ZA200500135B - Ether substituted imidazopyridines - Google Patents
Ether substituted imidazopyridines Download PDFInfo
- Publication number
- ZA200500135B ZA200500135B ZA200500135A ZA200500135A ZA200500135B ZA 200500135 B ZA200500135 B ZA 200500135B ZA 200500135 A ZA200500135 A ZA 200500135A ZA 200500135 A ZA200500135 A ZA 200500135A ZA 200500135 B ZA200500135 B ZA 200500135B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- alkylene
- compound
- aryl
- alkenyl
- Prior art date
Links
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 title description 11
- 125000001033 ether group Chemical group 0.000 title description 3
- 150000005232 imidazopyridines Chemical class 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 160
- 125000000217 alkyl group Chemical group 0.000 claims description 124
- 229910052739 hydrogen Inorganic materials 0.000 claims description 100
- 239000001257 hydrogen Substances 0.000 claims description 100
- 150000003839 salts Chemical class 0.000 claims description 90
- 125000003342 alkenyl group Chemical group 0.000 claims description 64
- 150000002431 hydrogen Chemical class 0.000 claims description 64
- 229910052736 halogen Inorganic materials 0.000 claims description 46
- 125000002947 alkylene group Chemical group 0.000 claims description 42
- 125000004419 alkynylene group Chemical group 0.000 claims description 34
- 125000004450 alkenylene group Chemical group 0.000 claims description 33
- 230000015572 biosynthetic process Effects 0.000 claims description 30
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 30
- 150000002367 halogens Chemical class 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 24
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 24
- 125000001424 substituent group Chemical group 0.000 claims description 23
- 102000004127 Cytokines Human genes 0.000 claims description 21
- 108090000695 Cytokines Proteins 0.000 claims description 21
- 125000003545 alkoxy group Chemical group 0.000 claims description 21
- 125000003282 alkyl amino group Chemical group 0.000 claims description 21
- 125000004414 alkyl thio group Chemical group 0.000 claims description 21
- 125000000304 alkynyl group Chemical group 0.000 claims description 21
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 21
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 17
- 125000001072 heteroaryl group Chemical group 0.000 claims description 17
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 14
- 229910052799 carbon Inorganic materials 0.000 claims description 14
- 230000001939 inductive effect Effects 0.000 claims description 14
- 125000004432 carbon atom Chemical group C* 0.000 claims description 12
- 125000000623 heterocyclic group Chemical group 0.000 claims description 11
- 230000001613 neoplastic effect Effects 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 230000003612 virological effect Effects 0.000 claims description 10
- 125000004429 atom Chemical group 0.000 claims description 9
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims description 7
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims description 7
- 125000005842 heteroatom Chemical group 0.000 claims description 7
- 125000003118 aryl group Chemical group 0.000 claims description 5
- 102000014150 Interferons Human genes 0.000 claims description 4
- 108010050904 Interferons Proteins 0.000 claims description 4
- 229940079322 interferon Drugs 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
- 230000002452 interceptive effect Effects 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 18
- 238000004519 manufacturing process Methods 0.000 claims 18
- 239000000203 mixture Substances 0.000 claims 17
- 239000000126 substance Substances 0.000 claims 15
