AU7530000A - Transgenic animal expressing a multiple mutated form of presenilin - Google Patents

Transgenic animal expressing a multiple mutated form of presenilin

Info

Publication number
AU7530000A
AU7530000A AU75300/00A AU7530000A AU7530000A AU 7530000 A AU7530000 A AU 7530000A AU 75300/00 A AU75300/00 A AU 75300/00A AU 7530000 A AU7530000 A AU 7530000A AU 7530000 A AU7530000 A AU 7530000A
Authority
AU
Australia
Prior art keywords
transgenic animal
presenilin
mutated form
animal expressing
multiple mutated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU75300/00A
Inventor
Christian Czech
Anne Eckert
Walter Muller
Laurent Pradier
Gunter Tremp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9912017A external-priority patent/FR2798821B1/en
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Publication of AU7530000A publication Critical patent/AU7530000A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Animal Husbandry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Fodder In General (AREA)

Abstract

The invention concerns the field of transgenic animal models and more particularly, animal models of Alzheimer disease. The invention relates to a transgenic animal expressing a multiple mutated form of presenilin 1 and enabling to detect an apoptotic phenomenon in a renewable peripheral tissue.
AU75300/00A 1999-09-27 2000-09-22 Transgenic animal expressing a multiple mutated form of presenilin Abandoned AU7530000A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FR9912017A FR2798821B1 (en) 1999-09-27 1999-09-27 TRANSGENIC ANIMAL EXPRESSING A MULTI-MUTE FORM OF PRESENILINE 1
FR9912017 1999-09-27
US18130600P 2000-02-09 2000-02-09
US60181306 2000-02-09
PCT/FR2000/002623 WO2001022811A1 (en) 1999-09-27 2000-09-22 Transgenic animal expressing a multiple mutated form of presenilin 1

Publications (1)

Publication Number Publication Date
AU7530000A true AU7530000A (en) 2001-04-30

Family

ID=26235119

Family Applications (1)

Application Number Title Priority Date Filing Date
AU75300/00A Abandoned AU7530000A (en) 1999-09-27 2000-09-22 Transgenic animal expressing a multiple mutated form of presenilin

Country Status (8)

Country Link
EP (1) EP1255437B1 (en)
AT (1) ATE463955T1 (en)
AU (1) AU7530000A (en)
CA (1) CA2383982C (en)
CY (1) CY1110304T1 (en)
DE (1) DE60044205D1 (en)
DK (1) DK1255437T3 (en)
WO (1) WO2001022811A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2860391B1 (en) * 2003-10-02 2006-01-27 Aventis Pharma Sa TRANSGENIC ANIMALS WITH MAJOR DISORDERS RELATED TO ALZHEIMER'S DISEASE
KR101890978B1 (en) 2014-06-17 2018-08-24 서울대학교산학협력단 Transgenic cloned porcine Models for alzheimer's disease and the Use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5898094A (en) * 1996-10-21 1999-04-27 University Of South Florida Transgenic mice expressing APPK670N,M671L and a mutant presenilin transgenes
CA2290039A1 (en) * 1997-05-14 1998-11-19 Merck & Co., Inc. Transgenic animal expressing non-native wild-type and familial alzheimer's disease mutant presenilin 1 protein on native presenilin 1 null background

Also Published As

Publication number Publication date
DK1255437T3 (en) 2010-08-09
EP1255437B1 (en) 2010-04-14
CA2383982C (en) 2013-05-07
CY1110304T1 (en) 2015-01-14
WO2001022811A1 (en) 2001-04-05
CA2383982A1 (en) 2001-04-05
ATE463955T1 (en) 2010-04-15
EP1255437A1 (en) 2002-11-13
DE60044205D1 (en) 2010-05-27

Similar Documents

Publication Publication Date Title
USD499226S1 (en) Dog chew
USD474026S1 (en) Electric toothbrush
USD495831S1 (en) Electric fluff remover
CA105575S (en) Dispensing aperture, primarily for a container with moist wipes
AU2001278084A1 (en) Model for alzheimer's disease and other neurodegenerative diseases
USD455228S1 (en) Electrical fluff remover
AU1280799A (en) Non-transgenic animal model of alzheimer's disease
AU2001286720A1 (en) Transgenic animal model for neurodegerative disease and uses thereof
USD674341S1 (en) Electrical transformer
CA103763S (en) Cosmetic container
USD508601S1 (en) Jacket
CY1110304T1 (en) DIAGNOSTIC ANIMAL EXPRESSION OF A MULTI-METHOD OF PRESENILIN 1
USD484702S1 (en) Hairbrush
USD474150S1 (en) AC transformer
USD487140S1 (en) Electric heater
USD486797S1 (en) Switch assembly
USD476963S1 (en) Outer shell of power box of autocar
USD451670S1 (en) Expandable fishing rod case
USD455398S1 (en) Portable electric power source
USD467046S1 (en) Animal halter
USD440525S1 (en) Mounted mechanical fish
USD470820S1 (en) Electric connector
USD430625S (en) Artificial dog
USD490443S1 (en) Stump grind teeth
USD497438S1 (en) Tree grate portion

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase