ZA200906811B - Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes - Google Patents
Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymesInfo
- Publication number
- ZA200906811B ZA200906811B ZA2009/06811A ZA200906811A ZA200906811B ZA 200906811 B ZA200906811 B ZA 200906811B ZA 2009/06811 A ZA2009/06811 A ZA 2009/06811A ZA 200906811 A ZA200906811 A ZA 200906811A ZA 200906811 B ZA200906811 B ZA 200906811B
- Authority
- ZA
- South Africa
- Prior art keywords
- isobutanol
- highly active
- acid reductoisomerase
- ketol
- fermentive production
- Prior art date
Links
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 title 2
- 108010000200 Ketol-acid reductoisomerase Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/16—Butanols
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91249107P | 2007-04-18 | 2007-04-18 | |
| PCT/US2008/060466 WO2008130995A2 (en) | 2007-04-18 | 2008-04-16 | Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200906811B true ZA200906811B (en) | 2010-12-29 |
Family
ID=39872591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2009/06811A ZA200906811B (en) | 2007-04-18 | 2009-09-30 | Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7910342B2 (enExample) |
| EP (2) | EP2134849B1 (enExample) |
| JP (2) | JP5582576B2 (enExample) |
| KR (1) | KR101573775B1 (enExample) |
| CN (1) | CN101680007A (enExample) |
| AU (1) | AU2008242978B2 (enExample) |
| BR (1) | BRPI0808600A2 (enExample) |
| CA (1) | CA2683898C (enExample) |
| ES (1) | ES2426070T3 (enExample) |
| MX (1) | MX2009011192A (enExample) |
| NZ (1) | NZ579780A (enExample) |
| WO (1) | WO2008130995A2 (enExample) |
| ZA (1) | ZA200906811B (enExample) |
Families Citing this family (127)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8945899B2 (en) | 2007-12-20 | 2015-02-03 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase using NADH |
| US8273558B2 (en) | 2005-10-26 | 2012-09-25 | Butamax(Tm) Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| US9303225B2 (en) | 2005-10-26 | 2016-04-05 | Butamax Advanced Biofuels Llc | Method for the production of isobutanol by recombinant yeast |
| US8956850B2 (en) * | 2008-06-05 | 2015-02-17 | Butamax Advanced Biofuels Llc | Enhanced pyruvate to acetolactate conversion in yeast |
| PL389665A1 (pl) | 2007-02-09 | 2010-07-05 | The Regents of the University of CaliforniaThe Regents of the University of California | Wytwarzanie biopaliwa przez rekombinowane mikroorganizmy |
| TWI568847B (zh) | 2007-03-16 | 2017-02-01 | 奇諾麥提卡公司 | 用於１，４-丁二醇及其前驅物之生物合成的組合物及方法 |
| US20090111154A1 (en) * | 2007-04-04 | 2009-04-30 | The Regents Of The University Of California | Butanol production by recombinant microorganisms |
| WO2008130995A2 (en) | 2007-04-18 | 2008-10-30 | E. I. Du Pont De Nemours And Company | Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes |
| US7947483B2 (en) | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
| CN101903530A (zh) * | 2007-10-12 | 2010-12-01 | 加利福尼亚大学董事会 | 被改造以产生异丙醇的微生物 |
| US8193402B2 (en) | 2007-12-03 | 2012-06-05 | Gevo, Inc. | Renewable compositions |
| EP2225351A4 (en) | 2007-12-03 | 2016-11-09 | Gevo Inc | RENEWABLE COMPOSITIONS |
| US8114641B2 (en) * | 2007-12-10 | 2012-02-14 | Synthetic Genomics, Inc. | Methylbutanol as an advanced biofuel |
| CA3081506A1 (en) | 2008-03-05 | 2009-09-11 | Genomatica, Inc. | Long chain alcohol-producing organisms |
| US7799545B2 (en) | 2008-03-27 | 2010-09-21 | Genomatica, Inc. | Microorganisms for the production of adipic acid and other compounds |
| US8188250B2 (en) | 2008-04-28 | 2012-05-29 | Butamax(Tm) Advanced Biofuels Llc | Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans |
| CA2722680A1 (en) * | 2008-05-01 | 2009-11-05 | Genomatica, Inc. | Microorganisms for the production of methacrylic acid |
| EP3514242A3 (en) | 2008-09-10 | 2019-08-28 | Genomatica, Inc. | Microrganisms for the production of 1,4-butanediol |
