CY1110788T1 - Διαγονιδιακα ζωα τα οποια παρουσιαζουν σημαντικες διαταραχες σχετικες με την νοσο alzheimer - Google Patents
Διαγονιδιακα ζωα τα οποια παρουσιαζουν σημαντικες διαταραχες σχετικες με την νοσο alzheimerInfo
- Publication number
- CY1110788T1 CY1110788T1 CY20101100849T CY101100849T CY1110788T1 CY 1110788 T1 CY1110788 T1 CY 1110788T1 CY 20101100849 T CY20101100849 T CY 20101100849T CY 101100849 T CY101100849 T CY 101100849T CY 1110788 T1 CY1110788 T1 CY 1110788T1
- Authority
- CY
- Cyprus
- Prior art keywords
- animals
- diagnostic
- alzheimer disease
- important diseases
- diseases relating
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 3
- 241001465754 Metazoa Species 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/107—Rabbit
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0312—Animal model for Alzheimer's disease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/02—Cells from transgenic animals
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Animal Husbandry (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
Η παρούσα εφεύρεση αφορά σε διαγονιδιακά ζώα, όχι ανθρώπους, τα οποία παρουσιάζουν σημαντικές διαταραχές σχετικές με την νόσο του Alzheimer. Τα ζώα μπορούν να χρησιμοποιηθούν για την απόδειξη ενώσεων οι οποίες προορίζονται για τη θεραπεία της νόσου του Alzheimer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0311578A FR2860391B1 (fr) | 2003-10-02 | 2003-10-02 | Animaux transgeniques presentant les troubles majeurs lies a la maladie d'alzheimer |
EP04787459A EP1670309B1 (fr) | 2003-10-02 | 2004-09-27 | Animaux transgeniques presentant les troubles majeurs lies a la maladie d'alzheimer |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1110788T1 true CY1110788T1 (el) | 2015-06-10 |
Family
ID=34307379
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20101100849T CY1110788T1 (el) | 2003-10-02 | 2010-09-22 | Διαγονιδιακα ζωα τα οποια παρουσιαζουν σημαντικες διαταραχες σχετικες με την νοσο alzheimer |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP1670309B1 (el) |
JP (1) | JP4806635B2 (el) |
KR (1) | KR101164691B1 (el) |
CN (1) | CN1889826A (el) |
AT (1) | ATE471661T1 (el) |
AU (1) | AU2004277357B2 (el) |
BR (1) | BRPI0415032A (el) |
CA (1) | CA2540622C (el) |
CY (1) | CY1110788T1 (el) |
DE (1) | DE602004027823D1 (el) |
DK (1) | DK1670309T3 (el) |
ES (1) | ES2347961T3 (el) |
FR (1) | FR2860391B1 (el) |
IL (1) | IL174726A (el) |
MX (2) | MXPA06003670A (el) |
NO (1) | NO334611B1 (el) |
PL (1) | PL1670309T3 (el) |
PT (1) | PT1670309E (el) |
RU (1) | RU2373707C2 (el) |
SI (1) | SI1670309T1 (el) |
WO (1) | WO2005032244A1 (el) |
ZA (1) | ZA200602670B (el) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2963791B1 (fr) * | 2010-08-11 | 2012-09-21 | Assist Publ Hopitaux De Paris | Methode de diagnostic des maladies neurodegeneratives |
WO2014007367A1 (ja) * | 2012-07-05 | 2014-01-09 | 国立大学法人東京大学 | 同一試料中の2種の物質を検出又は測定する方法 |
JP6583011B2 (ja) * | 2016-01-20 | 2019-10-02 | コニカミノルタ株式会社 | 酸性水溶液を用いた免疫染色スライドの洗浄方法 |
CN109776665B (zh) * | 2019-02-02 | 2021-02-05 | 首都医科大学宣武医院 | 阿尔茨海默病新突变、其稳转细胞模型及医药用途 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2798556B1 (fr) * | 1999-09-17 | 2004-02-27 | Aventis Pharma Sa | Nouveau modele animal de la maladie d'alzheimer presentant a la fois des plaques amyloides et des dysfonctionnements mitochondriaux |
