ZA200609237B - CXCR1 and CXCR2 chemokine antagonists - Google Patents

CXCR1 and CXCR2 chemokine antagonists

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Publication number
ZA200609237B
ZA200609237B ZA200609237A ZA200609237A ZA200609237B ZA 200609237 B ZA200609237 B ZA 200609237B ZA 200609237 A ZA200609237 A ZA 200609237A ZA 200609237 A ZA200609237 A ZA 200609237A ZA 200609237 B ZA200609237 B ZA 200609237B
Authority
ZA
South Africa
Prior art keywords
cxcr1
chemokine antagonists
cxcr2 chemokine
cxcr2
antagonists
Prior art date
Application number
ZA200609237A
Other languages
English (en)
Inventor
Chao Jianhua
Cynthia J Aki
Fine Jay
Reggiani Angelo
Arthur G Taveras
Lundell Daniel
Priestley Tony
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of ZA200609237B publication Critical patent/ZA200609237B/xx

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    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005008183A1 (de) * 2005-02-23 2006-08-31 Bayer Healthcare Ag Heterocyclylamid-substituierte Imidazole
EA014958B1 (ru) * 2006-04-21 2011-04-29 Смитклайн Бичам Корпорейшн Антагонисты рецептора il-8
NZ573352A (en) * 2006-06-08 2011-10-28 Lilly Co Eli Substituted carboxamides as group i metabotropic receptor antagonists
CA2664359A1 (en) * 2006-09-26 2008-04-03 Case Western Reserve University Cytokine signaling
CA2669579A1 (en) * 2006-11-23 2008-05-29 Novartis Ag 5-sulfanylmethyl-pyrazolo [1,5-a] pyrimidin-7-ol derivatives as cxcr2 antagonists
EP2094696B1 (en) * 2006-11-23 2010-10-13 Novartis AG 5-sulfanylmethyl-[1,2,4] triazol[1, 5-a] pyrimidin-7-ol derivatives as cxcr2 antagonists
WO2008105408A1 (ja) 2007-02-26 2008-09-04 Santen Pharmaceutical Co., Ltd. ウレイド基とアミノカルボニル基を置換基として有する新規ピロール誘導体
WO2009026248A2 (en) * 2007-08-17 2009-02-26 The Government Of The United States, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health, Office Of Technology Transfer Hydrazide, amide, phthalimide and phthalhydrazide analogs as inhibitors of retroviral integrase
KR101039235B1 (ko) * 2007-08-29 2011-06-07 메디포스트(주) 제대혈 유래 간엽줄기세포를 포함하는 인터루킨-8 또는지알오-알파 발현 세포가 관련된 질병의 진단, 예방 또는치료용 조성물
GB2455539B (en) * 2007-12-12 2012-01-18 Cambridge Entpr Ltd Anti-inflammatory compositions and combinations
JP2010043063A (ja) * 2008-05-09 2010-02-25 Agency For Science Technology & Research 川崎病の診断及び治療
KR20110093893A (ko) 2008-11-11 2011-08-18 더 리젠츠 오브 더 유니버시티 오브 미시간 항-cxcr1 조성물 및 방법
BR112013005108A2 (pt) * 2010-09-03 2016-05-10 Forma Tm Llc compostos e composições de guanidina para a inibição de nampt
ES2688081T3 (es) * 2011-06-13 2018-10-30 Tla Targeted Immunotherapies Ab Tratamiento de dolencias asociadas a septicemia
WO2013148370A1 (en) 2012-03-30 2013-10-03 Sloan-Kettering Institute For Cancer Research S100a8/a9 as a diagnostic marker and a therapeutic target
AU2013331626B2 (en) * 2012-10-15 2018-08-02 Agios Pharmaceuticals, Inc. Therapeutic compounds and compositions
US8865723B2 (en) 2012-10-25 2014-10-21 Tetra Discovery Partners Llc Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury
JP2016528185A (ja) 2013-06-18 2016-09-15 ニューヨーク・ユニバーシティ 黄色ブドウ球菌ロイコシジンの細胞毒性に関与する細胞因子:新規治療標的
