AT381933B - Verfahren zur herstellung neuer indole und ihrer salze - Google Patents

Verfahren zur herstellung neuer indole und ihrer salze

Info

Publication number
AT381933B
AT381933B AT0208483A AT208483A AT381933B AT 381933 B AT381933 B AT 381933B AT 0208483 A AT0208483 A AT 0208483A AT 208483 A AT208483 A AT 208483A AT 381933 B AT381933 B AT 381933B
Authority
AT
Austria
Prior art keywords
salts
producing new
new indoles
indoles
producing
Prior art date
Application number
AT0208483A
Other languages
English (en)
Other versions
ATA208483A (de
Inventor
Michael Dennis Dowle
Ian Harold Coates
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10530876&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AT381933(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ATA208483A publication Critical patent/ATA208483A/de
Application granted granted Critical
Publication of AT381933B publication Critical patent/AT381933B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
AT0208483A 1982-06-07 1983-06-07 Verfahren zur herstellung neuer indole und ihrer salze AT381933B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8216526 1982-06-07

Publications (2)

Publication Number Publication Date
ATA208483A ATA208483A (de) 1986-05-15
AT381933B true AT381933B (de) 1986-12-10

Family

ID=10530876

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0208483A AT381933B (de) 1982-06-07 1983-06-07 Verfahren zur herstellung neuer indole und ihrer salze

Country Status (33)

Country Link
US (1) US4816470A (de)
JP (1) JPS5942366A (de)
KR (1) KR900006681B1 (de)
AT (1) AT381933B (de)
AU (1) AU566149B2 (de)
BE (1) BE896986A (de)
CA (1) CA1199643A (de)
CH (1) CH657359A5 (de)
CY (1) CY1458A (de)
CZ (1) CZ280529B6 (de)
DE (2) DE3320521A1 (de)
DK (1) DK260183D0 (de)
DO (1) DOP1989476000A (de)
ES (3) ES8407473A1 (de)
FI (1) FI79530C (de)
FR (1) FR2530625B1 (de)
GB (1) GB2124210B (de)
GR (1) GR79215B (de)
HK (1) HK14789A (de)
IE (1) IE55358B1 (de)
IL (1) IL68913A (de)
IT (1) IT1170387B (de)
KE (1) KE3833A (de)
LU (1) LU84852A1 (de)
MX (1) MX9202623A (de)
MY (1) MY8700179A (de)
NL (1) NL193694C (de)
NZ (1) NZ204482A (de)
PH (1) PH19908A (de)
PT (1) PT76830B (de)
SE (1) SE452459B (de)
SK (1) SK277877B6 (de)
ZA (1) ZA834110B (de)

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GB8332435D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
GB8601959D0 (en) * 1986-01-28 1986-03-05 Glaxo Group Ltd Indole derivatives
US5270333A (en) * 1986-01-28 1993-12-14 Glaxo Group Limited Indole derivatives
GB8615599D0 (en) * 1986-06-26 1986-07-30 Glaxo Group Ltd Chemical compounds
DK172696B1 (da) * 1987-08-13 1999-05-31 Glaxo Group Ltd Indolderivater, fremgangsmåde til fremstilling deraf og farmaceutiske præparater indeholdende forbindelserne
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8903036D0 (en) * 1989-02-10 1989-03-30 Glaxo Group Ltd Chemical compounds
HUT57185A (en) * 1990-03-21 1991-11-28 Merrell Dow Pharma Process for producing 8-sulfamil-methylen-2-amino-tetraline derivatives and pharmaceutical compositions containing them
US5155218A (en) 1990-05-08 1992-10-13 Neurogenetic Corporation Dna encoding human 5-ht1d receptors
US5935925A (en) * 1990-05-08 1999-08-10 Synaptic Pharmaceutical Corporation Methods of treating migraine and compounds useful for such methods
MC2210A1 (fr) * 1990-06-07 1992-11-26 Wellcome Found Composes heterocycliques therapeutiques,leur utilisation et procede pour les preparer
GB9013845D0 (en) * 1990-06-21 1990-08-15 Glaxo Group Ltd Process
US5077293A (en) * 1990-06-29 1991-12-31 Bristol-Myers Squibb Co. 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines
CA2043709C (en) * 1990-06-29 2002-01-22 David W. Smith Antimigraine alkoxypyrimidine derivatives
GB9022250D0 (en) * 1990-10-12 1990-11-28 Glaxo Group Ltd Medicaments
GB9103770D0 (en) * 1991-02-22 1991-04-10 Glaxo Group Ltd Chemical compounds
GB9104890D0 (en) * 1991-03-08 1991-04-24 Glaxo Group Ltd Compositions
CA2084531A1 (en) * 1991-12-19 1993-06-20 David W. Smith Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
GB9211276D0 (en) * 1992-05-28 1992-07-15 Glaxo Lab Sa Pharmaceutical compositions
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
ES2055651B1 (es) * 1992-07-20 1995-03-01 Vita Invest Sa Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles.
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US5382592A (en) * 1993-09-16 1995-01-17 Bristol-Myers Squibb Company Antimigraine cyclobutenedione derivatives of tryptamines
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
ES2079323B1 (es) * 1994-06-21 1996-10-16 Vita Invest Sa Derivados de indol utiles para el tratamiento de la migraña, composicion y uso correspondientes.
US5618816A (en) * 1995-03-02 1997-04-08 Bristol-Myers Squibb Company Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridnyl and pyrimidinylpiperazines
FR2731224B1 (fr) * 1995-03-02 1997-05-30 Pf Medicament Nouveaux derives bi-tryptaminiques sulfonamides, leur procede de preparation et leur utilisation a titre de medicaments
US6586458B1 (en) 1996-08-16 2003-07-01 Pozen Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US8022095B2 (en) 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US5872145A (en) * 1996-08-16 1999-02-16 Pozen, Inc. Formulation of 5-HT agonist and NSAID for treatment of migraine
US6416472B1 (en) 1997-11-06 2002-07-09 Edus Inc. Method and device for measuring cognitive efficiency
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ATE546134T1 (de) 2002-12-26 2012-03-15 Pozen Inc Mehrschichtige dosierformen enthaltend naproxen und triptane
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CN102046621B (zh) 2008-05-27 2014-11-12 生物区科学管理控股有限公司 抗病毒盐
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US10537554B2 (en) * 2015-08-05 2020-01-21 Upsher-Smith Laboratories, Llc Pharmaceutical composition for treating migraine
CN108697637A (zh) 2016-01-27 2018-10-23 因斯塔尔科技股份公司 用于治疗性处理的口腔粘膜纳米纤维载体
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2940687A1 (de) * 1978-10-12 1980-04-30 Glaxo Group Ltd Indolverbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3131728A1 (de) * 1980-08-12 1982-03-11 Glaxo Group Ltd., London Indolverbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Family Cites Families (3)

