ZA9136B - 3-aminopiperidine derivatives and related nitrogen containing heterocycles - Google Patents
3-aminopiperidine derivatives and related nitrogen containing heterocyclesInfo
- Publication number
- ZA9136B ZA9136B ZA9136A ZA9136A ZA9136B ZA 9136 B ZA9136 B ZA 9136B ZA 9136 A ZA9136 A ZA 9136A ZA 9136 A ZA9136 A ZA 9136A ZA 9136 B ZA9136 B ZA 9136B
- Authority
- ZA
- South Africa
- Prior art keywords
- nitrogen containing
- containing heterocycles
- related nitrogen
- aminopiperidine derivatives
- aminopiperidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Addiction (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1990/000116 WO1991009844A1 (fr) | 1990-01-04 | 1990-01-04 | Antagonistes de la substance p |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA9136B true ZA9136B (en) | 1992-08-26 |
Family
ID=22220614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA9136A ZA9136B (en) | 1990-01-04 | 1991-01-03 | 3-aminopiperidine derivatives and related nitrogen containing heterocycles |
Country Status (27)
Country | Link |
---|---|
EP (2) | EP0436334B1 (fr) |
JP (1) | JPH0757748B2 (fr) |
KR (1) | KR930009441B1 (fr) |
CN (2) | CN1035944C (fr) |
AT (1) | ATE115127T1 (fr) |
AU (1) | AU625511B2 (fr) |
BR (1) | BR9100016A (fr) |
CA (1) | CA2033497C (fr) |
CZ (1) | CZ289485B6 (fr) |
DE (1) | DE69014848T2 (fr) |
DK (1) | DK0436334T3 (fr) |
ES (1) | ES2064667T3 (fr) |
FI (2) | FI114096B (fr) |
GR (1) | GR3014940T3 (fr) |
HU (5) | HUT68179A (fr) |
IE (1) | IE63770B1 (fr) |
IL (3) | IL96821A (fr) |
MY (1) | MY105438A (fr) |
NO (1) | NO178187C (fr) |
NZ (1) | NZ236581A (fr) |
PL (5) | PL164244B1 (fr) |
PT (1) | PT96405B (fr) |
RU (1) | RU2105758C1 (fr) |
UA (1) | UA41251C2 (fr) |
WO (1) | WO1991009844A1 (fr) |
YU (1) | YU48026B (fr) |
ZA (1) | ZA9136B (fr) |
Families Citing this family (117)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5830863A (en) * | 1988-06-20 | 1998-11-03 | Merrell Pharmaceuticals Inc. | Neurokinin A antagonists |
US6218364B1 (en) | 1988-06-20 | 2001-04-17 | Scott L. Harbeson | Fluorinated neurokinin A antagonists |
US5332817A (en) * | 1990-01-04 | 1994-07-26 | Pfizer Inc. | 3-aminopiperidine derivatives and related nitrogen containing heterocycles |
US5232929A (en) * | 1990-11-28 | 1993-08-03 | Pfizer Inc. | 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use |
PL169187B1 (pl) * | 1990-05-31 | 1996-06-28 | Pfizer | Sposób wytwarzania podstawionych piperydyn PL PL PL |
US5364943A (en) * | 1991-11-27 | 1994-11-15 | Pfizer Inc. | Preparation of substituted piperidines |
DK0532527T3 (da) * | 1990-06-01 | 1995-01-02 | Pfizer | 3-amino-2-arylquinuclidiner, fremgangsmåde til fremstilling deraf og farmaceutiske præparater indeholdende disse |
EP0540526B1 (fr) * | 1990-07-23 | 1994-12-28 | Pfizer Inc. | Derives de quinuclidine |
RU2105001C1 (ru) * | 1991-03-26 | 1998-02-20 | Пфайзер Инк. | Способ получения замещенных 3-аминопиперидинов |
US5716965A (en) * | 1991-05-22 | 1998-02-10 | Pfizer Inc. | Substituted 3-aminoquinuclidines |
RU2114848C1 (ru) * | 1991-06-20 | 1998-07-10 | Пфайзер Инк. | Фторалкоксибензиламинные производные азотсодержащих гетероциклов, фармацевтическая композиция, способ ингибирования действия вещества р у млекопитающих |
