ZA200308863B - Modulators of peroxisome proliferator activated receptors. - Google Patents
Modulators of peroxisome proliferator activated receptors. Download PDFInfo
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- ZA200308863B ZA200308863B ZA200308863A ZA200308863A ZA200308863B ZA 200308863 B ZA200308863 B ZA 200308863B ZA 200308863 A ZA200308863 A ZA 200308863A ZA 200308863 A ZA200308863 A ZA 200308863A ZA 200308863 B ZA200308863 B ZA 200308863B
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- South Africa
- Prior art keywords
- compound
- phenyl
- methoxy
- structural formula
- represented
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- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 title claims description 55
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 title claims description 55
- 150000001875 compounds Chemical class 0.000 claims description 565
- 239000000203 mixture Substances 0.000 claims description 114
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 113
- 238000000034 method Methods 0.000 claims description 105
- 125000003118 aryl group Chemical group 0.000 claims description 94
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 84
- 239000000126 substance Substances 0.000 claims description 72
- -1 -CHj Chemical group 0.000 claims description 61
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 59
- 125000001931 aliphatic group Chemical group 0.000 claims description 55
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- 229910052799 carbon Inorganic materials 0.000 claims description 35
- 150000003839 salts Chemical class 0.000 claims description 35
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 32
- 125000001424 substituent group Chemical group 0.000 claims description 32
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- 235000019260 propionic acid Nutrition 0.000 claims description 30
- 206010022489 Insulin Resistance Diseases 0.000 claims description 27
- 125000000217 alkyl group Chemical group 0.000 claims description 27
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- 150000001721 carbon Chemical group 0.000 claims description 23
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims description 23
- 125000004474 heteroalkylene group Chemical group 0.000 claims description 21
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 20
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- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims description 13
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- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 12
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- 150000004677 hydrates Chemical class 0.000 claims description 12
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- 239000003529 anticholesteremic agent Substances 0.000 claims description 11
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 11
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- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims description 10
- 239000004131 EU approved raising agent Substances 0.000 claims description 10
- 102000001494 Sterol O-Acyltransferase Human genes 0.000 claims description 10
- 108010054082 Sterol O-acyltransferase Proteins 0.000 claims description 10
- 229960001138 acetylsalicylic acid Drugs 0.000 claims description 10
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- 230000003579 anti-obesity Effects 0.000 claims description 10
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 10
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- 125000000753 cycloalkyl group Chemical group 0.000 claims description 8
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- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims description 7
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 7
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- 125000000524 functional group Chemical group 0.000 claims description 7
