DK0637299T3 - 20-methylsubstituerede vitamin D-derivater - Google Patents
20-methylsubstituerede vitamin D-derivaterInfo
- Publication number
- DK0637299T3 DK0637299T3 DK92924724.5T DK92924724T DK0637299T3 DK 0637299 T3 DK0637299 T3 DK 0637299T3 DK 92924724 T DK92924724 T DK 92924724T DK 0637299 T3 DK0637299 T3 DK 0637299T3
- Authority
- DK
- Denmark
- Prior art keywords
- group
- derivatives
- methyl
- carbon atoms
- production
- Prior art date
Links
- 150000003710 vitamin D derivatives Chemical class 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 239000004215 Carbon black (E152) Substances 0.000 abstract 2
- 229930195733 hydrocarbon Natural products 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 abstract 1
- 235000020964 calcitriol Nutrition 0.000 abstract 1
- 239000011612 calcitriol Substances 0.000 abstract 1
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 abstract 1
- 229960005084 calcitriol Drugs 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 230000024245 cell differentiation Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4141746A DE4141746A1 (de) | 1991-12-13 | 1991-12-13 | 20-methyl-substituierte vitamin d-derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0637299T3 true DK0637299T3 (da) | 1996-09-30 |
Family
ID=6447341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92924724.5T DK0637299T3 (da) | 1991-12-13 | 1992-12-14 | 20-methylsubstituerede vitamin D-derivater |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5446035A (fi) |
| EP (1) | EP0637299B1 (fi) |
| JP (1) | JP3280975B2 (fi) |
| KR (1) | KR100271462B1 (fi) |
| CN (1) | CN1035177C (fi) |
| AT (1) | ATE138366T1 (fi) |
| AU (1) | AU670585B2 (fi) |
| CA (1) | CA2125476C (fi) |
| CZ (1) | CZ286579B6 (fi) |
| DE (2) | DE4141746A1 (fi) |
| DK (1) | DK0637299T3 (fi) |
| ES (1) | ES2089585T3 (fi) |
| FI (1) | FI108226B (fi) |
| GR (1) | GR3020097T3 (fi) |
| HU (1) | HUT68263A (fi) |
| IL (1) | IL104074A (fi) |
| MX (1) | MX9207101A (fi) |
| NO (1) | NO305949B1 (fi) |
| NZ (1) | NZ246052A (fi) |
| PL (1) | PL171403B1 (fi) |
| SK (1) | SK280450B6 (fi) |
| TW (1) | TW275060B (fi) |
| WO (1) | WO1993012081A1 (fi) |
| ZA (1) | ZA929650B (fi) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4220757A1 (de) * | 1992-06-24 | 1994-01-05 | Schering Ag | Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln |
| GB9220272D0 (en) * | 1992-09-25 | 1992-11-11 | Leo Pharm Prod Ltd | Chemical compounds |
| IL107185A (en) * | 1992-10-06 | 1998-02-22 | Schering Ag | History of 52-carboxylic acid, processes for their preparation and pharmaceutical preparations containing them |
| US6407082B1 (en) * | 1996-09-13 | 2002-06-18 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of a vitamin D compound |
| US20040167106A1 (en) * | 1993-06-04 | 2004-08-26 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of a Vitamin D compound |
| GB9315253D0 (en) * | 1993-07-23 | 1993-09-08 | Res Inst Medicine Chem | Chemical compounds |
| US5428029A (en) * | 1993-11-24 | 1995-06-27 | Hoffmann-La Roche Inc. | Vitamin D3 fluorinated analogs |
| US5981597A (en) * | 1995-02-13 | 1999-11-09 | Trustees Of The University Of Pennsylvania | Differentiating agents for the treatment of inflammatory intestinal diseases |
| DE69733338T2 (de) * | 1996-02-13 | 2006-03-16 | G.D. Searle & Co., Chicago | Zubereitungen, enthaltend einen cyclooxygenase-2-inhibitor und einen leukotrien-b4-rezeptor-antagonisten |
| DE19619036A1 (de) | 1996-04-30 | 1997-11-13 | Schering Ag | Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| SG70010A1 (en) * | 1996-05-23 | 2000-01-25 | Hoffmann La Roche | Fluorinated vitamin d3 analogs |
