JP5066088B2 - セロトニン受容体モジュレーターとしてのピリミジン化合物 - Google Patents

セロトニン受容体モジュレーターとしてのピリミジン化合物 Download PDF

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Publication number
JP5066088B2
JP5066088B2 JP2008525054A JP2008525054A JP5066088B2 JP 5066088 B2 JP5066088 B2 JP 5066088B2 JP 2008525054 A JP2008525054 A JP 2008525054A JP 2008525054 A JP2008525054 A JP 2008525054A JP 5066088 B2 JP5066088 B2 JP 5066088B2
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tetrahydro
pyrido
phenyl
pyrimidine
fluoro
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JP2009503076A (ja
JP2009503076A5 (OSRAM
Inventor
ドボラク，カート・エイ
ルドルフ，デイル・エイ
シヤーマン，ブロツク・テイ
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems

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  • Pharmacology & Pharmacy (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nutrition Science (AREA)
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JP2008525054A 2005-08-04 2006-07-27 セロトニン受容体モジュレーターとしてのピリミジン化合物 Expired - Fee Related JP5066088B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70571905P 2005-08-04 2005-08-04
US60/705,719 2005-08-04
PCT/US2006/029437 WO2007019083A1 (en) 2005-08-04 2006-07-27 Pyrimidine compounds as serotonin receptor modulators

Publications (3)

Publication Number Publication Date
JP2009503076A JP2009503076A (ja) 2009-01-29
JP2009503076A5 JP2009503076A5 (OSRAM) 2009-08-13
JP5066088B2 true JP5066088B2 (ja) 2012-11-07

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JP2008525054A Expired - Fee Related JP5066088B2 (ja) 2005-08-04 2006-07-27 セロトニン受容体モジュレーターとしてのピリミジン化合物

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EP (1) EP1928461B1 (OSRAM)
JP (1) JP5066088B2 (OSRAM)
KR (1) KR101353268B1 (OSRAM)
CN (1) CN101277700B (OSRAM)
AT (1) ATE539753T1 (OSRAM)
AU (1) AU2006278759B2 (OSRAM)
BR (1) BRPI0614397A2 (OSRAM)
CA (1) CA2617760C (OSRAM)
CR (1) CR9791A (OSRAM)
EA (1) EA014495B1 (OSRAM)
IL (2) IL189164A (OSRAM)
NO (1) NO340744B1 (OSRAM)
NZ (1) NZ565334A (OSRAM)
UA (1) UA95247C2 (OSRAM)
WO (1) WO2007019083A1 (OSRAM)
ZA (1) ZA200802010B (OSRAM)

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US7598255B2 (en) * 2005-08-04 2009-10-06 Janssen Pharmaceutica Nv Pyrimidine compounds as serotonin receptor modulators
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CN107365314B (zh) * 2016-05-11 2024-09-27 国药集团国瑞药业有限公司 一种吡唑类化合物、其晶型及其制备方法
EP3541790B1 (en) * 2016-11-15 2025-09-03 Temple University - Of The Commonwealth System of Higher Education 3-(2-(4-phenylpiperazin-1-yl)ethyl)-2-oxa-8-azaspiro[4.5]decan-1-one derivatives and related compounds as 5-hydroxytryptamine receptor 7 (5-ht7) modulators for treating e.g. inflammatory bowel disease, circadian rhythm disorder or depression
NZ759297A (en) 2017-05-31 2026-03-27 Chemocentryx Inc 6-5 fused rings as c5a inhibitors
WO2019126424A1 (en) * 2017-12-22 2019-06-27 Chemocentryx, Inc. DIARYL SUBSTITUTED 6,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS
SG11202009438UA (en) 2018-04-18 2020-11-27 Constellation Pharmaceuticals Inc Modulators of methyl modifying enzymes, compositions and uses thereof
CN112262143A (zh) 2018-05-21 2021-01-22 星座制药公司 甲基修饰酶的调节剂、其组合物和用途
KR102282569B1 (ko) * 2019-02-08 2021-07-29 (주)퓨쳐켐 새로운 18F-표지된 친디엔체와 테트라진 화합물과의 IeDDA 반응을 이용한 18F-표지 방법
PH12022550188A1 (en) 2019-07-24 2022-11-21 Constellation Pharmaceuticals Inc Crystalline forms of 7-chloro-2-(4-(3-methoxyazetidin-1-yl)cyclohexyl)-2,4-dimethyl-n-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzo[d][1,3]dioxole-5-carboxamide
KR102483492B1 (ko) * 2019-09-02 2023-01-02 한양대학교 에리카산학협력단 2,5-이치환된 피리미딘 유도체 및 이를 포함하는 약학적 조성물
MX2022005819A (es) * 2019-11-13 2022-08-16 Univ Temple Nuevas lactonas funcionalizadas como moduladores del receptor 7 de 5-hidroxitriptamina y su método de uso.
EP4313967B1 (en) 2021-03-29 2025-11-12 Gilead Sciences, Inc. Khk inhibitors
WO2023150619A2 (en) * 2022-02-02 2023-08-10 The Katholieke Universiteit Leuven Tetrahydropyridopyrimidines and related analogs for inhibiting yap/taz-tead
US12600723B2 (en) 2022-07-18 2026-04-14 Incyte Corporation Tetracyclic compounds as DGK inhibitors
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CN101277700B (zh) 2013-02-20
UA95247C2 (ru) 2011-07-25
EP1928461B1 (en) 2012-01-04
EP1928461A1 (en) 2008-06-11
CR9791A (es) 2010-05-27
BRPI0614397A2 (pt) 2011-03-29
NZ565334A (en) 2010-12-24
NO340744B1 (no) 2017-06-12
AU2006278759A1 (en) 2007-02-15
WO2007019083A1 (en) 2007-02-15
ATE539753T1 (de) 2012-01-15
CA2617760C (en) 2015-02-17
CA2617760A1 (en) 2007-02-15
KR101353268B1 (ko) 2014-02-06
NO20081034L (no) 2008-02-28
AU2006278759B2 (en) 2012-08-16
KR20080033502A (ko) 2008-04-16
ZA200802010B (en) 2009-09-30
EA200800525A1 (ru) 2008-06-30
IL189164A0 (en) 2008-08-07
EA014495B1 (ru) 2010-12-30
IL213679A0 (en) 2011-07-31
IL189164A (en) 2013-08-29

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