ZA200500791B - Pyrimidyl sulphone amide derivatives as chemokine receptor modulators - Google Patents
Pyrimidyl sulphone amide derivatives as chemokine receptor modulators Download PDFInfo
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- ZA200500791B ZA200500791B ZA200500791A ZA200500791A ZA200500791B ZA 200500791 B ZA200500791 B ZA 200500791B ZA 200500791 A ZA200500791 A ZA 200500791A ZA 200500791 A ZA200500791 A ZA 200500791A ZA 200500791 B ZA200500791 B ZA 200500791B
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- compound
- composition
- phenyl
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- pharmaceutically acceptable
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- -1 Pyrimidyl sulphone amide Chemical class 0.000 title claims description 120
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- 125000001424 substituent group Chemical group 0.000 claims description 69
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 60
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 32
- 239000012453 solvate Substances 0.000 claims description 32
- 125000000217 alkyl group Chemical group 0.000 claims description 30
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 19
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 19
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- MSDQKJCHBXZYQG-UHFFFAOYSA-N n-[2-[(3-chloro-2-fluorophenyl)methylsulfanyl]-6-(1-hydroxypropan-2-ylamino)pyrimidin-4-yl]morpholine-4-sulfonamide Chemical compound N=1C(SCC=2C(=C(Cl)C=CC=2)F)=NC(NC(CO)C)=CC=1NS(=O)(=O)N1CCOCC1 MSDQKJCHBXZYQG-UHFFFAOYSA-N 0.000 claims description 2
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GBGB0217431.6A GB0217431D0 (en) | 2002-07-27 | 2002-07-27 | Novel compounds |
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ZA200500791B true ZA200500791B (en) | 2006-11-29 |
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ZA200500791A ZA200500791B (en) | 2002-07-27 | 2005-01-26 | Pyrimidyl sulphone amide derivatives as chemokine receptor modulators |
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EP (1) | EP1527051B1 (ru) |
JP (1) | JP4619782B2 (ru) |
KR (2) | KR101074626B1 (ru) |
CN (1) | CN100345829C (ru) |
AR (1) | AR040700A1 (ru) |
AU (1) | AU2003281684B2 (ru) |
BR (1) | BR0312967A (ru) |
CA (1) | CA2493785C (ru) |
CO (1) | CO5680479A2 (ru) |
EG (1) | EG25893A (ru) |
ES (1) | ES2392965T3 (ru) |
GB (1) | GB0217431D0 (ru) |
HK (1) | HK1076465A1 (ru) |
IL (1) | IL166290A0 (ru) |
IS (1) | IS7697A (ru) |
MX (1) | MXPA05000960A (ru) |
MY (1) | MY139561A (ru) |
NO (1) | NO330531B1 (ru) |
NZ (1) | NZ537914A (ru) |
PL (1) | PL375400A1 (ru) |
RU (1) | RU2342366C2 (ru) |
TW (1) | TWI340038B (ru) |
UA (1) | UA80283C2 (ru) |
WO (1) | WO2004011443A1 (ru) |
ZA (1) | ZA200500791B (ru) |
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GB0217431D0 (en) * | 2002-07-27 | 2002-09-04 | Astrazeneca Ab | Novel compounds |
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GB0401269D0 (en) * | 2004-01-21 | 2004-02-25 | Astrazeneca Ab | Compounds |
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EP1809624B1 (en) | 2004-08-28 | 2013-11-20 | AstraZeneca AB | Pyrimidine sulphonamide derivatives as chemokine receptor modulators |
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WO2006124744A1 (en) * | 2005-05-16 | 2006-11-23 | Vertex Pharmaceuticals Incorporated | Bicyclic derivatives as modulators of ion channels |
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US20090176785A1 (en) * | 2007-11-16 | 2009-07-09 | Abbott Laboratories | Method of treating arthritis |
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WO2009151910A2 (en) * | 2008-05-25 | 2009-12-17 | Wyeth | Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer |
BRPI0915908A2 (pt) * | 2008-07-16 | 2018-07-10 | Astrazeneca Ab | derivado de pirimidil sulfonamida e seu uso para o tratamento de doenças mediadas por quimiocina |
EP2516416A1 (en) | 2009-12-23 | 2012-10-31 | Ironwood Pharmaceuticals, Inc. | Crth2 modulators |
US20130259830A1 (en) | 2010-07-12 | 2013-10-03 | Ironwood Pharmaceuticals, Inc. | Crth2 modulators |
US20130216552A1 (en) | 2010-07-12 | 2013-08-22 | Ironwood Pharmaceuticals, Inc. | Crth2 modulators |
MY167869A (en) | 2010-07-13 | 2018-09-26 | Astrazeneca Ab | New Crystalline forms of N-[2-[[(2,3-difluorophenyl)methyl]thio]-6-{[(1R, 2S)-2,3-dihydroxy-1-methylpropyl]oxy}-4-pyrimidinyl]-1-azetidinesulfonamide |
JP5999177B2 (ja) | 2011-05-04 | 2016-09-28 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Egfr発動性がんの細胞増殖阻害用化合物 |
MY180039A (en) | 2011-07-12 | 2020-11-20 | Astrazeneca Ab | N- (6- ( (2r,3s) -3,4-dihydroxybutan-2-yloxy) -2- (4 - fluorobenzylthio) pyrimidin- 4 - yl) -3- methylazetidine- 1 - sulfonamide as chemokine receptor modulator |
AU2013204563B2 (en) | 2012-05-05 | 2016-05-19 | Takeda Pharmaceutical Company Limited | Compounds for inhibiting cell proliferation in EGFR-driven cancers |
US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
TW201512171A (zh) | 2013-04-19 | 2015-04-01 | Pfizer Ltd | 化學化合物 |
US9890158B2 (en) | 2015-10-09 | 2018-02-13 | Abbvie S.Á.R.L. | N-sulfonylated pyrazolo[3,4-b]pyridin-6-carboxamides and method of use |
AU2017231832B2 (en) | 2016-03-11 | 2021-11-11 | Ardea Biosciences, Inc. | CXCR-2 inhibitors for treating crystal arthropathy disorders |
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2002
- 2002-07-27 GB GBGB0217431.6A patent/GB0217431D0/en not_active Ceased
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2003
- 2003-07-23 AU AU2003281684A patent/AU2003281684B2/en not_active Ceased
- 2003-07-23 UA UAA200500513A patent/UA80283C2/uk unknown
- 2003-07-23 WO PCT/GB2003/003175 patent/WO2004011443A1/en active Application Filing
- 2003-07-23 KR KR1020057001454A patent/KR101074626B1/ko not_active IP Right Cessation
- 2003-07-23 EP EP03740844A patent/EP1527051B1/en not_active Expired - Lifetime
- 2003-07-23 CA CA2493785A patent/CA2493785C/en not_active Expired - Fee Related
- 2003-07-23 BR BR0312967-5A patent/BR0312967A/pt not_active IP Right Cessation
- 2003-07-23 PL PL03375400A patent/PL375400A1/xx not_active Application Discontinuation
- 2003-07-23 JP JP2004523926A patent/JP4619782B2/ja not_active Expired - Fee Related
- 2003-07-23 CN CNB038221497A patent/CN100345829C/zh not_active Expired - Fee Related
- 2003-07-23 RU RU2005101406/04A patent/RU2342366C2/ru not_active IP Right Cessation
- 2003-07-23 NZ NZ537914A patent/NZ537914A/en not_active IP Right Cessation
- 2003-07-23 KR KR1020117006101A patent/KR20110033313A/ko not_active Application Discontinuation
- 2003-07-23 US US10/522,871 patent/US7582644B2/en not_active Expired - Fee Related
- 2003-07-23 MX MXPA05000960A patent/MXPA05000960A/es active IP Right Grant
- 2003-07-23 ES ES03740844T patent/ES2392965T3/es not_active Expired - Lifetime
- 2003-07-25 AR AR20030102688A patent/AR040700A1/es unknown
- 2003-07-25 TW TW092120405A patent/TWI340038B/zh not_active IP Right Cessation
- 2003-07-25 MY MYPI20032818A patent/MY139561A/en unknown
- 2003-07-28 EG EG2003070726A patent/EG25893A/xx active
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2005
- 2005-01-13 IL IL16629005A patent/IL166290A0/xx unknown
- 2005-01-24 CO CO05005309A patent/CO5680479A2/es not_active Application Discontinuation
- 2005-01-26 ZA ZA200500791A patent/ZA200500791B/en unknown
- 2005-02-17 IS IS7697A patent/IS7697A/is unknown
- 2005-02-25 NO NO20051042A patent/NO330531B1/no not_active IP Right Cessation
- 2005-09-27 HK HK05108513.6A patent/HK1076465A1/xx not_active IP Right Cessation
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2009
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