| US6765002B2 (en) | 2000-03-21 | 2004-07-20 | Gustavo Rodriguez | Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium |
| US6511970B1 (en) | 1996-09-13 | 2003-01-28 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium |
| US6028064A (en) | 1996-09-13 | 2000-02-22 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of progestin products |
| US6034074A (en) | 1996-09-13 | 2000-03-07 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of a Vitamin D compound |
| JP4219553B2 (ja) | 1997-09-08 | 2009-02-04 | エフ．ホフマン−ラ ロシュ アーゲー | １，３−ジヒドロキシ−２０，２０−ジアルキル−ビタミンｄ３類似体 |
| AU762481C (en) | 1998-03-27 | 2004-08-19 | Oregon Health Sciences University | Vitamin D and its analogs in the treatment of tumors and other hyperproliferative disorders |
| US20030188756A1 (en) * | 2002-08-19 | 2003-10-09 | Cantorna Margherita T | Treatment of inflammatory bowel disease with vitamin d compounds |
| US6989377B2 (en) | 1999-12-21 | 2006-01-24 | Wisconsin Alumni Research Foundation | Treating vitamin D responsive diseases |
| US6358939B1 (en) | 1999-12-21 | 2002-03-19 | Northern Lights Pharmaceuticals, Llc | Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease |
| US20010044431A1 (en) * | 2000-03-21 | 2001-11-22 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium |
| EP1314427A4 (en) * | 2000-08-17 | 2006-05-03 | Chugai Pharmaceutical Co Ltd | THERAPEUTIC AGENT FOR THE TREATMENT OF OSTEOPOROSIS |
| TWI329105B (en) * | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| US8178671B2 (en) | 2003-07-30 | 2012-05-15 | Rigel Pharmaceuticals, Inc. | Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds |
| US8034788B2 (en) * | 2005-05-10 | 2011-10-11 | Dermipsor Ltd. | Composition and methods for skin care |
| CN101193641B (zh) | 2005-05-10 | 2013-05-29 | 德米普瑟尔有限公司 | 用于治疗表皮过度增殖疾病的组合物和方法 |
| CA2607901C (en) | 2005-06-13 | 2016-08-16 | Rigel Pharmaceuticals, Inc. | Methods and compositions for treating degenerative bone disorders using a syk inhibitory 2,4-pyrimidinediamine |
| ES2279500T3 (es) * | 2005-06-17 | 2007-08-16 | Magneti Marelli Powertrain S.P.A. | Inyector de carburante. |
| WO2008023278A2 (en) * | 2006-04-10 | 2008-02-28 | Wisconsin Alumni Research Foundation | 1alpha-hydroxy-2- (3 ' -hydroxypropylidene) -19-n0r- vitamin d compounds with a 1,1-dimethylpropyl side chain |
| EP2063963A2 (en) | 2006-08-25 | 2009-06-03 | Cougar Biotechnology, Inc. | Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent |
| US20080051375A1 (en) * | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| WO2009009132A1 (en) * | 2007-07-12 | 2009-01-15 | Cougar Biotechnology, Inc. | Use of 17alpha-hydroxylase/c17, 20-lyase inhibitors for the treatment of cancer |
| JP5932339B2 (ja) * | 2009-01-27 | 2016-06-08 | バーグ エルエルシー | 化学療法に付随する副作用を軽減するためのビタミンｄ３およびその類似体 |
| CN102655869B (zh) | 2009-08-14 | 2016-08-10 | 博格有限责任公司 | 用于治疗脱发的维生素d3及其类似物 |
| US20190183908A1 (en) | 2016-05-13 | 2019-06-20 | Case Western Reserve University | Autophagy activators for treating or preventing skin injury |
| PE20190403A1 (es) | 2016-07-29 | 2019-03-13 | Janssen Pharmaceutica Nv | Metodos para tratar el cancer de prostata |
| US10548908B2 (en) | 2016-09-15 | 2020-02-04 | Nostopharma, LLC | Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification |
| US11903952B2 (en) | 2020-05-27 | 2024-02-20 | Northwestern University | Vitamin D as an immune modulator to prevent immune-related complication from COVID-19 infection |
-
1991
- 1991-12-13 DE DE4141746A patent/DE4141746A1/de not_active Withdrawn
-
1992
- 1992-12-08 MX MX9207101A patent/MX9207101A/es not_active IP Right Cessation
