ZA200604864B - Monovalent antibody fragments useful as therapeutics - Google Patents

Monovalent antibody fragments useful as therapeutics Download PDF

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Publication number
ZA200604864B
ZA200604864B ZA200604864A ZA200604864A ZA200604864B ZA 200604864 B ZA200604864 B ZA 200604864B ZA 200604864 A ZA200604864 A ZA 200604864A ZA 200604864 A ZA200604864 A ZA 200604864A ZA 200604864 B ZA200604864 B ZA 200604864B
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antibody fragment
polypeptide
antibody
original
residue
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ZA200604864A
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English (en)
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Huang Arthur Jyh-Yen
Ralph H Schwall
Daniel G Yansura
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Genentech Inc
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
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    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/526CH3 domain
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/53Hinge
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    • C07K2317/55Fab or Fab'
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
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    • C07K2317/622Single chain antibody (scFv)
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    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
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    • C07ORGANIC CHEMISTRY
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    • C07K2319/00Fusion polypeptide

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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA200604864A 2003-12-19 2004-12-17 Monovalent antibody fragments useful as therapeutics ZA200604864B (en)

Applications Claiming Priority (1)

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US53140903P 2003-12-19 2003-12-19

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US (5) US20050227324A1 (pl)
EP (2) EP1718677B1 (pl)
JP (2) JP2008504007A (pl)
KR (1) KR100956913B1 (pl)
CN (1) CN1922210A (pl)
AT (1) ATE554107T1 (pl)
AU (1) AU2004309347B2 (pl)
BR (1) BRPI0417107A (pl)
CA (1) CA2548757A1 (pl)
CY (1) CY1112862T1 (pl)
DK (1) DK1718677T3 (pl)
ES (1) ES2384569T3 (pl)
HK (1) HK1099027A1 (pl)
IL (2) IL175885A (pl)
MX (1) MXPA06006985A (pl)
NZ (1) NZ547438A (pl)
PL (1) PL1718677T3 (pl)
PT (1) PT1718677E (pl)
RU (1) RU2006126097A (pl)
SI (1) SI1718677T1 (pl)
WO (1) WO2005063816A2 (pl)
ZA (1) ZA200604864B (pl)

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AU2004309347A1 (en) 2005-07-14
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JP2008504007A (ja) 2008-02-14
CN1922210A (zh) 2007-02-28
CY1112862T1 (el) 2016-04-13
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US20050227324A1 (en) 2005-10-13
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