ZA901982B - Pyrrolidine derivatives - Google Patents
Pyrrolidine derivativesInfo
- Publication number
- ZA901982B ZA901982B ZA901982A ZA901982A ZA901982B ZA 901982 B ZA901982 B ZA 901982B ZA 901982 A ZA901982 A ZA 901982A ZA 901982 A ZA901982 A ZA 901982A ZA 901982 B ZA901982 B ZA 901982B
- Authority
- ZA
- South Africa
- Prior art keywords
- chem
- formula
- pyrrolidine derivatives
- pyrrolidine
- ch2s
- Prior art date
Links
- 150000003235 pyrrolidines Chemical class 0.000 title 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898906166A GB8906166D0 (en) | 1989-03-17 | 1989-03-17 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA901982B true ZA901982B (en) | 1991-10-30 |
Family
ID=10653525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA901982A ZA901982B (en) | 1989-03-17 | 1990-03-15 | Pyrrolidine derivatives |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US5096890B1 (fi) |
| EP (1) | EP0388054B1 (fi) |
| JP (2) | JPH0764809B2 (fi) |
| KR (2) | KR920008166B1 (fi) |
| CN (1) | CN1023007C (fi) |
| AT (1) | ATE96783T1 (fi) |
| AU (1) | AU614224B2 (fi) |
| BA (1) | BA98300A (fi) |
| CA (1) | CA2012295C (fi) |
| CL (1) | CL2003002756A1 (fi) |
| CY (2) | CY1812A (fi) |
| CZ (1) | CZ280053B6 (fi) |
| DD (1) | DD292911A5 (fi) |
| DE (2) | DE122005000022I2 (fi) |
| DK (1) | DK0388054T3 (fi) |
| EG (1) | EG18951A (fi) |
| ES (1) | ES2060020T3 (fi) |
| FI (1) | FI95573C (fi) |
| GB (1) | GB8906166D0 (fi) |
| HK (1) | HK130294A (fi) |
| HU (2) | HU217433B (fi) |
| IE (1) | IE62515B1 (fi) |
| IL (1) | IL93694A (fi) |
| LU (1) | LU91161I2 (fi) |
| MX (1) | MX9319890A (fi) |
| MY (1) | MY105527A (fi) |
| NL (1) | NL300191I2 (fi) |
| NO (2) | NO176316C (fi) |
| NZ (1) | NZ232958A (fi) |
| PL (1) | PL164136B1 (fi) |
| PT (1) | PT93443B (fi) |
| RU (2) | RU1833374C (fi) |
| SG (1) | SG143394G (fi) |
| SK (1) | SK278434B6 (fi) |
| UA (1) | UA18263A (fi) |
| YU (1) | YU47587B (fi) |
| ZA (1) | ZA901982B (fi) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8825505D0 (en) * | 1988-11-01 | 1988-12-07 | Pfizer Ltd | Therapeutic agents |
| US5932594A (en) * | 1988-11-01 | 1999-08-03 | Pfizer, Inc. | Muscarinic receptor antagonists |
| GB8928042D0 (en) * | 1989-12-12 | 1990-02-14 | Pfizer Ltd | Muscarinic receptor antagonists |
| US5607950A (en) * | 1990-01-06 | 1997-03-04 | Pfizer Inc. | Muscarinic receptor antagonists |
| US5486527A (en) * | 1990-01-06 | 1996-01-23 | Pfizer Inc. | Anticholinergic agents |
| WO1993022309A1 (en) * | 1992-04-23 | 1993-11-11 | Merrell Dow Pharmaceuticals Inc. | 4-imidomethyl-1-[2'phenyl-2'oxoethyl-] piperidines as serotonin 5ht2-antagonists, their preparation and use in therapy |
| GB9400600D0 (en) * | 1994-01-14 | 1994-03-09 | Pfizer Ltd | Treatment of motion seckness |
| US6017931A (en) * | 1994-03-01 | 2000-01-25 | Fmc Corporation | Insecticidal compositions containing n-(substituted phenylmethyl)-4-[bis(substituted phenyl)methyl]piperidines |
| US5639763A (en) * | 1994-03-01 | 1997-06-17 | Fmc Corporation | Insecticidal N-(substituted arylmethyl)-4-[bis(substituted phenyl)methyl]piperidines |
| BR9508436A (pt) * | 1994-07-27 | 1998-07-14 | Procter & Gamble | Dihidro benzofurando e compostos correlacionados úteis como agentes anti-inflamatórios |
| US5674891A (en) * | 1994-07-27 | 1997-10-07 | The Procter & Gamble Company | Dihydrobenzothiophene compounds useful as anti-inflammatory agents |
| GB9518953D0 (en) * | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
| US5672620A (en) * | 1996-02-01 | 1997-09-30 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
| US5684031A (en) * | 1996-02-01 | 1997-11-04 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
| WO1998024431A1 (fr) * | 1996-12-02 | 1998-06-11 | Kyorin Pharmaceutical Co., Ltd. | Nouveaux derives de pyrrolidine n-substitues et procede de preparation de ces derives |
| US6131129A (en) * | 1997-07-30 | 2000-10-10 | Sony Corporation Of Japan | Computer system within an AV/C based media changer subunit providing a standarized command set |
| US6693202B1 (en) | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
| IL141235A (en) * | 2000-02-09 | 2012-04-30 | Novartis Int Pharm Ltd | Combined use of an alpha-adrenoceptor antagonist and a muscarinic antagonist in the preparation of a drug for the treatment of non-malignant prostatic hyperplasia |
| US6653339B2 (en) | 2001-08-15 | 2003-11-25 | Pfizer Inc. | Method of treating irritable bowel syndrome |
| ATE418534T1 (de) * | 2001-10-26 | 2009-01-15 | Pharmacia & Upjohn Co Llc | Quaternäre ammoniumverbindungen und deren verwendung als antimuscarinische wirkstoffe |
| SE0103668D0 (sv) * | 2001-11-02 | 2001-11-02 | Astrazeneca Ab | Method for the treatment of overactive blader |
| EP1441706A2 (en) * | 2001-11-05 | 2004-08-04 | Pharmacia & Upjohn Company | Antimuscarinic aerosol |
| GB0129962D0 (en) * | 2001-12-14 | 2002-02-06 | Pfizer Ltd | Method of treatment |
| GB0207104D0 (en) * | 2002-03-26 | 2002-05-08 | Pfizer Ltd | Stable hydrate of a muscarinic receptor antagonist |
| WO2004004629A2 (en) | 2002-07-08 | 2004-01-15 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists |
| ATE396969T1 (de) | 2002-07-31 | 2008-06-15 | Ranbaxy Lab Ltd | 3,6-disubstituierte azabicyclo (3.1.0)hexanderivate, die sich als muscarinrezeptorantagonisten eignen |
| WO2004014363A1 (en) | 2002-08-09 | 2004-02-19 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor antagonist |
| JP2006501236A (ja) | 2002-08-23 | 2006-01-12 | ランバクシー ラボラトリーズ リミテッド | ムスカリン性レセプター拮抗薬としてのフルオロおよびスルホニルアミノ含有３，６−二置換アザビシクロ（３．１．０）ヘキサン誘導体 |
| TW200412945A (en) * | 2002-10-25 | 2004-08-01 | Upjohn Co | Quaternary ammonium compounds |
| TWI295669B (en) * | 2002-10-30 | 2008-04-11 | Theravance Inc | Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds |
| US7232835B2 (en) | 2002-12-10 | 2007-06-19 | Ranbaxy Laboratories Limited | 3,6-Disubstituted azabicyclo derivatives as muscarinic receptor antagonists |
| EP1583741A1 (en) | 2002-12-23 | 2005-10-12 | Ranbaxy Laboratories, Limited | 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists |
| US7501443B2 (en) | 2002-12-23 | 2009-03-10 | Ranbaxy Laboratories Limited | Flavaxate derivatives as muscarinic receptor antagonists |
| US7488748B2 (en) | 2003-01-28 | 2009-02-10 | Ranbaxy Laboratories Limited | 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| JP4767842B2 (ja) | 2003-04-01 | 2011-09-07 | セラヴァンス， インコーポレーテッド | β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有するジアリールメチル化合物および関連化合物 |
| US7517905B2 (en) | 2003-04-09 | 2009-04-14 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| WO2004089363A1 (en) | 2003-04-10 | 2004-10-21 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| EP1615887A1 (en) | 2003-04-10 | 2006-01-18 | Ranbaxy Laboratories, Ltd. | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| AU2004228452A1 (en) | 2003-04-11 | 2004-10-21 | Ranbaxy Laboratories Limited | Azabicyclo derivatives as muscarinic receptor antagonists |
| EP1622606A1 (en) * | 2003-04-15 | 2006-02-08 | Pharmacia & Upjohn Company LLC | Quaternary ammonium compounds and their use as antimuscarinic agents |
| WO2004091597A2 (en) * | 2003-04-15 | 2004-10-28 | Pharmacia & Upjohn Company Llc | Method of treating irritable bowel syndrome (ibs) |
| CA2522666A1 (en) * | 2003-04-18 | 2004-10-28 | Pharmacia & Upjohn Company Llc | Combination therapies for chronic obstructive pulmonary disease (copd) |
| TW200510298A (en) * | 2003-06-13 | 2005-03-16 | Theravance Inc | Substituted pyrrolidine and related compounds |
| US7368463B2 (en) | 2003-07-11 | 2008-05-06 | Theravance, Inc. | Substituted 4-amino-1-benzylpiperidine compounds |
| EP1725525A1 (en) * | 2004-03-11 | 2006-11-29 | Theravance, Inc. | Diphenylmethyl compounds useful as muscarinic receptor antagonists |
| EP1723142A1 (en) * | 2004-03-11 | 2006-11-22 | Theravance, Inc. | Diphenylmethyl compounds useful as muscarinic receptor antagonists |
| WO2005092341A1 (en) * | 2004-03-22 | 2005-10-06 | Ranbaxy Laboratories Limited | Combination therapy for lower urinary tract symptoms |
| WO2007045979A1 (en) | 2005-10-19 | 2007-04-26 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of muscarinic receptor antagonists |
| WO2007076158A2 (en) * | 2005-12-27 | 2007-07-05 | Teva Pharmaceutical Industries Ltd. | Processes for preparing darifenacin hydrobromide |
| AR062676A1 (es) * | 2006-09-07 | 2008-11-26 | Medichem Sa | Procedimiento mejorado para preparar compuestos de pirrolidina 1,3-disustituidas |
| WO2008076269A2 (en) * | 2006-12-13 | 2008-06-26 | Gilead Sciences, Inc. | MONOPHOSPHATES AS MUTUAL PRODRUGS OF MUSCARINIC RECEPTOR ANTAGONISTS AND β-AGONISTS FOR THE TREATMENT OF COPD AND CHRONIC BRONCHITIS |
| WO2008100651A2 (en) * | 2007-01-05 | 2008-08-21 | Dr. Reddy's Laboratories Ltd. | Preparation of darifenacin and its salts |
| JP5528817B2 (ja) * | 2007-02-23 | 2014-06-25 | セラヴァンス， インコーポレーテッド | ムスカリン受容体アンタゴニストとして有用な第四級アンモニウムジフェニルメチル化合物 |
| WO2008126106A2 (en) * | 2007-04-16 | 2008-10-23 | Manne Satyanarayana Reddy | Novel and improved processes for the preparation of intermediates of darifenacin, darifenacin and its pharmaceutically acceptable salts |
| US20100204296A1 (en) * | 2007-06-08 | 2010-08-12 | Actavis Group Ptc Ehf | Novel Polymorphs of Darifenacin Free Base and its Hydrobromide Salt |
| WO2008152497A1 (en) * | 2007-06-15 | 2008-12-18 | Medichem, S.A. | Method for determining enantiomeric purity of darifenacin and intermediates |
| US20090005431A1 (en) * | 2007-06-30 | 2009-01-01 | Auspex Pharmaceuticals, Inc. | Substituted pyrrolidines |
| AR068322A1 (es) * | 2007-07-13 | 2009-11-11 | Medichem Sa | Forma amorfa de hidrobromuro de darifenacina y procedimientos para su preparacion |
| CZ300895B6 (cs) * | 2008-01-28 | 2009-09-02 | Zentiva, A. S. | Zpusob prípravy Darifenacinu |
| WO2009125430A2 (en) * | 2008-03-17 | 2009-10-15 | Matrix Laboratoires Limited | Improved process for producing darifenacin |
| CN101983187A (zh) * | 2008-04-02 | 2011-03-02 | 株式会社钟化 | (s)-3-(1-氰基-1，1-二苯基甲基)吡咯烷的制备方法 |
| WO2010032225A2 (en) * | 2008-09-22 | 2010-03-25 | Watson Pharma Private Limited | Process for preparation of darifenacin and intermediates used in the process |
| EP2236509A1 (en) | 2009-04-01 | 2010-10-06 | Ragactives, S.L. | Method for obtaining 1,3-difunctionalized pyrrolidine derivatives |
| SG176056A1 (en) | 2009-05-15 | 2011-12-29 | Redx Pharma Ltd | Redox drug derivatives |
| WO2011070419A1 (en) | 2009-12-10 | 2011-06-16 | Aurobindo Pharma Limited | An improved process for the preparation of darifenacin hydrobromide |
| JP5812500B2 (ja) | 2010-04-30 | 2015-11-17 | メルク・シャープ・エンド・ドーム・コーポレイション | 新規なβ３アドレナリン作動性受容体アゴニスト |
| CN101857581A (zh) * | 2010-06-22 | 2010-10-13 | 浙江美诺华药物化学有限公司 | 一种制备达非那新中间体5-(2-溴乙基)-2,3-二氢-1-苯并呋喃的方法 |
| WO2011161504A1 (en) | 2010-06-23 | 2011-12-29 | Micro Labs Limited | Extended release formulations containing darifenacin or pharmaceutically acceptable salts thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1057145A (en) * | 1963-08-16 | 1967-02-01 | Bellon Labor Sa Roger | Phenylcyclohexylacetonitrile derivatives |
| US4002766A (en) * | 1974-12-26 | 1977-01-11 | A. H. Robins Company, Incorporated | Antiarrhythmia methods |
| US4242261A (en) * | 1979-07-19 | 1980-12-30 | A. H. Robins Company, Inc. | Production of methylene-cycloamines |
| IL76583A (en) * | 1984-10-19 | 1988-08-31 | Robins Co Inc A H | 1-(aminoalkyl)-alpha'alpha-diaryl pyrrolidinyl,piperidino and homopiperidino acetamides and acetonitriles and pharmaceutical compositions containing them |
| US4594343A (en) * | 1984-10-19 | 1986-06-10 | Shanklin Jr James R | 1-[(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl]-α,α-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles |
| EP0235463A3 (en) * | 1985-12-20 | 1990-01-17 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | N-substituted-arylalkyl and arylalkylene piperidines as cardiovascular antihistaminic and antisecretory agents |
| IL78939A (en) * | 1986-01-17 | 1990-04-29 | Robins Co Inc A H | Pharmaceutical compositions containing n-substituted arylalkyl-and arylalkylene-piperidines and tetrahydropyridines and certain such novel compounds |
-
1989
- 1989-03-17 GB GB898906166A patent/GB8906166D0/en active Pending
-
1990
- 1990-03-02 EP EP90302269A patent/EP0388054B1/en not_active Expired - Lifetime
- 1990-03-02 DK DK90302269.7T patent/DK0388054T3/da active
- 1990-03-02 ES ES90302269T patent/ES2060020T3/es not_active Expired - Lifetime