JP2016534049A (ja) * 2013-10-08 2016-11-04 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイションTemple University−Of The Commonwealth System Of Higher Education 内皮リパーゼ阻害を示す官能基化フラン−2−スルホンアミド
US9763992B2 (en) 2014-02-13 2017-09-19 Father Flanagan's Boys' Home Treatment of noise induced hearing loss
JP6667187B2 (ja) * 2014-09-26 2020-03-18 シファ バイオメディカル コーポレーション 抗内皮リパーゼ化合物並びに心血管疾患の治療および/または予防におけるその使用方法
BR112018003515A2 (pt) * 2015-09-04 2018-09-18 Dow Agrosciences Llc moléculas tendo utilidade pesticida, e intermediários, composições e processos relacionados às mesmas
US10647665B2 (en) * 2016-06-22 2020-05-12 Fudan University Biaryl urea derivative or salt thereof and preparation process and use for the same
US20190216790A1 (en) * 2016-10-13 2019-07-18 The Regents Of The University Of California Methods for Treating Pruritis
EP3551047A1 (en) 2016-12-07 2019-10-16 Progenity, Inc. Gastrointestinal tract detection methods, devices and systems
CA3045310A1 (en) 2016-12-14 2018-06-21 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor
AU2019383976A1 (en) 2018-11-19 2021-06-10 Biora Therapeutics, Inc. Methods and devices for treating a disease with biotherapeutics
WO2021119482A1 (en) 2019-12-13 2021-06-17 Progenity, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3529247A1 (de) * 1985-05-17 1986-11-20 Bayer Ag, 5090 Leverkusen Verwendung von thienylharnstoffen und -isoharnstoffen als leistungsfoerdernde mittel bei tieren, neue thienylharnstoffe und -isoharnstoffe und ihre herstellung
DE3785507T2 (de) * 1986-07-31 1993-07-29 Beecham Group Plc Azabicyclische verbindungen, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung.
DE4412334A1 (de) * 1994-04-11 1995-10-19 Hoechst Ag Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US5780483A (en) * 1995-02-17 1998-07-14 Smithkline Beecham Corporation IL-8 receptor antagonists
WO1996025157A1 (en) * 1995-02-17 1996-08-22 Smithkline Beecham Corporation Il-8 receptor antagonists
JP2000514049A (ja) 1996-06-27 2000-10-24 スミスクライン・ビーチャム・コーポレイション Il―8受容体拮抗薬
WO1997049400A1 (en) 1996-06-27 1997-12-31 Smithkline Beecham Corporation Il-8 receptor antagonists
JP2000513359A (ja) 1996-06-27 2000-10-10 スミスクライン・ビーチャム・コーポレイション Il―8受容体拮抗薬
AU3499497A (en) 1996-06-27 1998-01-14 Smithkline Beecham Corporation Il-8 receptor antagonists
JP2000515495A (ja) 1996-06-27 2000-11-21 スミスクライン・ビーチャム・コーポレイション Il―8レセプターアンタゴニスト
EP0948330A4 (en) 1996-08-06 1999-12-01 Smithkline Beecham Corp COOLING ANTENNA WITH CURVED SEGMENTS
JP2001523220A (ja) 1996-08-06 2001-11-20 スミスクライン・ビーチャム・コーポレイション Il―8受容体アンタゴニスト
WO1998005329A1 (en) 1996-08-06 1998-02-12 Smithkline Beecham Corporation Il-8 receptor antagonists
US6335352B1 (en) 1996-08-15 2002-01-01 Smithkline Beecham Corporation IL-8 receptor antagonists
WO1998006398A1 (en) 1996-08-15 1998-02-19 Smithkline Beecham Corporation Il-8 receptor antagonists
WO1998006262A1 (en) 1996-08-15 1998-02-19 Smithkline Beecham Corporation Il-8 receptor antagonists
AR008290A1 (es) 1996-08-15 1999-12-29 Smithkline Beecham Corp Nuevos compuestos que contienen guanidina utiles como antagonistas de los receptores de il-8, composiciones farmaceuticas que los contienenprocedimiento para la preparacion de dichos compuestos y procedimiento para la preparacion de intermediarios.
