ZA200507567B - Novel method for the synthesis of S-indoline-2 carboxylic acid and application thereof in the synthesis of perindopril - Google Patents
Novel method for the synthesis of S-indoline-2 carboxylic acid and application thereof in the synthesis of perindoprilInfo
- Publication number
- ZA200507567B ZA200507567B ZA200507567A ZA200507567A ZA200507567B ZA 200507567 B ZA200507567 B ZA 200507567B ZA 200507567 A ZA200507567 A ZA 200507567A ZA 200507567 A ZA200507567 A ZA 200507567A ZA 200507567 B ZA200507567 B ZA 200507567B
- Authority
- ZA
- South Africa
- Prior art keywords
- synthesis
- perindopril
- indoline
- application
- carboxylic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B55/00—Racemisation; Complete or partial inversion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03290879A EP1348684B1 (de) | 2003-04-09 | 2003-04-09 | Verfahren zur Synthese von (2S)-Indolin-2-carbonsäure, und Verwendung in der Synthese von Perindopril |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200507567B true ZA200507567B (en) | 2006-11-29 |
Family
ID=27798985
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200507567A ZA200507567B (en) | 2003-04-09 | 2004-04-07 | Novel method for the synthesis of S-indoline-2 carboxylic acid and application thereof in the synthesis of perindopril |
Country Status (28)
Country | Link |
---|---|
US (2) | US7196204B2 (de) |
EP (1) | EP1348684B1 (de) |
JP (1) | JP5111849B2 (de) |
KR (1) | KR100722079B1 (de) |
CN (1) | CN100337996C (de) |
AR (1) | AR043993A1 (de) |
AT (1) | ATE319668T1 (de) |
AU (1) | AU2004230294B2 (de) |
BR (1) | BRPI0409095B1 (de) |
CA (1) | CA2521877C (de) |
DE (1) | DE60303904T2 (de) |
DK (1) | DK1348684T3 (de) |
EA (1) | EA008929B1 (de) |
EG (1) | EG24152A (de) |
ES (1) | ES2260585T3 (de) |
GE (1) | GEP20074257B (de) |
HK (1) | HK1086816A1 (de) |
MA (1) | MA27633A1 (de) |
MX (1) | MXPA05010398A (de) |
MY (1) | MY138698A (de) |
NO (1) | NO334199B1 (de) |
NZ (1) | NZ542396A (de) |
PL (1) | PL212544B1 (de) |
PT (1) | PT1348684E (de) |
SI (1) | SI1348684T1 (de) |
UA (1) | UA80040C2 (de) |
WO (1) | WO2004092095A1 (de) |
ZA (1) | ZA200507567B (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1348684T1 (sl) * | 2003-04-09 | 2006-06-30 | Servier Lab | Nov postopek sinteze (2s)-indolin-2-karboksilne kisline in uporaba pri sintezi perindoprila |
CA2488324A1 (en) * | 2004-11-22 | 2006-05-22 | Apotex Pharmachem Inc. | Optical resolution of n-acetyl-indoline-2-carboxylic acid with phenylglycinol |
CN100391945C (zh) * | 2005-05-31 | 2008-06-04 | 浙江大学 | 一种s-(-)-吲哚啉-2-羧酸的合成方法 |
EP1792896A1 (de) | 2005-12-01 | 2007-06-06 | KRKA, tovarna zdravil, d.d., Novo mesto | Verfahren zur Herstellung von Perindopril und deren Salze |
JP5176452B2 (ja) * | 2007-09-27 | 2013-04-03 | 住友化学株式会社 | 光学活性なテトラヒドロピラニルグリシン化合物の製造方法 |
CN101774960B (zh) * | 2009-12-31 | 2011-08-03 | 安徽美诺华药物化学有限公司 | 一种(2s)-二氢吲哚-2-甲酸的制备方法 |
CN101823993A (zh) * | 2010-03-31 | 2010-09-08 | 安徽世华化工有限公司 | L-八氢吲哚啉-2-甲酸的制备方法 |
CN104672124B (zh) * | 2014-12-31 | 2017-08-22 | 浙江昌明药业有限公司 | 对映体富集的二氢吲哚‑2‑甲酸的合成方法 |
CN112321538A (zh) * | 2020-10-28 | 2021-02-05 | 都创(上海)医药开发有限公司 | 一种合成单胺保护的哌嗪-(r/s)2-甲酸酯的方法 |
