ATE140237T1 - Oktapeptidanaloge von somatostatin mit threonin in position 6 - Google Patents
Oktapeptidanaloge von somatostatin mit threonin in position 6Info
- Publication number
- ATE140237T1 ATE140237T1 AT91901181T AT91901181T ATE140237T1 AT E140237 T1 ATE140237 T1 AT E140237T1 AT 91901181 T AT91901181 T AT 91901181T AT 91901181 T AT91901181 T AT 91901181T AT E140237 T1 ATE140237 T1 AT E140237T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- somatostatin
- threonine
- phenylalkyl
- r2oco
- Prior art date
Links
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 title 1
- 239000004473 Threonine Substances 0.000 title 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000006193 alkinyl group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/16—Somatostatin; related peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44787689A | 1989-12-08 | 1989-12-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE140237T1 true ATE140237T1 (de) | 1996-07-15 |
Family
ID=23778103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91901181T ATE140237T1 (de) | 1989-12-08 | 1990-12-04 | Oktapeptidanaloge von somatostatin mit threonin in position 6 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5506339A (de) |
| EP (1) | EP0457888B1 (de) |
| JP (1) | JP2925321B2 (de) |
| KR (1) | KR920702854A (de) |
| AT (1) | ATE140237T1 (de) |
| CA (1) | CA2046594A1 (de) |
| DE (1) | DE69027767T2 (de) |
| DK (1) | DK0457888T3 (de) |
| ES (1) | ES2091907T3 (de) |
| GR (1) | GR3020513T3 (de) |
| HU (1) | HUT59166A (de) |
| PT (1) | PT96135B (de) |
| WO (1) | WO1991009056A1 (de) |
| ZA (1) | ZA909896B (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU207104B (en) * | 1991-01-25 | 1993-03-01 | Biosignal Kutato Fejlesztoe Kf | Process for producing new somatostatin analogs inhibiting tumour growth and pharmaceutical compositions comprising such compounds |
| ATE181240T1 (de) * | 1991-02-08 | 1999-07-15 | Biomeasure Inc | Verwendung von somatostatinanalogen zur behandlung von melanomen |
| US7238340B1 (en) * | 1991-11-27 | 2007-07-03 | Cis Bio International | Monoamine, diamide, thiol-containing metal chelating agents |
| US5411943A (en) * | 1992-02-25 | 1995-05-02 | Biomeasure, Inc. | Hepatoma treatment with somatostatin analogs |
| US5871711A (en) * | 1992-06-23 | 1999-02-16 | Diatide, Inc. | Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses |
| US5716596A (en) * | 1992-06-23 | 1998-02-10 | Diatide, Inc. | Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses |
| US5462926A (en) * | 1992-07-27 | 1995-10-31 | Biomeasure, Inc. | Neuromedin B receptor antagonists which demonstrate selectivity |
| US5569741A (en) * | 1992-07-27 | 1996-10-29 | Biomeasure, Inc. | Cyclic octapeptide neuromedin B receptor antagonists |
| DE69330868T2 (de) * | 1992-07-27 | 2002-04-25 | Biomeasure, Inc. | Antagonisten des neuromedin b rezeptors |
| US5932189A (en) * | 1994-07-29 | 1999-08-03 | Diatech, Inc. | Cyclic peptide somatostatin analogs |
| US5597894A (en) * | 1995-06-05 | 1997-01-28 | The Louisiana State University Medical Center Foundation | Multi-tyrosinated somatostatin analogs |
| US5708135A (en) * | 1995-09-29 | 1998-01-13 | Biomeasure Incorporated | Cyclic peptide analogs of somatostatin |
| US6262229B1 (en) * | 1996-12-04 | 2001-07-17 | Biomeasure Incorporated | Somatostatin antagonists |
| EP0981364B1 (de) | 1997-05-13 | 2006-03-01 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Methoden und zusammensetzungen zur behandlung der hyperlipidämie |
| US6004928A (en) * | 1997-05-13 | 1999-12-21 | Biomeasure, Incorporated | Method of treating hyperlipidemia |