- 1992-12-11 ZA ZA929650A patent/ZA929650B/xx unknown
- 1992-12-12 CN CN92114249A patent/CN1035177C/zh not_active Expired - Fee Related
- 1992-12-13 IL IL104074A patent/IL104074A/en not_active IP Right Cessation
- 1992-12-14 SK SK661-94A patent/SK280450B6/sk unknown
- 1992-12-14 NZ NZ246052A patent/NZ246052A/xx unknown
- 1992-12-14 AU AU40356/93A patent/AU670585B2/en not_active Ceased
- 1992-12-14 HU HU9401456A patent/HUT68263A/hu unknown
- 1992-12-14 AT AT92924724T patent/ATE138366T1/de not_active IP Right Cessation
- 1992-12-14 WO PCT/EP1992/002887 patent/WO1993012081A1/de active IP Right Grant
- 1992-12-14 CZ CZ19941416A patent/CZ286579B6/cs not_active IP Right Cessation
- 1992-12-14 KR KR1019940702001A patent/KR100271462B1/ko not_active IP Right Cessation
- 1992-12-14 EP EP92924724A patent/EP0637299B1/de not_active Expired - Lifetime
- 1992-12-14 PL PL92304142A patent/PL171403B1/pl not_active IP Right Cessation
- 1992-12-14 CA CA002125476A patent/CA2125476C/en not_active Expired - Fee Related
- 1992-12-14 DK DK92924724.5T patent/DK0637299T3/da active
- 1992-12-14 JP JP51062193A patent/JP3280975B2/ja not_active Expired - Fee Related
- 1992-12-14 ES ES92924724T patent/ES2089585T3/es not_active Expired - Lifetime
- 1992-12-14 DE DE59206393T patent/DE59206393D1/de not_active Expired - Lifetime
-
1993
- 1993-01-13 TW TW082100181A patent/TW275060B/zh active
-
1994
- 1994-06-10 NO NO942178A patent/NO305949B1/no unknown
- 1994-06-10 FI FI942766A patent/FI108226B/fi not_active IP Right Cessation
- 1994-09-16 US US08/307,081 patent/US5446035A/en not_active Expired - Fee Related
-
1996
- 1996-05-30 GR GR960401459T patent/GR3020097T3/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE138366T1 (de) | 20-methyl-substituierte vitamin d-derivate | |
| ES2000823A6 (es) | Metodo para la produccion de compuestos analogos a la vitamina d | |
| NO951813L (no) | Bicyklisk heterocyklisk sulfonamid og sulfonester-derivater | |
| ES458264A1 (es) | Procedimiento para la preparacion de nuevos compuestos ana- logos a prostaglandinas. | |
| ATE45347T1 (de) | Vitamin d3-derivate. | |
| DE3575715D1 (de) | Adamantanamin-derivate, verfahren zur herstellung und diese enthaltende heilmittel. | |
| ES2126581T3 (es) | Derivados de 3-(piperazino-alquil)indol condensados en posiciones 1,7, asi como procedimiento y productos intermedios para su preparacion y medicamentos que contienen estos compuestos. | |
| ES449963A2 (es) | Procedimiento de preparacion de derivados piridinicos. | |
| ES464728A1 (es) | Procedimiento para producir derivados del acido propionico | |
| ES2155948T3 (es) | 20-oxopregna-derivados 17-cadena lateral alquinilica de la vitamina d, metodos para su produccion y composiciones farmaceuticas de los mismos. | |
| DE69415812D1 (de) | 15,15-dialkylsubstituierte östradiolderivate | |
| AU563426B2 (en) | 3-alkoxy-2(n-pyrrolidino)-n-pyridyl-n-furyl (or thienyl) methyl propylamines | |
| TW252976B (fi) | ||
| HUT35658A (en) | Process for producing 7-oxo-prostacycline derivatives of selective biological activity | |
| GB1416929A (en) | Fluoranthene derivatives | |
| DK0746556T3 (da) | Tricycliske forbindelser med affinitet for 5-HT1A-receptoren | |
| ES2085544T3 (es) | Procedimiento para la fabricacion de 8-n,n-dialquilaminotriciclo-(5.2.1.02,6)decano. | |
| JPS5229251A (en) | Support e1uipment for measurement instrument | |
| FI921238A (fi) | Välituotteina käytettävät N'-alkoksi- tai N'-aralkyylioksi-N6-syano-griseoliinihapon johdannaiset | |
| JPS53119874A (en) | Preparation of 2-mercaptobenzimidazole type derivatives |