CY1112109T1 - Σκευασμα αργατροβανης περιεχον ενα οξυ ως διαλυτοποιητη - Google Patents
Σκευασμα αργατροβανης περιεχον ενα οξυ ως διαλυτοποιητηInfo
- Publication number
- CY1112109T1 CY1112109T1 CY20111100825T CY111100825T CY1112109T1 CY 1112109 T1 CY1112109 T1 CY 1112109T1 CY 20111100825 T CY20111100825 T CY 20111100825T CY 111100825 T CY111100825 T CY 111100825T CY 1112109 T1 CY1112109 T1 CY 1112109T1
- Authority
- CY
- Cyprus
- Prior art keywords
- acid
- argatrovan
- solvent
- package containing
- argatroban
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Εδώ περιγράφεται μια υδατική, σταθερή, στείρα φαρμακευτική σύνθεση του αναστολέα της θρομβίνης αργατροβάνη εντός ενός διαλύματος που περιέχει ένα οξύ προς διαλυτοποίηση της αργατροβάνης, ουσιαστικώς ελεύθερη από άνυδρη αλκοόλη, καθώς και μια μέθοδος για την παραγωγή της.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71340305P | 2005-09-01 | 2005-09-01 | |
EP06802424A EP1948133B1 (en) | 2005-09-01 | 2006-08-28 | Argatroban formulation comprising an acid as solubilizer |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1112109T1 true CY1112109T1 (el) | 2015-11-04 |
Family
ID=37809398
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111100825T CY1112109T1 (el) | 2005-09-01 | 2011-08-30 | Σκευασμα αργατροβανης περιεχον ενα οξυ ως διαλυτοποιητη |
Country Status (23)
Country | Link |
---|---|
US (3) | US7642271B2 (el) |
EP (1) | EP1948133B1 (el) |
JP (1) | JP5189980B2 (el) |
KR (3) | KR101753949B1 (el) |
CN (2) | CN101257890B (el) |
AT (1) | ATE514416T1 (el) |
AU (1) | AU2006285097B2 (el) |
BR (1) | BRPI0616127B8 (el) |
CA (1) | CA2617920C (el) |
CY (1) | CY1112109T1 (el) |
DK (1) | DK1948133T3 (el) |
ES (1) | ES2368758T3 (el) |
HK (2) | HK1123193A1 (el) |
IL (2) | IL189290A (el) |
IN (1) | IN2015DN03947A (el) |
MX (1) | MX2008002177A (el) |
NZ (1) | NZ565821A (el) |
PL (1) | PL1948133T3 (el) |
PT (1) | PT1948133E (el) |
RU (1) | RU2416393C2 (el) |
SI (1) | SI1948133T1 (el) |
WO (1) | WO2007027565A2 (el) |
ZA (1) | ZA200802667B (el) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1948133B1 (en) * | 2005-09-01 | 2011-06-29 | BAXTER INTERNATIONAL INC. (a Delaware corporation) | Argatroban formulation comprising an acid as solubilizer |
US7589106B2 (en) | 2006-09-27 | 2009-09-15 | Eagle Pharmaceuticals, Inc. | Alcohol free formulation of argatroban |
US7687516B2 (en) * | 2006-09-27 | 2010-03-30 | Eagle Pharmaceuticals, Inc. | Alcohol free formulation of argatroban |
US20100076019A1 (en) * | 2006-10-11 | 2010-03-25 | Eagle Pharmaceuticals, Inc. | Alcohol free formulation of argatroban |
US20090221637A1 (en) * | 2008-02-29 | 2009-09-03 | Baxter International Inc. | Solid-state salt argatroban formulations and methods for producing and using the same |
US7915290B2 (en) | 2008-02-29 | 2011-03-29 | Baxter International Inc. | Argatroban formulations and methods for making and using same |
CN101598725B (zh) * | 2009-06-23 | 2012-07-18 | 南通大学附属医院 | 阿加曲班在血细胞和生化常规分析中的应用 |
ES2753981T3 (es) | 2010-10-21 | 2020-04-15 | Rtu Pharmaceuticals Llc | Formulaciones de ketorolaco listas para uso |
CN102119922A (zh) * | 2011-03-03 | 2011-07-13 | 天津市炜杰科技有限公司 | 以酸作为增溶剂的21(s)阿加曲班静脉注射液 |
CN102120026A (zh) * | 2011-03-03 | 2011-07-13 | 天津市炜杰科技有限公司 | 以醇作为增溶剂的21(s)阿加曲班静脉注射液 |
CN102228677A (zh) * | 2011-06-17 | 2011-11-02 | 天津市炜杰科技有限公司 | 以酸作为增溶剂的21(r)阿加曲班静脉注射液 |
TWI632921B (zh) * | 2011-10-19 | 2018-08-21 | 大塚製藥股份有限公司 | 口服溶液 |
EP3383494A4 (en) * | 2015-12-04 | 2019-08-07 | The Regents of The University of California | Histone deacetylase INHIBITORS |
CN107773533A (zh) * | 2016-08-26 | 2018-03-09 | 四川科瑞德制药股份有限公司 | 一种新型凝血酶抑制剂及其制备方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE420919B (sv) * | 1973-08-13 | 1981-11-09 | Mitsubishi Chem Ind | Forfarande for framstellning av n?722-dansyl-l-argininderivat och farmaceutiskt godtagbara syradditionssalter derav |
US5214052A (en) * | 1987-07-28 | 1993-05-25 | Mitsubishi Kasei Corporation | Method for dissolving arginineamides and pharmaceutical compositions containing them |