- 239000003937 drug carrier Substances 0.000 claims 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 description 6
- 150000003568 thioethers Chemical class 0.000 description 5
- 125000004857 imidazopyridinyl group Chemical class N1C(=NC2=C1C=CC=N2)* 0.000 description 4
- 230000028993 immune response Effects 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- ITIRVXDSMXFTPW-UHFFFAOYSA-N 1H-imidazo[4,5-c]quinoline Chemical group C1=CC=CC2=C(NC=N3)C3=CN=C21 ITIRVXDSMXFTPW-UHFFFAOYSA-N 0.000 description 2
- HQBUPOAKJGJGCD-UHFFFAOYSA-N 3h-imidazo[4,5-c]quinolin-4-amine Chemical class NC1=NC2=CC=CC=C2C2=C1N=CN2 HQBUPOAKJGJGCD-UHFFFAOYSA-N 0.000 description 2
- 239000003607 modifier Substances 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- HZPOJEMKSPPRCT-UHFFFAOYSA-N 1,2-dihydroimidazo[4,5-b]pyridin-4-amine Chemical class NN1C=CC=C2NCN=C12 HZPOJEMKSPPRCT-UHFFFAOYSA-N 0.000 description 1
- YJKZDGOMTKOYQK-UHFFFAOYSA-N 1-(2-piperidin-4-ylethyl)imidazo[4,5-c]quinoline Chemical compound C1=NC2=CN=C3C=CC=CC3=C2N1CCC1CCNCC1 YJKZDGOMTKOYQK-UHFFFAOYSA-N 0.000 description 1
- HDDNSPWJCZZICL-UHFFFAOYSA-N 1-(6-methoxyquinolin-8-yl)-2-methylimidazo[4,5-c]quinoline Chemical compound N1=CC=CC2=CC(OC)=CC(N3C4=C5C=CC=CC5=NC=C4N=C3C)=C21 HDDNSPWJCZZICL-UHFFFAOYSA-N 0.000 description 1
- 241000270299 Boa Species 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 230000001773 anti-convulsant effect Effects 0.000 description 1
- 229940125681 anticonvulsant agent Drugs 0.000 description 1
- 239000001961 anticonvulsive agent Substances 0.000 description 1
- 239000003430 antimalarial agent Substances 0.000 description 1
- 229940111121 antirheumatic drug quinolines Drugs 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 229940124630 bronchodilator Drugs 0.000 description 1
- 239000000168 bronchodilator agent Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 229940125692 cardiovascular agent Drugs 0.000 description 1
- 239000002327 cardiovascular agent Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002170 ethers Chemical group 0.000 description 1
- NSHFLKZNBPJNPA-UHFFFAOYSA-N imidazo[4,5-c]quinolin-2-one Chemical class C1=CC=C2C3=NC(=O)N=C3C=NC2=C1 NSHFLKZNBPJNPA-UHFFFAOYSA-N 0.000 description 1
- 239000002955 immunomodulating agent Substances 0.000 description 1
- 229940121354 immunomodulator Drugs 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 150000003248 quinolines Chemical class 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Neurosurgery (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38726802P | 2002-06-07 | 2002-06-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200500135B true ZA200500135B (en) | 2006-06-28 |
Family
ID=29736284
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200500135A ZA200500135B (en) | 2002-06-07 | 2005-01-06 | Ether substituted imidazopyridines |
Country Status (13)
Country | Link |
---|---|
US (3) | US6797718B2 (fr) |
EP (1) | EP1513524A4 (fr) |
JP (1) | JP2005538057A (fr) |
CN (1) | CN1674894A (fr) |
AU (1) | AU2003237386A1 (fr) |
BR (1) | BR0311648A (fr) |
CA (1) | CA2488801A1 (fr) |
IL (1) | IL165604A0 (fr) |
MX (1) | MXPA04012199A (fr) |
NO (1) | NO20045445L (fr) |
NZ (1) | NZ537054A (fr) |
WO (1) | WO2003103584A2 (fr) |
ZA (1) | ZA200500135B (fr) |
Families Citing this family (126)
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JP3436512B2 (ja) * | 1999-12-28 | 2003-08-11 | 株式会社デンソー | アクセル装置 |
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JP2006517974A (ja) | 2003-02-13 | 2006-08-03 | スリーエム イノベイティブ プロパティズ カンパニー | Irm化合物およびトル様受容体8に関する方法および組成物 |
US7485432B2 (en) | 2003-02-27 | 2009-02-03 | 3M Innovative Properties Company | Selective modulation of TLR-mediated biological activity |
