ZA200900030B - Improvements relating to pharmaceutical compositions - Google Patents

Improvements relating to pharmaceutical compositions

Info

Publication number
ZA200900030B
ZA200900030B ZA200900030A ZA200900030A ZA200900030B ZA 200900030 B ZA200900030 B ZA 200900030B ZA 200900030 A ZA200900030 A ZA 200900030A ZA 200900030 A ZA200900030 A ZA 200900030A ZA 200900030 B ZA200900030 B ZA 200900030B
Authority
ZA
South Africa
Prior art keywords
pharmaceutical compositions
improvements relating
relating
pharmaceutical
compositions
Prior art date
Application number
ZA200900030A
Other languages
English (en)
Inventor
David John Duncalf
Alison Jayne Foster
James Long
Steven Paul Rannard
Dong Wang
Original Assignee
Unilever Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Plc filed Critical Unilever Plc
Publication of ZA200900030B publication Critical patent/ZA200900030B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
ZA200900030A 2006-07-13 2007-06-29 Improvements relating to pharmaceutical compositions ZA200900030B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0613925.7A GB0613925D0 (en) 2006-07-13 2006-07-13 Improvements relating to nanodispersions

Publications (1)

Publication Number Publication Date
ZA200900030B true ZA200900030B (en) 2010-04-28

Family

ID=36955583

Family Applications (7)

Application Number Title Priority Date Filing Date
ZA200900030A ZA200900030B (en) 2006-07-13 2007-06-29 Improvements relating to pharmaceutical compositions
ZA200900029A ZA200900029B (en) 2006-07-13 2007-06-29 Improvements relating to biocidal compositions
ZA200900028A ZA200900028B (en) 2006-07-13 2007-06-29 Improvements relating to pharmaceutical compositions
ZA200900027A ZA200900027B (en) 2006-07-13 2007-06-29 Improvements relating to anti-parasitic compositions
ZA200900031A ZA200900031B (en) 2006-07-13 2007-06-29 Improvements relating to nanodispersions
ZA200900345A ZA200900345B (en) 2006-07-13 2007-07-13 Preparation of pharmaceutical formulations
ZA200900347A ZA200900347B (en) 2006-07-13 2007-07-13 Preparation of pharmaceutical compositions

Family Applications After (6)

Application Number Title Priority Date Filing Date
ZA200900029A ZA200900029B (en) 2006-07-13 2007-06-29 Improvements relating to biocidal compositions
ZA200900028A ZA200900028B (en) 2006-07-13 2007-06-29 Improvements relating to pharmaceutical compositions
ZA200900027A ZA200900027B (en) 2006-07-13 2007-06-29 Improvements relating to anti-parasitic compositions
ZA200900031A ZA200900031B (en) 2006-07-13 2007-06-29 Improvements relating to nanodispersions
ZA200900345A ZA200900345B (en) 2006-07-13 2007-07-13 Preparation of pharmaceutical formulations
ZA200900347A ZA200900347B (en) 2006-07-13 2007-07-13 Preparation of pharmaceutical compositions

Country Status (17)

Country Link
US (10) US9060937B2 (enExample)
EP (8) EP2387992A1 (enExample)
JP (9) JP2009542762A (enExample)
CN (11) CN102631874A (enExample)
AP (1) AP2008004713A0 (enExample)
AR (4) AR061990A1 (enExample)
AU (9) AU2007271827B2 (enExample)
BR (8) BRPI0722376A2 (enExample)
CA (8) CA2659666A1 (enExample)
CL (4) CL2007002031A1 (enExample)
ES (2) ES2741124T3 (enExample)
GB (1) GB0613925D0 (enExample)
IL (2) IL195911A0 (enExample)
MX (2) MX2009000307A (enExample)
TW (1) TW200812694A (enExample)
WO (8) WO2008006716A2 (enExample)
ZA (7) ZA200900030B (enExample)