| MX2011003313A (es) * | 2008-09-29 | 2011-06-16 | Butamax Tm Advanced Biofuels | Actividad enzimatica de fe-s heterologa aumentada en levadura. |
| EP2821484B1 (en) * | 2008-09-29 | 2016-06-29 | Butamax Advanced Biofuels LLC | Identification and use of Bacterial [2Fe-2S] dihydroxy-acid dehydratases |
| US8637281B2 (en) * | 2008-09-29 | 2014-01-28 | Butamax(Tm) Advanced Biofuels Llc | Enhanced dihydroxy-acid dehydratase activity in lactic acid bacteria |
| BRPI0921734A2 (pt) | 2008-10-31 | 2019-01-08 | California Inst Of Techn | micro-organismos criados geneticamente capazes de produzir compostos-alvo sob condições anaeróbicas |
| US8828694B2 (en) * | 2008-11-13 | 2014-09-09 | Butamax Advanced Biofuels Llc | Production of isobutanol in yeast mitochondria |
| US8465964B2 (en) * | 2008-11-13 | 2013-06-18 | Butamax (TM) Advanced Biofules LLC | Increased production of isobutanol in yeast with reduced mitochondrial amino acid biosynthesis |
| AU2009324539B2 (en) * | 2008-12-10 | 2015-10-01 | Synthetic Genomics, Inc. | Production of branched-chain alcohols by photosynthetic microorganisms |
| WO2010071697A1 (en) | 2008-12-16 | 2010-06-24 | Genomatica, Inc. | Microorganisms and methods for conversion of syngas and other carbon sources to useful products |
| WO2010075504A2 (en) * | 2008-12-23 | 2010-07-01 | Gevo, Inc. | Engineered microorganisms for the production of one or more target compounds |
| US8557562B2 (en) * | 2008-12-29 | 2013-10-15 | Butamax(Tm) Advanced Biofuels Llc | Yeast with increased butanol tolerance involving filamentous growth response |
| US8795992B2 (en) * | 2008-12-29 | 2014-08-05 | Butamax Advanced Biofuels Llc | Yeast with increased butanol tolerance involving cell wall integrity pathway |
| US8455225B2 (en) * | 2008-12-29 | 2013-06-04 | Butamax Advanced Biofuels Llc | Yeast with increased butanol tolerance involving high osmolarity/glycerol response pathway |
| US8614085B2 (en) * | 2009-02-27 | 2013-12-24 | Butamax(Tm) Advanced Biofuels Llc | Yeast with increased butanol tolerance involving a multidrug efflux pump gene |
| EP2419517A2 (en) * | 2009-04-13 | 2012-02-22 | Butamax(TM) Advanced Biofuels LLC | Method for producing butanol using extractive fermentation |
| EP4273255A3 (en) | 2009-05-07 | 2024-01-03 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of hexamethylenediamine |
| EP3696158A1 (en) | 2009-06-04 | 2020-08-19 | Genomatica, Inc. | Process of separating components of a fermentation broth |
| CN107384846B (zh) | 2009-06-04 | 2021-08-10 | 基因组股份公司 | 生产1,4-丁二醇的微生物和相关方法 |
| EP2464736A4 (en) * | 2009-08-12 | 2013-07-31 | Gevo Inc | PATIENT LOCALIZATION OF CYTOSOLIC ISOBUTANOL FOR THE MANUFACTURE OF ISOBUTANOL |
| US9260708B2 (en) * | 2009-09-29 | 2016-02-16 | Butamax Advanced Biofuels Llc | Yeast production host cells |
| JP2013505739A (ja) * | 2009-09-29 | 2013-02-21 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | 乳酸菌におけるアセト乳酸誘導生成物への改善されたフラックス |
| JP5805094B2 (ja) * | 2009-09-29 | 2015-11-04 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | 高有効性のケトール酸レダクトイソメラーゼ酵素を用いたイソブタノールの発酵生産 |
| US20110195505A1 (en) * | 2009-10-08 | 2011-08-11 | Butamax(Tm) Advanced Biofuels Llc | Bacterial strains for butanol production |
| PH12012500729A1 (en) | 2009-10-13 | 2012-10-29 | Genomatica Inc | Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-coa, putrescine and related compounds and methods related thereto |
| JP2013511284A (ja) | 2009-11-23 | 2013-04-04 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | オスモライトの添加を伴う抽出発酵を用いたブタノールの生成方法 |
| CN102656272A (zh) | 2009-11-23 | 2012-09-05 | 布特马斯先进生物燃料有限责任公司 | 使用添加电解质的萃取发酵来生产丁醇的方法 |
| WO2011066076A1 (en) | 2009-11-25 | 2011-06-03 | Genomatica, Inc. | Microorganisms and methods for the coproduction of 1,4-butanediol and gamma-butyrolactone |
