SE8001959L - NEW AMINO ACIDS - Google Patents

NEW AMINO ACIDS

Info

Publication number
SE8001959L
SE8001959L SE8001959A SE8001959A SE8001959L SE 8001959 L SE8001959 L SE 8001959L SE 8001959 A SE8001959 A SE 8001959A SE 8001959 A SE8001959 A SE 8001959A SE 8001959 L SE8001959 L SE 8001959L
Authority
SE
Sweden
Prior art keywords
formula
group
optionally
compounds
amino acids
Prior art date
Application number
SE8001959A
Other languages
Swedish (sv)
Other versions
SE452318B (en
Inventor
H Umezawa
T Aoyagi
T Takita
R Nishizawa
T Saino
Original Assignee
Microbial Chem Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chem Res Found filed Critical Microbial Chem Res Found
Publication of SE8001959L publication Critical patent/SE8001959L/en
Publication of SE452318B publication Critical patent/SE452318B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

For preparing the novel bestatin compounds of the formula having R1 and R2 in accordance with the preceding Patent Claim 1, an alpha -hydroxybeta -amino acid of the formula is used as the starting material. The latter is condensed, optionally after having protected the functional groups which are not to participate in the subsequent reaction, with a beta -amino acid of the formula using a peptide-linking method. Protective groups which may optionally be present are subsequently removed. The optically pure diastereoisomers can be readily obtained from the compounds of the formula (III). The alpha -hydroxybeta -amino acids can be prepared by hydrolysing a corresponding cyanohydrin whose amino group is optionally protected. The novel compounds inhibit certain enzymes which decompose bleomycin and in this way amplify the anti-tumour activity of the bleomycins.

Claims (1)

PATENTKRAVPATENT REQUIREMENTS 1. Forening med den allmanna formeln R, - CH - CH - COON NH2 OH van i 141 Hr en grupp vald bland alkylgrupp med 2-kolatomer, bensylgrupp och bensylgrupp SUbstituerad med en halogenatom, en nitrogrupp, en aminogrupp eller en hydroxigrupp, vilken aminogrupp och/eller hydroxigrupp pa fenylringen i bensylgruppen och en aminogrupp pa C, kolatomen eventuellt Hr skyddade.A compound of the general formula R 1 - CH - CH - COON NH 2 OH van in 141 Hr a group selected from alkyl group having 2 carbon atoms, benzyl group and benzyl group SU substituted by a halogen atom, a nitro group, an amino group or a hydroxy group, which amino group and / or hydroxy group on the phenyl ring of the benzyl group and an amino group on C, the carbon atom optionally Hr protected.
SE8001959A 1975-07-22 1980-03-13 AMINO ACIDS FOR USE AS INTERMEDIATES IN THE PRODUCTION OF BESTATIN SE452318B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB30632/75A GB1510477A (en) 1975-07-22 1975-07-22 Peptides and to amino acid intermediates thereof

Publications (2)

Publication Number Publication Date
SE8001959L true SE8001959L (en) 1980-03-13
SE452318B SE452318B (en) 1987-11-23

Family

ID=10310676

Family Applications (3)

Application Number Title Priority Date Filing Date
SE7606736A SE431642B (en) 1975-07-22 1976-06-14 PROCEDURE FOR THE PREPARATION OF BESTATIN SOCIETIES
SE8001959A SE452318B (en) 1975-07-22 1980-03-13 AMINO ACIDS FOR USE AS INTERMEDIATES IN THE PRODUCTION OF BESTATIN
SE8306145A SE8306145L (en) 1975-07-22 1983-11-09 PROCEDURE FOR THE PREPARATION OF BESTATE ASSOCIATIONS

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7606736A SE431642B (en) 1975-07-22 1976-06-14 PROCEDURE FOR THE PREPARATION OF BESTATIN SOCIETIES

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE8306145A SE8306145L (en) 1975-07-22 1983-11-09 PROCEDURE FOR THE PREPARATION OF BESTATE ASSOCIATIONS

Country Status (12)

Country Link
JP (2) JPS52136118A (en)
AU (1) AU506003B2 (en)
CA (1) CA1104156A (en)
CH (1) CH630892A5 (en)
CS (2) CS201033B2 (en)
DE (2) DE2660626C2 (en)
DK (1) DK149110C (en)
FR (1) FR2318863A1 (en)
GB (1) GB1510477A (en)
HU (1) HU183048B (en)
NL (1) NL7608064A (en)
SE (3) SE431642B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2760007C2 (en) * 1977-06-07 1988-10-06 Microbial Chem Res Found
DE2725732C2 (en) 1977-06-07 1983-01-05 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Tokyo Bestatin analogs, processes for their preparation and pharmaceutical preparations containing these compounds
JPS6026099B2 (en) * 1977-09-21 1985-06-21 財団法人微生物化学研究会 Peptide, its acid salt and its production method
AR227636A1 (en) * 1978-11-25 1982-11-30 Nippon Kayaku Kk PROCEDURE TO PRODUCE TREO-3-AMINO-2-HYDROXIBUTANOYL AMINOACETIC ACID INTERMEDIARIES TO PREPARE IT AND PROCEDURE TO PREPARE INTERMEDIARIES
US4370318A (en) * 1980-07-07 1983-01-25 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Bestatin-related compounds as immunopotentiator
JPS5767516A (en) * 1980-09-24 1982-04-24 Microbial Chem Res Found Novel analgesic agent
JPH0810855Y2 (en) * 1989-07-20 1996-03-29 タナシン電機株式会社 Auto-reverse type tape recorder
USRE36718E (en) * 1993-06-29 2000-05-30 Kaneka Corporation Optically active aminoalcohol derivatives and method of producing same
CZ292996B6 (en) * 1996-02-08 2004-01-14 Nippon Kayaku Kabushiki Kaisha Process for producing optically active cyanohydrin
WO1999057098A2 (en) * 1998-05-01 1999-11-11 Abbott Laboratories Substituted beta-amino acid inhibitors of methionine aminopeptidase-2
US6242494B1 (en) 1998-05-01 2001-06-05 Abbott Laboratories Substituted β-amino acid inhibitors of methionine aminopeptidase-2

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5439477B2 (en) * 1974-07-01 1979-11-28

Also Published As

Publication number Publication date
GB1510477A (en) 1978-05-10
AU506003B2 (en) 1979-12-13
DK331276A (en) 1977-01-23
CS201034B2 (en) 1980-10-31
FR2318863B1 (en) 1980-10-31
DK149110B (en) 1986-01-27
JPS6050780B2 (en) 1985-11-11
SE8306145D0 (en) 1983-11-09
SE7606736L (en) 1977-01-23
NL7608064A (en) 1977-01-25
DE2632396A1 (en) 1977-02-03
SE452318B (en) 1987-11-23
DE2632396C2 (en) 1982-11-25
HU183048B (en) 1984-04-28
DE2660626C2 (en) 1985-07-11
DK149110C (en) 1986-09-08
CH630892A5 (en) 1982-07-15
JPS52136118A (en) 1977-11-14
SE8306145L (en) 1983-11-09
CA1104156A (en) 1981-06-30
FR2318863A1 (en) 1977-02-18
JPS5758338B2 (en) 1982-12-09
SE431642B (en) 1984-02-20
AU1591276A (en) 1978-01-19
CS201033B2 (en) 1980-10-31
JPS5823654A (en) 1983-02-12

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