| CA2289499C (en) * | 1997-05-13 | 2010-02-23 | Michael Anthony Cawthorne | Somatostatin and somatostatin agonists for treating insulin insensitivity and syndrome x |
| CA2290592A1 (en) | 1997-05-13 | 1998-11-19 | Michael Anthony Cawthorne | Somatostatin and somatostatin agonists for decreasing body weight |
| CA2335654A1 (en) * | 1998-07-30 | 2000-02-10 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R | Methods of using a somatostatin analogue |
| EP1291022A1 (de) * | 1998-07-30 | 2003-03-12 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Anwendungsverfahren für lanreotid, ein somatostatin analogon |
| RU2263678C2 (ru) * | 2001-03-08 | 2005-11-10 | Дзе Администрейторс Оф Дзе Тьюлейн Эдьюкейшнл Фанд | Антагонисты соматостатина |
| JP2004531520A (ja) * | 2001-04-09 | 2004-10-14 | ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド | ソマトスタチンアゴニスト |
| NZ530007A (en) | 2001-06-08 | 2006-02-24 | Sod Conseils Rech Applic | Somatostatin-dopamine chimeric analogues that retain both somatostatin and dopamine activity in vivo and display enhanced biological activity |
| CA2523197C (en) | 2003-04-22 | 2016-05-24 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Peptide vectors |
| WO2009150470A2 (en) | 2008-06-12 | 2009-12-17 | Syntaxin Limited | Suppression of cancers |
| EP2310028B1 (de) | 2008-06-12 | 2016-11-16 | Ipsen Bioinnovation Limited | Fusionsproteine zur Verwendung bei der Behandlung von Akromegalie |
| GB0820970D0 (en) | 2008-11-17 | 2008-12-24 | Syntaxin Ltd | Suppression of cancer |
| EP3007704B1 (de) | 2013-06-13 | 2021-01-06 | Antisense Therapeutics Ltd | Kombinationstherapie der akromegalie |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4291022A (en) * | 1975-03-11 | 1981-09-22 | Sandoz Ltd. | Organic compounds |
| DE3062075D1 (en) * | 1979-11-27 | 1983-03-24 | Sandoz Ag | Polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use |
| US4328105A (en) * | 1980-02-06 | 1982-05-04 | Linde Aktiengesellschaft | Treatment of suspended solids--and adsorbable contaminant--containing liquid |
| US4282143A (en) * | 1980-06-13 | 1981-08-04 | American Home Products Corporation | Octapeptides lowering growth hormone |
| US4328135A (en) * | 1980-06-13 | 1982-05-04 | American Home Products Corporation | Octapeptides lowering growth hormone |
| DK81082A (da) * | 1981-03-06 | 1982-09-07 | Sandoz Ag | Fremgangsmaade til fremstilling af polypeptider |
| US4485101A (en) * | 1983-10-11 | 1984-11-27 | Administrators Of The Tulane Educational Fund | Peptides |
| US4684620A (en) * | 1984-09-04 | 1987-08-04 | Gibson-Stephens Neuropharmaceuticals, Inc. | Cyclic polypeptides having mu-receptor specificity |
| US4650787A (en) * | 1985-04-25 | 1987-03-17 | Schally Andrew Victor | Biologically active octapeptides |
| US4725577A (en) * | 1985-04-25 | 1988-02-16 | Administrators Of The Tulane Educational Fund | Biologically active lysine containing octapeptides |
| US4904642A (en) * | 1985-09-12 | 1990-02-27 | The Administrators Of The Tulane Educational Fund | Therapeutic somatostatin analogs |
| US4853371A (en) * | 1986-06-17 | 1989-08-01 | The Administrators Of The Tulane Educational Fund | Therapeutic somatostatin analogs |
| JP2568228B2 (ja) * | 1987-02-03 | 1996-12-25 | ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド | 治療用ソマトスタチンアナログ |
| JP2809403B2 (ja) * | 1987-07-07 | 1998-10-08 | ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド | 治療用ソマトスタチンアナログ化合物 |
| GB8813160D0 (en) * | 1988-06-03 | 1988-07-06 | Soc D Etudes Prod Chimique | Therapeutic methods |
-
1990
- 1990-12-04 ES ES91901181T patent/ES2091907T3/es not_active Expired - Lifetime
- 1990-12-04 KR KR1019910700860A patent/KR920702854A/ko not_active Ceased
