ES2091907T3 - Analogos octapeptidos de somatostina con una threonina en la sexta posicion. - Google Patents

Analogos octapeptidos de somatostina con una threonina en la sexta posicion.

Info

Publication number
ES2091907T3
ES2091907T3 ES91901181T ES91901181T ES2091907T3 ES 2091907 T3 ES2091907 T3 ES 2091907T3 ES 91901181 T ES91901181 T ES 91901181T ES 91901181 T ES91901181 T ES 91901181T ES 2091907 T3 ES2091907 T3 ES 2091907T3
Authority
ES
Spain
Prior art keywords
alkyl
somatostina
threonin
phenylalkyl
octapeptide analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91901181T
Other languages
English (en)
Inventor
David H Coy
William A Murphy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tulane University
Original Assignee
Tulane University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tulane University filed Critical Tulane University
Application granted granted Critical
Publication of ES2091907T3 publication Critical patent/ES2091907T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

UN COMPUESTO DE FORMULA (I), EN LA QUE CADA UNO DE A SUB 1 Y A SUB 2, INDEPENDIENTEMENTE, ES H ALQUILO C SUB 1-12 FENILALQUILO C SUB 7-10, R SUB 1 CO (DONDE R SUB 1 ES ALQUILO C SUB 1-20, ALQUENILO C SUB 3-20, ALQUENILO C SUB 3-20, FENILO, MAFTILO, O FENILALQUILO C SUB 7-10), O R SUB 2 OCO (DONDE R ES ALQUILO C SUB 1-10 O FENILALQUILO C SUB 7-10), SIEMPRE QUE CUANDO UNO DE A SUB 1 O A SUB 2 ES R SUB 1 CO O R SUB 2 OCO, EL OTRO TIENE QUE SER H; CADA UNO DE X SUB 1 Y X SUB 2, INDEPENDIENTEMENTE, ES H, F, CL, BR, OH, CH SUB 3, O CF SUB 3, SIEMPRE QUE AL MENOS UNO DE X SUB 1 Y X SUB 2 TIENE QUE SER H; A SUB 3 ES PHE O TYR; Y A SUB 4 ES OH, NH SUB 2 O NH-R SUB 3 (DONDE R SUB 3 ES UN ALQUILO C SUB 1-8 ALIFATICO SATURADO):O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE ESTOS; UNA COMPOSICION QUE COMPRENDE DICHO COMPUESTO; Y UN METODO DE USO DE DICHO COMPUESTO.
ES91901181T 1989-12-08 1990-12-04 Analogos octapeptidos de somatostina con una threonina en la sexta posicion. Expired - Lifetime ES2091907T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44787689A 1989-12-08 1989-12-08

Publications (1)

Publication Number Publication Date
ES2091907T3 true ES2091907T3 (es) 1996-11-16

Family

ID=23778103

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91901181T Expired - Lifetime ES2091907T3 (es) 1989-12-08 1990-12-04 Analogos octapeptidos de somatostina con una threonina en la sexta posicion.

Country Status (14)

