ZA200607053B - Novel compounds as inhibitors of hepatitis C virus NS3 serine protease - Google Patents
Novel compounds as inhibitors of hepatitis C virus NS3 serine proteaseInfo
- Publication number
- ZA200607053B ZA200607053B ZA200606953A ZA200607053A ZA200607053B ZA 200607053 B ZA200607053 B ZA 200607053B ZA 200606953 A ZA200606953 A ZA 200606953A ZA 200607053 A ZA200607053 A ZA 200607053A ZA 200607053 B ZA200607053 B ZA 200607053B
- Authority
- ZA
- South Africa
- Prior art keywords
- hepatitis
- virus
- inhibitors
- novel compounds
- serine protease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54853504P | 2004-02-27 | 2004-02-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200607053B true ZA200607053B (en) | 2009-02-25 |
Family
ID=34962125
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200606953A ZA200607053B (en) | 2004-02-27 | 2006-08-23 | Novel compounds as inhibitors of hepatitis C virus NS3 serine protease |
Country Status (20)
Country | Link |
---|---|
US (2) | US7186747B2 (ja) |
EP (2) | EP1939213B1 (ja) |
JP (1) | JP2007525511A (ja) |
KR (1) | KR20060124729A (ja) |
CN (1) | CN1972956A (ja) |
AR (1) | AR047903A1 (ja) |
AT (2) | ATE478889T1 (ja) |
AU (1) | AU2005222056A1 (ja) |
BR (1) | BRPI0508186A (ja) |
CA (1) | CA2557249A1 (ja) |
DE (2) | DE602005015093D1 (ja) |
EC (1) | ECSP066794A (ja) |
ES (2) | ES2327544T3 (ja) |
HK (2) | HK1095837A1 (ja) |
IL (1) | IL177627A0 (ja) |
NO (1) | NO20064357L (ja) |
RU (1) | RU2006134002A (ja) |
TW (1) | TW200529823A (ja) |
WO (1) | WO2005087725A2 (ja) |
ZA (1) | ZA200607053B (ja) |
Families Citing this family (59)
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US7491794B2 (en) * | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
US20060276406A1 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Methods of treating hepatitis C virus |
WO2006130607A2 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Controlled-release formulation useful for treating disorders associated with hepatitis c virus |
US20070237818A1 (en) * | 2005-06-02 | 2007-10-11 | Malcolm Bruce A | Controlled-release formulation of HCV protease inhibitor and methods using the same |
AU2006252553B2 (en) * | 2005-06-02 | 2012-03-29 | Merck Sharp & Dohme Corp. | Combination of HCV protease inhibitors with a surfactant |
US20060275366A1 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Controlled-release formulation |
WO2006130554A2 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Methods of treating hepatitis c virus |
US20070021351A1 (en) * | 2005-06-02 | 2007-01-25 | Schering Corporation | Liver/plasma concentration ratio for dosing hepatitis C virus protease inhibitor |
WO2006130686A2 (en) | 2005-06-02 | 2006-12-07 | Schering Corporation | Hcv protease inhibitors in combination with food |
US20060276404A1 (en) * | 2005-06-02 | 2006-12-07 | Anima Ghosal | Medicaments and methods combining a HCV protease inhibitor and an AKR competitor |
US20060281689A1 (en) * | 2005-06-02 | 2006-12-14 | Schering Corporation | Method for modulating activity of HCV protease through use of a novel HCV protease inhibitor to reduce duration of treatment period |
BRPI0613962A2 (pt) | 2005-07-25 | 2009-03-24 | Intermune Inc | inibidores macrocìclicos inovadores de replicação de vìrus da hepatite c |
AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
