WO2009148288A3 - 오미자로부터 추출한 신규한 α-ISO-CUBEBENE 화합물을 유효성분으로 하는 면역 질환의 예방 및 치료용 조성물 - Google Patents

오미자로부터 추출한 신규한 α-ISO-CUBEBENE 화합물을 유효성분으로 하는 면역 질환의 예방 및 치료용 조성물 Download PDF

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Publication number
WO2009148288A3
WO2009148288A3 PCT/KR2009/003024 KR2009003024W WO2009148288A3 WO 2009148288 A3 WO2009148288 A3 WO 2009148288A3 KR 2009003024 W KR2009003024 W KR 2009003024W WO 2009148288 A3 WO2009148288 A3 WO 2009148288A3
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WO
WIPO (PCT)
Prior art keywords
iso
cubebene
preventing
composition
active ingredient
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PCT/KR2009/003024
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English (en)
French (fr)
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WO2009148288A2 (ko
Inventor
최영환
윤식
배외식
심재웅
이유진
Original Assignee
부산대학교 산학협력단
동아대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 부산대학교 산학협력단, 동아대학교 산학협력단 filed Critical 부산대학교 산학협력단
Priority to KR1020117002868A priority Critical patent/KR101263900B1/ko
Publication of WO2009148288A2 publication Critical patent/WO2009148288A2/ko
Publication of WO2009148288A3 publication Critical patent/WO2009148288A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/79—Schisandraceae (Schisandra family)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C13/00—Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
    • C07C13/28—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
    • C07C13/32—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings
    • C07C13/54—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with three condensed rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

본 발명은 오미자로부터 추출한 신규한 α-iso-cubebene 화합물에 관한 것이다. 구체적으로, α-iso-cubebene 화합물은 인간 호중구내에서 CXCL8 생성을 강하게 자극하였으며, 또한 α-iso-cubebene-유도 CXCL8 생성은 칼슘 킬레이터, EGTA에 의해 거의 완전히 억제되며, 그 결과 상기 공정내 칼슘 시그널링의 역할을 수행함으로써, 추출된 신규한 화합물은 면역 질환에 대한 예방 및 치료용 조성물의 유효성분으로서 사용될 수 있다.
PCT/KR2009/003024 2008-06-05 2009-06-05 오미자로부터 추출한 신규한 α-ISO-CUBEBENE 화합물을 유효성분으로 하는 면역 질환의 예방 및 치료용 조성물 WO2009148288A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020117002868A KR101263900B1 (ko) 2008-06-05 2009-06-05 오미자로부터 추출한 신규한 알파-이소-쿠베벤 화합물을 유효성분으로 하는 면역 질환의 예방 및 치료용 조성물

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0053194 2008-06-05
KR20080053194 2008-06-05

Publications (2)

Publication Number Publication Date
WO2009148288A2 WO2009148288A2 (ko) 2009-12-10
WO2009148288A3 true WO2009148288A3 (ko) 2010-03-11

Family

ID=41398692

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/003024 WO2009148288A2 (ko) 2008-06-05 2009-06-05 오미자로부터 추출한 신규한 α-ISO-CUBEBENE 화합물을 유효성분으로 하는 면역 질환의 예방 및 치료용 조성물

Country Status (2)

Country Link
KR (1) KR101263900B1 (ko)
WO (1) WO2009148288A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101413374B1 (ko) * 2012-08-27 2014-07-01 부산대학교 산학협력단 오미자로부터 분리한 신규한 α-ｃｕｂｅｂｅｎoａｔｅ 화합물

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HYUN K. H. ET AL.: "Chemical Compositions of Schizandra nigra Maxium", KOREAN J. PLANT. RES., vol. 13, no. 1, 2000, pages 35 - 40 *
LOPEZ-RUBALCAVA C. ET AL.: "Anxiolytic-like actions of the hexane extract from leaves of Annona cherimolia in two anxiety paradigms: Possible involmement of the GABA/benzodiazepine receptor complex", LIFE SCIENCES, vol. 78, no. 7, 2006, pages 730 - 737 *

Also Published As

Publication number Publication date
WO2009148288A2 (ko) 2009-12-10
KR101263900B1 (ko) 2013-05-13
KR20110040890A (ko) 2011-04-20

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