CA2384865A1 (fr) * | 1999-09-17 | 2001-03-29 | Aventis Pharma S.A. | Nouveau modele animal de la maladie d'alzheimer presentant a la fois des plaques amyloides et des dysfonctionnements mitochondriaux |
EP1255437B1 (fr) * | 1999-09-27 | 2010-04-14 | Aventis Pharma S.A. | Animal transgenique exprimant une forme multi-mutee de la preseniline 1 |
AU2001276995C1 (en) * | 2000-07-20 | 2006-10-26 | Cephalon, Inc. | Gene-targeted non-human mammal with human fad presenilin mutation and generational offspring |
-
2003
- 2003-10-02 FR FR0311578A patent/FR2860391B1/fr not_active Expired - Lifetime
-
2004
- 2004-09-27 SI SI200431505T patent/SI1670309T1/sl unknown
- 2004-09-27 AT AT04787459T patent/ATE471661T1/de active
- 2004-09-27 WO PCT/FR2004/002436 patent/WO2005032244A1/fr active Application Filing
- 2004-09-27 JP JP2006530400A patent/JP4806635B2/ja not_active Expired - Fee Related
- 2004-09-27 ES ES04787459T patent/ES2347961T3/es not_active Expired - Lifetime
- 2004-09-27 PT PT04787459T patent/PT1670309E/pt unknown
- 2004-09-27 AU AU2004277357A patent/AU2004277357B2/en not_active Ceased
- 2004-09-27 MX MXPA06003670A patent/MXPA06003670A/es active IP Right Grant
- 2004-09-27 EP EP04787459A patent/EP1670309B1/fr not_active Expired - Lifetime
- 2004-09-27 PL PL04787459T patent/PL1670309T3/pl unknown
- 2004-09-27 CN CNA2004800357140A patent/CN1889826A/zh active Pending
- 2004-09-27 ZA ZA200602670A patent/ZA200602670B/en unknown
- 2004-09-27 BR BRPI0415032-5A patent/BRPI0415032A/pt not_active IP Right Cessation
- 2004-09-27 KR KR1020067006358A patent/KR101164691B1/ko not_active IP Right Cessation
- 2004-09-27 DE DE602004027823T patent/DE602004027823D1/de not_active Expired - Lifetime
- 2004-09-27 RU RU2006114692/13A patent/RU2373707C2/ru not_active IP Right Cessation
- 2004-09-27 DK DK04787459.9T patent/DK1670309T3/da active
- 2004-09-27 CA CA2540622A patent/CA2540622C/fr not_active Expired - Fee Related
- 2004-09-27 MX MXPA06003685A patent/MXPA06003685A/es unknown
-
2006
- 2006-04-02 IL IL174726A patent/IL174726A/en not_active IP Right Cessation
- 2006-05-02 NO NO20061954A patent/NO334611B1/no not_active IP Right Cessation
-
2010
- 2010-09-22 CY CY20101100849T patent/CY1110788T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
DK1670309T3 (da) | 2010-10-25 |
MXPA06003685A (es) | 2006-06-20 |
JP4806635B2 (ja) | 2011-11-02 |
AU2004277357A1 (en) | 2005-04-14 |
FR2860391A1 (fr) | 2005-04-08 |
KR20060090988A (ko) | 2006-08-17 |
PL1670309T3 (pl) | 2010-11-30 |
ZA200602670B (en) | 2007-07-25 |
RU2006114692A (ru) | 2007-11-10 |
CA2540622A1 (fr) | 2005-04-14 |
IL174726A0 (en) | 2006-08-20 |
IL174726A (en) | 2013-05-30 |
RU2373707C2 (ru) | 2009-11-27 |
ATE471661T1 (de) | 2010-07-15 |
MXPA06003670A (es) | 2006-06-20 |
CN1889826A (zh) | 2007-01-03 |
WO2005032244A1 (fr) | 2005-04-14 |
EP1670309A1 (fr) | 2006-06-21 |
DE602004027823D1 (de) | 2010-08-05 |
KR101164691B1 (ko) | 2012-07-11 |
CA2540622C (fr) | 2014-01-14 |
PT1670309E (pt) | 2010-09-28 |
JP2007507217A (ja) | 2007-03-29 |
NO20061954L (no) | 2006-06-26 |
ES2347961T3 (es) | 2010-11-26 |
AU2004277357B2 (en) | 2011-11-03 |
NO334611B1 (no) | 2014-04-22 |
SI1670309T1 (sl) | 2010-11-30 |
EP1670309B1 (fr) | 2010-06-23 |
BRPI0415032A (pt) | 2006-12-12 |
FR2860391B1 (fr) | 2006-01-27 |
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