DE60044205D1 - Transgenes tier welches ein mehrfach-mutiertes presenilin-1 exprimiert - Google Patents

Transgenes tier welches ein mehrfach-mutiertes presenilin-1 exprimiert

Info

Publication number
DE60044205D1
DE60044205D1 DE60044205T DE60044205T DE60044205D1 DE 60044205 D1 DE60044205 D1 DE 60044205D1 DE 60044205 T DE60044205 T DE 60044205T DE 60044205 T DE60044205 T DE 60044205T DE 60044205 D1 DE60044205 D1 DE 60044205D1
Authority
DE
Germany
Prior art keywords
presenilin
muted
animal expressing
transgene animal
transgene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60044205T
Other languages
English (en)
Inventor
Anne Eckert
Walter Muller
Christian Czech
Laurent Pradier
Gunter Tremp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9912017A external-priority patent/FR2798821B1/fr
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Application granted granted Critical
Publication of DE60044205D1 publication Critical patent/DE60044205D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Environmental Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Husbandry (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Fodder In General (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60044205T 1999-09-27 2000-09-22 Transgenes tier welches ein mehrfach-mutiertes presenilin-1 exprimiert Expired - Lifetime DE60044205D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9912017A FR2798821B1 (fr) 1999-09-27 1999-09-27 Animal transgenique exprimant une forme multi-mutee de la preseniline 1
US18130600P 2000-02-09 2000-02-09
PCT/FR2000/002623 WO2001022811A1 (fr) 1999-09-27 2000-09-22 Animal transgenique exprimant une forme multi-mutee de la preseniline 1

Publications (1)

Publication Number Publication Date
DE60044205D1 true DE60044205D1 (de) 2010-05-27

Family

ID=26235119

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60044205T Expired - Lifetime DE60044205D1 (de) 1999-09-27 2000-09-22 Transgenes tier welches ein mehrfach-mutiertes presenilin-1 exprimiert

Country Status (8)

Country Link
EP (1) EP1255437B1 (de)
AT (1) ATE463955T1 (de)
AU (1) AU7530000A (de)
CA (1) CA2383982C (de)
CY (1) CY1110304T1 (de)
DE (1) DE60044205D1 (de)
DK (1) DK1255437T3 (de)
WO (1) WO2001022811A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2860391B1 (fr) * 2003-10-02 2006-01-27 Aventis Pharma Sa Animaux transgeniques presentant les troubles majeurs lies a la maladie d'alzheimer
KR101890978B1 (ko) 2014-06-17 2018-08-24 서울대학교산학협력단 알츠하이머 질환 모델용 형질전환 돼지 및 이의 용도

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5898094A (en) * 1996-10-21 1999-04-27 University Of South Florida Transgenic mice expressing APPK670N,M671L and a mutant presenilin transgenes
JP2001514528A (ja) * 1997-05-14 2001-09-11 メルク エンド カンパニー インコーポレーテッド 天然プレセニリン１ヌルバックグラウンド上で非天然野生型および家族性アルツハイマー病突然変異プレセニリン１タンパク質を発現するトランスジェニック動物

Also Published As

Publication number Publication date
CA2383982A1 (fr) 2001-04-05
AU7530000A (en) 2001-04-30
ATE463955T1 (de) 2010-04-15
CY1110304T1 (el) 2015-01-14
CA2383982C (fr) 2013-05-07
DK1255437T3 (da) 2010-08-09
EP1255437A1 (de) 2002-11-13
WO2001022811A1 (fr) 2001-04-05
EP1255437B1 (de) 2010-04-14

Similar Documents

Publication Publication Date Title
DE69828574D1 (de) Transgenes Tier als Modell für Allergie und seine Verwendung
WO2000036106A3 (en) Non-invasive evaluation of physiological response in a mammal
KR970050600U (ko) 물고기 형상 인조 미끼
HUP0300054A3 (en) Tumour-specific animal proteins
DE60044205D1 (de) Transgenes tier welches ein mehrfach-mutiertes presenilin-1 exprimiert
HUP0000761A2 (en) Protein complementation in transgenic plants
AU2001262726A1 (en) Transgenic non-human mammal and method of constructing the same, animal disease model and method of clarifying gene function
NO20000233L (no) Oppdrettsanlegg
MXPA02004484A (es) Metodos para determinar el sexo de mamiferos que no son seres humanos.
NO20020010L (no) Transgene dyr som modeller for neurodegenerativ sykdom
CY1105641T1 (el) Μοντελο δια νευροεκφυλιστικη ασθενεια
DE69925565D1 (de) Medium für die Züchtung tierischer Embryonen
DE69735498D1 (de) Transgenes modell für herzversagen
DE69738668D1 (de) Transgentier-modell für die krankheit von alzheimer
FR2795739B1 (fr) Gene synthetique cryic et plantes transgeniques exprimant ledit gene
ATE332416T1 (de) Schlitzwand mit erweitertem, geräumten unterteil	
DE60239099D1 (de) Tier mit gen-hypoexpression
KR960006750U (ko) 양봉용 소비광
ES1037099Y (es) Cebo artificial para la pesca en la modalidad de palangre.
KR960013020U (ko) 양식어 양식장
KR980000152U (ko) 낚시용 수초 제거장치
GB0007563D0 (en) Fishing bait
GB0023040D0 (en) Fishing lures
ITRM950262U1 (it) Pesce in gabbia allevamento in mare aperto
KR960013032U (ko) 낚시용 구멍찌

Legal Events

Date Code Title Description
8364 No opposition during term of opposition