TW202432B (fr) * | 1991-06-21 | 1993-03-21 | Pfizer | |
US5459270A (en) * | 1991-08-20 | 1995-10-17 | Merck Sharp & Dohme Limited | Azacyclic compounds, processes for their preparation and pharmaceutical compositions containing them |
DK0533280T4 (da) | 1991-09-20 | 2005-02-28 | Glaxo Group Ltd | Ny medicinsk anvendelse af tachykininantagonister |
GB9201179D0 (en) * | 1992-01-21 | 1992-03-11 | Glaxo Group Ltd | Chemical compounds |
FR2688219B1 (fr) | 1992-03-03 | 1994-07-08 | Sanofi Elf | Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant. |
AU675786B2 (en) * | 1992-04-15 | 1997-02-20 | Merck Sharp & Dohme Limited | Azacyclic compounds |
US5444074A (en) * | 1992-04-15 | 1995-08-22 | Merck Sharp & Dohme Limited | Piperidine tachykinin receptor antagonists |
CA2134964C (fr) * | 1992-05-18 | 1997-12-30 | Manoj C. Desai | Derives aza-bicycliques pontes, utilises comme antagonistes de la substance p |
US5719147A (en) * | 1992-06-29 | 1998-02-17 | Merck & Co., Inc. | Morpholine and thiomorpholine tachykinin receptor antagonists |
US5637699A (en) * | 1992-06-29 | 1997-06-10 | Merck & Co., Inc. | Process for preparing morpholine tachykinin receptor antagonists |
US6048859A (en) | 1992-06-29 | 2000-04-11 | Merck & Co., Inc. | Morpholine and thiomorpholine tachykinin receptor antagonists |
CA2099233A1 (fr) * | 1992-06-29 | 1993-12-30 | Conrad P. Dorn | Antagonistes du recepteur de la tachykinine a base de morpholine et de thiomorpholine |
AU675447B2 (en) * | 1992-07-28 | 1997-02-06 | Merck Sharp & Dohme Limited | Carboxamidomethyl piperidine and analogues |
US5688804A (en) * | 1992-08-04 | 1997-11-18 | Pfizer Inc. | 3-Benzylamino-2-phenyl-piperidine derivatives as substance P receptor antagonists |
GB9216911D0 (en) * | 1992-08-10 | 1992-09-23 | Merck Sharp & Dohme | Therapeutic agents |
US5387595A (en) * | 1992-08-26 | 1995-02-07 | Merck & Co., Inc. | Alicyclic compounds as tachykinin receptor antagonists |
WO1994005625A1 (fr) * | 1992-09-10 | 1994-03-17 | Merck Sharp & Dohme Limited | Alcools et ethers a substituants aromatiques, utilises comme antagonistes de la tachykinine |
GB9220286D0 (en) * | 1992-09-25 | 1992-11-11 | Merck Sharp & Dohme | Therapeutic agents |
US5344830A (en) * | 1992-12-10 | 1994-09-06 | Merck & Co., Inc. | N,N-diacylpiperazine tachykinin antagonists |
ATE194340T1 (de) * | 1992-12-10 | 2000-07-15 | Pfizer | Aminomethylen substituierte heterocyclische verbindungen und ihre verwendung alssubstanz p antagonisten |
US6369074B1 (en) * | 1992-12-10 | 2002-04-09 | Pfizer Inc. | Aminomethylene substituted non-aromatic heterocycles and use as substance P antagonists |
US5830854A (en) * | 1992-12-14 | 1998-11-03 | Merck Sharp & Dohme, Limited | Method of treating cystic fibrosis using a tachykinin receptor antagonist |
GB9300051D0 (en) * | 1993-01-04 | 1993-03-03 | Merck Sharp & Dohme | Therapeutic agents |
DE69410784T2 (de) * | 1993-02-18 | 1999-01-14 | Merck Sharp & Dohme | Azacyclische verbindungen, sie enthaltende zusammensetzungen und ihre verwendung als tachykinin antagoniste |
US5496833A (en) * | 1993-04-13 | 1996-03-05 | Merck Sharp & Dohme Limited | Piperidine tachykinin receptor antagonists |
