SE8001959L - NEW AMINO ACIDS - Google Patents
NEW AMINO ACIDSInfo
- Publication number
- SE8001959L SE8001959L SE8001959A SE8001959A SE8001959L SE 8001959 L SE8001959 L SE 8001959L SE 8001959 A SE8001959 A SE 8001959A SE 8001959 A SE8001959 A SE 8001959A SE 8001959 L SE8001959 L SE 8001959L
- Authority
- SE
- Sweden
- Prior art keywords
- formula
- group
- optionally
- compounds
- amino acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
For preparing the novel bestatin compounds of the formula having R1 and R2 in accordance with the preceding Patent Claim 1, an alpha -hydroxybeta -amino acid of the formula is used as the starting material. The latter is condensed, optionally after having protected the functional groups which are not to participate in the subsequent reaction, with a beta -amino acid of the formula using a peptide-linking method. Protective groups which may optionally be present are subsequently removed. The optically pure diastereoisomers can be readily obtained from the compounds of the formula (III). The alpha -hydroxybeta -amino acids can be prepared by hydrolysing a corresponding cyanohydrin whose amino group is optionally protected. The novel compounds inhibit certain enzymes which decompose bleomycin and in this way amplify the anti-tumour activity of the bleomycins.
Claims (1)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB30632/75A GB1510477A (en) | 1975-07-22 | 1975-07-22 | Peptides and to amino acid intermediates thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
SE8001959L true SE8001959L (en) | 1980-03-13 |
SE452318B SE452318B (en) | 1987-11-23 |
Family
ID=10310676
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7606736A SE431642B (en) | 1975-07-22 | 1976-06-14 | PROCEDURE FOR THE PREPARATION OF BESTATIN SOCIETIES |
SE8001959A SE452318B (en) | 1975-07-22 | 1980-03-13 | AMINO ACIDS FOR USE AS INTERMEDIATES IN THE PRODUCTION OF BESTATIN |
SE8306145A SE8306145L (en) | 1975-07-22 | 1983-11-09 | PROCEDURE FOR THE PREPARATION OF BESTATE ASSOCIATIONS |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7606736A SE431642B (en) | 1975-07-22 | 1976-06-14 | PROCEDURE FOR THE PREPARATION OF BESTATIN SOCIETIES |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8306145A SE8306145L (en) | 1975-07-22 | 1983-11-09 | PROCEDURE FOR THE PREPARATION OF BESTATE ASSOCIATIONS |
Country Status (12)
Country | Link |
---|---|
JP (2) | JPS52136118A (en) |
AU (1) | AU506003B2 (en) |
CA (1) | CA1104156A (en) |
CH (1) | CH630892A5 (en) |
CS (2) | CS201033B2 (en) |
DE (2) | DE2660626C2 (en) |
DK (1) | DK149110C (en) |
FR (1) | FR2318863A1 (en) |
GB (1) | GB1510477A (en) |
HU (1) | HU183048B (en) |
NL (1) | NL7608064A (en) |
SE (3) | SE431642B (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2760007C2 (en) * | 1977-06-07 | 1988-10-06 | Microbial Chem Res Found | |
DE2725732C2 (en) | 1977-06-07 | 1983-01-05 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Tokyo | Bestatin analogs, processes for their preparation and pharmaceutical preparations containing these compounds |
JPS6026099B2 (en) * | 1977-09-21 | 1985-06-21 | 財団法人微生物化学研究会 | Peptide, its acid salt and its production method |
AR227636A1 (en) * | 1978-11-25 | 1982-11-30 | Nippon Kayaku Kk | PROCEDURE TO PRODUCE TREO-3-AMINO-2-HYDROXIBUTANOYL AMINOACETIC ACID INTERMEDIARIES TO PREPARE IT AND PROCEDURE TO PREPARE INTERMEDIARIES |
