ZA201101549B - Antisense oligonucleotides directed against connective tissue growth factor and uses thereof - Google Patents

Antisense oligonucleotides directed against connective tissue growth factor and uses thereof

Info

Publication number
ZA201101549B
ZA201101549B ZA2011/01549A ZA201101549A ZA201101549B ZA 201101549 B ZA201101549 B ZA 201101549B ZA 2011/01549 A ZA2011/01549 A ZA 2011/01549A ZA 201101549 A ZA201101549 A ZA 201101549A ZA 201101549 B ZA201101549 B ZA 201101549B
Authority
ZA
South Africa
Prior art keywords
growth factor
directed against
connective tissue
antisense oligonucleotides
tissue growth
Prior art date
Application number
ZA2011/01549A
Other languages
English (en)
Inventor
Nicholas Mark Dean
J Gordon Foulkes
Niall O'donnell
C Frank Bennett
Susan M Freier
Original Assignee
Excaliard Pharmaceuticals Inc
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Excaliard Pharmaceuticals Inc, Isis Pharmaceuticals Inc filed Critical Excaliard Pharmaceuticals Inc
Publication of ZA201101549B publication Critical patent/ZA201101549B/en

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
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ZA2011/01549A 2008-08-25 2011-02-28 Antisense oligonucleotides directed against connective tissue growth factor and uses thereof ZA201101549B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19012108P 2008-08-25 2008-08-25
PCT/US2009/054973 WO2010042281A2 (en) 2008-08-25 2009-08-25 Antisense oligonucleotides directed against connective tissue growth factor and uses thereof

Publications (1)

Publication Number Publication Date
ZA201101549B true ZA201101549B (en) 2012-06-27

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ZA2011/01549A ZA201101549B (en) 2008-08-25 2011-02-28 Antisense oligonucleotides directed against connective tissue growth factor and uses thereof

Country Status (19)

Country Link
US (6) US8252762B2 (cg-RX-API-DMAC7.html)
EP (2) EP3081648A1 (cg-RX-API-DMAC7.html)
JP (5) JP5420668B2 (cg-RX-API-DMAC7.html)
KR (2) KR101877698B1 (cg-RX-API-DMAC7.html)
CN (2) CN103429270B (cg-RX-API-DMAC7.html)
AU (2) AU2009275387B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0912923A8 (cg-RX-API-DMAC7.html)
CA (1) CA2733262C (cg-RX-API-DMAC7.html)
CO (1) CO6341577A2 (cg-RX-API-DMAC7.html)
DK (1) DK2331141T3 (cg-RX-API-DMAC7.html)
EA (1) EA022207B1 (cg-RX-API-DMAC7.html)
ES (1) ES2566508T3 (cg-RX-API-DMAC7.html)
GB (1) GB2465902B (cg-RX-API-DMAC7.html)
IL (3) IL211230A (cg-RX-API-DMAC7.html)
MX (2) MX2011002143A (cg-RX-API-DMAC7.html)
NZ (2) NZ601660A (cg-RX-API-DMAC7.html)
SG (1) SG196769A1 (cg-RX-API-DMAC7.html)
WO (1) WO2010042281A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA201101549B (cg-RX-API-DMAC7.html)

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