JPH08507297A (ja) * | 1993-05-28 | 1996-08-06 | ファイザー・インク. | 2−フェニル−3−アミノピペリジンを調製および分割する方法 |
US5348955A (en) * | 1993-06-22 | 1994-09-20 | Merck & Co., Inc. | N,N-diacylpiperazines |
GB9317104D0 (en) * | 1993-08-17 | 1993-09-29 | Zeneca Ltd | Therapeutic heterocycles |
US6083943A (en) * | 1993-09-17 | 2000-07-04 | Pfizer Inc | Substituted azaheterocyclecarboxylic acid |
CA2171637C (fr) * | 1993-09-17 | 2000-05-23 | Masaya Ikunaka | Derives de substitution d'acides azaheterocyclocarboxyliques |
EP1209157A1 (fr) * | 1993-09-17 | 2002-05-29 | Pfizer Inc. | 3-Benzylaminométhyl-pipéridines à substitution hétéroarylamino et hétéroarylsulfonamido, et composés apparents |
IL111002A (en) * | 1993-09-22 | 1998-09-24 | Glaxo Group Ltd | History of piperidine, their preparation and the pharmaceutical preparations containing them |
JPH09508376A (ja) * | 1994-01-28 | 1997-08-26 | メルク シヤープ エンド ドーム リミテツド | アラルキル置換アザシクロ系の治療薬 |
US5610165A (en) * | 1994-02-17 | 1997-03-11 | Merck & Co., Inc. | N-acylpiperidine tachykinin antagonists |
IL112778A0 (en) * | 1994-03-04 | 1995-05-26 | Merck & Co Inc | Substituted heterocycles, their preparation and pharmaceutical compositions containing them |
GB9408872D0 (en) * | 1994-05-03 | 1994-06-22 | Zeneca Ltd | Heterocyclic compounds |
GB9418545D0 (en) * | 1994-09-15 | 1994-11-02 | Merck Sharp & Dohme | Therapeutic agents |
FR2725900B1 (fr) * | 1994-10-21 | 1997-07-18 | Sanofi Sa | Utilisation d'antagonistes des recepteurs nk1 pour la preparation de medicaments a action cardioregulatrice |
US5998444A (en) * | 1995-10-24 | 1999-12-07 | Zeneca Ltd. | Piperidinyl compounds as NK1 or NK2 antagonists |
EP0709375B1 (fr) * | 1994-10-25 | 2005-05-18 | AstraZeneca AB | Hétérocycles thérapeutiquement actifs |
US6008223A (en) * | 1994-10-27 | 1999-12-28 | Zeneca Limited | Therapeutic compounds |
FR2728166A1 (fr) | 1994-12-19 | 1996-06-21 | Oreal | Composition topique contenant un antagoniste de substance p |
FR2728165A1 (fr) | 1994-12-19 | 1996-06-21 | Oreal | Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene |
FR2728169A1 (fr) | 1994-12-19 | 1996-06-21 | Oreal | Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales |
FR2729952B1 (fr) * | 1995-01-30 | 1997-04-18 | Sanofi Sa | Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant |
FR2729954B1 (fr) * | 1995-01-30 | 1997-08-01 | Sanofi Sa | Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant |
FR2741262B1 (fr) | 1995-11-20 | 1999-03-05 | Oreal | Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene |
PT780375E (pt) | 1995-12-21 | 2002-12-31 | Pfizer | 3-¬(benzilo substituido em 5)amino|-2-phenilpiperidinas como antagonistas da substancia p |
WO1998014193A1 (fr) * | 1996-10-04 | 1998-04-09 | Alcon Laboratories, Inc. | Utilisation d'un antagoniste de la substance p dans la fabrication d'un medicament pour traiter les douleurs oculaires |
US5750549A (en) * | 1996-10-15 | 1998-05-12 | Merck & Co., Inc. | Cycloalkyl tachykinin receptor antagonists |
CA2287487A1 (fr) * | 1997-04-24 | 1998-10-29 | Merck Sharp & Dohme Limited | Utilisation des antagonistes du recepteur de nk-1 dans le traitement des troubles alimentaires |