| US20110137088A1 (en) * | 2009-12-03 | 2011-06-09 | Bp Corporation North America Inc. | Methods and Apparatuses for Producing Renewable Materials From Inhibiting Compounds |
| KR20120099509A (ko) | 2009-12-29 | 2012-09-10 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 재조합 숙주 세포에서 육탄당 키나아제의 발현 |
| CN102762722B (zh) | 2009-12-29 | 2015-05-20 | 布特马斯先进生物燃料有限责任公司 | 用于发酵生产低级烷基醇的醇脱氢酶(adh) |
| BR112012016883A2 (pt) | 2010-01-08 | 2018-06-05 | Gevo Inc | metodos integrados de preparar produsot quimicos renovaveis |
| US8530221B2 (en) | 2010-01-14 | 2013-09-10 | Ls9, Inc. | Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells |
| US8574406B2 (en) * | 2010-02-09 | 2013-11-05 | Butamax Advanced Biofuels Llc | Process to remove product alcohol from a fermentation by vaporization under vacuum |
| WO2011103300A2 (en) | 2010-02-17 | 2011-08-25 | Butamax(Tm) Advanced Biofuels Llc | Improving activity of fe-s cluster requiring proteins |
| US8048661B2 (en) | 2010-02-23 | 2011-11-01 | Genomatica, Inc. | Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes |
| US8637286B2 (en) | 2010-02-23 | 2014-01-28 | Genomatica, Inc. | Methods for increasing product yields |
| CA2791219C (en) | 2010-03-15 | 2015-11-24 | Total Research & Technology Feluy | Production of propylene via simultaneous dehydration and skeletal isomerisation of isobutanol on acid catalysts followed by metathesis |
| WO2011113834A1 (en) | 2010-03-15 | 2011-09-22 | Total Petrochemicals Research Feluy | Simultaneous dehydration and skeletal isomerisation of isobutanol on acid catalysts |
| EP2374780A1 (en) | 2010-04-09 | 2011-10-12 | Total Petrochemicals Research Feluy | Production of propylene via simultaneous dehydration and skeletal isomerisation of isobutanol on acid catalysts followed by metathesis |
| EP2374781A1 (en) | 2010-04-09 | 2011-10-12 | Total Petrochemicals Research Feluy | Simultaneous dehydration and skeletal isomerisation of isobutanol on acid catalysts |
| US8373012B2 (en) | 2010-05-07 | 2013-02-12 | Gevo, Inc. | Renewable jet fuel blendstock from isobutanol |
| AU2011268247B2 (en) | 2010-06-16 | 2017-05-11 | Butamax(Tm) Advanced Biofuels Llc | Oxygenated butanol gasoline composition having good driveability performance |
| NZ603487A (en) * | 2010-06-16 | 2015-03-27 | Butamax Tm Advanced Biofuels | Oxygenated butanol gasoline composition having good driveability performance |
| AU2011268326B2 (en) | 2010-06-17 | 2015-02-05 | Butamax(Tm) Advanced Biofuels Llc | Yeast production culture for the production of butanol |
| US8871488B2 (en) | 2010-06-18 | 2014-10-28 | Butamax Advanced Biofuels Llc | Recombinant host cells comprising phosphoketolases |
| EP2582823A1 (en) | 2010-06-18 | 2013-04-24 | Butamax(tm) Advanced Biofuels LLC | Supplementation of fatty acids for improving alcohol productivity |
| US9040263B2 (en) | 2010-07-28 | 2015-05-26 | Butamax Advanced Biofuels Llc | Production of alcohol esters and in situ product removal during alcohol fermentation |
| US9012190B2 (en) | 2011-06-15 | 2015-04-21 | Butamax Advanced Biofuels Llc | Use of thiamine and nicotine adenine dinucleotide for butanol production |
| HUE044304T2 (hu) | 2010-06-18 | 2019-10-28 | Butamax Tm Advanced Biofuels | Olajból nyert oldószerek kivonása alkoholeltávolításra extraháló fermentációban |
| BR112013002357A2 (pt) | 2010-08-03 | 2016-05-24 | Total Res & Technology Feluy | processo para fazer olefinas a partir de metanol e isobutanol |
| WO2012016786A1 (en) | 2010-08-03 | 2012-02-09 | Total Petrochemicals Research Feluy | Process to make olefins from isobutanol |
| US9079813B2 (en) | 2010-08-03 | 2015-07-14 | Total Research & Technology Feluy | Process to make propylene from isobutanol by dehydration and subsequent cracking |
| CN103153920B (zh) | 2010-08-03 | 2015-04-15 | 道达尔研究技术弗吕公司 | 由异丁醇制造烯烃的方法 |
