929650A ZA 929650 B ZA929650 B ZA 929650B
- Authority
- ZA
- South Africa
- Prior art keywords
- group
- derivatives
- methyl
- carbon atoms
- production
- Prior art date
Links
- 150000003710 vitamin D derivatives Chemical class 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 239000004215 Carbon black (E152) Substances 0.000 abstract 2
- 229930195733 hydrocarbon Natural products 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 abstract 1
- 235000020964 calcitriol Nutrition 0.000 abstract 1
- 239000011612 calcitriol Substances 0.000 abstract 1
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 abstract 1
- 229960005084 calcitriol Drugs 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 230000024245 cell differentiation Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4141746A DE4141746A1 (de) | 1991-12-13 | 1991-12-13 | 20-methyl-substituierte vitamin d-derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA929650B true ZA929650B (en) | 1993-06-09 |
Family
ID=6447341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA929650A ZA929650B (en) | 1991-12-13 | 1992-12-11 | 20-methyl-substituted vitamin D derivatives. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5446035A (fi) |
| EP (1) | EP0637299B1 (fi) |
| JP (1) | JP3280975B2 (fi) |
| KR (1) | KR100271462B1 (fi) |
| CN (1) | CN1035177C (fi) |
| AT (1) | ATE138366T1 (fi) |
| AU (1) | AU670585B2 (fi) |
| CA (1) | CA2125476C (fi) |
| CZ (1) | CZ286579B6 (fi) |
| DE (2) | DE4141746A1 (fi) |
| DK (1) | DK0637299T3 (fi) |
| ES (1) | ES2089585T3 (fi) |
| FI (1) | FI108226B (fi) |
| GR (1) | GR3020097T3 (fi) |
| HU (1) | HUT68263A (fi) |
| IL (1) | IL104074A (fi) |
| MX (1) | MX9207101A (fi) |
| NO (1) | NO305949B1 (fi) |
| NZ (1) | NZ246052A (fi) |
| PL (1) | PL171403B1 (fi) |
| SK (1) | SK280450B6 (fi) |
| TW (1) | TW275060B (fi) |
| WO (1) | WO1993012081A1 (fi) |
| ZA (1) | ZA929650B (fi) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4220757A1 (de) * | 1992-06-24 | 1994-01-05 | Schering Ag | Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln |
| GB9220272D0 (en) * | 1992-09-25 | 1992-11-11 | Leo Pharm Prod Ltd | Chemical compounds |
| IL107185A (en) * | 1992-10-06 | 1998-02-22 | Schering Ag | History of 52-carboxylic acid, processes for their preparation and pharmaceutical preparations containing them |
| US20040167106A1 (en) * | 1993-06-04 | 2004-08-26 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of a Vitamin D compound |
| US6407082B1 (en) * | 1996-09-13 | 2002-06-18 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of a vitamin D compound |
| GB9315253D0 (en) * | 1993-07-23 | 1993-09-08 | Res Inst Medicine Chem | Chemical compounds |
| US5428029A (en) * | 1993-11-24 | 1995-06-27 | Hoffmann-La Roche Inc. | Vitamin D3 fluorinated analogs |
| US5981597A (en) * | 1995-02-13 | 1999-11-09 | Trustees Of The University Of Pennsylvania | Differentiating agents for the treatment of inflammatory intestinal diseases |
| EP1640003A2 (en) * | 1996-02-13 | 2006-03-29 | G.D. SEARLE & CO. | Compositions comprising a Cyclooxygenase-2 Inhibitor and a Leukotriene B4 receptor antagonist |
| DE19619036A1 (de) | 1996-04-30 | 1997-11-13 | Schering Ag | Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| SG70010A1 (en) * | 1996-05-23 | 2000-01-25 | Hoffmann La Roche | Fluorinated vitamin d3 analogs |