CA2298777A1 (fr) * | 1997-08-04 | 1999-02-18 | Merck Sharp & Dohme Limited | Utilisation d'antagonistes du recepteur nk-1 pour le traitement d'une manie |
GB9716463D0 (en) * | 1997-08-04 | 1997-10-08 | Merck Sharp & Dohme | Therapeutic agents |
CA2298779A1 (fr) * | 1997-08-04 | 1999-02-18 | Merck Sharp & Dohme Limited | Utilisation d'antagonistes du recepteur nk-1 pour le traitement de troubles du comportement agressifs |
GB9716457D0 (en) * | 1997-08-04 | 1997-10-08 | Merck Sharp & Dohme | Therapeutic agents |
GB9816897D0 (en) * | 1998-08-04 | 1998-09-30 | Merck Sharp & Dohme | Therapeutic use |
DE69907220T2 (de) * | 1998-08-25 | 2004-02-05 | Novartis Ag | Verwendung von substanz p antagonisten zur behandlung des chronischen ermüdungssyndroms und/oder der fibromyalgie |
ATE387429T1 (de) | 1999-11-03 | 2008-03-15 | Amr Technology Inc | Arly- und heteroaryl-substituierte tetrahydroisoquinoline und ihre verwendung als hemmer der wiederaufnahme von norepinephrin, dopamin und serotonin |
US7163949B1 (en) | 1999-11-03 | 2007-01-16 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines and use thereof |
SK13632002A3 (sk) | 2000-03-21 | 2003-02-04 | Smithkline Beecham Corporation | C1-6-alkyl-4-amino-azepán-3-ónové zlúčeniny, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty |
EP1299393A2 (fr) | 2000-07-11 | 2003-04-09 | Bristol-Myers Squibb Pharma Company | Tetrahydroisoquinoleines 4-phenyle substituees et leur utilisation therapeutique |
AU2001292320A1 (en) * | 2000-10-02 | 2002-04-15 | Tanabe Seiyaku Co., Ltd. | Benzylamine compound, process for producing the same, and intermediate therefor |
US6709651B2 (en) | 2001-07-03 | 2004-03-23 | B.M.R.A. Corporation B.V. | Treatment of substance P-related disorders |
US20050038072A1 (en) * | 2001-12-28 | 2005-02-17 | Takeda Chemical Industries, Ltd. | Nitrogeneous cyclic ketone derivative, process for producing the same, and use |
CA2573271C (fr) | 2004-07-15 | 2015-10-06 | Amr Technology, Inc. | Tetrahydroisoquinolines a substitution aryle et heteroaryle et leur utilisation pour bloquer le recaptage de la norepinephrine, la dopamine et la serotonine |
EP1805165B1 (fr) | 2004-10-18 | 2009-12-16 | Eli Lilly And Company | Dérivés 1-(hétero)aryle-3-amino-pyrrolidines utiles en tant qu'antagonistes du récepteur de mglur3 |
GB0423356D0 (en) | 2004-10-21 | 2004-11-24 | Merck Sharp & Dohme | Therapeutic agents |
WO2006123182A2 (fr) | 2005-05-17 | 2006-11-23 | Merck Sharp & Dohme Limited | Sulfones de cyclohexyle pour le traitement du cancer |
BRPI0613403A2 (pt) | 2005-07-15 | 2009-02-10 | Amr Technology Inc | tetrahidrobenzodiazepinas aril- e heteroarila-substituÍdas e uso das mesmas para bloquear a recaptaÇço de norepinefrina, dopamina e serotonina |
JP4879988B2 (ja) | 2005-09-29 | 2012-02-22 | メルク・シャープ・エンド・ドーム・コーポレイション | メラノコルチン−4受容体モジュレーターとしてのアシル化スピロピペリジン誘導体 |
GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
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Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE535451A (fr) * | 1954-02-05 | |||
GB1060160A (en) * | 1964-08-05 | 1967-03-01 | Allen & Hanburys Ltd | 4-phenylpiperidine derivatives |
US3560510A (en) * | 1969-03-05 | 1971-02-02 | Aldrich Chem Co Inc | 2-benzhydrylquinuclidines |
