CN101277700B - 作为5-羟色胺受体调节剂的嘧啶化合物 - Google Patents

作为5-羟色胺受体调节剂的嘧啶化合物 Download PDF

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Publication number
CN101277700B
CN101277700B CN2006800364302A CN200680036430A CN101277700B CN 101277700 B CN101277700 B CN 101277700B CN 2006800364302 A CN2006800364302 A CN 2006800364302A CN 200680036430 A CN200680036430 A CN 200680036430A CN 101277700 B CN101277700 B CN 101277700B
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phenyl
pyrimidine
pyrido
tetrahydrochysene
fluoro
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CN101277700A (zh
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C·A·德沃拉克
D·A·鲁多夫
B·T·希尔曼
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Janssen Pharmaceutica NV
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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CN2006800364302A 2005-08-04 2006-07-27 作为5-羟色胺受体调节剂的嘧啶化合物 Expired - Fee Related CN101277700B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70571905P 2005-08-04 2005-08-04
US60/705,719 2005-08-04
PCT/US2006/029437 WO2007019083A1 (en) 2005-08-04 2006-07-27 Pyrimidine compounds as serotonin receptor modulators

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CN101277700A CN101277700A (zh) 2008-10-01
CN101277700B true CN101277700B (zh) 2013-02-20

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EP (1) EP1928461B1 (OSRAM)
JP (1) JP5066088B2 (OSRAM)
KR (1) KR101353268B1 (OSRAM)
CN (1) CN101277700B (OSRAM)
AT (1) ATE539753T1 (OSRAM)
AU (1) AU2006278759B2 (OSRAM)
BR (1) BRPI0614397A2 (OSRAM)
CA (1) CA2617760C (OSRAM)
CR (1) CR9791A (OSRAM)
EA (1) EA014495B1 (OSRAM)
IL (2) IL189164A (OSRAM)
NO (1) NO340744B1 (OSRAM)
NZ (1) NZ565334A (OSRAM)
UA (1) UA95247C2 (OSRAM)
WO (1) WO2007019083A1 (OSRAM)
ZA (1) ZA200802010B (OSRAM)

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US7598255B2 (en) * 2005-08-04 2009-10-06 Janssen Pharmaceutica Nv Pyrimidine compounds as serotonin receptor modulators
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CN107365314B (zh) * 2016-05-11 2024-09-27 国药集团国瑞药业有限公司 一种吡唑类化合物、其晶型及其制备方法
EP3541790B1 (en) * 2016-11-15 2025-09-03 Temple University - Of The Commonwealth System of Higher Education 3-(2-(4-phenylpiperazin-1-yl)ethyl)-2-oxa-8-azaspiro[4.5]decan-1-one derivatives and related compounds as 5-hydroxytryptamine receptor 7 (5-ht7) modulators for treating e.g. inflammatory bowel disease, circadian rhythm disorder or depression
NZ759297A (en) 2017-05-31 2026-03-27 Chemocentryx Inc 6-5 fused rings as c5a inhibitors
WO2019126424A1 (en) * 2017-12-22 2019-06-27 Chemocentryx, Inc. DIARYL SUBSTITUTED 6,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS
SG11202009438UA (en) 2018-04-18 2020-11-27 Constellation Pharmaceuticals Inc Modulators of methyl modifying enzymes, compositions and uses thereof
CN112262143A (zh) 2018-05-21 2021-01-22 星座制药公司 甲基修饰酶的调节剂、其组合物和用途
KR102282569B1 (ko) * 2019-02-08 2021-07-29 (주)퓨쳐켐 새로운 18F-표지된 친디엔체와 테트라진 화합물과의 IeDDA 반응을 이용한 18F-표지 방법
PH12022550188A1 (en) 2019-07-24 2022-11-21 Constellation Pharmaceuticals Inc Crystalline forms of 7-chloro-2-(4-(3-methoxyazetidin-1-yl)cyclohexyl)-2,4-dimethyl-n-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzo[d][1,3]dioxole-5-carboxamide
KR102483492B1 (ko) * 2019-09-02 2023-01-02 한양대학교 에리카산학협력단 2,5-이치환된 피리미딘 유도체 및 이를 포함하는 약학적 조성물
MX2022005819A (es) * 2019-11-13 2022-08-16 Univ Temple Nuevas lactonas funcionalizadas como moduladores del receptor 7 de 5-hidroxitriptamina y su método de uso.
EP4313967B1 (en) 2021-03-29 2025-11-12 Gilead Sciences, Inc. Khk inhibitors
WO2023150619A2 (en) * 2022-02-02 2023-08-10 The Katholieke Universiteit Leuven Tetrahydropyridopyrimidines and related analogs for inhibiting yap/taz-tead
US12600723B2 (en) 2022-07-18 2026-04-14 Incyte Corporation Tetracyclic compounds as DGK inhibitors
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