| WO2012027642A1 (en) * | 2010-08-27 | 2012-03-01 | Gevo, Inc. | Balanced four-step pathways to renewable butanols |
| EP2614138B1 (en) | 2010-09-07 | 2017-08-30 | Butamax (TM) Advanced Biofuels LLC | Integration of a polynucleotide encoding a polypeptide that catalyzes pyruvate to acetolactate conversion |
| WO2012038247A1 (en) | 2010-09-24 | 2012-03-29 | Total Petrochemicals Research Feluy | Production of isoprene from iso-butanol |
| WO2012071121A1 (en) * | 2010-11-24 | 2012-05-31 | Gevo, Inc. | Methods of increasing dihydroxy acid dehydratase activity to improve production of fuels, chemicals, and amino acids |
| FR2969147B1 (fr) | 2010-12-21 | 2013-01-04 | Total Raffinage Marketing | Production d'additifs pour carburant par deshydratation et isomerisation squelettique simultanee d'isobutanol sur des catalyseurs acides suivies par une etherification |
| US20130040340A1 (en) | 2011-02-07 | 2013-02-14 | E. I. Du Pont De Nemours And Company | Production of alcohol esters in situ using alcohols and fatty acids produced by microorganisms |
| US8759044B2 (en) | 2011-03-23 | 2014-06-24 | Butamax Advanced Biofuels Llc | In situ expression of lipase for enzymatic production of alcohol esters during fermentation |
| US8765425B2 (en) | 2011-03-23 | 2014-07-01 | Butamax Advanced Biofuels Llc | In situ expression of lipase for enzymatic production of alcohol esters during fermentation |
| EP2689014B1 (en) * | 2011-03-24 | 2019-04-24 | Butamax (TM) Advanced Biofuels LLC | Host cells and methods for production of isobutanol |
| EP2699618A4 (en) | 2011-04-19 | 2014-12-17 | Gevo Inc | VARIATIONS OF A PRINS REACTION FOR THE PREPARATION OF 2,5-DIMETHYLHEXADIENE FROM ISOBUTANOL |
| US20140295512A1 (en) * | 2011-06-16 | 2014-10-02 | California Institute Of Technology | Ketol-Acid Reductoisomerases With Improved Performance Properties |
| US20130164795A1 (en) | 2011-06-17 | 2013-06-27 | Butamax(Tm) Advanced Biofuels Llc | Co-products from biofuel production processes and methods of making |
| US9238828B2 (en) | 2011-07-28 | 2016-01-19 | Butamax Advanced Biofuels Llc | Keto-isovalerate decarboxylase enzymes and methods of use thereof |
| AU2012347687A1 (en) | 2011-12-09 | 2014-05-29 | Butamax Advanced Biofuels Llc | Process to remove product alcohols from fermentation broth by multistep flash evaporation |
| EP2798072A2 (en) | 2011-12-30 | 2014-11-05 | Butamax Advanced Biofuels LLC | Fermentative production of alcohols |
| AU2012362144A1 (en) | 2011-12-30 | 2014-07-03 | Butamax (Tm) Advanced Biofuels Llc | Genetic switches for butanol production |
| JP2015510774A (ja) | 2012-03-23 | 2015-04-13 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | ブタノール産生菌用培地の酢酸補給 |
| AU2013266727A1 (en) | 2012-05-11 | 2014-11-06 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase enzymes and methods of use |
| US9677045B2 (en) | 2012-06-04 | 2017-06-13 | Genomatica, Inc. | Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds |
| US20140024064A1 (en) | 2012-07-23 | 2014-01-23 | Butamax(Tm) Advanced Biofuels Llc | Processes and systems for the production of fermentative alcohols |
| AU2013295626B2 (en) | 2012-07-26 | 2018-02-01 | Butamax Advanced Biofuels Llc | Butanol purification |
| WO2014028642A1 (en) | 2012-08-17 | 2014-02-20 | Easel Biotechnologies, Llc | Two stage production of higher alcohols |
| AU2013305714A1 (en) | 2012-08-22 | 2015-02-05 | Butamax Advanced Biofuels Llc | Production of fermentation products |
| WO2014043288A1 (en) | 2012-09-12 | 2014-03-20 | Butamax Advanced Biofuels Llc | Processes and systems for the production of fermentation products |
| CN104981544B (zh) | 2012-09-21 | 2018-05-15 | 布特马斯先进生物燃料有限责任公司 | 用于使用两相萃取发酵和可循环利用的提取剂组合物制备丁醇的方法 |
| WO2014047421A1 (en) | 2012-09-21 | 2014-03-27 | Butamax(Tm) Advanced Biofuels Llc | Production of renewable hydrocarbon compositions |
