ZA834110B - Indole derivatives,processes for their preparation and pharmaceutical compositions containing them - Google Patents

Indole derivatives,processes for their preparation and pharmaceutical compositions containing them

Info

Publication number
ZA834110B
ZA834110B ZA834110A ZA834110A ZA834110B ZA 834110 B ZA834110 B ZA 834110B ZA 834110 A ZA834110 A ZA 834110A ZA 834110 A ZA834110 A ZA 834110A ZA 834110 B ZA834110 B ZA 834110B
Authority
ZA
South Africa
Prior art keywords
processes
preparation
pharmaceutical compositions
compositions containing
indole derivatives
Prior art date
Application number
ZA834110A
Other languages
English (en)
Inventor
Michael Dennis Dowle
Ian Harold Coates
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10530876&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA834110(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ZA834110B publication Critical patent/ZA834110B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
ZA834110A 1982-06-07 1983-06-07 Indole derivatives,processes for their preparation and pharmaceutical compositions containing them ZA834110B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8216526 1982-06-07

Publications (1)

Publication Number Publication Date
ZA834110B true ZA834110B (en) 1985-01-30

Family

ID=10530876

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA834110A ZA834110B (en) 1982-06-07 1983-06-07 Indole derivatives,processes for their preparation and pharmaceutical compositions containing them

Country Status (33)

Country Link
US (1) US4816470A (es)
JP (1) JPS5942366A (es)
KR (1) KR900006681B1 (es)
AT (1) AT381933B (es)
AU (1) AU566149B2 (es)
BE (1) BE896986A (es)
CA (1) CA1199643A (es)
CH (1) CH657359A5 (es)
CY (1) CY1458A (es)
CZ (1) CZ280529B6 (es)
DE (2) DE19375045I2 (es)
DK (1) DK260183D0 (es)
DO (1) DOP1989476000A (es)
ES (3) ES523039A0 (es)
FI (1) FI79530C (es)
FR (1) FR2530625B1 (es)
GB (1) GB2124210B (es)
GR (1) GR79215B (es)
HK (1) HK14789A (es)
IE (1) IE55358B1 (es)
IL (1) IL68913A (es)
IT (1) IT1170387B (es)
KE (1) KE3833A (es)
LU (1) LU84852A1 (es)
MX (1) MX9202623A (es)
MY (1) MY8700179A (es)
NL (1) NL193694C (es)
NZ (1) NZ204482A (es)
PH (1) PH19908A (es)
PT (1) PT76830B (es)
SE (1) SE452459B (es)
SK (1) SK404091A3 (es)
ZA (1) ZA834110B (es)

