DK3069733T3 - Ny acetaminophenforbindelsessammensætning uden bivirkninger for leveren - Google Patents

Ny acetaminophenforbindelsessammensætning uden bivirkninger for leveren Download PDF

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Publication number
DK3069733T3
DK3069733T3 DK13897632.9T DK13897632T DK3069733T3 DK 3069733 T3 DK3069733 T3 DK 3069733T3 DK 13897632 T DK13897632 T DK 13897632T DK 3069733 T3 DK3069733 T3 DK 3069733T3
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Denmark
Prior art keywords
acetaminophydrate
compound
new
side effects
liver side
Prior art date
Application number
DK13897632.9T
Other languages
English (en)
Inventor
Oliver Yao-Pu Hu
Tung-Yuan Shih
Original Assignee
National Defense Education And Res Foundation
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Publication of DK3069733T3 publication Critical patent/DK3069733T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Botany (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
DK13897632.9T 2013-11-13 2013-11-13 Ny acetaminophenforbindelsessammensætning uden bivirkninger for leveren DK3069733T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2013/087049 WO2015070396A1 (zh) 2013-11-13 2013-11-13 无肝副作用的对乙酰胺基酚新复方组合

Publications (1)

Publication Number Publication Date
DK3069733T3 true DK3069733T3 (da) 2022-11-14

Family

ID=53056618

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13897632.9T DK3069733T3 (da) 2013-11-13 2013-11-13 Ny acetaminophenforbindelsessammensætning uden bivirkninger for leveren

Country Status (15)

Country Link
US (3) US10420737B2 (da)
EP (2) EP4173619A3 (da)
JP (1) JP2016520100A (da)
KR (2) KR102017550B1 (da)
CN (2) CN105188756B (da)
DK (1) DK3069733T3 (da)
EA (1) EA029454B1 (da)
ES (1) ES2929945T3 (da)
HR (1) HRP20221344T1 (da)
HU (1) HUE060309T2 (da)
LT (1) LT3069733T (da)
PL (1) PL3069733T3 (da)
PT (1) PT3069733T (da)
RS (1) RS63704B1 (da)
WO (1) WO2015070396A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3069733T (lt) * 2013-11-13 2022-11-25 National Defense Education And Research Foundation Nauja acetaminofeno junginio sudėtis be šalutinio poveikio kepenims
EP3353144A4 (en) * 2015-09-24 2019-06-05 Sinew Pharma Inc. EFFECTIVE COMPOUNDS FOR TREATING HEPATOTOXICITY AND HEPATIC STAATOSES, AND USES THEREOF
EP3391881A4 (en) * 2015-11-19 2020-03-11 Sinew Pharma Inc. PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING HEPATIC STEATOSIS
CN111867572A (zh) * 2018-02-14 2020-10-30 欣耀生医股份有限公司 用于预防、减少或消除由对乙酰氨基酚(apap)引起的毒性的方法和组合物
JP6858729B2 (ja) * 2018-05-25 2021-04-14 ▲財▼▲団▼法人国防教育研究基金会Ｎａｔｉｏｎａｌ Ｄｅｆｅｎｓｅ Ｅｄｕｃａｔｉｏｎ Ａｎｄ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ 肝臓に対する副作用がない、新しいアセトアミノフェン複合組成
CN113164469A (zh) * 2018-09-03 2021-07-23 雅各生技有限公司 双那布扶林己二酸酯和乙酰胺酚的药物制剂及治疗疼痛的方法