| JP6407869B2 (ja) | 2012-09-26 | 2018-10-17 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | ケトール酸レダクトイソメラーゼ活性を有するポリペプチド |
| WO2014052735A1 (en) | 2012-09-28 | 2014-04-03 | Butamax Advanced Biofuels Llc | Production of fermentation products |
| US9273330B2 (en) | 2012-10-03 | 2016-03-01 | Butamax Advanced Biofuels Llc | Butanol tolerance in microorganisms |
| CA2887574A1 (en) | 2012-10-11 | 2014-04-17 | Butamax Advanced Biofuels Llc | Processes and systems for the production of fermentation products |
| WO2014081848A1 (en) | 2012-11-20 | 2014-05-30 | Butamax Advanced Biofuels Llc | Butanol purification |
| CN104837799B (zh) | 2012-12-07 | 2020-07-31 | 艾菲纽技术公司 | 将可自生物质衍生得的脂肪醇催化转化制得有价值的烯烃或含氧化合物 |
| WO2014106107A2 (en) | 2012-12-28 | 2014-07-03 | Butamax (Tm) Advanced Biofuels Llc | Dhad variants for butanol production |
| WO2014105840A1 (en) | 2012-12-31 | 2014-07-03 | Butamax Advanced Biofuels Llc | Fermentative production of alcohols |
| US20160002131A1 (en) | 2013-02-21 | 2016-01-07 | Butamax Advanced Biofuels Llc | Vapor recompression |
| WO2014159309A1 (en) | 2013-03-12 | 2014-10-02 | Butamax Advanced Biofuels Llc | Processes and systems for the production of alcohols |
| US9267158B2 (en) | 2013-03-14 | 2016-02-23 | Intrexon Corporation | Biological production of multi-carbon compounds from methane |
| AU2014244216A1 (en) | 2013-03-14 | 2015-09-24 | E.I. Du Pont De Nemours And Company | Glycerol 3- phosphate dehydrogenase for butanol production |
| WO2014144210A2 (en) | 2013-03-15 | 2014-09-18 | Butamax Advanced Biofuels Llc | Competitive growth and/or production advantage for butanologen microorganism |
| WO2014144643A1 (en) | 2013-03-15 | 2014-09-18 | Butamax Advanced Biofuels Llc | Method for producing butanol using extractive fermentation |
| US9580705B2 (en) | 2013-03-15 | 2017-02-28 | Butamax Advanced Biofuels Llc | DHAD variants and methods of screening |
| WO2014151645A1 (en) | 2013-03-15 | 2014-09-25 | Butamax Advanced Biofuels Llc | Process for maximizing biomass growth and butanol yield by feedback control |
| BR112015020685A2 (pt) | 2013-03-15 | 2017-07-18 | Butamax Advanced Biofuels Llc | método para a recuperação do butanol, composição, métodos para a extração de álcool e de secagem |
| WO2015002913A1 (en) | 2013-07-03 | 2015-01-08 | Butamax Advanced Biofuels Llc | Partial adaptation for butanol production |
| EA033071B1 (ru) * | 2013-09-22 | 2019-08-30 | Ланцатек Нью Зилэнд Лимитед | Способ увеличения выхода продуктов из ацетолактата |
| WO2015065871A1 (en) | 2013-10-28 | 2015-05-07 | Danisco Us Inc. | Large scale genetically engineered active dry yeast |
| CN104195125B (zh) * | 2014-07-01 | 2017-01-11 | 中国科学院广州能源研究所 | 一种α-酮酸脱羧酶KIVD-LL及其编码基因和应用 |
| CA2957920A1 (en) | 2014-08-11 | 2016-02-18 | Butamax Advanced Biofuels Llc | Yeast preparations and methods of making the same |
| BR112017014234A2 (pt) | 2014-12-31 | 2018-03-06 | Ifp Energies Now | processo para a preparação olefinas pela desidratação de álcoois com menores efeitos colaterais compreendendo a adição de compostos contendo enxofre |
| WO2016107758A1 (en) | 2014-12-31 | 2016-07-07 | Total Research & Technology Feluy | Process for preparing olefins by dehydrating alcohols with less side effects comprising addition of organic acids |
| EP3162763A1 (en) | 2015-10-30 | 2017-05-03 | Total Research & Technology Feluy SA | Simultaneous dehydration and skeletal isomerisation of isobutanol on ti-containing zeolite catalysts |
| US11326193B1 (en) * | 2016-03-03 | 2022-05-10 | National Technology & Engineering Solutions Of Sandia, Llc | Enrichment of amino acids from biomass residuum |
| KR101960501B1 (ko) | 2017-09-15 | 2019-03-21 | 고려대학교 산학협력단 | Ｎａｄｈ 친화적인 신규 케톨산 리덕토아이소머라제 |
| CN111394325A (zh) * | 2019-07-05 | 2020-07-10 | 成都高界科技有限公司 | 一种耐热乙酰乳酸异构还原酶 |
| FR3115988A1 (fr) | 2020-11-06 | 2022-05-13 | Global Bioenergies | Composition de maquillage à base d’isododécane biosourcé et son procédé de préparation |