GEP20104956B (en) | 2005-10-11 | 2010-04-12 | Array Biopharma Inc | Compounds for inhibiting hepatitis c viral replication and use thereof |
US7705138B2 (en) | 2005-11-11 | 2010-04-27 | Vertex Pharmaceuticals Incorporated | Hepatitis C virus variants |
EP2392589A3 (en) | 2005-11-11 | 2012-06-20 | Vertex Pharmaceuticals Incorporated | Hepatitis C virus variants |
US7816348B2 (en) | 2006-02-03 | 2010-10-19 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
CN101322175B (zh) | 2006-02-14 | 2011-08-17 | 松下电器产业株式会社 | 等离子体显示面板的驱动方法和等离子体显示装置 |
KR20090024834A (ko) * | 2006-07-05 | 2009-03-09 | 인터뮨, 인크. | C형 간염 바이러스 복제의 신규 억제제 |
US20090098085A1 (en) * | 2006-08-11 | 2009-04-16 | Ying Sun | Tetrazolyl acyclic hepatitis c serine protease inhibitors |
RU2009109355A (ru) | 2006-08-17 | 2010-09-27 | БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) | Ингибиторы вырусной полимеразы |
KR20090049600A (ko) * | 2006-09-13 | 2009-05-18 | 노파르티스 아게 | 마크로시클릭 hcv 억제제 및 그의 용도 |
MX2009006056A (es) | 2006-12-07 | 2009-06-16 | Schering Corp | Formulacion de matriz sensible al ph. |
US7910587B2 (en) * | 2007-04-26 | 2011-03-22 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl dipeptide hepatitis C virus inhibitors |
NZ581606A (en) * | 2007-05-03 | 2012-06-29 | Intermune Inc | Novel macrocyclic inhibitors of hepatitis c virus replication |
AU2008251425A1 (en) | 2007-05-10 | 2008-11-20 | Array Biopharma, Inc. | Novel peptide inhibitors of hepatitis C virus replication |
US8242140B2 (en) | 2007-08-03 | 2012-08-14 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US8419332B2 (en) * | 2007-10-19 | 2013-04-16 | Atlas Bolt & Screw Company Llc | Non-dimpling fastener |
JP5623289B2 (ja) | 2007-12-19 | 2014-11-12 | ベーリンガーインゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ウイルスポリメラーゼインヒビター |
AP2010005416A0 (en) | 2008-04-15 | 2010-10-31 | Intermune Inc | Novel macrocyclic inhibitors of hepatitis c virus replication. |
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JP2013541499A (ja) | 2010-07-26 | 2013-11-14 | メルク・シャープ・エンド・ドーム・コーポレイション | 置換されたビフェニレン化合物およびウイルス性疾患の治療のためのその使用方法 |
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US9156872B2 (en) | 2011-04-13 | 2015-10-13 | Merck Sharp & Dohme Corp. | 2′-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
BR112013026345A2 (pt) | 2011-04-13 | 2019-04-24 | Merck Sharp & Dohe Corp. | composto, composição farmacêutica, uso de um composto, e, método para tratar um paciente infectado com hcv |
US9540343B2 (en) | 2011-07-06 | 2017-01-10 | Gilead Sciences, Inc. | Compounds for the treatment of HIV |
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EP2755981A4 (en) | 2011-09-14 | 2015-03-25 | Merck Sharp & Dohme | HETEROCYCLIC COMPOUNDS CONTAINING SILYL AND METHODS OF USING THE SAME FOR TREATING VIRAL DISEASES |
WO2015065817A1 (en) | 2013-10-30 | 2015-05-07 | Merck Sharp & Dohme Corp. | Pseudopolymorphs of an hcv ns5a inhibitor and uses thereof |
CA3021227C (en) | 2016-08-19 | 2020-11-03 | Gilead Sciences, Inc. | Therapeutic compounds useful for the prophylactic or therapeutic treatment of an hiv virus infection |
AR112412A1 (es) | 2017-08-17 | 2019-10-23 | Gilead Sciences Inc | Formas de sal de colina de un inhibidor de la cápside del vih |
TW202024061A (zh) | 2017-08-17 | 2020-07-01 | 美商基利科學股份有限公司 | Hiv蛋白質膜抑制劑之固體形式 |
KR102587510B1 (ko) | 2018-02-15 | 2023-10-11 | 길리애드 사이언시즈, 인코포레이티드 | 피리딘 유도체 및 hiv 감염을 치료하기 위한 그의 용도 |
