PT93443A - Processo para a preparacao de derivados de pirrolidina - Google Patents

Processo para a preparacao de derivados de pirrolidina

Info

Publication number
PT93443A
PT93443A PT93443A PT9344390A PT93443A PT 93443 A PT93443 A PT 93443A PT 93443 A PT93443 A PT 93443A PT 9344390 A PT9344390 A PT 9344390A PT 93443 A PT93443 A PT 93443A
Authority
PT
Portugal
Prior art keywords
preparation
chem
pyrrolidine derivatives
formula
pyrrolidine
Prior art date
Application number
PT93443A
Other languages
English (en)
Other versions
PT93443B (pt
Inventor
Peter Edward Cross
Alexander Roderick Mackenzie
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10653525&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT93443(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of PT93443A publication Critical patent/PT93443A/pt
Publication of PT93443B publication Critical patent/PT93443B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
PT93443A 1989-03-17 1990-03-15 Processo para a preparacao de derivados de pirrolidina PT93443B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898906166A GB8906166D0 (en) 1989-03-17 1989-03-17 Therapeutic agents

Publications (2)

Publication Number Publication Date
PT93443A true PT93443A (pt) 1990-11-07
PT93443B PT93443B (pt) 1996-02-29

Family

ID=10653525

Family Applications (1)

Application Number Title Priority Date Filing Date
PT93443A PT93443B (pt) 1989-03-17 1990-03-15 Processo para a preparacao de derivados de pirrolidina

Country Status (37)

Country Link
US (1) US5096890B1 (pt)
EP (1) EP0388054B1 (pt)
JP (2) JPH0764809B2 (pt)
KR (2) KR920008166B1 (pt)
CN (1) CN1023007C (pt)
AT (1) ATE96783T1 (pt)
AU (1) AU614224B2 (pt)
BA (1) BA98300A (pt)
CA (1) CA2012295C (pt)
CL (1) CL2003002756A1 (pt)
CY (2) CY1812A (pt)
CZ (1) CZ280053B6 (pt)
DD (1) DD292911A5 (pt)
DE (2) DE69004302T2 (pt)
DK (1) DK0388054T3 (pt)
EG (1) EG18951A (pt)
ES (1) ES2060020T3 (pt)
FI (1) FI95573C (pt)
GB (1) GB8906166D0 (pt)
HK (1) HK130294A (pt)
HU (2) HU217433B (pt)
IE (1) IE62515B1 (pt)
IL (1) IL93694A (pt)
LU (1) LU91161I2 (pt)
MX (1) MX9319890A (pt)
MY (1) MY105527A (pt)
NL (1) NL300191I2 (pt)
NO (2) NO176316C (pt)
NZ (1) NZ232958A (pt)
PL (1) PL164136B1 (pt)
PT (1) PT93443B (pt)
RU (2) RU1833374C (pt)
SG (1) SG143394G (pt)
SK (1) SK129590A3 (pt)
UA (1) UA18263A (pt)
YU (1) YU47587B (pt)
ZA (1) ZA901982B (pt)

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US6017931A (en) * 1994-03-01 2000-01-25 Fmc Corporation Insecticidal compositions containing n-(substituted phenylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
US5639763A (en) * 1994-03-01 1997-06-17 Fmc Corporation Insecticidal N-(substituted arylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
US5656661A (en) * 1994-07-27 1997-08-12 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
EP0773939B1 (en) * 1994-07-27 2008-02-06 Vanderbilt University Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
GB9518953D0 (en) * 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
US5672620A (en) * 1996-02-01 1997-09-30 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5684031A (en) * 1996-02-01 1997-11-04 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
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US6131129A (en) * 1997-07-30 2000-10-10 Sony Corporation Of Japan Computer system within an AV/C based media changer subunit providing a standarized command set
US6693202B1 (en) 1999-02-16 2004-02-17 Theravance, Inc. Muscarinic receptor antagonists
IL141235A (en) * 2000-02-09 2012-04-30 Novartis Int Pharm Ltd Combined use of an alpha-adrenoceptor antagonist and a muscarinic antagonist in the preparation of a drug for the treatment of non-malignant prostatic hyperplasia
US6653339B2 (en) 2001-08-15 2003-11-25 Pfizer Inc. Method of treating irritable bowel syndrome
EP1461306B1 (en) * 2001-10-26 2008-12-24 Pharmacia & Upjohn Company LLC Quaternary ammonium compounds and their use as antimuscarinic agents
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BR0215801A (pt) 2002-07-08 2005-05-10 Ranbaxy Lab Ltd Derivados de 3,6-dissubstituìdos azabiciclo [3.1.0] hexano úteis como antagonistas de receptores muscarìnicos
US7265147B2 (en) 2002-07-31 2007-09-04 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
AU2002321711A1 (en) 2002-08-09 2004-02-25 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives useful as muscarinic receptor antagonist
CN1688544A (zh) 2002-08-23 2005-10-26 兰贝克赛实验室有限公司 作为蕈毒碱受体拮抗剂的含氟代和磺酰氨基的3,6－二取代的氮杂双环(3.1.0)己烷衍生物
TW200412945A (en) * 2002-10-25 2004-08-01 Upjohn Co Quaternary ammonium compounds
TW200800953A (en) * 2002-10-30 2008-01-01 Theravance Inc Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine
AU2002353286A1 (en) 2002-12-10 2004-06-30 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists
WO2004056767A1 (en) * 2002-12-23 2004-07-08 Ranbaxy Laboratories Limited 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
US7501443B2 (en) 2002-12-23 2009-03-10 Ranbaxy Laboratories Limited Flavaxate derivatives as muscarinic receptor antagonists
US7488748B2 (en) 2003-01-28 2009-02-10 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
JP4767842B2 (ja) 2003-04-01 2011-09-07 セラヴァンス， インコーポレーテッド β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有するジアリールメチル化合物および関連化合物
WO2004089898A1 (en) 2003-04-09 2004-10-21 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
ATE362364T1 (de) 2003-04-10 2007-06-15 Ranbaxy Lab Ltd Substituierte azabicyclo hexane derivate als muscarin rezeptor antagonisten
US7560479B2 (en) 2003-04-10 2009-07-14 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
EP1626957A1 (en) 2003-04-11 2006-02-22 Ranbaxy Laboratories Limited Azabicyclo derivatives as muscarinic receptor antagonists
US20040242569A1 (en) * 2003-04-15 2004-12-02 Pfizer Inc. Quatemary ammonium compounds
WO2004091597A2 (en) * 2003-04-15 2004-10-28 Pharmacia & Upjohn Company Llc Method of treating irritable bowel syndrome (ibs)
JP2006523674A (ja) * 2003-04-18 2006-10-19 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 慢性閉塞性肺疾患（ｃｏｐｄ）のための組合せ治療法
TW200510298A (en) * 2003-06-13 2005-03-16 Theravance Inc Substituted pyrrolidine and related compounds
WO2005007645A1 (en) 2003-07-11 2005-01-27 Theravance, Inc. Substituted 4-amino-1-benzylpiperidine compounds
WO2005087722A1 (en) * 2004-03-11 2005-09-22 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
WO2005087763A1 (en) * 2004-03-11 2005-09-22 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
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US7442806B2 (en) * 2005-12-27 2008-10-28 Teva Pharmaceutical Industries Ltd. Processes for preparing darifenacin hydrobromide
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WO2008076269A2 (en) * 2006-12-13 2008-06-26 Gilead Sciences, Inc. MONOPHOSPHATES AS MUTUAL PRODRUGS OF MUSCARINIC RECEPTOR ANTAGONISTS AND β-AGONISTS FOR THE TREATMENT OF COPD AND CHRONIC BRONCHITIS
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WO2009007853A2 (en) * 2007-06-08 2009-01-15 Actavis Group Ptc Ehf Novel polymorphs of darifenacin free base and its hydrobromide salt
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WO2009006413A1 (en) * 2007-06-30 2009-01-08 Auspex Pharmaceuticals, Inc. Substituted pyrrolidines
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WO2009125430A2 (en) * 2008-03-17 2009-10-15 Matrix Laboratoires Limited Improved process for producing darifenacin
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WO2011070419A1 (en) 2009-12-10 2011-06-16 Aurobindo Pharma Limited An improved process for the preparation of darifenacin hydrobromide
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Also Published As

Publication number Publication date
SK278434B6 (en) 1997-05-07
KR960015142B1 (ko) 1996-11-01
EG18951A (en) 1994-03-30
CY1812A (en) 1995-10-20
MY105527A (en) 1994-10-31
US5096890A (en) 1992-03-17
RU2015965C1 (ru) 1994-07-15
NO2005008I1 (en) 2005-04-11
NO176316C (no) 1995-03-15
CA2012295C (en) 1996-11-12
SG143394G (en) 1995-01-13
US5096890B1 (en) 1995-03-28
NL300191I2 (nl) 2005-08-01
IE62515B1 (en) 1995-02-08
PL164136B1 (pl) 1994-06-30
NO901241D0 (no) 1990-03-16
HK130294A (en) 1994-12-02
SK129590A3 (en) 1997-05-07
CZ280053B6 (cs) 1995-10-18
AU5140290A (en) 1990-09-20
JPH07149640A (ja) 1995-06-13
ZA901982B (en) 1991-10-30
JPH0764809B2 (ja) 1995-07-12
IE900955L (en) 1990-09-17
MX9319890A (es) 1993-08-01
DK0388054T3 (da) 1993-12-06
CN1045580A (zh) 1990-09-26
DE69004302D1 (de) 1993-12-09
NO176316B (no) 1994-12-05
CY2005005I2 (el) 2010-07-28
GB8906166D0 (en) 1989-05-04
CY2005005I1 (el) 2010-07-28
NO2005008I2 (no) 2006-11-27
DE69004302T2 (de) 1994-02-24
RU1833374C (ru) 1993-08-07
EP0388054B1 (en) 1993-11-03
YU52790A (sh) 1992-07-20
KR920008166B1 (ko) 1992-09-24
CZ129590A3 (en) 1995-05-17
DE122005000022I1 (de) 2005-08-04
DD292911A5 (de) 1991-08-14
ATE96783T1 (de) 1993-11-15
NL300191I1 (nl) 2005-07-01
FI95573C (fi) 1996-02-26
CA2012295A1 (en) 1990-09-17
YU47587B (sh) 1995-10-24
JPH02282360A (ja) 1990-11-19
UA18263A (uk) 1997-12-25
HU211640A9 (en) 1995-12-28
CN1023007C (zh) 1993-12-08
HUT58313A (en) 1992-02-28
FI95573B (fi) 1995-11-15
FI901333A0 (fi) 1990-03-16
BA98300A (bs) 2001-09-14
PT93443B (pt) 1996-02-29
IL93694A0 (en) 1990-12-23
HU217433B (hu) 2000-01-28
HU901580D0 (en) 1990-06-28
NZ232958A (en) 1992-05-26
DE122005000022I2 (de) 2006-02-02
KR900014367A (ko) 1990-10-23
CL2003002756A1 (es) 2005-02-11
NO901241L (no) 1990-09-18
AU614224B2 (en) 1991-08-22
EP0388054A1 (en) 1990-09-19
ES2060020T3 (es) 1994-11-16
IL93694A (en) 1994-08-26
LU91161I2 (fr) 2005-06-13

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