ZA200406940B - Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane as NMDA, 5HT3, and neuronal nicotinic receptor antagonists. - Google Patents
Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane as NMDA, 5HT3, and neuronal nicotinic receptor antagonists. Download PDFInfo
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- ZA200406940B ZA200406940B ZA200406940A ZA200406940A ZA200406940B ZA 200406940 B ZA200406940 B ZA 200406940B ZA 200406940 A ZA200406940 A ZA 200406940A ZA 200406940 A ZA200406940 A ZA 200406940A ZA 200406940 B ZA200406940 B ZA 200406940B
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- disease
- nmda
- mrz
- nicotinic receptor
- azatricyclic
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- PAFZNILMFXTMIY-UHFFFAOYSA-N cyclohexylamine Chemical class NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 title 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 12
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- KJNPYCPXGWCVRN-UHFFFAOYSA-N 1,3,3,5-tetramethyl-6-azabicyclo[3.2.1]octane Chemical compound C1C2(C)NCC1(C)CC(C)(C)C2 KJNPYCPXGWCVRN-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
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- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- AIDS & HIV (AREA)
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- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36638602P | 2002-03-21 | 2002-03-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200406940B true ZA200406940B (en) | 2005-09-22 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200406940A ZA200406940B (en) | 2002-03-21 | 2004-08-31 | Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane as NMDA, 5HT3, and neuronal nicotinic receptor antagonists. |
Country Status (19)
| Country | Link |
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| US (4) | US7022729B2 (xx) |
| EP (1) | EP1485086A1 (xx) |
| JP (1) | JP4262606B2 (xx) |
| KR (1) | KR100741257B1 (xx) |
| CN (1) | CN1638762A (xx) |
| AR (1) | AR039008A1 (xx) |
| AU (1) | AU2003216855B2 (xx) |
| CA (1) | CA2474637A1 (xx) |
| CO (1) | CO5611104A2 (xx) |
| EA (1) | EA007098B1 (xx) |
| GE (1) | GEP20063954B (xx) |
| IL (1) | IL164041A0 (xx) |
| MX (1) | MXPA04007755A (xx) |
| NO (1) | NO20044481L (xx) |
| PL (1) | PL372701A1 (xx) |
| TW (1) | TW200306189A (xx) |
| UA (1) | UA77778C2 (xx) |
| WO (1) | WO2003080046A1 (xx) |
| ZA (1) | ZA200406940B (xx) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1765287A2 (en) | 2004-06-17 | 2007-03-28 | Merz Pharma GmbH & Co. KGaA | Immediate release formulations of memantine oral dosage forms |
| US20060205822A1 (en) * | 2004-12-22 | 2006-09-14 | Forest Laboratories, Inc. | 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect |
| EP2111858A1 (en) | 2008-04-25 | 2009-10-28 | EPFL Ecole Polytechnique Fédérale de Lausanne | Novel treatment for alzheimer's disease |
| US20090275597A1 (en) * | 2008-05-02 | 2009-11-05 | Forest Laboratories Holdings Limited | Methods of treating cns disorders |
| CN102918021B (zh) * | 2010-05-27 | 2015-02-11 | 塔加西普特公司 | 烟碱受体非竞争性拮抗剂 |
| BR112014010719A2 (pt) * | 2011-11-03 | 2017-05-02 | Targacept Inc | moduladores não competitivos de receptor nicotínico |
| US9173878B2 (en) | 2012-01-25 | 2015-11-03 | Tohoku University | Brain function improving agent |
| EA029052B1 (ru) | 2013-03-14 | 2018-02-28 | Бёрингер Ингельхайм Интернациональ Гмбх | Замещенные (бензилцианометил)амиды 2-азабицикло[2.2.1]гептан-3-карбоновых кислот в качестве ингибиторов катепсина с |
| AP2017009733A0 (en) | 2014-09-12 | 2017-02-28 | Boehringer Ingelheim Int | Spirocyclic inhibitors of cathepsin c |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1153973A (en) | 1966-03-14 | 1969-06-04 | Upjohn Co | alpha,alpha-Diphenyl-beta-Methyl-1-Azaspiro[4,5]Decane (and [4,4]Nonane)-1-Propanols |
| GB1472334A (en) | 1973-07-14 | 1977-05-04 | Tanabe Seiyaku Co | 1-3-hydroxyphenyl-6-azabicyclo-3,2,1-octane derivatives and their use in pharmaceutical preparations |
| FR2451368A1 (fr) | 1979-03-12 | 1980-10-10 | Lilly Co Eli | Phenylmorphanes, intermediaires et procedes de synthese, et leur utilisation therapeutique |
| DE3132020A1 (de) | 1981-08-13 | 1983-03-03 | Basf Ag, 6700 Ludwigshafen | N-benzoyl-n'-phenylharnstoffe, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung von insekten und spinnentieren |
| JPS62297848A (ja) * | 1986-06-17 | 1987-12-25 | Konica Corp | ハロゲン化銀写真感光材料 |
| EP0566609A1 (en) | 1991-01-09 | 1993-10-27 | Smithkline Beecham Plc | Azabicydic and azatricydic derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them |
| JP3134952B2 (ja) * | 1991-09-18 | 2001-02-13 | 東洋紡績株式会社 | 難撚性ポリエステル樹脂組成物の製造方法 |
| FR2693462B1 (fr) | 1992-07-08 | 1994-09-30 | Cepbepe | Préparation de nouveaux dérivés amido-alcools et leurs applications en thérapeutique. |
| WO1994008964A1 (en) | 1992-10-16 | 1994-04-28 | Asahi Kasei Kogyo Kabushiki Kaisha | N-phenethylazepine derivative and use thereof |
| NZ284852A (en) | 1994-08-18 | 1998-06-26 | Pfizer | 3-(piperidin-1-yl)-chroman-4,7-diol and 1-(4-hydrophenyl)-2-(piperidin-1-yl) alkanol derivatives; medicaments; used as a neuroprotective agent |
| WO1997011073A1 (en) * | 1995-09-22 | 1997-03-27 | Novo Nordisk A/S | Novel substituted azacyclic or azabicyclic compounds |
| US5900227A (en) * | 1996-06-17 | 1999-05-04 | Oklahoma Medical Research Foundation | Multicyclic nitrone spin trapping compositions |
| AU761055B2 (en) * | 1998-11-27 | 2003-05-29 | Neurosearch A/S | 8-azabicyclo(3.2.1)oct-2-ene and -octane derivatives |
| TW593223B (en) * | 2000-06-20 | 2004-06-21 | Merz Pharma Gmbh & Co Kgaa | 1-amino-alkylcyclohexanes as 5-HT3 and neuronal nicotinic receptor antagonists |
| US6951961B2 (en) * | 2002-05-17 | 2005-10-04 | Marina Nikolaevna Protopopova | Methods of use and compositions for the diagnosis and treatment of infectious disease |
-
2003
- 2003-03-17 TW TW092105796A patent/TW200306189A/zh unknown
- 2003-03-18 AR ARP030100948A patent/AR039008A1/es unknown
- 2003-03-21 MX MXPA04007755A patent/MXPA04007755A/es not_active Application Discontinuation
- 2003-03-21 IL IL16404103A patent/IL164041A0/xx unknown
- 2003-03-21 AU AU2003216855A patent/AU2003216855B2/en not_active Ceased
- 2003-03-21 KR KR1020047011982A patent/KR100741257B1/ko not_active IP Right Cessation
- 2003-03-21 EP EP03712394A patent/EP1485086A1/en not_active Withdrawn
- 2003-03-21 PL PL03372701A patent/PL372701A1/xx not_active Application Discontinuation
- 2003-03-21 UA UA20041008550A patent/UA77778C2/uk unknown
- 2003-03-21 CA CA002474637A patent/CA2474637A1/en not_active Abandoned
- 2003-03-21 JP JP2003577874A patent/JP4262606B2/ja not_active Expired - Fee Related
- 2003-03-21 US US10/394,670 patent/US7022729B2/en not_active Expired - Fee Related
- 2003-03-21 GE GEAP8454A patent/GEP20063954B/en unknown
- 2003-03-21 WO PCT/GB2003/001236 patent/WO2003080046A1/en active IP Right Grant
- 2003-03-21 CN CNA038044900A patent/CN1638762A/zh active Pending
- 2003-03-21 EA EA200401230A patent/EA007098B1/ru unknown
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2004
- 2004-08-31 CO CO04085290A patent/CO5611104A2/es not_active Application Discontinuation
- 2004-08-31 ZA ZA200406940A patent/ZA200406940B/en unknown
- 2004-10-20 NO NO20044481A patent/NO20044481L/no not_active Application Discontinuation
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2005
- 2005-08-11 US US11/202,012 patent/US7238703B2/en not_active Expired - Fee Related
- 2005-08-11 US US11/202,115 patent/US20060019983A1/en not_active Abandoned
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2007
- 2007-04-04 US US11/732,764 patent/US20070185151A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20040034055A1 (en) | 2004-02-19 |
| US7022729B2 (en) | 2006-04-04 |
| CN1638762A (zh) | 2005-07-13 |
| KR20040091005A (ko) | 2004-10-27 |
| CO5611104A2 (es) | 2006-02-28 |
| UA77778C2 (en) | 2007-01-15 |
| GEP20063954B (en) | 2006-10-25 |
| CA2474637A1 (en) | 2003-10-02 |
| IL164041A0 (en) | 2005-12-18 |
| AU2003216855A1 (en) | 2003-10-08 |
| US20060019982A1 (en) | 2006-01-26 |
| EP1485086A1 (en) | 2004-12-15 |
| EA200401230A1 (ru) | 2005-02-24 |
| JP2005525385A (ja) | 2005-08-25 |
| WO2003080046A1 (en) | 2003-10-02 |
| EA007098B1 (ru) | 2006-06-30 |
| MXPA04007755A (es) | 2004-10-15 |
| AR039008A1 (es) | 2005-02-02 |
| AU2003216855B2 (en) | 2005-08-18 |
| NO20044481L (no) | 2004-10-20 |
| JP4262606B2 (ja) | 2009-05-13 |
| US20070185151A1 (en) | 2007-08-09 |
| US20060019983A1 (en) | 2006-01-26 |
| KR100741257B1 (ko) | 2007-07-19 |
| TW200306189A (en) | 2003-11-16 |
| PL372701A1 (en) | 2005-07-25 |
| US7238703B2 (en) | 2007-07-03 |
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