WO2006103119A3 - Tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and also in cosmetics - Google Patents

Tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and also in cosmetics Download PDF

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Publication number
WO2006103119A3
WO2006103119A3 PCT/EP2006/003786 EP2006003786W WO2006103119A3 WO 2006103119 A3 WO2006103119 A3 WO 2006103119A3 EP 2006003786 W EP2006003786 W EP 2006003786W WO 2006103119 A3 WO2006103119 A3 WO 2006103119A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
cosmetics
human medicine
tyrosinase inhibitors
human
Prior art date
Application number
PCT/EP2006/003786
Other languages
French (fr)
Other versions
WO2006103119A2 (en
Inventor
Philippe Diaz
Catherine Raffin
Original Assignee
Galderma Res & Dev
Philippe Diaz
Catherine Raffin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0503249A external-priority patent/FR2883875A1/en
Application filed by Galderma Res & Dev, Philippe Diaz, Catherine Raffin filed Critical Galderma Res & Dev
Publication of WO2006103119A2 publication Critical patent/WO2006103119A2/en
Publication of WO2006103119A3 publication Critical patent/WO2006103119A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/496—Triazoles or their condensed derivatives, e.g. benzotriazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/69—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

The present invention relates to novel compounds corresponding to general formula (I) to the compositions containing them, to the process for the preparation thereof and to the use thereof in pharmaceutical compositions for use in human or veterinary medicine, or alternatively in cosmetic compositions .
PCT/EP2006/003786 2005-04-01 2006-03-29 Tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and also in cosmetics WO2006103119A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR0503249 2005-04-01
FR0503249A FR2883875A1 (en) 2005-04-01 2005-04-01 New triazole derivatives, useful e.g. to treat melasma, chloasma, lentigines, senile lentigo, vitiligo, freckles and aging signs and for bodily and hair hygiene, are tyrosinase inhibitors
US67336205P 2005-04-21 2005-04-21
US60/673,362 2005-04-21

Publications (2)

Publication Number Publication Date
WO2006103119A2 WO2006103119A2 (en) 2006-10-05
WO2006103119A3 true WO2006103119A3 (en) 2007-02-15

Family

ID=37053739

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/003786 WO2006103119A2 (en) 2005-04-01 2006-03-29 Tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and also in cosmetics

Country Status (1)

Country Link
WO (1) WO2006103119A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150152122A1 (en) * 2013-03-13 2015-06-04 Avon Products, Inc. Tyrosinase inhibitors
WO2014164195A1 (en) 2013-03-13 2014-10-09 Avon Products, Inc Tyrosinase inhibitors
US20150174034A1 (en) 2013-03-13 2015-06-25 Avon Products, Inc. Tyrosinase inhibitors
WO2023245291A1 (en) * 2022-06-22 2023-12-28 Scotiaderm Inc. Compositions for the prevention and treatment of moisture-associated skin damage

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4160839A (en) * 1976-03-01 1979-07-10 Gulf Oil Corporation Carbamyltriazole insecticides
EP0371438A2 (en) * 1988-11-29 1990-06-06 Warner-Lambert Company 3,5-Di-tertiary-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, and oxadiazoles and 3,5-di-tertiary-butyl-4-hydroxiphenyl- 1,2,4-thiadiazoles, -oxadiazoles as antiinflammatory agents
JPH05124947A (en) * 1991-04-09 1993-05-21 Sansho Seiyaku Co Ltd Medicine for external use capable of inhibiting melanogenesis
JPH05124948A (en) * 1991-04-09 1993-05-21 Sansho Seiyaku Co Ltd Medicine for external use capable of inhibiting melanogenesis
WO2000012489A1 (en) * 1998-09-01 2000-03-09 Astrazeneca Ab 1, 2, 4-triazole-3-thione compounds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4160839A (en) * 1976-03-01 1979-07-10 Gulf Oil Corporation Carbamyltriazole insecticides
EP0371438A2 (en) * 1988-11-29 1990-06-06 Warner-Lambert Company 3,5-Di-tertiary-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, and oxadiazoles and 3,5-di-tertiary-butyl-4-hydroxiphenyl- 1,2,4-thiadiazoles, -oxadiazoles as antiinflammatory agents
JPH05124947A (en) * 1991-04-09 1993-05-21 Sansho Seiyaku Co Ltd Medicine for external use capable of inhibiting melanogenesis
JPH05124948A (en) * 1991-04-09 1993-05-21 Sansho Seiyaku Co Ltd Medicine for external use capable of inhibiting melanogenesis
WO2000012489A1 (en) * 1998-09-01 2000-03-09 Astrazeneca Ab 1, 2, 4-triazole-3-thione compounds

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
BOOTS ET AL.: "Hill Reaction Inhibitors. 3. Conformational Aspects of Ureas", J. MED. CHEM., vol. 15, no. 3, 1972, pages 330 - 332, XP002357113 *
DATABASE BEILSTEIN *
DHAKA ET AL.: "Heterocyclic Systems Containing Bridgehead Nitrogen Atom: Part XIX-Reaction of 2,3-Dichloroquinoxaline with Thioureas", INDIAN JOURNAL OF CHEMISTRY, vol. 12, 1974, pages 966 - 968, XP009058148 *
DUSCHINSKY ET AL.: "Oxidation and reduction of 4-acetamidobenzaldehyde thiosemicarbazone", J. AM. CHEM. SOC., vol. 73, 1951, pages 4464 - 4466, XP002357112 *
GOSWAMI B N ET AL: "SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 1-(2,4-DICHLOROBENZOYL)-4-SUB STITUTED THIOSEMICARBAZIDES 1,2,4-TRIAZOLES AND THEIR METHYL DERIVATIVES", JOURNAL OF HETEROCYCLIC CHEMISTRY, PROVO, UT, US, vol. 21, no. 4, July 1984 (1984-07-01), pages 1225 - 1229, XP001193356, ISSN: 0022-152X *
JONES ET AL.: "Antiviral Chemotherapy. I. The Activity of Pyridine and Quinoline Derivatives against Neurovaccinia in Mice", J. MED. CHEM., vol. 8, 1965, pages 676 - 680, XP002357111 *
KUMAMOTO T ET AL: "Effect of 2,4-dihydro-3H-1,2,4-triazole-3-thiones and thiosemicarbazones on iodide uptake by the mouse thyroid: the relationship between their structure and anti-thyroid activity", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO, JP, vol. 38, no. 9, September 1990 (1990-09-01), pages 2595259 - 6, XP002146751, ISSN: 0009-2363 *
MARS U ET AL: "NEW THIOUREAS AND RELATED SUBSTANCES INTENDED FOR MELANOMA TARGETING", PIGMENT CELL RESEARCH, MUNKSGAARD INTERNATIONAL PUBLISHERS, CAMBRIDGE, MA, DK, vol. 8, no. 4, August 1995 (1995-08-01), pages 194 - 201, XP009037885, ISSN: 0893-5785 *
OVSEPYAN: "Synthesis of substituted 1,2,4-triazoles and 1,3,4-thiadiazoles", ARM. KHIM. ZH., vol. 30, no. 1, 1977, pages 70 - 73, XP009058149 *
PATENT ABSTRACTS OF JAPAN *
YAMANOTO S: "Melanin formation-inhibiting topical preparations containing 1,2,4-triazoles", CHEMICAL ABSTRACTS + INDEXES, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 119, no. 14, 1993, XP002200694, ISSN: 0009-2258 *

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