- 1990-03-02 DE DE200512000022 patent/DE122005000022I2/de active Active
- 1990-03-02 AT AT90302269T patent/ATE96783T1/de active
- 1990-03-02 DE DE90302269T patent/DE69004302T2/de not_active Expired - Lifetime
- 1990-03-09 IL IL9369490A patent/IL93694A/en not_active IP Right Cessation
- 1990-03-13 US US07493068 patent/US5096890B1/en not_active Expired - Lifetime
- 1990-03-14 HU HU580/90A patent/HU217433B/hu unknown
- 1990-03-14 MX MX1989090A patent/MX9319890A/es unknown
- 1990-03-15 JP JP2065521A patent/JPH0764809B2/ja not_active Expired - Lifetime
- 1990-03-15 ZA ZA901982A patent/ZA901982B/xx unknown
- 1990-03-15 KR KR1019900003453A patent/KR920008166B1/ko not_active IP Right Cessation
- 1990-03-15 EG EG17090A patent/EG18951A/xx active
- 1990-03-15 CA CA002012295A patent/CA2012295C/en not_active Expired - Lifetime
- 1990-03-15 PT PT93443A patent/PT93443B/pt not_active IP Right Cessation
- 1990-03-16 SK SK1295-90A patent/SK278434B6/sk not_active IP Right Cessation
- 1990-03-16 CZ CS901295A patent/CZ280053B6/cs not_active IP Right Cessation
- 1990-03-16 YU YU52790A patent/YU47587B/sh unknown
- 1990-03-16 RU SU904743599A patent/RU1833374C/ru active
- 1990-03-16 NZ NZ232958A patent/NZ232958A/en unknown
- 1990-03-16 IE IE95590A patent/IE62515B1/en not_active IP Right Cessation
- 1990-03-16 DD DD90338829A patent/DD292911A5/de not_active IP Right Cessation
- 1990-03-16 FI FI901333A patent/FI95573C/fi active Protection Beyond IP Right Term
- 1990-03-16 UA UA4743599A patent/UA18263A/uk unknown
- 1990-03-16 MY MYPI90000416A patent/MY105527A/en unknown
- 1990-03-16 AU AU51402/90A patent/AU614224B2/en not_active Expired
- 1990-03-16 PL PL90284342A patent/PL164136B1/pl unknown
- 1990-03-16 NO NO901241A patent/NO176316C/no not_active IP Right Cessation
- 1990-03-17 CN CN90101543A patent/CN1023007C/zh not_active Expired - Lifetime
-
1991
- 1991-03-13 RU SU914894696A patent/RU2015965C1/ru active
-
1992
- 1992-08-12 KR KR1019920014485A patent/KR960015142B1/ko not_active IP Right Cessation
-
1994
- 1994-09-26 JP JP6229807A patent/JPH07149640A/ja active Pending
- 1994-10-03 SG SG143394A patent/SG143394G/en unknown
- 1994-11-24 HK HK130294A patent/HK130294A/xx not_active IP Right Cessation
-
1995
- 1995-06-28 HU HU95P/P00505P patent/HU211640A9/hu active Protection Beyond IP Right Term
- 1995-10-20 CY CY181295A patent/CY1812A/xx unknown
-
1998
- 1998-03-30 BA BA980300A patent/BA98300A/bs unknown
-
2003
- 2003-12-26 CL CL200302756A patent/CL2003002756A1/es unknown
-
2005
- 2005-04-01 NO NO2005008C patent/NO2005008I2/no unknown
- 2005-04-04 CY CY2005005C patent/CY2005005I2/el unknown
- 2005-04-08 NL NL300191C patent/NL300191I2/nl unknown
- 2005-04-11 LU LU91161C patent/LU91161I2/fr unknown
Also Published As
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| Publication | Publication Date | Title |
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| US5096890B1 (en) | Pyrrolidine derivatives | |
| DE69007126T2 (de) | Muscarin-rezeptor-antagonisten. | |
| CA2072575A1 (en) | Anticholinergic agents | |
| DE69006745T2 (de) | Muscarin-rezeptor-antagonisten. |