US4370318A (en) * | 1980-07-07 | 1983-01-25 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Bestatin-related compounds as immunopotentiator |
JPS5767516A (en) * | 1980-09-24 | 1982-04-24 | Microbial Chem Res Found | Novel analgesic agent |
JPH0810855Y2 (en) * | 1989-07-20 | 1996-03-29 | タナシン電機株式会社 | Auto-reverse type tape recorder |
USRE36718E (en) * | 1993-06-29 | 2000-05-30 | Kaneka Corporation | Optically active aminoalcohol derivatives and method of producing same |
CZ292996B6 (en) * | 1996-02-08 | 2004-01-14 | Nippon Kayaku Kabushiki Kaisha | Process for producing optically active cyanohydrin |
WO1999057098A2 (en) * | 1998-05-01 | 1999-11-11 | Abbott Laboratories | Substituted beta-amino acid inhibitors of methionine aminopeptidase-2 |
US6242494B1 (en) | 1998-05-01 | 2001-06-05 | Abbott Laboratories | Substituted β-amino acid inhibitors of methionine aminopeptidase-2 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5439477B2 (en) * | 1974-07-01 | 1979-11-28 |
-
1975
- 1975-07-22 GB GB30632/75A patent/GB1510477A/en not_active Expired
-
1976
- 1976-06-14 SE SE7606736A patent/SE431642B/en not_active IP Right Cessation
- 1976-07-15 AU AU15912/76A patent/AU506003B2/en not_active Expired
- 1976-07-16 CS CS764736A patent/CS201033B2/en unknown
- 1976-07-16 CS CS793519A patent/CS201034B2/en unknown
- 1976-07-19 DE DE2660626A patent/DE2660626C2/en not_active Expired
- 1976-07-19 DE DE2632396A patent/DE2632396C2/en not_active Expired
- 1976-07-20 CA CA257,393A patent/CA1104156A/en not_active Expired
- 1976-07-21 JP JP8599276A patent/JPS52136118A/en active Granted
- 1976-07-21 NL NL7608064A patent/NL7608064A/en not_active Application Discontinuation
- 1976-07-21 FR FR7622279A patent/FR2318863A1/en active Granted
- 1976-07-21 CH CH933676A patent/CH630892A5/en not_active IP Right Cessation
- 1976-07-22 DK DK331276A patent/DK149110C/en not_active IP Right Cessation
- 1976-07-22 HU HU76ZA395A patent/HU183048B/en unknown
-
1980
- 1980-03-13 SE SE8001959A patent/SE452318B/en unknown
-
1982
- 1982-04-22 JP JP57066233A patent/JPS6050780B2/en not_active Expired
-
1983
- 1983-11-09 SE SE8306145A patent/SE8306145L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
GB1510477A (en) | 1978-05-10 |
AU506003B2 (en) | 1979-12-13 |
DK331276A (en) | 1977-01-23 |
CS201034B2 (en) | 1980-10-31 |
FR2318863B1 (en) | 1980-10-31 |
DK149110B (en) | 1986-01-27 |
JPS6050780B2 (en) | 1985-11-11 |
SE8306145D0 (en) | 1983-11-09 |
SE7606736L (en) | 1977-01-23 |
NL7608064A (en) | 1977-01-25 |
DE2632396A1 (en) | 1977-02-03 |
SE452318B (en) | 1987-11-23 |
DE2632396C2 (en) | 1982-11-25 |
HU183048B (en) | 1984-04-28 |
DE2660626C2 (en) | 1985-07-11 |
DK149110C (en) | 1986-09-08 |
CH630892A5 (en) | 1982-07-15 |
JPS52136118A (en) | 1977-11-14 |
SE8306145L (en) | 1983-11-09 |
CA1104156A (en) | 1981-06-30 |
FR2318863A1 (en) | 1977-02-18 |
JPS5758338B2 (en) | 1982-12-09 |
SE431642B (en) | 1984-02-20 |
AU1591276A (en) | 1978-01-19 |
CS201033B2 (en) | 1980-10-31 |
JPS5823654A (en) | 1983-02-12 |
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Legal Events
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NAL | Patent in force |
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