CA3090280A1 (en) | 2018-02-16 | 2019-08-22 | Gilead Sciences, Inc. | Methods and intermediates for preparing therapeutic compounds useful in the treatment of retroviridae viral infection |
JP2021530523A (ja) | 2018-07-16 | 2021-11-11 | ギリアード サイエンシーズ, インコーポレイテッド | Hivの処置のためのカプシド阻害剤 |
CN114727999A (zh) | 2019-11-26 | 2022-07-08 | 吉利德科学公司 | 用于预防hiv的衣壳抑制剂 |
CA3181690A1 (en) | 2020-06-25 | 2021-12-30 | Chienhung CHOU | Capsid inhibitors for the treatment of hiv |
US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
WO2023102239A1 (en) | 2021-12-03 | 2023-06-08 | Gilead Sciences, Inc. | Therapeutic compounds for hiv virus infection |
CN114133350B (zh) * | 2021-12-16 | 2023-05-23 | 浙江乐普药业股份有限公司 | 一种抗新冠药物Paxlovid中间体的制备方法 |
WO2023151188A1 (zh) * | 2022-02-08 | 2023-08-17 | 上海皓元医药股份有限公司 | 一种抗病毒药物中间体的绿色合成方法 |
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ES2012739T5 (es) | 1987-11-18 | 2001-12-01 | Chiron Corp | Diagnosticos para nanbv. |
DE69024378T2 (de) | 1989-02-01 | 1996-09-12 | Asahi Glass Co. Ltd., Tokio/Tokyo | Azeotrope oder azeotropähnliche Zusammensetzung auf der Basis von Chlorfluorkohlenwasserstoffen |
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US5922757A (en) | 1996-09-30 | 1999-07-13 | The Regents Of The University Of California | Treatment and prevention of hepatic disorders |
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GB9623908D0 (en) | 1996-11-18 | 1997-01-08 | Hoffmann La Roche | Amino acid derivatives |
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AR022061A1 (es) | 1998-08-10 | 2002-09-04 | Boehringer Ingelheim Ca Ltd | Peptidos inhibidores de la hepatitis c, una composicion farmaceutica que los contiene, el uso de los mismos para preparar una composicion farmaceutica, el uso de un producto intermedio para la preparacion de estos peptidos y un procedimiento para la preparacion de un peptido analogo de los mismos. |
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UA74546C2 (en) | 1999-04-06 | 2006-01-16 | Boehringer Ingelheim Ca Ltd | Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition |
DE60111509T2 (de) | 2000-04-03 | 2006-05-11 | Vertex Pharmaceuticals Inc., Cambridge | Inhibitoren von Serin-Proteasen, insbesondere der Hepatitis-C-Virus NS23-Protease |
PL359359A1 (en) | 2000-04-05 | 2004-08-23 | Schering Corporation | Macrocyclic ns3-serine protease inhibitors of hepatitis c virus comprising n-cyclic p2 moieties |
CZ20023473A3 (cs) | 2000-04-19 | 2003-01-15 | Schering Corporation | Makrocyklická sloučenina a farmaceutický prostředek |
AR029851A1 (es) | 2000-07-21 | 2003-07-16 | Dendreon Corp | Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c |
EP1301527A2 (en) | 2000-07-21 | 2003-04-16 | Corvas International, Inc. | Peptides as ns3-serine protease inhibitors of hepatitis c virus |
RU2355700C9 (ru) * | 2000-07-21 | 2010-03-20 | Шеринг Корпорейшн | Новые пептиды как ингибиторы ns3-серинпротеазы вируса гепатита с |
BR0112666A (pt) | 2000-07-21 | 2003-06-10 | Schering Corp | Peptìdeos como inibidores de ns3-serina protease de vìrus da hepatite c |
AR034127A1 (es) | 2000-07-21 | 2004-02-04 | Schering Corp | Imidazolidinonas como inhibidores de ns3-serina proteasa del virus de hepatitis c, composicion farmaceutica, un metodo para su preparacion, y el uso de las mismas para la manufactura de un medicamento |