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GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
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US5270333A (en) * 1986-01-28 1993-12-14 Glaxo Group Limited Indole derivatives
GB8615599D0 (en) * 1986-06-26 1986-07-30 Glaxo Group Ltd Chemical compounds
PT88255B (pt) * 1987-08-13 1995-03-01 Glaxo Group Ltd Processo para a preparacao de derivados do indole
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8903036D0 (en) * 1989-02-10 1989-03-30 Glaxo Group Ltd Chemical compounds
HUT57185A (en) * 1990-03-21 1991-11-28 Merrell Dow Pharma Process for producing 8-sulfamil-methylen-2-amino-tetraline derivatives and pharmaceutical compositions containing them
US5935925A (en) * 1990-05-08 1999-08-10 Synaptic Pharmaceutical Corporation Methods of treating migraine and compounds useful for such methods
US5155218A (en) * 1990-05-08 1992-10-13 Neurogenetic Corporation Dna encoding human 5-ht1d receptors
NZ238424A (en) * 1990-06-07 1993-12-23 Wellcome Found 3,5-substituted indole derivatives; medicaments and preparatory processes.
GB9013845D0 (en) * 1990-06-21 1990-08-15 Glaxo Group Ltd Process
US5077293A (en) * 1990-06-29 1991-12-31 Bristol-Myers Squibb Co. 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines
CA2043709C (en) * 1990-06-29 2002-01-22 David W. Smith Antimigraine alkoxypyrimidine derivatives
GB9022250D0 (en) * 1990-10-12 1990-11-28 Glaxo Group Ltd Medicaments
GB9103770D0 (en) * 1991-02-22 1991-04-10 Glaxo Group Ltd Chemical compounds
GB9104890D0 (en) 1991-03-08 1991-04-24 Glaxo Group Ltd Compositions
CA2084531A1 (en) * 1991-12-19 1993-06-20 David W. Smith Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
GB9211276D0 (en) * 1992-05-28 1992-07-15 Glaxo Lab Sa Pharmaceutical compositions
ES2055651B1 (es) * 1992-07-20 1995-03-01 Vita Invest Sa Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles.
GB9216009D0 (en) * 1992-07-28 1992-09-09 Almirall Lab New indol derivatives
ES2056025B1 (es) * 1992-10-08 1995-05-01 Almirall Lab Nuevos derivados de indol.
US5382592A (en) * 1993-09-16 1995-01-17 Bristol-Myers Squibb Company Antimigraine cyclobutenedione derivatives of tryptamines
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
ES2079323B1 (es) * 1994-06-21 1996-10-16 Vita Invest Sa Derivados de indol utiles para el tratamiento de la migraña, composicion y uso correspondientes.
FR2731224B1 (fr) * 1995-03-02 1997-05-30 Pf Medicament Nouveaux derives bi-tryptaminiques sulfonamides, leur procede de preparation et leur utilisation a titre de medicaments
US5618816A (en) * 1995-03-02 1997-04-08 Bristol-Myers Squibb Company Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridnyl and pyrimidinylpiperazines
US8022095B2 (en) 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US5872145A (en) * 1996-08-16 1999-02-16 Pozen, Inc. Formulation of 5-HT agonist and NSAID for treatment of migraine
US6586458B1 (en) 1996-08-16 2003-07-01 Pozen Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6416472B1 (en) 1997-11-06 2002-07-09 Edus Inc. Method and device for measuring cognitive efficiency
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
GB9926250D0 (en) * 1999-11-06 2000-01-12 Knoll Ag Chemical process
AU2001285156A1 (en) * 2000-08-23 2002-03-04 Bristol-Myers Squibb Company Combination therapy for the treatment of migraine
NZ528377A (en) * 2001-03-27 2005-05-27 Galen Chemicals Ltd Intravaginal drug delivery devices for the administration of an antimicrobial agent
EP1435945B1 (en) * 2001-06-05 2008-08-13 Aung-din, Ronald Topical migraine therapy
US8329734B2 (en) 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
CN1649614A (zh) 2002-02-22 2005-08-03 新河药品股份有限公司 活性剂传递系统和保护及施用活性剂的方法
WO2003105836A1 (en) * 2002-06-13 2003-12-24 Dr. Reddy's Laboratories Limited 3-'2-(Dimethylamino) ethyl!-N-methyl-1H-indole-5-methanesulfonamide and the Succinate Thereof
US20040068000A1 (en) * 2002-10-02 2004-04-08 Mintong Guo Compression coated tablets
EP1572647B1 (en) 2002-12-20 2016-09-21 Basf Se Synthesis of amines and intermediates for the synthesis thereof
EP1575566B1 (en) 2002-12-26 2012-02-22 Pozen, Inc. Multilayer dosage forms containing naproxen and triptans
