ZA200602670B - Transgenic animals with serious disorders related to alzheimer's disease - Google Patents

Transgenic animals with serious disorders related to alzheimer's disease Download PDF

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Publication number
ZA200602670B
ZA200602670B ZA200602670A ZA200602670A ZA200602670B ZA 200602670 B ZA200602670 B ZA 200602670B ZA 200602670 A ZA200602670 A ZA 200602670A ZA 200602670 A ZA200602670 A ZA 200602670A ZA 200602670 B ZA200602670 B ZA 200602670B
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ZA
South Africa
Prior art keywords
animal
protein
mutations
mice
mouse
Prior art date
Application number
ZA200602670A
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English (en)
Inventor
Casas Louzao Caty
Benoit Patrick
Pradier Laurent
Tremp Gunter
Itier Jean-Michel
Blanchard-Bregeon Veronique
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of ZA200602670B publication Critical patent/ZA200602670B/en

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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711Alzheimer's disease; Amyloid plaque core protein
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278Knock-in vertebrates, e.g. humanised vertebrates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00Modified animals
    • A01K2207/15Humanized animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/072Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/107Rabbit
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • A01K2267/0306Animal model for genetic diseases
    • A01K2267/0312Animal model for Alzheimer's disease
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00Cells related to new breeds of animals
    • C12N2517/02Cells from transgenic animals

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA200602670A 2003-10-02 2004-09-27 Transgenic animals with serious disorders related to alzheimer's disease ZA200602670B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0311578A FR2860391B1 (fr) 2003-10-02 2003-10-02 Animaux transgeniques presentant les troubles majeurs lies a la maladie d'alzheimer

Publications (1)

Publication Number Publication Date
ZA200602670B true ZA200602670B (en) 2007-07-25

Family

ID=34307379

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200602670A ZA200602670B (en) 2003-10-02 2004-09-27 Transgenic animals with serious disorders related to alzheimer's disease

Country Status (22)

Country Link
EP (1) EP1670309B1 (de)
JP (1) JP4806635B2 (de)
KR (1) KR101164691B1 (de)
CN (1) CN1889826A (de)
AT (1) ATE471661T1 (de)
AU (1) AU2004277357B2 (de)
BR (1) BRPI0415032A (de)
CA (1) CA2540622C (de)
CY (1) CY1110788T1 (de)
DE (1) DE602004027823D1 (de)
DK (1) DK1670309T3 (de)
ES (1) ES2347961T3 (de)
FR (1) FR2860391B1 (de)
IL (1) IL174726A (de)
MX (2) MXPA06003685A (de)
NO (1) NO334611B1 (de)
PL (1) PL1670309T3 (de)
PT (1) PT1670309E (de)
RU (1) RU2373707C2 (de)
SI (1) SI1670309T1 (de)
WO (1) WO2005032244A1 (de)
ZA (1) ZA200602670B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2963791B1 (fr) * 2010-08-11 2012-09-21 Assist Publ Hopitaux De Paris Methode de diagnostic des maladies neurodegeneratives
WO2014007367A1 (ja) * 2012-07-05 2014-01-09 国立大学法人東京大学 同一試料中の2種の物質を検出又は測定する方法
JP6583011B2 (ja) * 2016-01-20 2019-10-02 コニカミノルタ株式会社 酸性水溶液を用いた免疫染色スライドの洗浄方法
CN109776665B (zh) * 2019-02-02 2021-02-05 首都医科大学宣武医院 阿尔茨海默病新突变、其稳转细胞模型及医药用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003509071A (ja) * 1999-09-17 2003-03-11 アバンテイス・フアルマ・エス・アー アミロイド斑およびミトコンドリア機能障害を示すアルツハイマー病の新規の動物モデル
FR2798556B1 (fr) * 1999-09-17 2004-02-27 Aventis Pharma Sa Nouveau modele animal de la maladie d'alzheimer presentant a la fois des plaques amyloides et des dysfonctionnements mitochondriaux
DE60044205D1 (de) * 1999-09-27 2010-05-27 Aventis Pharma Sa Transgenes tier welches ein mehrfach-mutiertes presenilin-1 exprimiert
EP1304922A2 (de) * 2000-07-20 2003-05-02 Cephalon, Inc. Nicht-menschliches säugetier mit der menschlichen fad-presenilin-mutation und seine nachkommenschaft

Also Published As

Publication number Publication date
AU2004277357A1 (en) 2005-04-14
FR2860391A1 (fr) 2005-04-08
CA2540622A1 (fr) 2005-04-14
ES2347961T3 (es) 2010-11-26
AU2004277357B2 (en) 2011-11-03
NO20061954L (no) 2006-06-26
IL174726A (en) 2013-05-30
PL1670309T3 (pl) 2010-11-30
BRPI0415032A (pt) 2006-12-12
DE602004027823D1 (de) 2010-08-05
RU2373707C2 (ru) 2009-11-27
EP1670309A1 (de) 2006-06-21
EP1670309B1 (de) 2010-06-23
JP2007507217A (ja) 2007-03-29
MXPA06003670A (es) 2006-06-20
KR20060090988A (ko) 2006-08-17
KR101164691B1 (ko) 2012-07-11
SI1670309T1 (sl) 2010-11-30
ATE471661T1 (de) 2010-07-15
PT1670309E (pt) 2010-09-28
RU2006114692A (ru) 2007-11-10
FR2860391B1 (fr) 2006-01-27
NO334611B1 (no) 2014-04-22
CN1889826A (zh) 2007-01-03
IL174726A0 (en) 2006-08-20
CA2540622C (fr) 2014-01-14
JP4806635B2 (ja) 2011-11-02
CY1110788T1 (el) 2015-06-10
MXPA06003685A (es) 2006-06-20
DK1670309T3 (da) 2010-10-25
WO2005032244A1 (fr) 2005-04-14

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