ZA891680B - Hypoglycemic thiazolidinedione derivatives - Google Patents
Hypoglycemic thiazolidinedione derivativesInfo
- Publication number
- ZA891680B ZA891680B ZA891680A ZA891680A ZA891680B ZA 891680 B ZA891680 B ZA 891680B ZA 891680 A ZA891680 A ZA 891680A ZA 891680 A ZA891680 A ZA 891680A ZA 891680 B ZA891680 B ZA 891680B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- hydrogen
- bond
- pharmaceutically acceptable
- phenyl
- Prior art date
Links
- 230000002218 hypoglycaemic effect Effects 0.000 title abstract 2
- 150000001467 thiazolidinediones Chemical class 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 150000001473 2,4-thiazolidinediones Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines Containing Plant Substances (AREA)
- Paints Or Removers (AREA)
- Photoreceptors In Electrophotography (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Indole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1988/000733 WO1989008651A1 (en) | 1988-03-08 | 1988-03-08 | Hypoglycemic thiazolidinedione derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA891680B true ZA891680B (en) | 1990-10-31 |
Family
ID=22208589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA891680A ZA891680B (en) | 1988-03-08 | 1989-03-06 | Hypoglycemic thiazolidinedione derivatives |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP0332332B1 (pl) |
| JP (1) | JP2610990B2 (pl) |
| KR (1) | KR910000723B1 (pl) |
| AT (1) | ATE87624T1 (pl) |
| AU (1) | AU593754B2 (pl) |
| CA (1) | CA1328873C (pl) |
| CZ (1) | CZ285957B6 (pl) |
| DD (1) | DD279245A5 (pl) |
| DE (1) | DE68905639T2 (pl) |
| DK (1) | DK108089A (pl) |
| EG (1) | EG19168A (pl) |
| ES (1) | ES2053977T3 (pl) |
| FI (1) | FI93115C (pl) |
| IE (1) | IE62776B1 (pl) |
| IL (1) | IL89482A (pl) |
| MX (1) | MX15171A (pl) |
| MY (1) | MY103979A (pl) |
| NO (1) | NO177008C (pl) |
| NZ (1) | NZ228249A (pl) |
| PH (1) | PH26572A (pl) |
| PL (1) | PL159728B1 (pl) |
| PT (1) | PT89912B (pl) |
| WO (1) | WO1989008651A1 (pl) |
| YU (1) | YU47066B (pl) |
| ZA (1) | ZA891680B (pl) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5089514A (en) * | 1990-06-14 | 1992-02-18 | Pfizer Inc. | 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents |
| EP0544696B1 (en) * | 1990-08-23 | 1995-01-11 | Pfizer Inc. | Hypoglycemic hydroxyurea derivatives |
| GB9023585D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
| TW222626B (pl) * | 1991-07-22 | 1994-04-21 | Pfizer | |
| US5175179A (en) * | 1991-09-25 | 1992-12-29 | Pfizer Inc. | Method for treating hypertension |
| FR2696743B1 (fr) * | 1992-10-12 | 1994-12-23 | Adir | Nouveaux composés de thiazolidine dione, leur procédé de préparation et les compositions pharmaceutiques les contenant. |
| TW245716B (pl) * | 1992-12-28 | 1995-04-21 | Takeda Pharm Industry Co | |
| US5614544A (en) * | 1993-09-14 | 1997-03-25 | Takeda Chemical Industries, Ltd. | Oxazolidinedione derivatives and their use |
| US6046222A (en) * | 1993-09-15 | 2000-04-04 | Warner-Lambert Company | Use of thiazolidinedione derivatives in the treatment of polycystic ovary syndrome, gestational diabetes and disease states at risk for progressing to noninsulin-dependent diabetes mellitus |
| US5457109A (en) * | 1993-09-15 | 1995-10-10 | Warner-Lambert Company | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of disease states at risk for progressing to noninsulin-dependent diabetes mellitus |
| EP0719140B1 (en) * | 1993-09-15 | 2007-10-31 | Daiichi Sankyo Company, Limited | Use of thiazolidinediones to prevent or delay onset of niddm |
| US5874454A (en) * | 1993-09-15 | 1999-02-23 | Warner-Lambert Company | Use of thiazolidinedione derivatives in the treatment of polycystic ovary syndrome, gestational diabetes and disease states at risk for progressing to noninsulin-dependent diabetes mellitus |
| TW420669B (en) * | 1994-03-28 | 2001-02-01 | Nissan Chemical Ind Ltd | Pyridine type thiazolidines |
| EP0783496B9 (en) * | 1994-08-10 | 2003-09-03 | Takeda Chemical Industries, Ltd. | Thiazolidinedione derivatives, their production and use |
| US5925656A (en) * | 1995-04-10 | 1999-07-20 | Dr. Reddy's Research Foundation | Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US5708012A (en) * | 1995-04-28 | 1998-01-13 | Sankyo Company, Limited | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of insulin resistant subjects with normal glucose tolerance in order to prevent or delay the onset of noninsulin-dependent mellitus |
| AU706628B2 (en) * | 1995-07-03 | 1999-06-17 | Sankyo Company Limited | Treatment of arteriosclerosis and xanthoma |
| NZ314406A (en) * | 1996-03-18 | 2000-12-22 | Sankyo Co | Treatment or prophylaxis of pancreatitis with a medicament containing an insulin sensitiser including oxazoles and thiazoles |
| US5889025A (en) * | 1996-05-06 | 1999-03-30 | Reddy's Research Foundation | Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US5801173A (en) * | 1996-05-06 | 1998-09-01 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US5919782A (en) * | 1996-05-06 | 1999-07-06 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| ZA973848B (en) * | 1996-05-06 | 1997-12-02 | Reddy Research Foundation | Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them. |
| CA2257284C (en) * | 1996-05-31 | 2005-10-04 | Sankyo Company Limited | Remedy for autoimmune diseases |
| US6114526A (en) * | 1996-07-01 | 2000-09-05 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US5885997A (en) * | 1996-07-01 | 1999-03-23 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| BR9711098B1 (pt) * | 1996-07-01 | 2011-10-04 | compostos heterocìclicos, processo para sua preparação e composições farmacêuticas contendo os mesmos e seu uso no tratamento de diabetes e doenças relacionadas. | |
| USRE39266E1 (en) * | 1996-07-01 | 2006-09-05 | Dr. Reddy's Laboratories, Limited | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US6372750B2 (en) | 1996-07-01 | 2002-04-16 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases |
| DK0930076T3 (da) * | 1996-07-15 | 2005-01-31 | Sankyo Co | Farmaceutiske præparater omfattende CS-866 og insulinresistensforbedrende midler og deres anvendelse i behandlingen af arteriosclerose og xanthom |
| JP2000514041A (ja) * | 1996-07-26 | 2000-10-24 | ドクター・レディーズ・リサーチ・ファウンデーション | 抗糖尿病、低脂血、抗高血圧特性を有するチアゾリジンジオン化合物、それらの調製法、及びその薬学的組成物 |
| EP1006794B1 (en) | 1997-03-12 | 2007-11-28 | Robert W. Esmond | A method for treating or preventing alzheimer's disease |
| DE19711616A1 (de) | 1997-03-20 | 1998-09-24 | Boehringer Mannheim Gmbh | Verbessertes Verfahren zur Herstellung von Thiazolidindionen |
| UA67743C2 (uk) | 1997-06-18 | 2004-07-15 | Смітклайн Бічам П.Л.С. | Фармацевтична композиція, що містить тіазолідиндіон і сульфонілсечовину, для лікування діабету |
| GB9715306D0 (en) * | 1997-07-18 | 1997-09-24 | Smithkline Beecham Plc | Novel method of treatment |
| GB9715295D0 (en) * | 1997-07-18 | 1997-09-24 | Smithkline Beecham Plc | Novel method of treatment |
| HUP9902721A2 (hu) * | 1997-11-25 | 1999-12-28 | The Procter & Gamble Co. | Tömény textillágyító készítmény és ehhez alkalmazható magas telítetlenségű textillágyító vegyület |
| AU1507799A (en) * | 1997-12-16 | 1999-07-05 | Sankyo Company Limited | Leukemia remedy |