| US6034074A (en) * | 1996-09-13 | 2000-03-07 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of a Vitamin D compound |
| US6511970B1 (en) | 1996-09-13 | 2003-01-28 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium |
| US6765002B2 (en) | 2000-03-21 | 2004-07-20 | Gustavo Rodriguez | Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium |
| US6028064A (en) | 1996-09-13 | 2000-02-22 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of progestin products |
| ATE238986T1 (de) | 1997-09-08 | 2003-05-15 | Hoffmann La Roche | 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analoga |
| WO1999049870A1 (en) | 1998-03-27 | 1999-10-07 | Oregon Health Sciences University | Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders |
| US20030188756A1 (en) * | 2002-08-19 | 2003-10-09 | Cantorna Margherita T | Treatment of inflammatory bowel disease with vitamin d compounds |
| US6989377B2 (en) | 1999-12-21 | 2006-01-24 | Wisconsin Alumni Research Foundation | Treating vitamin D responsive diseases |
| US6358939B1 (en) | 1999-12-21 | 2002-03-19 | Northern Lights Pharmaceuticals, Llc | Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease |
| US20010044431A1 (en) * | 2000-03-21 | 2001-11-22 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium |
| AU2001278744A1 (en) * | 2000-08-17 | 2002-02-25 | Chugai Seiyaku Kabushiki Kaisha | Remedial agent for osteoporosis |
| TWI329105B (en) * | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| JP4886511B2 (ja) * | 2003-07-30 | 2012-02-29 | ライジェル ファーマシューティカルズ， インコーポレイテッド | ２，４−ピリミジンジアミン化合物による自己免疫疾患の治療または予防方法 |
| AU2006245283B2 (en) | 2005-05-10 | 2012-11-01 | Dermipsor Ltd. | Compositions and methods for treating hyperproliferative epidermal diseases |
| US8034788B2 (en) * | 2005-05-10 | 2011-10-11 | Dermipsor Ltd. | Composition and methods for skin care |
| JP2008543855A (ja) | 2005-06-13 | 2008-12-04 | ライジェル ファーマシューティカルズ， インコーポレイテッド | 変形性骨疾患を処置するための方法および組成物 |
| EP1734251B1 (en) * | 2005-06-17 | 2007-01-24 | MAGNETI MARELLI POWERTRAIN S.p.A. | Fuel injector |
| AU2007287263A1 (en) * | 2006-04-10 | 2008-02-28 | Wisconsin Alumni Research Foundation | Lalpha-hydroxy-2- (3 ' -hydroxypropylidene) -19-nor- vitamin D compounds with a 1,1-dimethylpropyl side chain |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| US20080051375A1 (en) * | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same |
| EP2063963A2 (en) | 2006-08-25 | 2009-06-03 | Cougar Biotechnology, Inc. | Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent |
| WO2009009132A1 (en) * | 2007-07-12 | 2009-01-15 | Cougar Biotechnology, Inc. | Use of 17alpha-hydroxylase/c17, 20-lyase inhibitors for the treatment of cancer |
| MX339746B (es) | 2009-01-27 | 2016-06-08 | Berg Llc | Vitamina d3 y análogos de la misma para aliviar efectos secundarios asociados con la quimioterapia. |
| WO2011019617A2 (en) | 2009-08-14 | 2011-02-17 | Cytotech Labs, Llc | Vitamin d3 and analogs thereof for treating alopecia |
| WO2017209934A1 (en) | 2016-05-13 | 2017-12-07 | Case Western Reserve University | Autophagy activators for treating or preventing skin injury |
| SG11201900361RA (en) | 2016-07-29 | 2019-02-27 | Janssen Pharmaceutica Nv | Methods of treating prostate cancer |
| US10548908B2 (en) * | 2016-09-15 | 2020-02-04 | Nostopharma, LLC | Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification |
| US11903952B2 (en) | 2020-05-27 | 2024-02-20 | Northwestern University | Vitamin D as an immune modulator to prevent immune-related complication from COVID-19 infection |
-
1991
- 1991-12-13 DE DE4141746A patent/DE4141746A1/de not_active Withdrawn
-
1992
- 1992-12-08 MX MX9207101A patent/MX9207101A/es not_active IP Right Cessation
- 1992-12-11 ZA ZA929650A patent/ZA929650B/xx unknown
- 1992-12-12 CN CN92114249A patent/CN1035177C/zh not_active Expired - Fee Related
- 1992-12-13 IL IL104074A patent/IL104074A/en not_active IP Right Cessation
- 1992-12-14 PL PL92304142A patent/PL171403B1/pl not_active IP Right Cessation
- 1992-12-14 KR KR1019940702001A patent/KR100271462B1/ko not_active IP Right Cessation
- 1992-12-14 AT AT92924724T patent/ATE138366T1/de not_active IP Right Cessation
- 1992-12-14 ES ES92924724T patent/ES2089585T3/es not_active Expired - Lifetime
- 1992-12-14 CZ CZ19941416A patent/CZ286579B6/cs not_active IP Right Cessation
- 1992-12-14 EP EP92924724A patent/EP0637299B1/de not_active Expired - Lifetime
- 1992-12-14 CA CA002125476A patent/CA2125476C/en not_active Expired - Fee Related
- 1992-12-14 DE DE59206393T patent/DE59206393D1/de not_active Expired - Lifetime
- 1992-12-14 NZ NZ246052A patent/NZ246052A/xx unknown
- 1992-12-14 DK DK92924724.5T patent/DK0637299T3/da active
- 1992-12-14 JP JP51062193A patent/JP3280975B2/ja not_active Expired - Fee Related
- 1992-12-14 AU AU40356/93A patent/AU670585B2/en not_active Ceased
- 1992-12-14 SK SK661-94A patent/SK280450B6/sk unknown
- 1992-12-14 WO PCT/EP1992/002887 patent/WO1993012081A1/de active IP Right Grant
- 1992-12-14 HU HU9401456A patent/HUT68263A/hu unknown
-
1993
- 1993-01-13 TW TW082100181A patent/TW275060B/zh active
-
1994
- 1994-06-10 FI FI942766A patent/FI108226B/fi not_active IP Right Cessation
- 1994-06-10 NO NO942178A patent/NO305949B1/no unknown
- 1994-09-16 US US08/307,081 patent/US5446035A/en not_active Expired - Fee Related
-
1996
- 1996-05-30 GR GR960401459T patent/GR3020097T3/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TW275060B (fi) | ||
| ES2000823A6 (es) | Metodo para la produccion de compuestos analogos a la vitamina d | |
| HK116296A (en) | Amide derivatives and dermatologic preparations containing the same | |
| DE3664909D1 (en) | Vitamin d3 derivatives | |
| DE3575715D1 (de) | Adamantanamin-derivate, verfahren zur herstellung und diese enthaltende heilmittel. | |
| ES2126581T3 (es) | Derivados de 3-(piperazino-alquil)indol condensados en posiciones 1,7, asi como procedimiento y productos intermedios para su preparacion y medicamentos que contienen estos compuestos. | |
| DE69415812D1 (de) | 15,15-dialkylsubstituierte östradiolderivate | |
| IL64614A (en) | 6alpha-methylhydrocortisone derivatives,processes for their preparation and pharmaceutical compositions containing them | |
| AU563426B2 (en) | 3-alkoxy-2(n-pyrrolidino)-n-pyridyl-n-furyl (or thienyl) methyl propylamines | |
| TW252976B (fi) | ||
| HUT35658A (en) | Process for producing 7-oxo-prostacycline derivatives of selective biological activity | |
| GB1416929A (en) | Fluoranthene derivatives | |
| ES8200703A1 (es) | Procedimiento para la preparacion de 1-hidroxi-esteroides | |
| SI0746556T1 (en) | Tricyclic compounds having affinity for the 5-ht1a receptor | |
| ES2085544T3 (es) | Procedimiento para la fabricacion de 8-n,n-dialquilaminotriciclo-(5.2.1.02,6)decano. |