ZA200802667B - Argatroban formulation - Google Patents
Argatroban formulationInfo
- Publication number
- ZA200802667B ZA200802667B ZA200802667A ZA200802667A ZA200802667B ZA 200802667 B ZA200802667 B ZA 200802667B ZA 200802667 A ZA200802667 A ZA 200802667A ZA 200802667 A ZA200802667 A ZA 200802667A ZA 200802667 B ZA200802667 B ZA 200802667B
- Authority
- ZA
- South Africa
- Prior art keywords
- argatroban
- formulation
- argatroban formulation
- solubilize
- aqueous
- Prior art date
Links
- KXNPVXPOPUZYGB-XYVMCAHJSA-N argatroban Chemical compound OC(=O)[C@H]1C[C@H](C)CCN1C(=O)[C@H](CCCN=C(N)N)NS(=O)(=O)C1=CC=CC2=C1NC[C@H](C)C2 KXNPVXPOPUZYGB-XYVMCAHJSA-N 0.000 title abstract 3
- 229960003856 argatroban Drugs 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 101000712605 Theromyzon tessulatum Theromin Proteins 0.000 abstract 1
- 229940122388 Thrombin inhibitor Drugs 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229960000935 dehydrated alcohol Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000003868 thrombin inhibitor Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71340305P | 2005-09-01 | 2005-09-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200802667B true ZA200802667B (en) | 2009-01-28 |
Family
ID=37809398
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200802667A ZA200802667B (en) | 2005-09-01 | 2008-03-26 | Argatroban formulation |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US7642271B2 (cs) |
| EP (1) | EP1948133B1 (cs) |
| JP (1) | JP5189980B2 (cs) |
| KR (3) | KR20080042155A (cs) |
| CN (2) | CN101257890B (cs) |
| AT (1) | ATE514416T1 (cs) |
| AU (1) | AU2006285097B2 (cs) |
| BR (1) | BRPI0616127B8 (cs) |
| CA (1) | CA2617920C (cs) |
| CY (1) | CY1112109T1 (cs) |
| DK (1) | DK1948133T3 (cs) |
| ES (1) | ES2368758T3 (cs) |
| IL (2) | IL189290A (cs) |
| IN (1) | IN2015DN03947A (cs) |
| MX (1) | MX2008002177A (cs) |
| NZ (1) | NZ565821A (cs) |
| PL (1) | PL1948133T3 (cs) |
| PT (1) | PT1948133E (cs) |
| RU (1) | RU2416393C2 (cs) |
| SI (1) | SI1948133T1 (cs) |
| WO (1) | WO2007027565A2 (cs) |
| ZA (1) | ZA200802667B (cs) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2008002177A (es) * | 2005-09-01 | 2008-04-22 | Baxter Healthcare Sa | Formulacion de argatroban. |
| US7687516B2 (en) * | 2006-09-27 | 2010-03-30 | Eagle Pharmaceuticals, Inc. | Alcohol free formulation of argatroban |
| WO2008039473A2 (en) * | 2006-09-27 | 2008-04-03 | Scidose Llc | Alcohol free formulation of argatroban |
| US20100076019A1 (en) * | 2006-10-11 | 2010-03-25 | Eagle Pharmaceuticals, Inc. | Alcohol free formulation of argatroban |
| US20090221637A1 (en) * | 2008-02-29 | 2009-09-03 | Baxter International Inc. | Solid-state salt argatroban formulations and methods for producing and using the same |
| US7915290B2 (en) * | 2008-02-29 | 2011-03-29 | Baxter International Inc. | Argatroban formulations and methods for making and using same |
| CN101598725B (zh) * | 2009-06-23 | 2012-07-18 | 南通大学附属医院 | 阿加曲班在血细胞和生化常规分析中的应用 |
| KR102307601B1 (ko) | 2010-10-21 | 2021-09-30 | 알티유 파머수티컬즈, 엘엘시 | 즉시 사용가능한 케토로락 제제 |
| CN102119922A (zh) * | 2011-03-03 | 2011-07-13 | 天津市炜杰科技有限公司 | 以酸作为增溶剂的21(s)阿加曲班静脉注射液 |
| CN102120026A (zh) * | 2011-03-03 | 2011-07-13 | 天津市炜杰科技有限公司 | 以醇作为增溶剂的21(s)阿加曲班静脉注射液 |
| CN102228677A (zh) * | 2011-06-17 | 2011-11-02 | 天津市炜杰科技有限公司 | 以酸作为增溶剂的21(r)阿加曲班静脉注射液 |
| TWI679977B (zh) * | 2011-10-19 | 2019-12-21 | 大塚製藥股份有限公司 | 口服溶液 |
| EP3383494A4 (en) * | 2015-12-04 | 2019-08-07 | The Regents of The University of California | Histone deacetylase INHIBITORS |
| CN107773533A (zh) * | 2016-08-26 | 2018-03-09 | 四川科瑞德制药股份有限公司 | 一种新型凝血酶抑制剂及其制备方法 |
| CN115381927A (zh) * | 2022-09-20 | 2022-11-25 | 晓恩医药包装材料(安庆)有限公司 | 一种用于治疗缺血性脑梗塞的药物预灌装注射剂 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE420919B (sv) * | 1973-08-13 | 1981-11-09 | Mitsubishi Chem Ind | Forfarande for framstellning av n?722-dansyl-l-argininderivat och farmaceutiskt godtagbara syradditionssalter derav |
