ZA200802010B - Pyrimidine compounds as serotonin receptor modulators - Google Patents

Pyrimidine compounds as serotonin receptor modulators

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Publication number
ZA200802010B
ZA200802010B ZA200802010A ZA200802010A ZA200802010B ZA 200802010 B ZA200802010 B ZA 200802010B ZA 200802010 A ZA200802010 A ZA 200802010A ZA 200802010 A ZA200802010 A ZA 200802010A ZA 200802010 B ZA200802010 B ZA 200802010B
Authority
ZA
South Africa
Prior art keywords
receptor modulators
serotonin receptor
pyrimidine compounds
serotonin
pyrimidine
Prior art date
Application number
ZA200802010A
Other languages
English (en)
Inventor
Curt A Dvorak
Brock T Shireman
Dale A Rudolph
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ZA200802010B publication Critical patent/ZA200802010B/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems

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ZA200802010A 2005-08-04 2008-03-03 Pyrimidine compounds as serotonin receptor modulators ZA200802010B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70571905P 2005-08-04 2005-08-04

Publications (1)

Publication Number Publication Date
ZA200802010B true ZA200802010B (en) 2009-09-30

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ZA200802010A ZA200802010B (en) 2005-08-04 2008-03-03 Pyrimidine compounds as serotonin receptor modulators

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EP (1) EP1928461B1 (OSRAM)
JP (1) JP5066088B2 (OSRAM)
KR (1) KR101353268B1 (OSRAM)
CN (1) CN101277700B (OSRAM)
AT (1) ATE539753T1 (OSRAM)
AU (1) AU2006278759B2 (OSRAM)
BR (1) BRPI0614397A2 (OSRAM)
CA (1) CA2617760C (OSRAM)
CR (1) CR9791A (OSRAM)
EA (1) EA014495B1 (OSRAM)
IL (2) IL189164A (OSRAM)
NO (1) NO340744B1 (OSRAM)
NZ (1) NZ565334A (OSRAM)
UA (1) UA95247C2 (OSRAM)
WO (1) WO2007019083A1 (OSRAM)
ZA (1) ZA200802010B (OSRAM)

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DE602004019118D1 (de) 2003-09-17 2009-03-05 Janssen Pharmaceutica Nv Kondensierte heterocyclische verbindungen als modulatoren des serotoninrezeptors
US7598255B2 (en) * 2005-08-04 2009-10-06 Janssen Pharmaceutica Nv Pyrimidine compounds as serotonin receptor modulators
PE20080145A1 (es) * 2006-03-21 2008-02-11 Janssen Pharmaceutica Nv Tetrahidro-pirimidoazepinas como moduladores de trpv1
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EP3541790B1 (en) * 2016-11-15 2025-09-03 Temple University - Of The Commonwealth System of Higher Education 3-(2-(4-phenylpiperazin-1-yl)ethyl)-2-oxa-8-azaspiro[4.5]decan-1-one derivatives and related compounds as 5-hydroxytryptamine receptor 7 (5-ht7) modulators for treating e.g. inflammatory bowel disease, circadian rhythm disorder or depression
NZ759297A (en) 2017-05-31 2026-03-27 Chemocentryx Inc 6-5 fused rings as c5a inhibitors
WO2019126424A1 (en) * 2017-12-22 2019-06-27 Chemocentryx, Inc. DIARYL SUBSTITUTED 6,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS
SG11202009438UA (en) 2018-04-18 2020-11-27 Constellation Pharmaceuticals Inc Modulators of methyl modifying enzymes, compositions and uses thereof
CN112262143A (zh) 2018-05-21 2021-01-22 星座制药公司 甲基修饰酶的调节剂、其组合物和用途
KR102282569B1 (ko) * 2019-02-08 2021-07-29 (주)퓨쳐켐 새로운 18F-표지된 친디엔체와 테트라진 화합물과의 IeDDA 반응을 이용한 18F-표지 방법
PH12022550188A1 (en) 2019-07-24 2022-11-21 Constellation Pharmaceuticals Inc Crystalline forms of 7-chloro-2-(4-(3-methoxyazetidin-1-yl)cyclohexyl)-2,4-dimethyl-n-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzo[d][1,3]dioxole-5-carboxamide
KR102483492B1 (ko) * 2019-09-02 2023-01-02 한양대학교 에리카산학협력단 2,5-이치환된 피리미딘 유도체 및 이를 포함하는 약학적 조성물
MX2022005819A (es) * 2019-11-13 2022-08-16 Univ Temple Nuevas lactonas funcionalizadas como moduladores del receptor 7 de 5-hidroxitriptamina y su método de uso.
EP4313967B1 (en) 2021-03-29 2025-11-12 Gilead Sciences, Inc. Khk inhibitors
WO2023150619A2 (en) * 2022-02-02 2023-08-10 The Katholieke Universiteit Leuven Tetrahydropyridopyrimidines and related analogs for inhibiting yap/taz-tead
US12600723B2 (en) 2022-07-18 2026-04-14 Incyte Corporation Tetracyclic compounds as DGK inhibitors
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CN101277700A (zh) 2008-10-01
HK1118469A1 (en) 2009-02-13
JP2009503076A (ja) 2009-01-29
CN101277700B (zh) 2013-02-20
UA95247C2 (ru) 2011-07-25
EP1928461B1 (en) 2012-01-04
EP1928461A1 (en) 2008-06-11
CR9791A (es) 2010-05-27
BRPI0614397A2 (pt) 2011-03-29
NZ565334A (en) 2010-12-24
NO340744B1 (no) 2017-06-12
AU2006278759A1 (en) 2007-02-15
WO2007019083A1 (en) 2007-02-15
ATE539753T1 (de) 2012-01-15
CA2617760C (en) 2015-02-17
CA2617760A1 (en) 2007-02-15
KR101353268B1 (ko) 2014-02-06
NO20081034L (no) 2008-02-28
AU2006278759B2 (en) 2012-08-16
JP5066088B2 (ja) 2012-11-07
KR20080033502A (ko) 2008-04-16
EA200800525A1 (ru) 2008-06-30
IL189164A0 (en) 2008-08-07
EA014495B1 (ru) 2010-12-30
IL213679A0 (en) 2011-07-31
IL189164A (en) 2013-08-29

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