Country Link
US (1) US5506339A (es)
EP (1) EP0457888B1 (es)
JP (1) JP2925321B2 (es)
KR (1) KR920702854A (es)
AT (1) ATE140237T1 (es)
CA (1) CA2046594A1 (es)
DE (1) DE69027767T2 (es)
DK (1) DK0457888T3 (es)
ES (1) ES2091907T3 (es)
GR (1) GR3020513T3 (es)
HU (1) HUT59166A (es)
PT (1) PT96135B (es)
WO (1) WO1991009056A1 (es)
ZA (1) ZA909896B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU207104B (en) * 1991-01-25 1993-03-01 Biosignal Kutato Fejlesztoe Kf Process for producing new somatostatin analogs inhibiting tumour growth and pharmaceutical compositions comprising such compounds
US7238340B1 (en) * 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
ATE181240T1 (de) * 1991-02-08 1999-07-15 Biomeasure Inc Verwendung von somatostatinanalogen zur behandlung von melanomen
US5411943A (en) * 1992-02-25 1995-05-02 Biomeasure, Inc. Hepatoma treatment with somatostatin analogs
US5871711A (en) * 1992-06-23 1999-02-16 Diatide, Inc. Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5462926A (en) * 1992-07-27 1995-10-31 Biomeasure, Inc. Neuromedin B receptor antagonists which demonstrate selectivity
US5569741A (en) * 1992-07-27 1996-10-29 Biomeasure, Inc. Cyclic octapeptide neuromedin B receptor antagonists
DE69330868T2 (de) * 1992-07-27 2002-04-25 Biomeasure Inc Antagonisten des neuromedin b rezeptors
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
US5708135A (en) * 1995-09-29 1998-01-13 Biomeasure Incorporated Cyclic peptide analogs of somatostatin
US6262229B1 (en) 1996-12-04 2001-07-17 Biomeasure Incorporated Somatostatin antagonists
EP0981364B1 (en) 1997-05-13 2006-03-01 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Method and compositions for treating hyperlipidemia
PT980253E (pt) * 1997-05-13 2004-08-31 Conseils De Rec Appl Scient S Somatostatina e agonistas de somatostatina para tratar a insensibilidade a insulina e a sindrome x
ATE245998T1 (de) 1997-05-13 2003-08-15 Sod Conseils Rech Applic Somatostatin agoniste zur reduzierung von körpergewicht
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
EP1291022A1 (en) * 1998-07-30 2003-03-12 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Methods of using lanreotide, a somatostatin analogue
CN1334742A (zh) * 1998-07-30 2002-02-06 研究及应用科学协会股份有限公司 促生长素抑制素类似物兰瑞肽的应用方法
ES2306766T3 (es) * 2001-03-08 2008-11-16 The Administrators Of The Tulane Educational Fund Antagonistas de somatostatina.
HUP0303727A2 (hu) * 2001-04-09 2004-03-01 The Administrators Of The Tulane Educational Fund Szomatosztatin agonisták és ezek alkalmazása
ES2325880T3 (es) 2001-06-08 2009-09-23 Ipsen Pharma Analogos quimericos de somatostatina-dopamina.
US8709998B2 (en) 2003-04-22 2014-04-29 Ipsen Pharma S.A.S. Peptide vectors
KR101642363B1 (ko) 2008-06-12 2016-07-25 입센 바이오이노베이션 리미티드 신경내분비계 질환의 억제
CN102083451A (zh) 2008-06-12 2011-06-01 赛恩泰新公司 癌症的抑制
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
WO2014197938A1 (en) 2013-06-13 2014-12-18 Antisense Therapeutics Ltd Combination therapy

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4291022A (en) * 1975-03-11 1981-09-22 Sandoz Ltd. Organic compounds
ATE2512T1 (de) * 1979-11-27 1983-03-15 Sandoz Ag Polypeptide, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen, die diese polypeptide enthalten, und ihre verwendung.
US4328105A (en) * 1980-02-06 1982-05-04 Linde Aktiengesellschaft Treatment of suspended solids--and adsorbable contaminant--containing liquid
US4282143A (en) * 1980-06-13 1981-08-04 American Home Products Corporation Octapeptides lowering growth hormone
US4328135A (en) * 1980-06-13 1982-05-04 American Home Products Corporation Octapeptides lowering growth hormone
DK81082A (da) * 1981-03-06 1982-09-07 Sandoz Ag Fremgangsmaade til fremstilling af polypeptider
US4485101A (en) * 1983-10-11 1984-11-27 Administrators Of The Tulane Educational Fund Peptides
US4684620A (en) * 1984-09-04 1987-08-04 Gibson-Stephens Neuropharmaceuticals, Inc. Cyclic polypeptides having mu-receptor specificity
US4725577A (en) * 1985-04-25 1988-02-16 Administrators Of The Tulane Educational Fund Biologically active lysine containing octapeptides
US4650787A (en) * 1985-04-25 1987-03-17 Schally Andrew Victor Biologically active octapeptides
US4904642A (en) * 1985-09-12 1990-02-27 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
US4853371A (en) * 1986-06-17 1989-08-01 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
JP2568228B2 (ja) * 1987-02-03 1996-12-25 ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド 治療用ソマトスタチンアナログ
JP2809403B2 (ja) * 1987-07-07 1998-10-08 ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド 治療用ソマトスタチンアナログ化合物
GB8813160D0 (en) * 1988-06-03 1988-07-06 Soc D Etudes Prod Chimique Therapeutic methods

Also Published As

Publication number Publication date
EP0457888B1 (en) 1996-07-10
US5506339A (en) 1996-04-09
PT96135A (pt) 1991-09-30
KR920702854A (ko) 1992-10-28
EP0457888A1 (en) 1991-11-27
CA2046594A1 (en) 1991-06-09
JPH04505456A (ja) 1992-09-24
HUT59166A (en) 1992-04-28
ATE140237T1 (de) 1996-07-15
DE69027767T2 (de) 1997-01-02
ZA909896B (en) 1991-09-25
JP2925321B2 (ja) 1999-07-28
DE69027767D1 (de) 1996-08-14
GR3020513T3 (en) 1996-10-31
DK0457888T3 (da) 1996-08-12
PT96135B (pt) 1998-04-30
EP0457888A4 (en) 1992-01-02
WO1991009056A1 (en) 1991-06-27

Similar Documents

Publication Publication Date Title
ES2091907T3 (es) Analogos octapeptidos de somatostina con una threonina en la sexta posicion.
AR247213A1 (es) Preparacion de acido 7-¡(1-carboxi-3-fenilpropil)amino¿-3,4,6,7,8,12b-octahidro-6-oxopirido ¡2,1-a¿ o hexahidro-6-oxo-1h(1,4-tiazino¡3,4-a¿¡2¿-benzazepin-4-carboxilico, agentes hipertensivos.
AU518470B2 (en) 2-(2-alkoxyethyl)-2:-hydroxy-6,7-benzomorphanes
LU88579I2 (fr) ATOVAQUONE et ses sels pharmaceutiquement acceptables (WELLVONE R)
FI934680A (fi) Arylmorfolin, framstaellning och anvaending
DK624989D0 (da) Hidtil ukendte forbindelser
NO914375D0 (no) Fremgangsmaate for fremstilling av 7-acyl-3-(substituerte carbamoyloxy)cefem-forbindelser
ES2086528T3 (es) Nuevos compuestos biciclicos sustituidos con amino.
BR9400016A (pt) Processo para preparação de compostos, e compostos
GB2135997B (en) N-(m-trifluoromethylphenyl)-n'-propargylpiperazine
CA2051460A1 (en) Pharmaceutical compounds
ES8500907A1 (es) Procedimiento para preparar derivados de (indenil-2)-2-imidazolina
FI961423A (fi) Antrasykliinidisakkaridit, menetelmä niiden valmistamiseksi sekä niitä sisältävät farmaseuttiset koostumukset
ES8307712A1 (es) "procedimiento para la preparacion de n-(2,6-diclorofenil)-acetamidina".
IL70630A (en) Triazolopyridoquinazolinones,analogs thereof,their preparation and pharmaceutical compositions containing them
IT9022320A0 (it) Procedimento per impedire che un rotore di filatura ad estremita' aperta diventi inservibile
ITMI913295A1 (it) Procedimento di avanzamento di gallerie come pure macchine di avanzamento a scudo per l'attuazione di questo procedimento
FI875626A (fi) Foerfarande foer framstaellning av dibenzo/be/ixepinaettiksyraderivat.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 457888

Country of ref document: ES