WO2007039821A3 - Novel inhibitors of tyrosinase, their method of preparation and their use in human medicine and in cosmetics - Google Patents

Novel inhibitors of tyrosinase, their method of preparation and their use in human medicine and in cosmetics Download PDF

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Publication number
WO2007039821A3
WO2007039821A3 PCT/IB2006/003208 IB2006003208W WO2007039821A3 WO 2007039821 A3 WO2007039821 A3 WO 2007039821A3 IB 2006003208 W IB2006003208 W IB 2006003208W WO 2007039821 A3 WO2007039821 A3 WO 2007039821A3
Authority
WO
WIPO (PCT)
Prior art keywords
tyrosinase
cosmetics
preparation
human medicine
novel inhibitors
Prior art date
Application number
PCT/IB2006/003208
Other languages
French (fr)
Other versions
WO2007039821A2 (en
Inventor
Jean-Claude Yadan
Irene Erdelmeier
Itaru Suzuki
Philippe Diaz
Original Assignee
Galderma Res & Dev
Jean-Claude Yadan
Irene Erdelmeier
Itaru Suzuki
Philippe Diaz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0508926A external-priority patent/FR2890070A1/en
Application filed by Galderma Res & Dev, Jean-Claude Yadan, Irene Erdelmeier, Itaru Suzuki, Philippe Diaz filed Critical Galderma Res & Dev
Publication of WO2007039821A2 publication Critical patent/WO2007039821A2/en
Publication of WO2007039821A3 publication Critical patent/WO2007039821A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

The present invention relates to novel compounds corresponding to the following general formula (I): to compositions containing them, and to their use in pharmaceutical compositions intended for use in human or veterinary medicine, or alternatively in cosmetic compositions.
PCT/IB2006/003208 2005-08-31 2006-08-29 Novel inhibitors of tyrosinase, their method of preparation and their use in human medicine and in cosmetics WO2007039821A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR0508926A FR2890070A1 (en) 2005-08-31 2005-08-31 New imidazole compounds are tyrosinase inhibitors useful to treat e.g. melasma, chloasma, lentigines, senile lentigo, and vitiligo, and to prevent and/or treat the signs of ageing
FR0508926 2005-08-31
US71489905P 2005-09-08 2005-09-08
US60/714,899 2005-09-08

Publications (2)

Publication Number Publication Date
WO2007039821A2 WO2007039821A2 (en) 2007-04-12
WO2007039821A3 true WO2007039821A3 (en) 2007-06-21

Family

ID=37845104

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/003208 WO2007039821A2 (en) 2005-08-31 2006-08-29 Novel inhibitors of tyrosinase, their method of preparation and their use in human medicine and in cosmetics

Country Status (1)

Country Link
WO (1) WO2007039821A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2917087B1 (en) * 2007-06-05 2012-09-21 Galderma Res & Dev NOVEL 4-PHENYL-IMIDAZOLE-2-THIONES AS INHIBITORS OF TYROSINASE, PROCESS FOR THEIR PREPARATION AND THEIR USE IN HUMAN MEDICINE AND COSMETICS

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001064206A2 (en) * 2000-02-29 2001-09-07 Integriderm, Inc. Inhibitors of melanocyte tyrosinase as topical skin lighteners
WO2002020474A2 (en) * 2000-09-11 2002-03-14 Pfizer Products Inc. Resorcinol derivatives
FR2845599A1 (en) * 2002-10-11 2004-04-16 Lmd Tyrosinase and melanin synthesis inhibiting medicaments, useful for lightening the skin or eliminating age spots, comprising 1,3-bis-(sulfinylalkyl)-thiourea compounds or sulfonyl analogs
DE10342839A1 (en) * 2003-09-17 2005-04-28 Symrise Gmbh & Co Kg Use of hydantoin derivatives for cosmetic, dermatological or therapeutic lightening of the skin and hair, act by inhibiting tyrosinase or other processes involved in pigmentation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001064206A2 (en) * 2000-02-29 2001-09-07 Integriderm, Inc. Inhibitors of melanocyte tyrosinase as topical skin lighteners
WO2002020474A2 (en) * 2000-09-11 2002-03-14 Pfizer Products Inc. Resorcinol derivatives
FR2845599A1 (en) * 2002-10-11 2004-04-16 Lmd Tyrosinase and melanin synthesis inhibiting medicaments, useful for lightening the skin or eliminating age spots, comprising 1,3-bis-(sulfinylalkyl)-thiourea compounds or sulfonyl analogs
DE10342839A1 (en) * 2003-09-17 2005-04-28 Symrise Gmbh & Co Kg Use of hydantoin derivatives for cosmetic, dermatological or therapeutic lightening of the skin and hair, act by inhibiting tyrosinase or other processes involved in pigmentation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HAUSER H ET AL: "1-HYDROXYIMIDAZOLE DERIVATIVES II. SYNTHESIS AND REACTIONS OF 1-BENZYLOXY-2,3-DIHYDROIMIDAZOLE-2-THIONE. PREPARATION OF 1-BENZYLOXY-1H-IMIDAZOLES", SCIENTIA PHARMACEUTICA, OESTERREICHISCHE APOTHEKER VERLAGSGESELLSCHAFT,, AT, vol. 56, 1988, pages 235 - 241, XP009061180, ISSN: 0036-8709 *

Also Published As

Publication number Publication date
WO2007039821A2 (en) 2007-04-12

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