- 1990-12-04 DE DE69027767T patent/DE69027767T2/de not_active Expired - Fee Related
- 1990-12-04 EP EP91901181A patent/EP0457888B1/de not_active Expired - Lifetime
- 1990-12-04 HU HU912648A patent/HUT59166A/hu unknown
- 1990-12-04 CA CA002046594A patent/CA2046594A1/en not_active Abandoned
- 1990-12-04 WO PCT/US1990/007074 patent/WO1991009056A1/en not_active Ceased
- 1990-12-04 DK DK91901181.7T patent/DK0457888T3/da active
- 1990-12-04 AT AT91901181T patent/ATE140237T1/de not_active IP Right Cessation
- 1990-12-04 JP JP3501584A patent/JP2925321B2/ja not_active Expired - Lifetime
- 1990-12-07 PT PT96135A patent/PT96135B/pt not_active IP Right Cessation
- 1990-12-10 ZA ZA909896A patent/ZA909896B/xx unknown
-
1992
- 1992-02-21 US US07/840,621 patent/US5506339A/en not_active Expired - Lifetime
-
1996
- 1996-07-11 GR GR960401779T patent/GR3020513T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH04505456A (ja) | 1992-09-24 |
| ZA909896B (en) | 1991-09-25 |
| EP0457888A4 (en) | 1992-01-02 |
| PT96135B (pt) | 1998-04-30 |
| HUT59166A (en) | 1992-04-28 |
| US5506339A (en) | 1996-04-09 |
| DK0457888T3 (da) | 1996-08-12 |
| ES2091907T3 (es) | 1996-11-16 |
| PT96135A (pt) | 1991-09-30 |
| GR3020513T3 (en) | 1996-10-31 |
| WO1991009056A1 (en) | 1991-06-27 |
| DE69027767T2 (de) | 1997-01-02 |
| KR920702854A (ko) | 1992-10-28 |
| CA2046594A1 (en) | 1991-06-09 |
| EP0457888B1 (de) | 1996-07-10 |
| EP0457888A1 (de) | 1991-11-27 |
| DE69027767D1 (de) | 1996-08-14 |
| JP2925321B2 (ja) | 1999-07-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69027767D1 (de) | Oktapeptidanaloge von somatostatin mit threonin in position 6 | |
| DK0565549T3 (da) | Anvendelse af 1,3-oxathiolannucleosidanaloger til fremstilling af et præparat til behandling af hepatitis B | |
| GR69233B (de) | ||
| EP0235692A3 (en) | Oligopeptidyl nitrile derivatives, the agents containing them, process for their preparation and their use | |
| JPS53119844A (en) | Optically active amino acid-mandelic acid complexes and theire preparation | |
| EP0307880A3 (en) | Ferroelectric liquid-crystal mixtures | |
| PT93488A (pt) | Processo de preparacao de composicoes farmaceuticas a base de (7 alfa, 17 alfa)-17-hidroxi-7-metil-19-nor-17-pregn-5(10)-en-20-in-3-ona e destes compostos numa forma pura e cristalina | |
| DE69022593D1 (de) | Neue methylenbisphosphonsäurederivate. | |
| JPS52136118A (en) | Modification of bestatin and analogous compounds and their preparation | |
| ATE188217T1 (de) | 1,2,3,4,10,14b-hexahydrodibenzo-c,f)pyrazino-1, - a)azepino-derivate | |
| GB8829593D0 (en) | Novel compounds | |
| NO176018C (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive S-enantiomerer av substituerte 2-aminotetraliner | |
| MY111439A (en) | Thymosin alpha 1 derivatives | |
| ES2046923A1 (es) | Procedimiento para la estabilizacion de elastomeros. | |
| JPS5358506A (en) | Detergent composition | |
| GB2135997B (en) | N-(m-trifluoromethylphenyl)-n'-propargylpiperazine | |
| NZ216125A (en) | Isoxazoles and pharmaceutical compositions | |
| CA2051460A1 (en) | Pharmaceutical compounds | |
| FI841992A0 (fi) | Substituerade isokinolinderivat. | |
| SE8302452D0 (sv) | Method for treatment of senile dementia | |
| ES8307712A1 (es) | "procedimiento para la preparacion de n-(2,6-diclorofenil)-acetamidina". | |
| NO914074D0 (no) | Polyvinylkloridsammensetninger med forbedret bearbeidelses stabilite | |
| DK551487A (da) | 1-hydroxyalkylxanthiner samt farmaceutiske praeparater med indhold af saadanne forbindelser | |
| ATE89551T1 (de) | Verfahren zur herstellung von optisch aktiven acyloxyazetidinonen. | |
| JPS57108050A (en) | Novel peptide and its preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |