JPS52136118A - Modification of bestatin and analogous compounds and their preparation - Google Patents

Modification of bestatin and analogous compounds and their preparation

Info

Publication number
JPS52136118A
JPS52136118A JP8599276A JP8599276A JPS52136118A JP S52136118 A JPS52136118 A JP S52136118A JP 8599276 A JP8599276 A JP 8599276A JP 8599276 A JP8599276 A JP 8599276A JP S52136118 A JPS52136118 A JP S52136118A
Authority
JP
Japan
Prior art keywords
bestatin
modification
preparation
analogous compounds
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8599276A
Other languages
Japanese (ja)
Other versions
JPS5758338B2 (en
Inventor
Hamao Umezawa
Takaaki Aoyanagi
Tomohisa Takita
Rinzo Nishizawa
Tetsuyuki Saino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to US05/809,835 priority Critical patent/US4189604A/en
Priority to CA282,958A priority patent/CA1108180A/en
Publication of JPS52136118A publication Critical patent/JPS52136118A/en
Priority to US06/079,777 priority patent/US4240975A/en
Priority to CA000372019A priority patent/CA1118441A/en
Publication of JPS5758338B2 publication Critical patent/JPS5758338B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: The compounds I (R1 is lower alkyl, cycloalkanoyl, phenyl, benzyl, etc.; R2 is 1-6C alkyl, hydroxyalkyl, mercaptoalkyl, etc.), e.g. (2S, 3R) -3-amino-2-hydroxy-4-phenylbutanoyl-(R)-leucine.
COPYRIGHT: (C)1977,JPO&Japio
JP8599276A 1975-07-22 1976-07-21 Modification of bestatin and analogous compounds and their preparation Granted JPS52136118A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US05/809,835 US4189604A (en) 1975-07-22 1977-06-24 Bestatin
CA282,958A CA1108180A (en) 1976-07-21 1977-07-18 Analogs of bestatin
US06/079,777 US4240975A (en) 1976-07-21 1979-09-26 Bestatin
CA000372019A CA1118441A (en) 1976-07-21 1981-02-27 Analogs of bestatin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB30632/75A GB1510477A (en) 1975-07-22 1975-07-22 Peptides and to amino acid intermediates thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP57066233A Division JPS6050780B2 (en) 1975-07-22 1982-04-22 3-Amino-2-hydroxypropionic acid derivative

Publications (2)

Publication Number Publication Date
JPS52136118A true JPS52136118A (en) 1977-11-14
JPS5758338B2 JPS5758338B2 (en) 1982-12-09

Family

ID=10310676

Family Applications (2)

Application Number Title Priority Date Filing Date
JP8599276A Granted JPS52136118A (en) 1975-07-22 1976-07-21 Modification of bestatin and analogous compounds and their preparation
JP57066233A Expired JPS6050780B2 (en) 1975-07-22 1982-04-22 3-Amino-2-hydroxypropionic acid derivative

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP57066233A Expired JPS6050780B2 (en) 1975-07-22 1982-04-22 3-Amino-2-hydroxypropionic acid derivative

Country Status (12)

Country Link
JP (2) JPS52136118A (en)
AU (1) AU506003B2 (en)
CA (1) CA1104156A (en)
CH (1) CH630892A5 (en)
CS (2) CS201034B2 (en)
DE (2) DE2660626C2 (en)
DK (1) DK149110C (en)
FR (1) FR2318863A1 (en)
GB (1) GB1510477A (en)
HU (1) HU183048B (en)
NL (1) NL7608064A (en)
SE (3) SE431642B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2725732C2 (en) 1977-06-07 1983-01-05 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Tokyo Bestatin analogs, processes for their preparation and pharmaceutical preparations containing these compounds
DE2760007C2 (en) * 1977-06-07 1988-10-06 Microbial Chem Res Found
JPS6026099B2 (en) * 1977-09-21 1985-06-21 財団法人微生物化学研究会 Peptide, its acid salt and its production method
NL188162C (en) * 1978-11-25 1992-04-16 Nippon Kayaku Kk PROCESS FOR PREPARING A BESTATIN DERIVATIVE.
US4370318A (en) * 1980-07-07 1983-01-25 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Bestatin-related compounds as immunopotentiator
JPS5767516A (en) * 1980-09-24 1982-04-24 Microbial Chem Res Found Novel analgesic agent
JPH0810855Y2 (en) * 1989-07-20 1996-03-29 タナシン電機株式会社 Auto-reverse type tape recorder
DE69420524T2 (en) * 1993-06-29 2000-02-17 Kaneka Corp., Osaka METHOD FOR PRODUCING DERIVATIVES OF 3-AMINE-2-HYDROXY-4-PHENYLBUTTERIC ACID AND 1-NITRO-4-PHENYL-2-BUTANOL INTERMEDIATE PRODUCTS
US5900503A (en) * 1996-02-08 1999-05-04 Nippon Kayaku Kabushiki Kaisha Process for producing optically active cyanohydrins
US6242494B1 (en) 1998-05-01 2001-06-05 Abbott Laboratories Substituted β-amino acid inhibitors of methionine aminopeptidase-2
BR9910092A (en) * 1998-05-01 2002-01-22 Abbott Lab Beta-amino acid inhibitors substituted for methionine aminopeptidase-2

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5439477B2 (en) * 1974-07-01 1979-11-28

Also Published As

Publication number Publication date
CS201034B2 (en) 1980-10-31
FR2318863A1 (en) 1977-02-18
FR2318863B1 (en) 1980-10-31
GB1510477A (en) 1978-05-10
JPS6050780B2 (en) 1985-11-11
DE2632396C2 (en) 1982-11-25
HU183048B (en) 1984-04-28
SE452318B (en) 1987-11-23
SE431642B (en) 1984-02-20
SE7606736L (en) 1977-01-23
AU506003B2 (en) 1979-12-13
JPS5758338B2 (en) 1982-12-09
CH630892A5 (en) 1982-07-15
NL7608064A (en) 1977-01-25
AU1591276A (en) 1978-01-19
CS201033B2 (en) 1980-10-31
CA1104156A (en) 1981-06-30
SE8306145D0 (en) 1983-11-09
SE8001959L (en) 1980-03-13
DE2632396A1 (en) 1977-02-03
DK331276A (en) 1977-01-23
JPS5823654A (en) 1983-02-12
DE2660626C2 (en) 1985-07-11
DK149110B (en) 1986-01-27
SE8306145L (en) 1983-11-09
DK149110C (en) 1986-09-08

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