CA2091715A1 (en) | 1992-03-18 | 1993-09-19 | Mitsubishi Kasei Corporation | Argatroban preparations for ophthalmic use |
US5506241A (en) * | 1992-03-18 | 1996-04-09 | Mitsubishi Chemical Corporation | Argatroban preparations for ophthalmic use |
JPH06219948A (ja) * | 1993-01-25 | 1994-08-09 | Mitsubishi Kasei Corp | 抗トロンビン剤及びその製造方法 |
JPH06219949A (ja) * | 1993-01-25 | 1994-08-09 | Mitsubishi Kasei Corp | 抗トロンビン剤及びその製造方法 |
ATE177635T1 (de) | 1993-04-22 | 1999-04-15 | Senju Pharma Co | Wässrige arzneizubereitungen enthaltend argatroban und cyclodextrin oder coffein |
JPH07228532A (ja) * | 1993-04-22 | 1995-08-29 | Senju Pharmaceut Co Ltd | 水性液剤、その有効成分の溶解性向上方法および安定化方法 |
US5849843A (en) * | 1993-11-16 | 1998-12-15 | Baxter International Inc. | Polymeric compositions for medical packaging and devices |
US5998019A (en) * | 1993-11-16 | 1999-12-07 | Baxter International Inc. | Multi-layered polymer structure for medical products |
FR2715566B1 (fr) * | 1994-02-03 | 1996-03-08 | Synthelabo | Solutions aqueuses concentrées d'argatroban. |
US5840733A (en) * | 1996-07-01 | 1998-11-24 | Redcell, Canada, Inc. | Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes |
JPH10316569A (ja) * | 1997-05-19 | 1998-12-02 | Mitsubishi Chem Corp | アルガトロバンの可溶化方法及びそれによるアルガトロバン含有外用水性薬剤 |
CN100344624C (zh) * | 2003-03-20 | 2007-10-24 | 三菱制药株式会社 | 含有精氨酰胺类的医药制剂 |
WO2005009361A2 (en) | 2003-07-17 | 2005-02-03 | Smithkline Beecham Corporation | Method of treating hit patients with argatroban |
EP1948133B1 (en) * | 2005-09-01 | 2011-06-29 | BAXTER INTERNATIONAL INC. (a Delaware corporation) | Argatroban formulation comprising an acid as solubilizer |
-
2006
- 2006-08-28 EP EP06802424A patent/EP1948133B1/en not_active Not-in-force
- 2006-08-28 KR KR1020147000036A patent/KR101753949B1/ko active IP Right Grant
- 2006-08-28 JP JP2008529147A patent/JP5189980B2/ja not_active Expired - Fee Related
- 2006-08-28 PL PL06802424T patent/PL1948133T3/pl unknown
- 2006-08-28 RU RU2008112311/15A patent/RU2416393C2/ru active
- 2006-08-28 BR BRPI0616127A patent/BRPI0616127B8/pt not_active IP Right Cessation
- 2006-08-28 CA CA2617920A patent/CA2617920C/en not_active Expired - Fee Related
- 2006-08-28 CN CN2006800322085A patent/CN101257890B/zh not_active Expired - Fee Related
- 2006-08-28 CN CN201210353437.4A patent/CN102895179B/zh not_active Expired - Fee Related
- 2006-08-28 KR KR1020157025457A patent/KR20150108430A/ko not_active Application Discontinuation
- 2006-08-28 US US11/510,981 patent/US7642271B2/en active Active
- 2006-08-28 IN IN3947DEN2015 patent/IN2015DN03947A/en unknown
- 2006-08-28 DK DK06802424.9T patent/DK1948133T3/da active
- 2006-08-28 PT PT06802424T patent/PT1948133E/pt unknown
- 2006-08-28 MX MX2008002177A patent/MX2008002177A/es active IP Right Grant
- 2006-08-28 ES ES06802424T patent/ES2368758T3/es active Active
- 2006-08-28 AU AU2006285097A patent/AU2006285097B2/en not_active Ceased
- 2006-08-28 AT AT06802424T patent/ATE514416T1/de active
- 2006-08-28 NZ NZ565821A patent/NZ565821A/en not_active IP Right Cessation
- 2006-08-28 KR KR1020087007748A patent/KR20080042155A/ko active Application Filing
- 2006-08-28 WO PCT/US2006/033432 patent/WO2007027565A2/en active Application Filing
- 2006-08-28 SI SI200631063T patent/SI1948133T1/sl unknown
-
2008
- 2008-02-05 IL IL189290A patent/IL189290A/en active IP Right Grant
- 2008-03-26 ZA ZA200802667A patent/ZA200802667B/xx unknown
-
2009
- 2009-01-19 HK HK09100496.0A patent/HK1123193A1/xx not_active IP Right Cessation
- 2009-12-28 US US12/647,854 patent/US8034830B2/en active Active
- 2009-12-28 US US12/647,841 patent/US7985757B2/en active Active
-
2010
- 2010-09-16 IL IL208183A patent/IL208183A0/en unknown
-
2011
- 2011-08-30 CY CY20111100825T patent/CY1112109T1/el unknown
-
2013
- 2013-04-26 HK HK13105080.5A patent/HK1178053A1/xx not_active IP Right Cessation
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