JP2001501918A (ja) 1996-08-21 2001-02-13 スミスクライン・ビーチャム・コーポレイション Il―8レセプターアンタゴニスト
AU726858B2 (en) 1997-01-23 2000-11-23 Smithkline Beecham Corporation IL-8 receptor antagonists
AR008331A1 (es) 1997-01-23 1999-12-29 Smithkline Beecham Corp Compuestos antagonistas de un receptor de il-8, uso de los mismos para la fabricacion de medicamentos, procedimiento para su obtencion, composicionesfarmaceuticas que los contienen
AR015425A1 (es) 1997-09-05 2001-05-02 Smithkline Beecham Corp Compuestos de benzotiazol, composicion farmaceutica que los contiene, su uso en la manufactura de un medicamento, procedimiento para su preparacion,compuestos intermediarios y procedimiento para su preparacion
AR015426A1 (es) 1997-09-05 2001-05-02 Smithkline Beecham Corp Compuestos de benzotiazol antagonistas del receptor de il-8, composicion farmaceutica que los contiene, su uso para la manufactura de un medicamento,procedimiento para su preparacion, compuestos intermediarios y procedimiento para su preparacion
CZ299156B6 (cs) * 1997-12-22 2008-05-07 Bayer Corporation Substituované heterocyklické mocoviny, farmaceutické prípravky je obsahující a jejich použití
EP1047424A4 (en) 1998-01-20 2002-05-22 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
US6525069B1 (en) * 1998-12-18 2003-02-25 Bristol-Myers Squibb Pharma Co. N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
CO5200760A1 (es) * 1999-06-16 2002-09-27 Smithkline Beecham Corp Antagonistas del receptor de la il-8 ceptor il-8
PE20010321A1 (es) 1999-06-16 2001-05-18 Smithkline Beecham Corp Antagonistas de los receptores de la il-8
WO2001007029A2 (en) * 1999-07-21 2001-02-01 Kadmus Pharmaceuticals, Inc. Substituted guanidines and the use thereof
EP1104759B1 (en) * 1999-12-03 2003-10-22 Pfizer Products Inc. Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents
EP1265905A4 (en) 2000-03-01 2003-03-12 Smithkline Beecham Corp IL-2 RECEPTOR ANTAGONISTS
AU2001241896A1 (en) 2000-03-01 2001-09-12 Smith Kline Beecham Corporation Il-8 receptor antagonists
CO5280089A1 (es) 2000-03-16 2003-05-30 Smithkline Beecham Corp Antagonistas del receptor il-8
UY26627A1 (es) 2000-03-24 2001-09-28 Smithkline Beecham Corp Antagonistas de receptores de il-8
JP2004516238A (ja) * 2000-06-21 2004-06-03 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー ケモカイン受容体活性調節剤としてのn−ウレイドアルキル−ピペリジン
US20030097004A1 (en) 2001-02-02 2003-05-22 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC chemokine receptor antagonists
US20040106794A1 (en) * 2001-04-16 2004-06-03 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
US7132445B2 (en) * 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
EP1270551A1 (en) * 2001-06-26 2003-01-02 Aventis Pharma Deutschland GmbH Urea derivatives with antiproteolytic activity
AUPR738301A0 (en) * 2001-08-30 2001-09-20 Starpharma Limited Chemotherapeutic agents
JP2005505595A (ja) * 2001-10-12 2005-02-24 シェーリング コーポレイション Cxc−ケモカインレセプターアンタゴニストとしての3,4−二置換マレイミド化合物
US6878709B2 (en) * 2002-01-04 2005-04-12 Schering Corporation 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
EP1485089B1 (en) * 2002-03-18 2013-04-17 Merck Sharp & Dohme Corp. Combination treatments for chemokine-mediated diseases
EP1402888A1 (en) * 2002-09-18 2004-03-31 Jerini AG The use of substituted carbocyclic compounds as rotamases inhibitors
MXPA05003867A (es) 2002-10-09 2005-11-23 Schering Corp Tiadiazoldioxidos y tiadiazoloxidos como ligandos de receptor cxc-y cc-quimiocina.
CN1918138B (zh) * 2003-12-19 2011-05-04 先灵公司 作为cxc-和cc-趋化因子受体配体的噻二唑化合物
US7671212B2 (en) * 2003-12-22 2010-03-02 Schering Corporation Isothiazole dioxides as CXC- and CC-chemokine receptor ligands
ES2353401T3 (es) * 2005-06-29 2011-03-01 Schering Corporation Oxidiazolopirazinas y tiadiazolopirazinas 5,6-di-sustituidas como ligandos del receptor de cxc-quimiocina.
US7718678B2 (en) * 2005-06-29 2010-05-18 Schering Corporation Di-substituted oxadiazoles as CXC-chemokine receptor ligands

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