| FR3157389A1 (fr) | 2023-12-22 | 2025-06-27 | Axens | Procédé de production de bioalkylat ou d’essence biosourcée |
| WO2025226576A1 (en) | 2024-04-25 | 2025-10-30 | ExxonMobil Technology and Engineering Company | Processes for producing isobutylene and isobutylene-based polymers |
Family Cites Families (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4865973A (en) | 1985-09-13 | 1989-09-12 | Queen's University At Kingston | Process for extractive fermentation |
| FR2696190B1 (fr) | 1992-09-25 | 1994-12-09 | Agronomique Inst Nat Rech | Acide nucléique codant pour une alpha-acétolactate synthase et ses applications. |
| US6514733B1 (en) * | 1999-08-18 | 2003-02-04 | E. I. Du Pont De Nemours And Company | Process for the biological production of 1,3-propanediol with high titer |
| US20020061569A1 (en) | 2000-03-21 | 2002-05-23 | Robert Haselbeck | Identification of essential genes in prokaryotes |
| US6586229B1 (en) | 2000-06-01 | 2003-07-01 | North Carolina State University | Method for the production of ρ-Hydroxybenzoate in species of pseudomonas and agrobacterium |
| US20040248250A1 (en) | 2001-07-02 | 2004-12-09 | Takahisa Nakai | Method for modifying enzyme and oxidoreductive variant |
| MXPA05009553A (es) | 2003-03-10 | 2006-03-17 | Broin And Associates Inc | Metodo para producir etanol utilizando almidon como materia prima. |
| SE526429C2 (sv) | 2003-10-24 | 2005-09-13 | Swedish Biofuels Ab | Metod för att framställa syreinnehållande föreningar utgående från biomassa |
| WO2006110900A2 (en) | 2005-04-12 | 2006-10-19 | E. I. Du Pont De Nemours And Company | Treatment of biomass to obtain ethanol |
| US9297028B2 (en) | 2005-09-29 | 2016-03-29 | Butamax Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| US8956850B2 (en) | 2008-06-05 | 2015-02-17 | Butamax Advanced Biofuels Llc | Enhanced pyruvate to acetolactate conversion in yeast |
| NZ566406A (en) | 2005-10-26 | 2012-04-27 | Butamax Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| US8945899B2 (en) | 2007-12-20 | 2015-02-03 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase using NADH |
| US9303225B2 (en) | 2005-10-26 | 2016-04-05 | Butamax Advanced Biofuels Llc | Method for the production of isobutanol by recombinant yeast |
| US8273558B2 (en) | 2005-10-26 | 2012-09-25 | Butamax(Tm) Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| US8828704B2 (en) | 2006-05-02 | 2014-09-09 | Butamax Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| US8206970B2 (en) | 2006-05-02 | 2012-06-26 | Butamax(Tm) Advanced Biofuels Llc | Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase |
| US7659104B2 (en) | 2006-05-05 | 2010-02-09 | E.I. Du Pont De Nemours And Company | Solvent tolerant microorganisms and methods of isolation |
| US7541173B2 (en) | 2006-06-15 | 2009-06-02 | E.I. Du Pont De Nemours And Company | Solvent tolerant microorganisms and methods of isolation |
| US8017364B2 (en) | 2006-12-12 | 2011-09-13 | Butamax(Tm) Advanced Biofuels Llc | Solvent tolerant microorganisms |
| PL389665A1 (pl) * | 2007-02-09 | 2010-07-05 | The Regents of the University of CaliforniaThe Regents of the University of California | Wytwarzanie biopaliwa przez rekombinowane mikroorganizmy |
| WO2008130995A2 (en) | 2007-04-18 | 2008-10-30 | E. I. Du Pont De Nemours And Company | Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes |
| EP2060632A1 (en) | 2007-10-29 | 2009-05-20 | Technische Universität Berlin | Method of modifying a yeast cell for the production of ethanol |
| WO2009059254A2 (en) | 2007-10-31 | 2009-05-07 | Gevo, Inc | Methods for the economical production of biofuel precursor that is also a biofuel from biomass |
| DE602007011966D1 (de) | 2007-12-17 | 2011-02-24 | Suntory Holdings Ltd | Mutantes ilv5-gen und verwendung davon |