US3992389A (en) * | 1970-09-03 | 1976-11-16 | John Wyeth & Brother Limited | Heterocyclic compounds |
MX18467A (es) * | 1988-11-23 | 1993-07-01 | Pfizer | Agentes terapeuticos de quinuclidinas |
PL169187B1 (pl) * | 1990-05-31 | 1996-06-28 | Pfizer | Sposób wytwarzania podstawionych piperydyn PL PL PL |
-
1990
- 1990-01-04 WO PCT/US1990/000116 patent/WO1991009844A1/fr unknown
- 1990-01-04 UA UA5010406A patent/UA41251C2/uk unknown
- 1990-12-14 EP EP90313680A patent/EP0436334B1/fr not_active Expired - Lifetime
- 1990-12-14 ES ES90313680T patent/ES2064667T3/es not_active Expired - Lifetime
- 1990-12-14 DK DK90313680.2T patent/DK0436334T3/da active
- 1990-12-14 AT AT90313680T patent/ATE115127T1/de not_active IP Right Cessation
- 1990-12-14 EP EP19930201034 patent/EP0558156A3/fr not_active Ceased
- 1990-12-14 DE DE69014848T patent/DE69014848T2/de not_active Expired - Fee Related
- 1990-12-20 NZ NZ236581A patent/NZ236581A/xx unknown
- 1990-12-28 IL IL96821A patent/IL96821A/xx not_active IP Right Cessation
- 1990-12-28 JP JP2409476A patent/JPH0757748B2/ja not_active Expired - Fee Related
- 1990-12-28 IL IL112348A patent/IL112348A/en not_active IP Right Cessation
-
1991
- 1991-01-02 PL PL91293389A patent/PL164244B1/pl unknown
- 1991-01-02 CA CA002033497A patent/CA2033497C/fr not_active Expired - Fee Related
- 1991-01-02 MY MYPI91000002A patent/MY105438A/en unknown
- 1991-01-02 PL PL91293390A patent/PL164203B1/pl not_active IP Right Cessation
- 1991-01-02 PL PL91293391A patent/PL164204B1/pl not_active IP Right Cessation
- 1991-01-02 HU HU9203405A patent/HUT68179A/hu unknown
- 1991-01-02 PL PL91293392A patent/PL164205B1/pl not_active IP Right Cessation
- 1991-01-02 HU HU9203403A patent/HUT68130A/hu unknown
- 1991-01-02 PL PL91288592A patent/PL163967B1/pl not_active IP Right Cessation
- 1991-01-02 PT PT96405A patent/PT96405B/pt active IP Right Grant
- 1991-01-02 HU HU9203403A patent/HU222724B1/hu not_active IP Right Cessation
- 1991-01-02 HU HU9203404A patent/HU220602B1/hu unknown
- 1991-01-02 HU HU916A patent/HUT60719A/hu unknown
- 1991-01-02 AU AU68621/91A patent/AU625511B2/en not_active Ceased
- 1991-01-03 CN CN91100039A patent/CN1035944C/zh not_active Expired - Fee Related
- 1991-01-03 KR KR1019910000001A patent/KR930009441B1/ko not_active IP Right Cessation
- 1991-01-03 IE IE791A patent/IE63770B1/en not_active IP Right Cessation
- 1991-01-03 NO NO910016A patent/NO178187C/no unknown
- 1991-01-03 BR BR919100016A patent/BR9100016A/pt not_active Application Discontinuation
- 1991-01-03 YU YU491A patent/YU48026B/sh unknown
- 1991-01-03 ZA ZA9136A patent/ZA9136B/xx unknown
- 1991-01-03 FI FI910034A patent/FI114096B/fi active
- 1991-01-04 CZ CS199110A patent/CZ289485B6/cs not_active IP Right Cessation
- 1991-12-23 RU SU5010406A patent/RU2105758C1/ru not_active IP Right Cessation
-
1993
- 1993-08-20 CN CN93116286A patent/CN1045595C/zh not_active Expired - Fee Related
-
1995
- 1995-01-16 IL IL11234895A patent/IL112348A0/xx unknown
- 1995-02-01 GR GR950400206T patent/GR3014940T3/el unknown
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2004
- 2004-04-01 FI FI20040479A patent/FI20040479A/fi not_active Application Discontinuation
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