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5584166A (en) * 1978-12-20 1980-06-25 Lion Hamigaki Kk Band for spongy medicine
ZA837556B (en) * 1982-11-15 1984-06-27 Upjohn Co Acetominophen and ibuprofen/flurbiprofen
JPS62502194A (ja) * 1985-03-18 1987-08-27 プロダクト・リソ−シズ・インタ−ナショナル・インコ−ポレイテッド エ−ロゾル発泡体
PT83241B (pt) * 1985-08-26 1988-07-01 Searle & Co Processo para a preparacao de composicoes de drogas de matriz polimerica, capazes de mascarar o sabor de um ingrediente activo, contendo um polimero tendo uma serie de grupos acido e ester carboxilicos
JPH01190628A (ja) * 1988-01-21 1989-07-31 Sumitomo Pharmaceut Co Ltd 持続性坐剤
FR2646773B1 (fr) * 1989-05-12 1994-05-13 Chauvin Sa Laboratoire Composition pharmaceutique a base de paracetamol
JP3165438B2 (ja) * 1990-04-04 2001-05-14 バーウィンド・ファーマス―ティカル・サーヴィスィーズ・インコーポレーテッド 水性のマルトデキストリン及びセルロースポリマーフィルムコーティング
DE69425453T2 (de) * 1993-04-23 2001-04-12 Novartis Ag, Basel Wirkstoffabgabevorrichtung mit gesteuerter Freigabe
US5733578A (en) * 1995-11-15 1998-03-31 Edward Mendell Co., Inc. Directly compressible high load acetaminophen formulations
EP0901376A1 (en) * 1996-05-20 1999-03-17 Fuisz Technologies Ltd. Malatonin in combination with analgesics
US5858997A (en) * 1997-12-04 1999-01-12 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Method and composition for skin lightening
US8524277B2 (en) * 1998-03-06 2013-09-03 Alza Corporation Extended release dosage form
ES2153786B1 (es) * 1999-06-10 2001-10-16 S A L V A T Lab Sa Composicion farmaceutica liquida para la administracion oral de principios activos amargos y susceptibles de hidrolisis.
FR2798289B1 (fr) * 1999-09-15 2004-12-31 Cll Pharma Formes galeniques a delitement rapide en bouche et leur procede de preparation
EP1231901A4 (en) * 1999-10-29 2005-03-23 Fmc Corp EDIBLE COATING COMPOSITION
ES2174734B1 (es) * 2000-11-03 2003-10-01 Belmac S A Lab Nueva formulacion galenica de paracetamol dispersable y soluble, procedimiento para su preparacion y aplicaciones.
HUP0401079A3 (en) * 2001-07-10 2008-04-28 Teva Pharma Drug delivery system for zero order, zero order-biphasic, ascending or descending drug delivery
NZ530889A (en) * 2001-07-31 2005-03-24 Wyeth Corp Use of sucralose as a sweetening agent combined with pH modulation of chemical formulations generates enhanced taste-masking effects
US7101572B2 (en) * 2001-12-07 2006-09-05 Unilab Pharmatech, Ltd. Taste masked aqueous liquid pharmaceutical composition
KR100522239B1 (ko) * 2002-07-16 2005-10-18 주식회사 서울제약 아세트아미노펜을 함유하는 제어방출성의 경구용 제제
KR100507771B1 (ko) * 2002-11-08 2005-08-17 한미약품 주식회사 난용성 감기약 활성 성분의 경구투여용 조성물 및 그의제조 방법
US20070259033A1 (en) * 2003-09-26 2007-11-08 Evangeline Cruz Controlled release formulations exhibiting an ascending rate of release
EP1708684A2 (en) * 2003-09-26 2006-10-11 Alza Corporation Drug coating providing high drug loading and methods for providing the same
GB0330255D0 (en) * 2003-12-31 2004-02-04 Vectura Ltd Multiparticulate formulations for oral delivery
WO2006129668A1 (ja) * 2005-05-30 2006-12-07 Meiji Seika Kaisha, Ltd. 糖衣を施した丸剤
US20080085314A1 (en) * 2005-07-29 2008-04-10 Shalaby Shalaby W Solid oral formulations for combination therapy
WO2007050631A2 (en) * 2005-10-25 2007-05-03 Cima Labs Inc. Dosage form with coated active
WO2007074472A2 (en) * 2005-12-27 2007-07-05 Jubilant Organosys Limited Mouth dissolving pharmaceutical composition and process for preparing the same using a high amount of silicon dioxide
US10022339B2 (en) * 2006-04-21 2018-07-17 The Procter & Gamble Company Compositions and methods useful for treatment of respiratory illness
GB0613925D0 (en) * 2006-07-13 2006-08-23 Unilever Plc Improvements relating to nanodispersions
CN101917977B (zh) * 2007-07-20 2013-05-29 艾博特股份有限两合公司 非阿片样物质和限制的阿片样物质止痛药的制剂
CA2711211A1 (en) * 2008-01-03 2009-07-09 Aft Pharmaceuticals Ltd. Oral pharmaceutical suspension comprising paracetamol and ibuprofen
EP2249808A2 (en) * 2008-01-11 2010-11-17 Cipla Limited Solid pharmaceutical dosage form
US8304394B2 (en) * 2008-07-23 2012-11-06 National Defense Education And Research Foundation Low side effect pharmaceutical composition containing isoniazid
WO2010103365A2 (en) * 2009-03-09 2010-09-16 Council Of Scientific & Industrial Research Sustained release composition of therapeutic agent
JP2011046666A (ja) * 2009-08-28 2011-03-10 Lion Corp 医薬組成物
CN101695498A (zh) * 2009-10-26 2010-04-21 昆明理工大学 对乙酰氨基酚所致肝损伤保护药物及其应用
CA3065589C (en) * 2010-06-03 2022-04-26 Catalent Ontario Limited Multi phase soft gel capsules, apparatus and method thereof
AU2011336300B2 (en) * 2010-12-02 2015-05-21 Adare Pharmaceuticals, Inc. Rapidly dispersing granules, orally disintegrating tablets and methods
EA026922B1 (ru) * 2011-04-20 2017-05-31 Нэшнл Дифенс Эдьюкейшн Энд Рисерч Фаундейшн Противотуберкулезная фармацевтическая комбинация с низким побочным эффектом, включающая противотуберкулезные препараты
CN102988993B (zh) * 2011-09-13 2017-03-15 广东九明制药有限公司 复方对乙酰氨基酚片主要辅料的筛选和组成及其制备方法
JP5828280B2 (ja) * 2011-12-28 2015-12-02 ライオン株式会社 錠剤及びその製造方法
ES2414557B1 (es) 2012-01-16 2014-06-10 Novocat Farma, S.A. Composición acuosa de paracetamol para inyección
CN102600119B (zh) * 2012-02-07 2013-03-27 海南卫康制药(潜山)有限公司 一种小儿对乙酰氨基酚组合物
CN103110629B (zh) * 2013-02-19 2014-03-19 青岛正大海尔制药有限公司 复方酚麻美敏滴丸及其制备方法
LT3069733T (lt) * 2013-11-13 2022-11-25 National Defense Education And Research Foundation Nauja acetaminofeno junginio sudėtis be šalutinio poveikio kepenims
EP3353144A4 (en) * 2015-09-24 2019-06-05 Sinew Pharma Inc. EFFECTIVE COMPOUNDS FOR TREATING HEPATOTOXICITY AND HEPATIC STAATOSES, AND USES THEREOF
CN111867572A (zh) * 2018-02-14 2020-10-30 欣耀生医股份有限公司 用于预防、减少或消除由对乙酰氨基酚(apap)引起的毒性的方法和组合物