| AU768994B2 (en) | 1998-11-12 | 2004-01-15 | Smithkline Beecham Plc | Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent |
| DZ2937A1 (fr) | 1998-11-12 | 2004-03-15 | Smithkline Beecham Plc | Compositions nouvelles de sensibilidants à l'insuline. |
| GB9824893D0 (en) * | 1998-11-12 | 1999-01-06 | Smithkline Beckman Corp | Novel method of treatment |
| US6191154B1 (en) | 1998-11-27 | 2001-02-20 | Case Western Reserve University | Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases |
| ID29875A (id) * | 1999-07-01 | 2001-10-18 | Geron Corp Cs | Penghambat-penghambat telomerase dan metode penggunaannya |
| JP2001072592A (ja) | 1999-07-01 | 2001-03-21 | Kyowa Hakko Kogyo Co Ltd | テロメラーゼ阻害剤 |
| US6559188B1 (en) | 1999-09-17 | 2003-05-06 | Novartis Ag | Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes |
| US6878749B2 (en) | 1999-09-17 | 2005-04-12 | Novartis Ag | Method of treating metabolic disorders, especially diabetes, or a disease or condition associated with diabetes |
| CO5200844A1 (es) | 1999-09-17 | 2002-09-27 | Novartis Ag | Una combinacion que comprende nateglinida y cuando por menos otro compuesto antidiabetico usada para el tratamiento de desordenes metabolicos, especialmente diabetes, o de una enfermedad o condicion asociada con dibetes |
| BRPI0107715B8 (pt) | 2000-01-21 | 2021-05-25 | Novartis Ag | produto farmacêutico compreendendo um inibidor de dipeptidilpeptidase-iv e metformina, bem como usos do dito produto farmacêutico e do inibidor de dipeptidilpeptidase-iv |
| JP2001199888A (ja) | 2000-01-24 | 2001-07-24 | Fujimoto Brothers:Kk | 糖尿病治療剤 |
| US6680387B2 (en) | 2000-04-24 | 2004-01-20 | Aryx Therapeutics | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
| US6784199B2 (en) | 2000-09-21 | 2004-08-31 | Aryx Therapeutics | Isoxazolidine compounds useful in the treatment of diabetes, hyperlipidemia, and atherosclerosis in mammals |
| GB0014969D0 (en) | 2000-06-19 | 2000-08-09 | Smithkline Beecham Plc | Novel method of treatment |
| US6452014B1 (en) | 2000-12-22 | 2002-09-17 | Geron Corporation | Telomerase inhibitors and methods of their use |
| US7659409B2 (en) | 2002-03-19 | 2010-02-09 | Mitsubishi Chemical Corporation | 3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same |
| US8268352B2 (en) | 2002-08-05 | 2012-09-18 | Torrent Pharmaceuticals Limited | Modified release composition for highly soluble drugs |
| US8216609B2 (en) | 2002-08-05 | 2012-07-10 | Torrent Pharmaceuticals Limited | Modified release composition of highly soluble drugs |
| JP5305914B2 (ja) * | 2005-11-15 | 2013-10-02 | 大塚製薬株式会社 | オキサゾール化合物及び医薬組成物 |
| US20120094959A1 (en) | 2010-10-19 | 2012-04-19 | Bonnie Blazer-Yost | Treatment of cystic diseases |
| WO2014068397A1 (en) | 2012-11-05 | 2014-05-08 | Commissariat A L'energie Atomique Et Aux Energies Atlternatives (Cea) | Combination of an anti-cancer agent such as a tyrosinekinase inhibitor and a stat5 antagonist, preferably a thiazolidinedione, for eliminating hematologic cancer stem cells in vivo and for preventing hematologic cancer relapse |
| US10034868B2 (en) | 2014-11-04 | 2018-07-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the prevention and the treatment of rapidly progressive glomerulonephritis |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5522636A (en) * | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
| CN1003445B (zh) * | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物，其制备方法和用途 |
| WO1986007056A1 (en) * | 1985-05-21 | 1986-12-04 | Pfizer Inc. | Hypoglycemic thiazolidinediones |
| US5061717A (en) * | 1988-03-08 | 1991-10-29 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
| HU217432B (hu) * | 1988-03-08 | 2000-01-28 | Pfizer Inc. | Eljárás tiazolidin-dion-származékok és az ezeket tartalmazó gyógyszerkészítmények előállítására, a vegyületek és a készítmények |
-
1988
- 1988-03-08 WO PCT/US1988/000733 patent/WO1989008651A1/en active IP Right Grant
- 1988-03-08 MX MX1517189A patent/MX15171A/es unknown
-
1989
- 1989-03-01 DE DE8989302017T patent/DE68905639T2/de not_active Expired - Fee Related
- 1989-03-01 ES ES89302017T patent/ES2053977T3/es not_active Expired - Lifetime
- 1989-03-01 EP EP89302017A patent/EP0332332B1/en not_active Expired - Lifetime
- 1989-03-01 AT AT89302017T patent/ATE87624T1/de not_active IP Right Cessation
- 1989-03-03 IL IL89482A patent/IL89482A/xx not_active IP Right Cessation
- 1989-03-06 MY MYPI89000271A patent/MY103979A/en unknown
- 1989-03-06 EG EG11789A patent/EG19168A/xx active
- 1989-03-06 CA CA000592855A patent/CA1328873C/en not_active Expired - Fee Related
- 1989-03-06 ZA ZA891680A patent/ZA891680B/xx unknown
- 1989-03-06 PT PT89912A patent/PT89912B/pt not_active IP Right Cessation
- 1989-03-07 CZ CS891439A patent/CZ285957B6/cs not_active IP Right Cessation
- 1989-03-07 AU AU31078/89A patent/AU593754B2/en not_active Ceased
- 1989-03-07 DK DK108089A patent/DK108089A/da not_active Application Discontinuation
- 1989-03-07 DD DD89326340A patent/DD279245A5/de not_active IP Right Cessation
- 1989-03-07 NZ NZ228249A patent/NZ228249A/xx unknown
- 1989-03-07 YU YU47989A patent/YU47066B/sh unknown
- 1989-03-07 PL PL1989278115A patent/PL159728B1/pl unknown
- 1989-03-07 KR KR1019890002787A patent/KR910000723B1/ko not_active IP Right Cessation
- 1989-03-07 IE IE73889A patent/IE62776B1/en not_active IP Right Cessation
- 1989-03-08 JP JP1055968A patent/JP2610990B2/ja not_active Expired - Fee Related
- 1989-03-08 PH PH38301A patent/PH26572A/en unknown
- 1989-11-06 FI FI895258A patent/FI93115C/fi not_active IP Right Cessation
- 1989-11-07 NO NO894425A patent/NO177008C/no not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA891680B (en) | Hypoglycemic thiazolidinedione derivatives | |
| MY103837A (en) | Thiazolidinedione derivatives as hypoglycemic agents. | |
| AU3107589A (en) | Thiazolidinedione hypoglycemic agents | |
| AU2001277723A1 (en) | Ppardelta activators | |
| KR960704546A (ko) | 인슐린 비의존성 당뇨병으로 진행할 위험이 있는 질병의 치료에 있어서 티아졸리딘디온 유도체 및 관련 고혈당 억제제의 용도(Use of Thiazolidinedione Derivatives and Related Antihyperglycemic Agents in the Treatment of Disease States at Risk for Progressing to Noninsulin-Dependent Diabetes Mellitus) | |
| DK0428312T3 (da) | Hypoglykæmiske oxazolidindionderivater | |
| AU3822193A (en) | Azole compounds, their production and use | |
| PT1300401E (pt) | Derivados de tiazole para utilização como anti-inflamatórios | |
| EP0632031A4 (pl) | ||
| KR880002829A (ko) | 디하이드로피리딘 항알러지제 및 소염제 | |
| EP0714897A4 (en) | FUSED HETEROAROMATIC CYCLOPENTENE DERIVATIVE HAVING ENDOTHELIN ANTAGONIST ACTIVITY | |
| HU9203284D0 (en) | Method for producing thiazolidine-2,4-dione derivatives and medical preparatives containing these compounds | |
| KR920016422A (ko) | N-페닐카바메이트 화합물, 이의 제조방법 및 유해한 유기체를 방제하기 위한 살균 조성물 | |
| IL102573A (en) | Hypoglycemic thiazolidinediones | |
| CS743389A3 (en) | Amino(methyl)phenyl derivatives, process for their preparation and use | |
| DK147588A (da) | Benzoxazinderivat samt fremgangsmaade til fremstilling deraf | |
| AU2983792A (en) | Diaminomethyleneamino substituted substituted phenyl thiazoles | |
| DK0534655T3 (da) | Thiazolidin-2,4-dioner til behandling af hypertension |