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Publication number Priority date Publication date Assignee Title
GB2082175B (en) * 1980-08-12 1984-05-02 Glaxo Group Ltd Heterocyclic compounds
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
ES504694A0 (es) * 1980-08-12 1982-11-01 Glaxo Group Ltd Procedimiento para la preparacion de derivados del indol.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2940687A1 (de) * 1978-10-12 1980-04-30 Glaxo Group Ltd Indolverbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3131728A1 (de) * 1980-08-12 1982-03-11 Glaxo Group Ltd., London Indolverbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
ZA834110B (en) 1985-01-30
IE831335L (en) 1983-12-07
PT76830A (en) 1983-07-01
IL68913A0 (en) 1983-10-31
AU566149B2 (en) 1987-10-08
ES544281A0 (es) 1986-07-16
NL193694B (nl) 2000-03-01
DE19375045I2 (de) 2002-09-05
ES523039A0 (es) 1984-10-01
PT76830B (en) 1986-04-21
FI79530B (fi) 1989-09-29
GB2124210B (en) 1985-11-13
FI79530C (fi) 1990-01-10
GB2124210A (en) 1984-02-15
CZ404091A3 (en) 1993-04-14
ES529802A0 (es) 1985-11-16
GR79215B (de) 1984-10-22
FI832035L (fi) 1983-12-08
KR840005095A (ko) 1984-11-03
JPS5942366A (ja) 1984-03-08
DE3320521C2 (de) 1992-06-25
FR2530625A1 (fr) 1984-01-27
DK260183D0 (da) 1983-06-06
BE896986A (fr) 1983-12-07
AU1544183A (en) 1983-12-15
IT8348422A0 (it) 1983-06-03
CY1458A (en) 1989-07-21
IE55358B1 (en) 1990-08-29
LU84852A1 (fr) 1985-03-29
DOP1989476000A (es) 1996-02-03
ATA208483A (de) 1986-05-15
IL68913A (en) 1987-08-31
SK404091A3 (en) 1995-06-07
JPH0329069B2 (de) 1991-04-23
DE3320521A1 (de) 1983-12-08
FR2530625B1 (fr) 1986-04-18
US4816470A (en) 1989-03-28
NL193694C (nl) 2000-07-04
SK277877B6 (en) 1995-06-07
ES8601880A1 (es) 1985-11-16
PH19908A (en) 1986-08-13
SE8303208D0 (sv) 1983-06-07
CZ280529B6 (cs) 1996-02-14
KR900006681B1 (ko) 1990-09-17
MX9202623A (es) 1992-06-30
ES8609247A1 (es) 1986-07-16
HK14789A (en) 1989-02-24
GB8315564D0 (en) 1983-07-13
MY8700179A (en) 1987-12-31
NL8302031A (nl) 1984-01-02
CH657359A5 (fr) 1986-08-29
IT1170387B (it) 1987-06-03
ES8407473A1 (es) 1984-10-01
SE452459B (sv) 1987-11-30
FI832035A0 (fi) 1983-06-07
NZ204482A (en) 1986-09-10
SE8303208L (sv) 1983-12-08
CA1199643A (en) 1986-01-21
KE3833A (en) 1988-11-18

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