- 229910052736 halogen Inorganic materials 0.000 claims description 7
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- 229910052708 sodium Inorganic materials 0.000 claims description 7
- 229940124530 sulfonamide Drugs 0.000 claims description 7
- 150000003456 sulfonamides Chemical class 0.000 claims description 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 6
- 239000005977 Ethylene Substances 0.000 claims description 6
- 239000004305 biphenyl Substances 0.000 claims description 6
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- 125000001188 haloalkyl group Chemical group 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 6
- 150000003536 tetrazoles Chemical class 0.000 claims description 6
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 5
- QGMKLFTYMSXDGA-UHFFFAOYSA-N 2-methoxy-3-[3-[3-(4-phenylphenoxy)propoxy]phenyl]propanoic acid Chemical compound COC(C(O)=O)CC1=CC=CC(OCCCOC=2C=CC(=CC=2)C=2C=CC=CC=2)=C1 QGMKLFTYMSXDGA-UHFFFAOYSA-N 0.000 claims description 5
- 108010016731 PPAR gamma Proteins 0.000 claims description 5
- 239000007858 starting material Substances 0.000 claims description 5
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 4
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- 239000001257 hydrogen Substances 0.000 claims description 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 4
- 125000003107 substituted aryl group Chemical group 0.000 claims description 4
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- OZALPJGJNKMBKA-SANMLTNESA-N (2s)-3-[4-[3-(4-benzylphenoxy)propoxy]phenyl]-2-ethoxypropanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OCCCOC(C=C1)=CC=C1CC1=CC=CC=C1 OZALPJGJNKMBKA-SANMLTNESA-N 0.000 claims description 3
- RUZMFRVKJHDPGO-QFIPXVFZSA-N (2s)-3-[4-[3-(4-butylphenoxy)propoxy]phenyl]-2-methoxypropanoic acid Chemical compound C1=CC(CCCC)=CC=C1OCCCOC1=CC=C(C[C@H](OC)C(O)=O)C=C1 RUZMFRVKJHDPGO-QFIPXVFZSA-N 0.000 claims description 3
- WRDRSTYCGZZUHX-DEOSSOPVSA-N (2s)-3-[4-[3-[4-(4-fluorobenzoyl)phenoxy]propoxy]phenyl]-2-methoxypropanoic acid Chemical compound C1=CC(C[C@H](OC)C(O)=O)=CC=C1OCCCOC1=CC=C(C(=O)C=2C=CC(F)=CC=2)C=C1 WRDRSTYCGZZUHX-DEOSSOPVSA-N 0.000 claims description 3
- GWQRMQDREIBEJB-UHFFFAOYSA-N 2-methoxy-3-[2-methoxy-4-[3-(4-phenoxyphenoxy)propoxy]phenyl]propanoic acid Chemical compound C1=C(OC)C(CC(OC)C(O)=O)=CC=C1OCCCOC(C=C1)=CC=C1OC1=CC=CC=C1 GWQRMQDREIBEJB-UHFFFAOYSA-N 0.000 claims description 3
- ICPWFHKNYYRBSZ-UHFFFAOYSA-N 2-methoxypropanoic acid Chemical compound COC(C)C(O)=O ICPWFHKNYYRBSZ-UHFFFAOYSA-N 0.000 claims description 3
- MOJOXRWSSSIPOI-UHFFFAOYSA-N 3-[4-[3-(4-benzoylphenoxy)propoxy]-2-chlorophenyl]-2-methoxypropanoic acid Chemical compound C1=C(Cl)C(CC(OC)C(O)=O)=CC=C1OCCCOC1=CC=C(C(=O)C=2C=CC=CC=2)C=C1 MOJOXRWSSSIPOI-UHFFFAOYSA-N 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 150000003857 carboxamides Chemical class 0.000 claims description 3
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- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 claims description 3
- IHTNLIQRRZWXPI-QHCPKHFHSA-N (2s)-2-methoxy-3-[4-[2-(4-phenylphenoxy)ethoxy]phenyl]propanoic acid Chemical compound C1=CC(C[C@H](OC)C(O)=O)=CC=C1OCCOC1=CC=C(C=2C=CC=CC=2)C=C1 IHTNLIQRRZWXPI-QHCPKHFHSA-N 0.000 claims description 2
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- KNNHPJKYTMZLEP-SANMLTNESA-N (2s)-2-methoxy-3-[4-[5-(4-phenoxyphenoxy)pent-1-ynyl]phenyl]propanoic acid Chemical compound C1=CC(C[C@H](OC)C(O)=O)=CC=C1C#CCCCOC(C=C1)=CC=C1OC1=CC=CC=C1 KNNHPJKYTMZLEP-SANMLTNESA-N 0.000 claims description 2
- ZXVKVZHFWBHAAB-VWLOTQADSA-N (2s)-3-[4-[4-(4-benzoylphenoxy)but-1-ynyl]phenyl]-2-methoxypropanoic acid Chemical compound C1=CC(C[C@H](OC)C(O)=O)=CC=C1C#CCCOC1=CC=C(C(=O)C=2C=CC=CC=2)C=C1 ZXVKVZHFWBHAAB-VWLOTQADSA-N 0.000 claims description 2
