ZA200704130B - Protassium salt of an HIV integrase inhibitor - Google Patents

Protassium salt of an HIV integrase inhibitor

Info

Publication number
ZA200704130B
ZA200704130B ZA200704130A ZA200704130A ZA200704130B ZA 200704130 B ZA200704130 B ZA 200704130B ZA 200704130 A ZA200704130 A ZA 200704130A ZA 200704130 A ZA200704130 A ZA 200704130A ZA 200704130 B ZA200704130 B ZA 200704130B
Authority
ZA
South Africa
Prior art keywords
protassium
salt
hiv integrase
integrase inhibitor
inhibitor
Prior art date
Application number
ZA200704130A
Other languages
English (en)
Inventor
Kevin M Belyk
Henry G Morrison
Jones Philip
Summa Vincenzo
Original Assignee
Merck & Co Inc
Angeletti P Ist Richerche Bio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36171569&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200704130(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc, Angeletti P Ist Richerche Bio filed Critical Merck & Co Inc
Publication of ZA200704130B publication Critical patent/ZA200704130B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/422Oxazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D313/00Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02Seven-membered rings
    • C07D313/06Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12[b,e]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA200704130A 2004-12-03 2007-05-22 Protassium salt of an HIV integrase inhibitor ZA200704130B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63313204P 2004-12-03 2004-12-03

Publications (1)

Publication Number Publication Date
ZA200704130B true ZA200704130B (en) 2008-08-27

Family

ID=36171569

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200704130A ZA200704130B (en) 2004-12-03 2007-05-22 Protassium salt of an HIV integrase inhibitor

Country Status (35)

Country Link
US (2) US7754731B2 (OSRAM)
EP (2) EP1819683B1 (OSRAM)
JP (1) JP4705956B2 (OSRAM)
KR (2) KR101350420B1 (OSRAM)
CN (1) CN101068793B (OSRAM)
AR (2) AR052034A1 (OSRAM)
AT (2) ATE534645T1 (OSRAM)
AU (1) AU2005311671B8 (OSRAM)
BR (1) BRPI0518760A8 (OSRAM)
CA (1) CA2588398C (OSRAM)
CR (1) CR9146A (OSRAM)
CY (1) CY1112859T1 (OSRAM)
DK (1) DK1819700T3 (OSRAM)
EA (1) EA012418B1 (OSRAM)
ES (2) ES2375788T3 (OSRAM)
GE (1) GEP20105086B (OSRAM)
HR (1) HRP20120066T1 (OSRAM)
IL (1) IL183614A (OSRAM)
MA (1) MA29120B1 (OSRAM)
ME (1) ME01985B (OSRAM)
MX (1) MX2007006639A (OSRAM)
MY (1) MY144320A (OSRAM)
NI (1) NI200700138A (OSRAM)
NO (1) NO338784B1 (OSRAM)
NZ (1) NZ555376A (OSRAM)
PE (1) PE20061148A1 (OSRAM)
PL (1) PL1819700T3 (OSRAM)
PT (1) PT1819700E (OSRAM)
RS (1) RS52197B (OSRAM)
SI (1) SI1819700T1 (OSRAM)
TN (1) TNSN07215A1 (OSRAM)
TW (1) TWI344463B (OSRAM)
UA (1) UA87884C2 (OSRAM)
WO (2) WO2006060712A2 (OSRAM)
ZA (1) ZA200704130B (OSRAM)