| EP2677028B1 (en) | 2007-12-20 | 2016-03-09 | Butamax (TM) Advanced Biofuels LLC | Ketol-acid reductoisomerase using NADH |
| US8518678B2 (en) | 2007-12-21 | 2013-08-27 | Butamax(Tm) Advanced Biofuels Llc | Strain comprising increased expression of a CFA coding region for butanol production |
| US8372612B2 (en) | 2007-12-21 | 2013-02-12 | Butamax(Tm) Advanced Biofuels Llc | Production of four carbon alcohols using improved strain |
| CN101952448A (zh) | 2007-12-23 | 2011-01-19 | 格沃股份有限公司 | 高产率产生异丁醇的酵母生物 |
| US8188250B2 (en) | 2008-04-28 | 2012-05-29 | Butamax(Tm) Advanced Biofuels Llc | Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans |
| US8389252B2 (en) | 2008-05-12 | 2013-03-05 | Butamax(Tm) Advanced Biofuels Llc | Yeast strain for production of four carbon alcohols |
| WO2009143455A2 (en) | 2008-05-22 | 2009-11-26 | Microbia, Inc. | Engineering resistance to aliphatic alcohols |
| US8637281B2 (en) | 2008-09-29 | 2014-01-28 | Butamax(Tm) Advanced Biofuels Llc | Enhanced dihydroxy-acid dehydratase activity in lactic acid bacteria |
| EP2821484B1 (en) | 2008-09-29 | 2016-06-29 | Butamax Advanced Biofuels LLC | Identification and use of Bacterial [2Fe-2S] dihydroxy-acid dehydratases |
| CA2735948A1 (en) | 2008-09-29 | 2011-04-01 | Butamaxtm Advanced Biofuels Llc | Enhanced pyruvate to 2,3-butanediol conversion in lactic acid bacteria |
| EP2342330A1 (en) | 2008-09-29 | 2011-07-13 | Butamax Advanced Biofuels Llc | Enhanced iron-sulfur cluster formation for increased dihydroxy-acid dehydratase activity in lactic acid bacteria |
| MX2011003313A (es) | 2008-09-29 | 2011-06-16 | Butamax Tm Advanced Biofuels | Actividad enzimatica de fe-s heterologa aumentada en levadura. |
| AU2009320163B2 (en) | 2008-10-27 | 2014-10-02 | Butamax(Tm) Advanced Biofuels Llc | Carbon pathway optimized production hosts for the production of isobutanol |
| BRPI0921734A2 (pt) | 2008-10-31 | 2019-01-08 | California Inst Of Techn | micro-organismos criados geneticamente capazes de produzir compostos-alvo sob condições anaeróbicas |
| US8465964B2 (en) | 2008-11-13 | 2013-06-18 | Butamax (TM) Advanced Biofules LLC | Increased production of isobutanol in yeast with reduced mitochondrial amino acid biosynthesis |
| US8828694B2 (en) | 2008-11-13 | 2014-09-09 | Butamax Advanced Biofuels Llc | Production of isobutanol in yeast mitochondria |
| US8652823B2 (en) | 2008-12-03 | 2014-02-18 | Butamax(Tm) Advanced Biofuels Llc | Strain for butanol production with increased membrane unsaturated trans fatty acids |
| US8455225B2 (en) | 2008-12-29 | 2013-06-04 | Butamax Advanced Biofuels Llc | Yeast with increased butanol tolerance involving high osmolarity/glycerol response pathway |
| US8557562B2 (en) | 2008-12-29 | 2013-10-15 | Butamax(Tm) Advanced Biofuels Llc | Yeast with increased butanol tolerance involving filamentous growth response |
| US8795992B2 (en) | 2008-12-29 | 2014-08-05 | Butamax Advanced Biofuels Llc | Yeast with increased butanol tolerance involving cell wall integrity pathway |
| US8614085B2 (en) | 2009-02-27 | 2013-12-24 | Butamax(Tm) Advanced Biofuels Llc | Yeast with increased butanol tolerance involving a multidrug efflux pump gene |
| US20120058541A1 (en) | 2009-05-22 | 2012-03-08 | Butamax(Tm) Advanced Biofuels Llc | Engineering resistance to aliphatic alcohols |
| EP2464736A4 (en) | 2009-08-12 | 2013-07-31 | Gevo Inc | PATIENT LOCALIZATION OF CYTOSOLIC ISOBUTANOL FOR THE MANUFACTURE OF ISOBUTANOL |
| JP5805094B2 (ja) | 2009-09-29 | 2015-11-04 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | 高有効性のケトール酸レダクトイソメラーゼ酵素を用いたイソブタノールの発酵生産 |
| US9260708B2 (en) | 2009-09-29 | 2016-02-16 | Butamax Advanced Biofuels Llc | Yeast production host cells |
| JP2013505739A (ja) | 2009-09-29 | 2013-02-21 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | 乳酸菌におけるアセト乳酸誘導生成物への改善されたフラックス |