CA2517528A1 (fr) | 2003-03-04 | 2004-09-16 | 3M Innovative Properties Company | Traitement prophylactique de la neoplasie epidermique induite par les uv |
US20040176367A1 (en) | 2003-03-07 | 2004-09-09 | 3M Innovative Properties Company | 1-Amino 1H-imidazoquinolines |
KR20050109562A (ko) | 2003-03-13 | 2005-11-21 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 피부의 질을 개선시키는 방법 |
WO2004080293A2 (fr) | 2003-03-13 | 2004-09-23 | 3M Innovative Properties Company | Methodes de diagnostic de lesions de la peau |
AU2004220465A1 (en) | 2003-03-13 | 2004-09-23 | 3M Innovative Properties Company | Method of tattoo removal |
EP1613956A2 (fr) | 2003-03-25 | 2006-01-11 | 3M Innovative Properties Company | Activation selective d'activites cellulaires realisee par l'intermediaire d'un recepteur toll commun |
US20040192585A1 (en) | 2003-03-25 | 2004-09-30 | 3M Innovative Properties Company | Treatment for basal cell carcinoma |
JP2007500210A (ja) | 2003-04-10 | 2007-01-11 | スリーエム イノベイティブ プロパティズ カンパニー | 金属含有微粒子担体材料を使用した免疫反応調節物質化合物の送達 |
WO2004096144A2 (fr) | 2003-04-28 | 2004-11-11 | 3M Innovative Properties Company | Compositions et methodes d'induction de recepteurs opoides |
JP2007502293A (ja) | 2003-08-12 | 2007-02-08 | スリーエム イノベイティブ プロパティズ カンパニー | ヒドロキシルアミン置換イミダゾ含有化合物 |
EP2939693A1 (fr) | 2003-08-14 | 2015-11-04 | 3M Innovative Properties Company | Modificateurs de réponse immunitaire modifiée par un lipide |
AP2006003542A0 (en) | 2003-09-05 | 2006-04-30 | Anadys Pharmaceuticals Inc | Administration of TLR7 ligands and prodrugs for treatment of infection by hepatitis C virus. |
US7687628B2 (en) | 2003-10-01 | 2010-03-30 | Taro Pharmaceuticals U.S.A., Inc. | Method of preparing 4-amino-1H-imidazo(4,5-c)quinolines and acid addition salts thereof |
ITMI20032121A1 (it) | 2003-11-04 | 2005-05-05 | Dinamite Dipharma Spa In Forma Abbr Eviata Dipharm | Procedimento per la preparazione di imiquimod e suoi intermedi |
-
2003
- 2003-06-06 CA CA002488801A patent/CA2488801A1/fr not_active Abandoned
- 2003-06-06 BR BR0311648-4A patent/BR0311648A/pt not_active IP Right Cessation
- 2003-06-06 CN CNA038186780A patent/CN1674894A/zh active Pending
- 2003-06-06 AU AU2003237386A patent/AU2003237386A1/en not_active Abandoned
- 2003-06-06 WO PCT/US2003/017659 patent/WO2003103584A2/fr active Application Filing
- 2003-06-06 EP EP03736844A patent/EP1513524A4/fr not_active Withdrawn
- 2003-06-06 US US10/456,308 patent/US6797718B2/en not_active Expired - Fee Related
- 2003-06-06 NZ NZ537054A patent/NZ537054A/en unknown
- 2003-06-06 MX MXPA04012199A patent/MXPA04012199A/es not_active Application Discontinuation
- 2003-06-06 JP JP2004510705A patent/JP2005538057A/ja active Pending
-
2004
- 2004-08-11 US US10/916,125 patent/US7125890B2/en not_active Expired - Fee Related
- 2004-12-07 IL IL16560404A patent/IL165604A0/xx unknown
- 2004-12-14 NO NO20045445A patent/NO20045445L/no not_active Application Discontinuation
-
2005
- 2005-01-06 ZA ZA200500135A patent/ZA200500135B/en unknown
-
2006
- 2006-07-24 US US11/459,489 patent/US7220758B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1513524A2 (fr) | 2005-03-16 |
IL165604A0 (en) | 2006-01-15 |
JP2005538057A (ja) | 2005-12-15 |
US6797718B2 (en) | 2004-09-28 |
US7125890B2 (en) | 2006-10-24 |
EP1513524A4 (fr) | 2008-09-03 |
MXPA04012199A (es) | 2005-02-25 |
US20060252792A1 (en) | 2006-11-09 |
CN1674894A (zh) | 2005-09-28 |
NO20045445L (no) | 2005-02-18 |
US20050032830A1 (en) | 2005-02-10 |
AU2003237386A1 (en) | 2003-12-22 |
WO2003103584A2 (fr) | 2003-12-18 |
US7220758B2 (en) | 2007-05-22 |
BR0311648A (pt) | 2005-04-19 |
NZ537054A (en) | 2006-10-27 |
US20040010007A1 (en) | 2004-01-15 |
WO2003103584A3 (fr) | 2004-02-26 |
CA2488801A1 (fr) | 2003-12-18 |
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