CN112375028A (zh) * | 2020-12-14 | 2021-02-19 | 安徽美诺华药物化学有限公司 | 合成(2s)-二氢吲哚-甲酸的方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS535134A (en) * | 1976-06-30 | 1978-01-18 | Sumitomo Chem Co Ltd | Racemization of optical active 2-(4)chlorophenyl)-3-methylbutylic acid |
JPS58216147A (ja) * | 1982-06-11 | 1983-12-15 | Banyu Pharmaceut Co Ltd | 光学活性なn−アセチル−3−ヒドロキシ−4−(ヒドロキシメチル)フエニルグリシンのラセミ化方法 |
DE3571969D1 (en) * | 1984-05-30 | 1989-09-07 | Du Pont | Preparation of optically-active alpha-substituted phenylacetic acids |
DE3727411A1 (de) * | 1986-08-19 | 1988-03-24 | Ciba Geigy Ag | Verfahren zur herstellung von 2-indolincarbonsaeure |
JPH0780823B2 (ja) * | 1986-08-26 | 1995-08-30 | 東ソー株式会社 | 光学活性フェニルアラニンのラセミ化方法 |
FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
JP2513001B2 (ja) * | 1988-11-01 | 1996-07-03 | 山川薬品工業株式会社 | 光学活性テトラヒドロフラン−2−カルボン酸のラセミ化方法 |
JP3010694B2 (ja) * | 1990-07-09 | 2000-02-21 | 日産化学工業株式会社 | 2―(3―ベンゾイル)フェニルプロピオン酸のラセミ化法 |
NL9001703A (nl) * | 1990-07-27 | 1992-02-17 | Westspur Investment Ltd | Werkwijze voor de bereiding van s(+)-6-methoxy-alfa-methyl-2-naftaleen-azijnzuur. |
US5220053A (en) * | 1992-01-24 | 1993-06-15 | Ethyl Corporation | Preparation of optically active aliphatic carboxylic acids |
ES2061403B1 (es) * | 1993-04-16 | 1995-06-16 | Medichem Sa | Procedimiento de obtencion del acido d-(-) -3 acetiltio-2- metilpropionico. |
JPH08151344A (ja) * | 1994-09-26 | 1996-06-11 | Nagase & Co Ltd | 2−(3−ベンゾイルフェニル)プロピオン酸の光学分割方法 |
US5677469A (en) * | 1995-05-18 | 1997-10-14 | Sepracor, Inc. | Process for resolving chiral acids with 1-aminoindan-2-ols |
SI1348684T1 (sl) * | 2003-04-09 | 2006-06-30 | Servier Lab | Nov postopek sinteze (2s)-indolin-2-karboksilne kisline in uporaba pri sintezi perindoprila |
-
2003
- 2003-04-09 SI SI200330204T patent/SI1348684T1/sl unknown
- 2003-04-09 ES ES03290879T patent/ES2260585T3/es not_active Expired - Lifetime
- 2003-04-09 DE DE60303904T patent/DE60303904T2/de not_active Expired - Lifetime
- 2003-04-09 AT AT03290879T patent/ATE319668T1/de active
- 2003-04-09 PT PT03290879T patent/PT1348684E/pt unknown
- 2003-04-09 DK DK03290879T patent/DK1348684T3/da active
- 2003-04-09 EP EP03290879A patent/EP1348684B1/de not_active Expired - Lifetime
-
2004
- 2004-04-07 US US10/552,676 patent/US7196204B2/en not_active Expired - Fee Related
- 2004-04-07 NZ NZ542396A patent/NZ542396A/en not_active IP Right Cessation
- 2004-04-07 ZA ZA200507567A patent/ZA200507567B/xx unknown
- 2004-04-07 MX MXPA05010398A patent/MXPA05010398A/es active IP Right Grant
- 2004-04-07 JP JP2006500165A patent/JP5111849B2/ja not_active Expired - Fee Related
- 2004-04-07 AU AU2004230294A patent/AU2004230294B2/en not_active Ceased
- 2004-04-07 PL PL377832A patent/PL212544B1/pl unknown
- 2004-04-07 KR KR1020057019123A patent/KR100722079B1/ko not_active IP Right Cessation
- 2004-04-07 CN CNB200480009239XA patent/CN100337996C/zh not_active Expired - Fee Related
- 2004-04-07 GE GEAP20049046A patent/GEP20074257B/en unknown
- 2004-04-07 BR BRPI0409095A patent/BRPI0409095B1/pt not_active IP Right Cessation
- 2004-04-07 CA CA2521877A patent/CA2521877C/fr not_active Expired - Fee Related
- 2004-04-07 EA EA200501557A patent/EA008929B1/ru not_active IP Right Cessation
- 2004-04-07 WO PCT/FR2004/000857 patent/WO2004092095A1/fr active Application Filing
- 2004-04-07 AR ARP040101173A patent/AR043993A1/es not_active Application Discontinuation
- 2004-04-08 MY MYPI20041284A patent/MY138698A/en unknown
- 2004-07-04 UA UAA200510564A patent/UA80040C2/uk unknown
-
2005
- 2005-09-19 MA MA28504A patent/MA27633A1/fr unknown
- 2005-10-09 EG EGNA2005000629 patent/EG24152A/xx active
- 2005-11-09 NO NO20055257A patent/NO334199B1/no not_active IP Right Cessation
-
2006
- 2006-06-19 HK HK06106955A patent/HK1086816A1/xx not_active IP Right Cessation
-
2007
- 2007-01-05 US US11/649,980 patent/US7323575B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EG24152A (en) | Novel method for the synthesis of s-indoline-2-carboxylic acid and application thereof in synthesis of perindopril | |
HK1076101A1 (en) | Process for the preparation of high purity perindopril and intermediates useful in the synthesis | |
HK1089187A1 (en) | Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof | |
EG26629A (en) | A new process for the synthesis of pyridopril and its pharmaceutically acceptable salts | |
EP1633851A4 (de) | Verfahren und zusammensetzungen zur aminosäureproduktion | |
EP1487776A4 (de) | Säure- und esterverbindungen und verfahren zu deren anwendung | |
HK1096409A1 (en) | Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof | |
HK1080453A1 (en) | Intermediates in producing phenoxyacetic acid derivatives and method of using the same | |
PT1753720E (pt) | Processo para a preparação de perindopril e sais do mesmo | |
HK1096408A1 (en) | Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof | |
HK1095839A1 (en) | Method for the synthesis of perindopril and the pharmaceutically-acceptable salts thereof | |
GB0308934D0 (en) | Labels and method of manufacture thereof | |
ZA200601426B (en) | Novel method for the synthesis of perindopril and the pharmaceutically-acceptable salts thereof | |
HK1086281A1 (en) | Novel method for synthesising perindopril and the pharmaceutically acceptable salt thereof | |
AU2003294684A8 (en) | Ketoprofen compositions and methods of making them | |
ZA200510463B (en) | Methods and compositions for amino acid production | |
HK1096406A1 (en) | Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof | |
HK1096407A1 (en) | Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof | |
SI1338591T1 (sl) | NOV POSTOPEK ZA SINTEZO (2S,3aS,7aS)-PERHIDROINDOL-2-KARBOKSILNE KISLINE IN NJENIH ESTROV TER UPORABA PRI SINTEZI PERINDOPRILA | |
SI1323729T1 (en) | Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof derivatives; and use in the synthesis of perindopril | |
MXPA02004180A (es) | Metodos de sintesis de dl-hidroxi-alquil-fenil amidas. | |
EP1541546A4 (de) | KRISTALL EINES AMINOSûUREESTERSALZES UND VERFAHREN ZU DESSEN HERSTELLUNG | |
SI1354874T1 (en) | Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof; and use in the synthesis of perindopril | |
SI1354875T1 (en) | Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof; and use in the synthesis of perindopril | |
AU2003250142A1 (en) | Method for the production of hydroxyalkyl carbonic acid esters |