ZA909896B - Octapeptide analogs of somatostatin having threonine at the sixth position - Google Patents

Octapeptide analogs of somatostatin having threonine at the sixth position

Info

Publication number
ZA909896B
ZA909896B ZA909896A ZA909896A ZA909896B ZA 909896 B ZA909896 B ZA 909896B ZA 909896 A ZA909896 A ZA 909896A ZA 909896 A ZA909896 A ZA 909896A ZA 909896 B ZA909896 B ZA 909896B
Authority
ZA
South Africa
Prior art keywords
alkyl
somatostatin
threonine
phenylalkyl
r2oco
Prior art date
Application number
ZA909896A
Other languages
English (en)
Inventor
David H Coy
H Coy David
William A Murphy
A Murphy William
Original Assignee
Univ Tulane
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Tulane filed Critical Univ Tulane
Publication of ZA909896B publication Critical patent/ZA909896B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA909896A 1989-12-08 1990-12-10 Octapeptide analogs of somatostatin having threonine at the sixth position ZA909896B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44787689A 1989-12-08 1989-12-08

Publications (1)

Publication Number Publication Date
ZA909896B true ZA909896B (en) 1991-09-25

Family

ID=23778103

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA909896A ZA909896B (en) 1989-12-08 1990-12-10 Octapeptide analogs of somatostatin having threonine at the sixth position

Country Status (14)

Country Link
US (1) US5506339A (de)
EP (1) EP0457888B1 (de)
JP (1) JP2925321B2 (de)
KR (1) KR920702854A (de)
AT (1) ATE140237T1 (de)
CA (1) CA2046594A1 (de)
DE (1) DE69027767T2 (de)
DK (1) DK0457888T3 (de)
ES (1) ES2091907T3 (de)
GR (1) GR3020513T3 (de)
HU (1) HUT59166A (de)
PT (1) PT96135B (de)
WO (1) WO1991009056A1 (de)
ZA (1) ZA909896B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU207104B (en) * 1991-01-25 1993-03-01 Biosignal Kutato Fejlesztoe Kf Process for producing new somatostatin analogs inhibiting tumour growth and pharmaceutical compositions comprising such compounds
US7238340B1 (en) * 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
ATE181240T1 (de) * 1991-02-08 1999-07-15 Biomeasure Inc Verwendung von somatostatinanalogen zur behandlung von melanomen
US5411943A (en) * 1992-02-25 1995-05-02 Biomeasure, Inc. Hepatoma treatment with somatostatin analogs
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5871711A (en) * 1992-06-23 1999-02-16 Diatide, Inc. Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
US5462926A (en) * 1992-07-27 1995-10-31 Biomeasure, Inc. Neuromedin B receptor antagonists which demonstrate selectivity
US5569741A (en) * 1992-07-27 1996-10-29 Biomeasure, Inc. Cyclic octapeptide neuromedin B receptor antagonists
JP3553062B2 (ja) * 1992-07-27 2004-08-11 ジ アドミニストレイターズ オブ ザ トュラン エデュケーショナル ファンド ニューロメジンｂ受容体拮抗物質
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
US5708135A (en) * 1995-09-29 1998-01-13 Biomeasure Incorporated Cyclic peptide analogs of somatostatin
US6262229B1 (en) 1996-12-04 2001-07-17 Biomeasure Incorporated Somatostatin antagonists
ATE245998T1 (de) 1997-05-13 2003-08-15 Sod Conseils Rech Applic Somatostatin agoniste zur reduzierung von körpergewicht
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
WO1998051330A1 (en) 1997-05-13 1998-11-19 Societe De Conseils De Recherches Et D'applications Scientifiques S.A. (S.C.R.A.S.) Method and compositions for treating hyperlipidemia and other conditions
DE69822810T2 (de) * 1997-05-13 2005-02-03 Société de Conseils de Recherches et d'Applications Scientifiques S.A.S. Somatostatin und somatostatin agoniste zur behandlung der insulinsunempfindlichkeit und syndrome x
NZ509348A (en) * 1998-07-30 2004-02-27 Sod Conseils Rech Applic Use of a somatostatin analogue Lanreotide
EP1291022A1 (de) * 1998-07-30 2003-03-12 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Anwendungsverfahren für lanreotid, ein somatostatin analogon
DE60226419D1 (de) * 2001-03-08 2008-06-19 Univ Tulane Somatostatin-antagonisten
MXPA03009048A (es) * 2001-04-09 2004-02-12 Univ Tulane Agonistas de la somatostatina.
ATE424414T1 (de) 2001-06-08 2009-03-15 Sod Conseils Rech Applic Chimere somatostatin-dopamin-analoga
US8709998B2 (en) 2003-04-22 2014-04-29 Ipsen Pharma S.A.S. Peptide vectors
CN102112145B (zh) 2008-06-12 2014-07-30 辛它可辛有限公司 神经内分泌病的抑制
EP2310029B1 (de) 2008-06-12 2019-04-03 Ipsen Bioinnovation Limited Fusionsproteine zur Verwendung bei der Behandlung von Krebs
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
ES2862125T3 (es) 2013-06-13 2021-10-07 Antisense Therapeutics Ltd Terapia combinada para acromegalia

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4291022A (en) * 1975-03-11 1981-09-22 Sandoz Ltd. Organic compounds
ATE2512T1 (de) * 1979-11-27 1983-03-15 Sandoz Ag Polypeptide, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen, die diese polypeptide enthalten, und ihre verwendung.
US4328105A (en) * 1980-02-06 1982-05-04 Linde Aktiengesellschaft Treatment of suspended solids--and adsorbable contaminant--containing liquid
US4282143A (en) * 1980-06-13 1981-08-04 American Home Products Corporation Octapeptides lowering growth hormone
US4328135A (en) * 1980-06-13 1982-05-04 American Home Products Corporation Octapeptides lowering growth hormone
DK81082A (da) * 1981-03-06 1982-09-07 Sandoz Ag Fremgangsmaade til fremstilling af polypeptider
US4485101A (en) * 1983-10-11 1984-11-27 Administrators Of The Tulane Educational Fund Peptides
US4684620A (en) * 1984-09-04 1987-08-04 Gibson-Stephens Neuropharmaceuticals, Inc. Cyclic polypeptides having mu-receptor specificity
US4650787A (en) * 1985-04-25 1987-03-17 Schally Andrew Victor Biologically active octapeptides
US4725577A (en) * 1985-04-25 1988-02-16 Administrators Of The Tulane Educational Fund Biologically active lysine containing octapeptides
US4904642A (en) * 1985-09-12 1990-02-27 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
US4853371A (en) * 1986-06-17 1989-08-01 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
JP2568228B2 (ja) * 1987-02-03 1996-12-25 ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド 治療用ソマトスタチンアナログ
JP2809403B2 (ja) * 1987-07-07 1998-10-08 ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド 治療用ソマトスタチンアナログ化合物
GB8813160D0 (en) * 1988-06-03 1988-07-06 Soc D Etudes Prod Chimique Therapeutic methods

Also Published As

Publication number Publication date
ATE140237T1 (de) 1996-07-15
ES2091907T3 (es) 1996-11-16
EP0457888B1 (de) 1996-07-10
JPH04505456A (ja) 1992-09-24
KR920702854A (ko) 1992-10-28
PT96135A (pt) 1991-09-30
DE69027767D1 (de) 1996-08-14
PT96135B (pt) 1998-04-30
CA2046594A1 (en) 1991-06-09
US5506339A (en) 1996-04-09
DE69027767T2 (de) 1997-01-02
EP0457888A1 (de) 1991-11-27
EP0457888A4 (en) 1992-01-02
HUT59166A (en) 1992-04-28
DK0457888T3 (da) 1996-08-12
JP2925321B2 (ja) 1999-07-28
GR3020513T3 (en) 1996-10-31
WO1991009056A1 (en) 1991-06-27

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