Also Published As

Publication number Publication date
US20170172950A1 (en) 2017-06-22
EA201591435A1 (ru) 2016-05-31
US20190262289A1 (en) 2019-08-29
RS63704B1 (sr) 2022-11-30
US20230082397A1 (en) 2023-03-16
CN105188756A (zh) 2015-12-23
KR101881074B1 (ko) 2018-08-17
ES2929945T3 (es) 2022-12-05
CN105188756B (zh) 2020-06-12
LT3069733T (lt) 2022-11-25
EP3069733A1 (en) 2016-09-21
HRP20221344T1 (hr) 2022-12-23
EP4173619A3 (en) 2023-07-19
PL3069733T3 (pl) 2023-02-13
JP2016520100A (ja) 2016-07-11
CN111904924A (zh) 2020-11-10
US11534416B2 (en) 2022-12-27
WO2015070396A1 (zh) 2015-05-21
EP3069733A4 (en) 2017-08-23
HUE060309T2 (hu) 2023-02-28
EP4173619A2 (en) 2023-05-03
PT3069733T (pt) 2022-11-09
EA029454B1 (ru) 2018-03-30
KR20170085607A (ko) 2017-07-24
KR102017550B1 (ko) 2019-09-03
KR20150115846A (ko) 2015-10-14
EP3069733B1 (en) 2022-08-10
US10420737B2 (en) 2019-09-24

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