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AU2007275805A1 (en) 2006-07-19 2008-01-24 University Of Georgia Research Foundation, Inc. Pyridinone diketo acids: Inhibitors of HIV replication in combination therapy
US7687509B2 (en) * 2007-07-09 2010-03-30 Concert Pharmaceuticals Inc. Pyrimidinecarboxamide derivatives
CN103254138A (zh) * 2008-01-08 2013-08-21 默沙东公司 用于制备n-取代的羟基嘧啶酮羧酰胺类化合物的方法
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WO2011024192A2 (en) 2009-07-27 2011-03-03 Matrix Laboratories Ltd Novel polymorphs of raltegravir
HUE057248T2 (hu) * 2009-10-26 2022-04-28 Merck Sharp & Dohme Integráz inhibitort tartalmazó szilárd gyógyszerészeti kompozíciók
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CN101914067B (zh) * 2010-08-26 2012-07-11 陈岱岭 N-甲基嘧啶酮的合成方法
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WO2012106534A2 (en) * 2011-02-02 2012-08-09 The Regents Of The University Of California Hiv integrase inhibitors
AU2012241050B2 (en) 2011-04-06 2016-05-19 Lupin Limited Novel salts of raltegravir
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EP2522665A1 (en) * 2011-05-03 2012-11-14 Sandoz Ag Crystalline sodium salt of an HIV integrase inhibitor
EP2529741B1 (en) 2011-06-01 2014-02-12 Ratiopharm GmbH Composition and Tablet Comprising Raltegravir
WO2013037731A1 (de) 2011-09-16 2013-03-21 Hexal Ag Neue polymorphe form von raltegravir-kalium
CN103130787B (zh) * 2011-11-24 2015-06-10 南开大学 嘧啶酮酰胺类化合物及其制备方法、抗hiv活性和抗tmv活性
CN103130788B (zh) * 2011-11-24 2015-09-02 南开大学 嘧啶酰胺类化合物及其制备方法、抗hiv活性和抗tmv活性
WO2013098854A2 (en) * 2011-12-26 2013-07-04 Emcure Pharmaceuticals Limited Synthesis of raltegravir
JP2015504913A (ja) 2012-01-25 2015-02-16 ルピン・リミテッドLupin Limited 安定な非晶質のラルテグラビルカリウムプレミックス、及び、その調製方法
WO2014064711A2 (en) * 2012-10-22 2014-05-01 Hetero Research Foundation Methods of administering raltegravir and raltegravir compositions
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US10391178B2 (en) 2014-03-21 2019-08-27 Mylan Laboratories Limited Premix of crystalline raltegravir potassium salt and a process for the preparation thereof
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EP3472134B1 (en) 2016-06-21 2021-10-20 Pharmathen S.A. Process for preparing compounds useful as intermediates for the preparation of raltegravir
US10752618B2 (en) 2016-09-15 2020-08-25 Lupin Limited Process for the preparation of pure and stable crystalline Raltegravir potassium form 3
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US8852632B2 (en) * 2004-12-03 2014-10-07 Merck Sharp & Dohme Corp. Pharmaceutical formulation containing a release rate controlling composition
TR201907729T4 (tr) 2004-12-03 2019-06-21 Merck Sharp & Dohme Bir anti-çekirdekleştirici ajan içeren farmasötik bileşim.
US20070259894A1 (en) 2004-12-03 2007-11-08 Kelem Kassahun Use of Atazanavir for Improving the Pharmacokinetics of Drugs Metabolized by Ugt1a1

Also Published As

Publication number Publication date
BRPI0518760A8 (pt) 2017-12-12
ATE518844T1 (de) 2011-08-15
HRP20120066T1 (hr) 2012-03-31
MY144320A (en) 2011-08-29
CN101068793A (zh) 2007-11-07
NO20073404L (no) 2007-07-02
EA200701204A1 (ru) 2007-12-28
NO338784B1 (no) 2016-10-17
HK1115011A1 (en) 2008-11-14
IL183614A (en) 2012-03-29
KR20130122031A (ko) 2013-11-06
PL1819700T3 (pl) 2012-04-30
EP1819700B1 (en) 2011-11-23
MX2007006639A (es) 2007-06-19
GEP20105086B (en) 2010-10-11
TNSN07215A1 (en) 2008-11-21
JP2008521933A (ja) 2008-06-26
CN101068793B (zh) 2011-05-25
CA2588398C (en) 2011-07-12
WO2006060712A3 (en) 2006-09-21
KR20070089990A (ko) 2007-09-04
TWI344463B (en) 2011-07-01
AR052034A1 (es) 2007-02-28
TW200631944A (en) 2006-09-16
PE20061148A1 (es) 2006-11-09
JP4705956B2 (ja) 2011-06-22
CA2588398A1 (en) 2006-06-08
RS52197B (sr) 2012-10-31
US20060122205A1 (en) 2006-06-08
ES2370136T3 (es) 2011-12-13
MA29120B1 (fr) 2007-12-03
IL183614A0 (en) 2007-09-20
UA87884C2 (uk) 2009-08-25
US8357798B2 (en) 2013-01-22
NI200700138A (es) 2008-05-13
PT1819700E (pt) 2012-02-01
AR101429A2 (es) 2016-12-21
AU2005311671B2 (en) 2011-01-27
WO2006060730A2 (en) 2006-06-08
ES2375788T3 (es) 2012-03-06
DK1819700T3 (da) 2012-03-19
EP1819683B1 (en) 2011-08-03
CR9146A (es) 2007-10-04
EP1819683A2 (en) 2007-08-22
NZ555376A (en) 2009-11-27
SI1819700T1 (sl) 2012-07-31
AU2005311671B8 (en) 2011-02-10
AU2005311671A1 (en) 2006-06-08
WO2006060730A3 (en) 2006-08-17
EA012418B1 (ru) 2009-10-30
BRPI0518760A2 (pt) 2008-12-09
US20100249410A1 (en) 2010-09-30
US7754731B2 (en) 2010-07-13
WO2006060712A9 (en) 2006-07-27
WO2006060712A2 (en) 2006-06-08
ME01985B (me) 2012-10-31
KR101350420B1 (ko) 2014-02-17
EP1819700A2 (en) 2007-08-22
ATE534645T1 (de) 2011-12-15
CY1112859T1 (el) 2016-04-13

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