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AR063704A1 (es) 2006-09-14 2009-02-11 Makhteshim Chem Works Ltd Nanoparticulas de pesticida obtenida obtenidas a partir de microemulsiones y nanoemulsiones
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US8372432B2 (en) 2008-03-11 2013-02-12 Depomed, Inc. Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
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EP3378310B1 (en) 2008-09-25 2021-08-04 Vive Crop Protection Inc. Methods to produce polymer nanoparticles and formulations of active ingredients
FR2938433B1 (fr) * 2008-11-19 2011-09-09 Francois Fauran Compositions pharmaceutiques utilisant l'inuline comme excipient de granulation
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EP2243477A1 (de) 2009-04-22 2010-10-27 Fresenius Kabi Deutschland GmbH Paracetamol zur parenteralen Verabreichung
KR101374854B1 (ko) 2009-05-27 2014-03-19 주식회사 삼양바이오팜 생체이용률이 향상된 난용성 약물 함유 미립구 및 그 제조 방법
HUP0900376A2 (en) * 2009-06-19 2011-01-28 Nangenex Nanotechnologiai Zartkoerueen Muekoedoe Reszvenytarsasag Nanoparticulate candesartan cilexetil composition
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US20120135058A1 (en) 2012-05-31
CA2659666A1 (en) 2008-01-17
EP2040680A2 (en) 2009-04-01
CL2007002031A1 (es) 2008-01-18
MX2009000309A (es) 2009-01-26
CA2656223A1 (en) 2008-01-17
US20100015233A1 (en) 2010-01-21
ZA200900028B (en) 2010-04-28
CN102631874A (zh) 2012-08-15
BRPI0714179A2 (pt) 2012-12-25
AU2007271827A1 (en) 2008-01-17
CN101489534A (zh) 2009-07-22
CL2010000516A1 (es) 2010-10-15
WO2008006713A2 (en) 2008-01-17
WO2008006714A2 (en) 2008-01-17
AR061992A1 (es) 2008-08-10
AU2010201900A1 (en) 2010-06-03
US20100068282A1 (en) 2010-03-18
AU2007271831A1 (en) 2008-01-17
CN101516342A (zh) 2009-08-26
EP2040678A2 (en) 2009-04-01
CN101516341A (zh) 2009-08-26
CA2657582A1 (en) 2008-01-17
EP2040681A2 (en) 2009-04-01
AU2007271828B2 (en) 2010-12-02
WO2008006715A2 (en) 2008-01-17
JP2009542793A (ja) 2009-12-03
CA2656233A1 (en) 2008-01-17
JP2009542795A (ja) 2009-12-03
ZA200900347B (en) 2010-04-28
CL2007002030A1 (es) 2008-01-18
US20120134940A1 (en) 2012-05-31
ZA200900027B (en) 2010-04-28
EP2386292A1 (en) 2011-11-16
AR061991A1 (es) 2008-08-10
CA2656229C (en) 2014-05-27
BRPI0714176A2 (pt) 2012-12-25
US7691873B2 (en) 2010-04-06
CL2007002032A1 (es) 2008-01-18
MX2009000307A (es) 2009-01-26
JP2009542762A (ja) 2009-12-03
WO2008006712A3 (en) 2009-02-26
AR077195A2 (es) 2011-08-10
WO2008006714A3 (en) 2008-02-21
CN101489531A (zh) 2009-07-22
BRPI0714230A2 (pt) 2013-01-15
WO2008006716A3 (en) 2008-03-13
EP2040681B1 (en) 2017-08-09
US9060937B2 (en) 2015-06-23
CN101516340A (zh) 2009-08-26
JP2009542761A (ja) 2009-12-03
BRPI0722376A2 (pt) 2012-05-22
JP2009542764A (ja) 2009-12-03
IL195911A0 (en) 2009-09-01
TW200812694A (en) 2008-03-16
EP2040679A2 (en) 2009-04-01
AU2007274039A1 (en) 2008-01-17
JP2009542763A (ja) 2009-12-03
WO2008006715A3 (en) 2008-05-08
EP2040677B1 (en) 2019-05-08
JP2009542794A (ja) 2009-12-03
EP2269581A1 (en) 2011-01-05
CA2656229A1 (en) 2008-01-17
ZA200900029B (en) 2010-04-28
EP2040680B1 (en) 2019-08-07
JP2009542760A (ja) 2009-12-03
AU2007271829B2 (en) 2011-10-27
EP2040677A2 (en) 2009-04-01
US8945626B2 (en) 2015-02-03
US20090304806A1 (en) 2009-12-10
AU2007271830A1 (en) 2008-01-17
AU2007271828A1 (en) 2008-01-17
CN101489532A (zh) 2009-07-22
WO2008007152A2 (en) 2008-01-17
EP2387992A1 (en) 2011-11-23
CA2656217A1 (en) 2008-01-17
CN101849911A (zh) 2010-10-06
WO2008007151A3 (en) 2008-03-06
ES2752460T3 (es) 2020-04-06
BRPI0714353A2 (pt) 2013-05-07
US20090175953A1 (en) 2009-07-09
ZA200900031B (en) 2010-04-28
AU2007271829A1 (en) 2008-01-17
CN101489535A (zh) 2009-07-22
AU2007271827B2 (en) 2010-10-14
WO2008007151A2 (en) 2008-01-17
IL195933A0 (en) 2009-09-01
US20100015229A1 (en) 2010-01-21
GB0613925D0 (en) 2006-08-23
BRPI0714177A2 (pt) 2011-05-03
JP2010202665A (ja) 2010-09-16
CN102671585A (zh) 2012-09-19
AU2007274040A1 (en) 2008-01-17

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