ZA895255B - New process for the synthesis of the levodopa - Google Patents

New process for the synthesis of the levodopa

Info

Publication number
ZA895255B
ZA895255B ZA895255A ZA895255A ZA895255B ZA 895255 B ZA895255 B ZA 895255B ZA 895255 A ZA895255 A ZA 895255A ZA 895255 A ZA895255 A ZA 895255A ZA 895255 B ZA895255 B ZA 895255B
Authority
ZA
South Africa
Prior art keywords
levodopa
synthesis
new process
new
Prior art date
Application number
ZA895255A
Other languages
English (en)
Inventor
Cannata Vincenzo
Vincenzo Cannata
Tamerlani Giancarlo
Giancarlo Tamerlani
Morotti Mauro Morotti
Mauro Morotti Morotti
Original Assignee
Mini Univ Ricerc Scient Tec
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mini Univ Ricerc Scient Tec filed Critical Mini Univ Ricerc Scient Tec
Publication of ZA895255B publication Critical patent/ZA895255B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C07C255/43—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms the carbon skeleton being further substituted by singly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA895255A 1988-07-12 1989-07-11 New process for the synthesis of the levodopa ZA895255B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8821322A IT1226902B (it) 1988-07-12 1988-07-12 Processo per la sintesi del levodopa

Publications (1)

Publication Number Publication Date
ZA895255B true ZA895255B (en) 1990-04-25

Family

ID=11180092

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA895255A ZA895255B (en) 1988-07-12 1989-07-11 New process for the synthesis of the levodopa

Country Status (23)

Country Link
US (1) US4962223A (sv)
EP (1) EP0357565B1 (sv)
JP (1) JP2507069B2 (sv)
KR (1) KR960004185B1 (sv)
AR (1) AR248267A1 (sv)
AT (1) ATE111439T1 (sv)
AU (1) AU615083B2 (sv)
CA (1) CA1338672C (sv)
DD (1) DD284674A5 (sv)
DE (1) DE68918207T2 (sv)
DK (1) DK172106B1 (sv)
ES (1) ES2063837T3 (sv)
FI (1) FI101534B1 (sv)
HU (1) HU203318B (sv)
IE (1) IE65956B1 (sv)
IL (1) IL90844A0 (sv)
IT (1) IT1226902B (sv)
NO (1) NO174293C (sv)
NZ (1) NZ229910A (sv)
PL (1) PL160103B1 (sv)
PT (1) PT91144B (sv)
YU (1) YU47907B (sv)
ZA (1) ZA895255B (sv)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5459145A (en) * 1988-01-19 1995-10-17 Pfizer Inc. Calcium independent camp phosphodiesterase inhibitor antidepressant
IT1226903B (it) * 1988-07-12 1991-02-21 Mini Ricerca Scient Tecnolog Processo per la sintesi di aminoacidi otticamente attivi
US5395935A (en) * 1992-05-08 1995-03-07 Pfizer Inc. Endo-bicyclo[2.2.1]heptan-2-ol and derived pharmaceutical agents
DE19502967A1 (de) * 1995-01-31 1996-08-01 Basf Ag Verfahren zur Racemattrennung von 2-Aryl-2-omega-alkylaminoalkannitrilen
JP3634207B2 (ja) * 1999-09-14 2005-03-30 独立行政法人科学技術振興機構 光学活性なα−アミノニトリル並びにα−アミノ酸類の製造方法
US20040002615A1 (en) * 2002-06-28 2004-01-01 Allen David Robert Preparation of chiral amino-nitriles
AU2003282603A1 (en) * 2002-10-11 2004-05-04 Depomed Development Ltd Gastro-retentive levodopa delivery form
DE10261807A1 (de) * 2002-12-19 2004-07-01 Turicum Drug Development Ag Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel
WO2004069146A2 (en) * 2003-02-07 2004-08-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem L-dopa amide derivatives and uses thereof
CA2642593C (en) 2006-02-17 2014-11-04 Birds Pharma Gmbh Berolina Innovative Research & Development Services Deuterated catecholamine derivatives and medicaments comprising said compounds
PT3116475T (pt) 2014-03-13 2020-12-15 Neuroderm Ltd Composições de inibidores de dopa-descarboxilase
US10258585B2 (en) 2014-03-13 2019-04-16 Neuroderm, Ltd. DOPA decarboxylase inhibitor compositions
WO2020061649A1 (en) 2018-09-28 2020-04-02 Griffith University Agents and methods for modulating pathogen activity
US11844754B2 (en) 2020-11-17 2023-12-19 Neuroderm, Ltd. Methods for treatment of Parkinson's disease
US11331293B1 (en) 2020-11-17 2022-05-17 Neuroderm, Ltd. Method for treatment of Parkinson's disease
US11213502B1 (en) 2020-11-17 2022-01-04 Neuroderm, Ltd. Method for treatment of parkinson's disease

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA504449A (en) * 1954-07-20 C. Britton Edgar Alpha-amino-beta-alkoxy-butyronitriles and method of making same
BE638485A (sv) * 1962-10-11
US3845076A (en) * 1971-04-20 1974-10-29 Sagami Chem Res Method of preparing aldehydes
JPS4920305A (sv) * 1972-06-21 1974-02-22
HU165026B (sv) * 1972-08-11 1974-06-28
US4072698A (en) * 1976-12-02 1978-02-07 The Upjohn Company Resolution of aminonitriles
YU93877A (en) * 1977-04-08 1982-06-30 Krka Process for the resolution of racemic alpha-aminonitrils
IL59048A (en) * 1979-12-27 1984-01-31 Plantex Ltd Process for the preparation of alpha-amino-3-phenyl-propionitriles and novel benzylidene amino acetonitriles as intermediates therefor
DE3002543A1 (de) * 1980-01-25 1981-07-30 Basf Ag, 6700 Ludwigshafen 4-tert.-butoxyphenylglycinnitril sowie verfahren zur herstellung von d-(-)- und l-(+)-4-hydroxyphenylglycin
JPS56115749A (en) * 1980-02-18 1981-09-11 Sagami Chem Res Center Dopa derivative
JPS61275253A (ja) * 1985-05-30 1986-12-05 Nippon Kayaku Co Ltd ３−（３，４−ジヒドロキシフエニル）−２−メチルアラニンの製造法
FR2614626B1 (fr) * 1987-04-30 1989-07-21 Ranoux Claude Conteneur pour fecondation des ovocytes et replacement des embryons chez l'homme et l'animal

Also Published As

Publication number Publication date
NO174293B (no) 1994-01-03
DD284674A5 (de) 1990-11-21
FI101534B (sv) 1998-07-15
ES2063837T3 (es) 1995-01-16
NZ229910A (en) 1991-04-26
IE65956B1 (en) 1995-11-29
EP0357565A2 (en) 1990-03-07
PT91144B (pt) 1995-01-31
FI893368A0 (fi) 1989-07-11
AR248267A1 (es) 1995-07-12
FI101534B1 (sv) 1998-07-15
DE68918207D1 (de) 1994-10-20
YU139989A (en) 1990-12-31
ATE111439T1 (de) 1994-09-15
NO174293C (no) 1994-04-13
AU3805789A (en) 1990-01-25
EP0357565B1 (en) 1994-09-14
IL90844A0 (en) 1990-02-09
EP0357565A3 (en) 1991-09-25
JPH02231457A (ja) 1990-09-13
DE68918207T2 (de) 1995-05-11
DK172106B1 (da) 1997-10-27
JP2507069B2 (ja) 1996-06-12
PL160103B1 (pl) 1993-02-26
DK342489A (da) 1990-01-13
DK342489D0 (da) 1989-07-11
HUT51596A (en) 1990-05-28
KR960004185B1 (ko) 1996-03-27
YU47907B (sh) 1996-05-20
IT8821322A0 (it) 1988-07-12
PT91144A (pt) 1990-02-08
IT1226902B (it) 1991-02-21
NO892861L (no) 1990-01-15
NO892861D0 (no) 1989-07-11
AU615083B2 (en) 1991-09-19
IE892227L (en) 1990-01-12
CA1338672C (en) 1996-10-22
US4962223A (en) 1990-10-09
HU203318B (en) 1991-07-29
FI893368A (fi) 1990-01-13
KR900001641A (ko) 1990-02-27

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