| US20110195505A1 (en) | 2009-10-08 | 2011-08-11 | Butamax(Tm) Advanced Biofuels Llc | Bacterial strains for butanol production |
| GB2487889B (en) | 2009-11-24 | 2012-12-19 | Gevo Inc | Methods of increasing dihydroxy acid dehydratase activity to improve production of fuels, chemicals, and amino acids |
| CN102762722B (zh) | 2009-12-29 | 2015-05-20 | 布特马斯先进生物燃料有限责任公司 | 用于发酵生产低级烷基醇的醇脱氢酶(adh) |
| KR20120099509A (ko) | 2009-12-29 | 2012-09-10 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 재조합 숙주 세포에서 육탄당 키나아제의 발현 |
| CN102869763A (zh) | 2010-02-12 | 2013-01-09 | 格沃股份有限公司 | 用于提高燃料、化学品和氨基酸产生的副产物蓄积减少的酵母微生物 |
| WO2011103300A2 (en) | 2010-02-17 | 2011-08-25 | Butamax(Tm) Advanced Biofuels Llc | Improving activity of fe-s cluster requiring proteins |
| AU2011268326B2 (en) | 2010-06-17 | 2015-02-05 | Butamax(Tm) Advanced Biofuels Llc | Yeast production culture for the production of butanol |
| US8871488B2 (en) | 2010-06-18 | 2014-10-28 | Butamax Advanced Biofuels Llc | Recombinant host cells comprising phosphoketolases |
| EP2614138B1 (en) | 2010-09-07 | 2017-08-30 | Butamax (TM) Advanced Biofuels LLC | Integration of a polynucleotide encoding a polypeptide that catalyzes pyruvate to acetolactate conversion |
| EP2689014B1 (en) | 2011-03-24 | 2019-04-24 | Butamax (TM) Advanced Biofuels LLC | Host cells and methods for production of isobutanol |
| US20120258873A1 (en) | 2011-04-06 | 2012-10-11 | Butamax(Tm) Advanced Biofuels Llc | Reduction of 2,3-dihydroxy-2-methyl butyrate (dhmb) in butanol production |
| BR112013032320A2 (pt) | 2011-06-17 | 2016-12-20 | Butamax Advanced Biofuels Llc | método e composição de produção de butanol, composição de butanol e isobutanol, método de cultivo de um micro-organismo produtor de butanol em material lignocelulósico e método para inibir o crescimento de micro-organismos que não produzem butanol em uma composição |
| US9238828B2 (en) | 2011-07-28 | 2016-01-19 | Butamax Advanced Biofuels Llc | Keto-isovalerate decarboxylase enzymes and methods of use thereof |
| EP2798072A2 (en) | 2011-12-30 | 2014-11-05 | Butamax Advanced Biofuels LLC | Fermentative production of alcohols |
| AU2012362144A1 (en) | 2011-12-30 | 2014-07-03 | Butamax (Tm) Advanced Biofuels Llc | Genetic switches for butanol production |
| JP2015510774A (ja) | 2012-03-23 | 2015-04-13 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | ブタノール産生菌用培地の酢酸補給 |
| AU2013266727A1 (en) | 2012-05-11 | 2014-11-06 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase enzymes and methods of use |
| JP6407869B2 (ja) | 2012-09-26 | 2018-10-17 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | ケトール酸レダクトイソメラーゼ活性を有するポリペプチド |
| US9273330B2 (en) | 2012-10-03 | 2016-03-01 | Butamax Advanced Biofuels Llc | Butanol tolerance in microorganisms |
| WO2014106107A2 (en) | 2012-12-28 | 2014-07-03 | Butamax (Tm) Advanced Biofuels Llc | Dhad variants for butanol production |
| US20140186911A1 (en) | 2012-12-28 | 2014-07-03 | Butamax Advanced Biofuels Llc | Recombinant host cells and methods for producing butanol |
| AU2014244216A1 (en) | 2013-03-14 | 2015-09-24 | E.I. Du Pont De Nemours And Company | Glycerol 3- phosphate dehydrogenase for butanol production |
| US9580705B2 (en) | 2013-03-15 | 2017-02-28 | Butamax Advanced Biofuels Llc | DHAD variants and methods of screening |
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| JP2014176386A (ja) | 2014-09-25 |
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| MX2009011192A (es) | 2009-10-30 |
| KR20100016602A (ko) | 2010-02-12 |
| NZ579780A (en) | 2012-07-27 |
| CA2683898A1 (en) | 2008-10-30 |
| US9284612B2 (en) | 2016-03-15 |
| US7910342B2 (en) | 2011-03-22 |
| JP5582576B2 (ja) | 2014-09-03 |
| EP2134849A2 (en) | 2009-12-23 |
| EP2134849B1 (en) | 2013-07-10 |
| US20080261230A1 (en) | 2008-10-23 |
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