US20080213363A1 (en) * 2003-01-23 2008-09-04 Singh Nikhilesh N Methods and compositions for delivering 5-HT3 antagonists across the oral mucosa
WO2004076403A1 (en) * 2003-02-24 2004-09-10 Transform Pharmaceuticals, Inc. Sumatriptan crystalline forms, pharmaceutical compositions and methods
BRPI0410807A (pt) * 2003-06-06 2006-06-27 Glaxo Group Ltd composição farmacêutica, e, método pata tratar um mamìfero sofrendo de ou susceptìvel a condições associadas com dor cefálica
WO2004112723A2 (en) 2003-06-20 2004-12-29 Ronald Aung-Din Tropical therapy for the treatment of migraines, muscle sprains, muscle spasm, spasticity and related conditions
EP1708684A2 (en) * 2003-09-26 2006-10-11 Alza Corporation Drug coating providing high drug loading and methods for providing the same
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US8541026B2 (en) * 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
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BRPI0820632A2 (pt) * 2007-11-16 2015-06-16 Neuraxon Inc Compostos de indol e métodos para tratamento de dor visceral
US20090252791A1 (en) * 2008-04-02 2009-10-08 Venkata Nookaraju Sreedharala Pharmaceutical compositions comprising a triptan and a nonsteroidal anti-inflammatory drug
CN102046621B (zh) 2008-05-27 2014-11-12 生物区科学管理控股有限公司 抗病毒盐
CN102088966B (zh) * 2008-06-20 2015-06-10 阿尔法制药有限公司 药物制剂
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US11337962B2 (en) 2009-09-25 2022-05-24 Upsher-Smith Laboratories, Llc Formulations comprising triptan compounds
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CN107530318A (zh) 2015-03-02 2018-01-02 阿福金制药有限责任公司 用大麻素的局部区域神经影响性疗法
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
US10537554B2 (en) * 2015-08-05 2020-01-21 Upsher-Smith Laboratories, Llc Pharmaceutical composition for treating migraine
EP3407869A1 (en) 2016-01-27 2018-12-05 Instar Technologies A.S. Oromucosal nanofiber carriers for therapeutic treatment
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
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ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
IT1171449B (it) * 1980-08-12 1987-06-10 Glaxo Group Ltd Composti eterociclici indolici procedimento per produrli e composizioni farmaceutiche che li contengono
NZ197998A (en) * 1980-08-12 1985-08-16 Glaxo Group Ltd 5-amino(methyl)-1h-indol-3-ylalkaneamines
GB2082175B (en) * 1980-08-12 1984-05-02 Glaxo Group Ltd Heterocyclic compounds
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
CZ280529B6 (cs) 1996-02-14
KR900006681B1 (ko) 1990-09-17
GR79215B (es) 1984-10-22
JPS5942366A (ja) 1984-03-08
LU84852A1 (fr) 1985-03-29
FI832035L (fi) 1983-12-08
IL68913A (en) 1987-08-31
FI832035A0 (fi) 1983-06-07
AU1544183A (en) 1983-12-15
GB2124210A (en) 1984-02-15
ES8407473A1 (es) 1984-10-01
US4816470A (en) 1989-03-28
IE831335L (en) 1983-12-07
ES544281A0 (es) 1986-07-16
ES523039A0 (es) 1984-10-01
FR2530625B1 (fr) 1986-04-18
KR840005095A (ko) 1984-11-03
PH19908A (en) 1986-08-13
ATA208483A (de) 1986-05-15
SK277877B6 (en) 1995-06-07
KE3833A (en) 1988-11-18
CY1458A (en) 1989-07-21
FI79530C (fi) 1990-01-10
DOP1989476000A (es) 1996-02-03
DE19375045I2 (de) 2002-09-05
DE3320521C2 (es) 1992-06-25
CZ404091A3 (en) 1993-04-14
CA1199643A (en) 1986-01-21
MX9202623A (es) 1992-06-30
AT381933B (de) 1986-12-10
JPH0329069B2 (es) 1991-04-23
PT76830A (en) 1983-07-01
GB2124210B (en) 1985-11-13
IT8348422A0 (it) 1983-06-03
SE452459B (sv) 1987-11-30
FI79530B (fi) 1989-09-29
GB8315564D0 (en) 1983-07-13
DE3320521A1 (de) 1983-12-08
BE896986A (fr) 1983-12-07
PT76830B (en) 1986-04-21
SE8303208D0 (sv) 1983-06-07
ES8609247A1 (es) 1986-07-16
IL68913A0 (en) 1983-10-31
IT1170387B (it) 1987-06-03
SE8303208L (sv) 1983-12-08
ES529802A0 (es) 1985-11-16
NZ204482A (en) 1986-09-10
MY8700179A (en) 1987-12-31
AU566149B2 (en) 1987-10-08
ES8601880A1 (es) 1985-11-16
NL193694C (nl) 2000-07-04
SK404091A3 (en) 1995-06-07
IE55358B1 (en) 1990-08-29
NL193694B (nl) 2000-03-01
CH657359A5 (fr) 1986-08-29
DK260183D0 (da) 1983-06-06
HK14789A (en) 1989-02-24
FR2530625A1 (fr) 1984-01-27
NL8302031A (nl) 1984-01-02

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