US7244721B2 (en) * | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
ES2324594T3 (es) | 2000-12-12 | 2009-08-11 | Schering Corporation | Diaril peptidicos utilizados como inhibidores de la serina proteasa ns3 del virus de la hepatitis c. |
JP2002349498A (ja) * | 2001-05-24 | 2002-12-04 | Ishikawajima Harima Heavy Ind Co Ltd | 低騒音ファン静翼 |
-
2005
- 2005-02-24 TW TW094105642A patent/TW200529823A/zh unknown
- 2005-02-24 AU AU2005222056A patent/AU2005222056A1/en not_active Abandoned
- 2005-02-24 WO PCT/US2005/005773 patent/WO2005087725A2/en active Application Filing
- 2005-02-24 KR KR1020067017296A patent/KR20060124729A/ko not_active Application Discontinuation
- 2005-02-24 EP EP08102711A patent/EP1939213B1/en active Active
- 2005-02-24 DE DE602005015093T patent/DE602005015093D1/de active Active
- 2005-02-24 CN CNA2005800126954A patent/CN1972956A/zh active Pending
- 2005-02-24 AT AT08102711T patent/ATE478889T1/de not_active IP Right Cessation
- 2005-02-24 RU RU2006134002/04A patent/RU2006134002A/ru not_active Application Discontinuation
- 2005-02-24 CA CA002557249A patent/CA2557249A1/en not_active Abandoned
- 2005-02-24 AT AT05723590T patent/ATE434621T1/de not_active IP Right Cessation
- 2005-02-24 US US11/065,531 patent/US7186747B2/en active Active
- 2005-02-24 DE DE602005023224T patent/DE602005023224D1/de active Active
- 2005-02-24 JP JP2007500947A patent/JP2007525511A/ja not_active Ceased
- 2005-02-24 ES ES05723590T patent/ES2327544T3/es active Active
- 2005-02-24 BR BRPI0508186-6A patent/BRPI0508186A/pt not_active IP Right Cessation
- 2005-02-24 EP EP05723590A patent/EP1737881B1/en active Active
- 2005-02-24 ES ES08102711T patent/ES2349328T3/es active Active
- 2005-02-25 AR ARP050100721A patent/AR047903A1/es unknown
-
2006
- 2006-08-22 IL IL177627A patent/IL177627A0/en unknown
- 2006-08-23 ZA ZA200606953A patent/ZA200607053B/xx unknown
- 2006-08-25 EC EC2006006794A patent/ECSP066794A/es unknown
- 2006-09-26 NO NO20064357A patent/NO20064357L/no not_active Application Discontinuation
- 2006-12-21 US US11/644,708 patent/US7425576B2/en active Active
-
2007
- 2007-03-19 HK HK07102949.1A patent/HK1095837A1/xx not_active IP Right Cessation
-
2008
- 2008-08-19 HK HK08109243.8A patent/HK1118066A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
TW200529823A (en) | 2005-09-16 |
NO20064357L (no) | 2006-11-24 |
US20050245458A1 (en) | 2005-11-03 |
DE602005015093D1 (de) | 2009-08-06 |
ECSP066794A (es) | 2006-11-16 |
CN1972956A (zh) | 2007-05-30 |
RU2006134002A (ru) | 2008-04-10 |
BRPI0508186A (pt) | 2007-08-14 |
EP1737881A2 (en) | 2007-01-03 |
ES2327544T3 (es) | 2009-10-30 |
AR047903A1 (es) | 2006-03-01 |
EP1939213B1 (en) | 2010-08-25 |
WO2005087725A2 (en) | 2005-09-22 |
AU2005222056A1 (en) | 2005-09-22 |
US7425576B2 (en) | 2008-09-16 |
US7186747B2 (en) | 2007-03-06 |
HK1095837A1 (en) | 2007-05-18 |
WO2005087725A3 (en) | 2005-10-27 |
US20070142300A1 (en) | 2007-06-21 |
ATE478889T1 (de) | 2010-09-15 |
CA2557249A1 (en) | 2005-09-22 |
ATE434621T1 (de) | 2009-07-15 |
IL177627A0 (en) | 2006-12-31 |
EP1737881B1 (en) | 2009-06-24 |
JP2007525511A (ja) | 2007-09-06 |
ES2349328T3 (es) | 2010-12-30 |
DE602005023224D1 (de) | 2010-10-07 |
KR20060124729A (ko) | 2006-12-05 |
EP1939213A1 (en) | 2008-07-02 |
HK1118066A1 (en) | 2009-01-30 |
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