| US5214052A (en) * | 1987-07-28 | 1993-05-25 | Mitsubishi Kasei Corporation | Method for dissolving arginineamides and pharmaceutical compositions containing them |
| US5506241A (en) * | 1992-03-18 | 1996-04-09 | Mitsubishi Chemical Corporation | Argatroban preparations for ophthalmic use |
| CA2091715A1 (en) * | 1992-03-18 | 1993-09-19 | Mitsubishi Kasei Corporation | Argatroban preparations for ophthalmic use |
| JPH06219948A (ja) * | 1993-01-25 | 1994-08-09 | Mitsubishi Kasei Corp | 抗トロンビン剤及びその製造方法 |
| JPH06219949A (ja) * | 1993-01-25 | 1994-08-09 | Mitsubishi Kasei Corp | 抗トロンビン剤及びその製造方法 |
| DE69417087T2 (de) | 1993-04-22 | 1999-07-15 | Mitsubishi Chemical Corp., Tokio/Tokyo | Wässrige Arzneizubereitungen enthaltend Argatroban und Cyclodextrin oder Coffein |
| JPH07228532A (ja) * | 1993-04-22 | 1995-08-29 | Senju Pharmaceut Co Ltd | 水性液剤、その有効成分の溶解性向上方法および安定化方法 |
| US5849843A (en) | 1993-11-16 | 1998-12-15 | Baxter International Inc. | Polymeric compositions for medical packaging and devices |
| US5998019A (en) | 1993-11-16 | 1999-12-07 | Baxter International Inc. | Multi-layered polymer structure for medical products |
| FR2715566B1 (fr) | 1994-02-03 | 1996-03-08 | Synthelabo | Solutions aqueuses concentrées d'argatroban. |
| US5840733A (en) | 1996-07-01 | 1998-11-24 | Redcell, Canada, Inc. | Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes |
| JPH10316569A (ja) * | 1997-05-19 | 1998-12-02 | Mitsubishi Chem Corp | アルガトロバンの可溶化方法及びそれによるアルガトロバン含有外用水性薬剤 |
| KR101010547B1 (ko) * | 2003-03-20 | 2011-01-24 | 미쓰비시 타나베 파마 코퍼레이션 | 알기닌아미드류를 함유하는 의약 제제 |
| JP2007523876A (ja) | 2003-07-17 | 2007-08-23 | スミスクライン・ビーチャム・コーポレイション | Ｈｉｔ患者をアルガトロバンを用いて治療する方法 |
| MX2008002177A (es) * | 2005-09-01 | 2008-04-22 | Baxter Healthcare Sa | Formulacion de argatroban. |
-
2006
- 2006-08-28 MX MX2008002177A patent/MX2008002177A/es active IP Right Grant
- 2006-08-28 PL PL06802424T patent/PL1948133T3/pl unknown
- 2006-08-28 KR KR1020087007748A patent/KR20080042155A/ko not_active Ceased
- 2006-08-28 PT PT06802424T patent/PT1948133E/pt unknown
- 2006-08-28 NZ NZ565821A patent/NZ565821A/en not_active IP Right Cessation
- 2006-08-28 JP JP2008529147A patent/JP5189980B2/ja not_active Expired - Fee Related
- 2006-08-28 US US11/510,981 patent/US7642271B2/en active Active
- 2006-08-28 SI SI200631063T patent/SI1948133T1/sl unknown
- 2006-08-28 ES ES06802424T patent/ES2368758T3/es active Active
- 2006-08-28 BR BRPI0616127A patent/BRPI0616127B8/pt not_active IP Right Cessation
- 2006-08-28 WO PCT/US2006/033432 patent/WO2007027565A2/en active Application Filing
- 2006-08-28 KR KR1020147000036A patent/KR101753949B1/ko not_active Expired - Fee Related
- 2006-08-28 AT AT06802424T patent/ATE514416T1/de active
- 2006-08-28 AU AU2006285097A patent/AU2006285097B2/en not_active Ceased
- 2006-08-28 CN CN2006800322085A patent/CN101257890B/zh not_active Expired - Fee Related
- 2006-08-28 IN IN3947DEN2015 patent/IN2015DN03947A/en unknown
- 2006-08-28 DK DK06802424.9T patent/DK1948133T3/da active
- 2006-08-28 EP EP06802424A patent/EP1948133B1/en not_active Not-in-force
- 2006-08-28 KR KR1020157025457A patent/KR20150108430A/ko not_active Ceased
- 2006-08-28 CN CN201210353437.4A patent/CN102895179B/zh not_active Expired - Fee Related
- 2006-08-28 RU RU2008112311/15A patent/RU2416393C2/ru active
- 2006-08-28 CA CA2617920A patent/CA2617920C/en not_active Expired - Fee Related
-
2008
- 2008-02-05 IL IL189290A patent/IL189290A/en active IP Right Grant
- 2008-03-26 ZA ZA200802667A patent/ZA200802667B/xx unknown
-
2009
- 2009-12-28 US US12/647,854 patent/US8034830B2/en active Active
- 2009-12-28 US US12/647,841 patent/US7985757B2/en active Active
-
2010
- 2010-09-16 IL IL208183A patent/IL208183A0/en unknown
-
2011
- 2011-08-30 CY CY20111100825T patent/CY1112109T1/el unknown
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