- KISZHXKXASQTNR-SANMLTNESA-N (2s)-3-[4-[5-(4-benzoylphenoxy)pentanoyl]phenyl]-2-methoxypropanoic acid Chemical compound C1=CC(C[C@H](OC)C(O)=O)=CC=C1C(=O)CCCCOC1=CC=C(C(=O)C=2C=CC=CC=2)C=C1 KISZHXKXASQTNR-SANMLTNESA-N 0.000 claims description 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 2
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims description 2
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- NGBDEPKVJPUCGK-QFIPXVFZSA-N (2s)-2-methoxy-3-[4-[3-(4-morpholin-4-ylphenoxy)propoxy]phenyl]propanoic acid Chemical compound C1=CC(C[C@H](OC)C(O)=O)=CC=C1OCCCOC1=CC=C(N2CCOCC2)C=C1 NGBDEPKVJPUCGK-QFIPXVFZSA-N 0.000 claims 1
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- NBCNXIGHQPZPBX-MHZLTWQESA-N (2s)-2-methoxy-3-[4-[3-[4-(3-phenylpropanoyl)phenoxy]propoxy]phenyl]propanoic acid Chemical compound C1=CC(C[C@H](OC)C(O)=O)=CC=C1OCCCOC1=CC=C(C(=O)CCC=2C=CC=CC=2)C=C1 NBCNXIGHQPZPBX-MHZLTWQESA-N 0.000 claims 1
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
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- C07D317/20—Free hydroxyl or mercaptan
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- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
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- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/54—Radicals substituted by oxygen atoms
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- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/64—Oxygen atoms
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- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
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- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/76—Dibenzothiophenes
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- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
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- Steroid Compounds (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
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US29714401P | 2001-06-07 | 2001-06-07 |
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ZA200308863A ZA200308863B (en) | 2001-06-07 | 2003-11-13 | Modulators of peroxisome proliferator activated receptors. |
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EP (1) | EP1392637A2 (es) |
JP (1) | JP2005509590A (es) |
KR (1) | KR20040012905A (es) |
CN (1) | CN1543451A (es) |
AR (1) | AR036084A1 (es) |
BR (1) | BR0210190A (es) |
CA (1) | CA2449256A1 (es) |
CO (1) | CO5640097A2 (es) |
CZ (1) | CZ20033309A3 (es) |
EA (1) | EA200400010A1 (es) |
EC (1) | ECSP034877A (es) |
EE (1) | EE200400001A (es) |
HR (1) | HRP20031001A2 (es) |
HU (1) | HUP0400280A3 (es) |
IL (1) | IL158873A0 (es) |
MX (1) | MXPA03011201A (es) |
NO (1) | NO20035439D0 (es) |
NZ (1) | NZ529351A (es) |
PE (1) | PE20030099A1 (es) |
PL (1) | PL368051A1 (es) |
SK (1) | SK14912003A3 (es) |
WO (1) | WO2002100813A2 (es) |
ZA (1) | ZA200308863B (es) |
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US7101910B2 (en) * | 2001-06-12 | 2006-09-05 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
ITRM20020016A1 (it) * | 2002-01-15 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Derivati di acidi fenil(alchil)carbossilici e derivati fenilalchileterociclici dionici, loro uso come medicamenti ad attivita' ipoglicemizza |
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RU2005119990A (ru) * | 2002-11-25 | 2006-02-27 | Галдерма Ресерч Энд Девелопмент, С.Н.С. (Fr) | Новые биароматические соединения, являющиеся активаторами рецепторов типа ppar гамма и их применение в косметических или фармацевтических композициях |
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MY147518A (en) * | 2004-09-15 | 2012-12-31 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
MY145712A (en) * | 2004-09-15 | 2012-03-30 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
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FR2882359A1 (fr) * | 2005-02-24 | 2006-08-25 | Negma Lerads Soc Par Actions S | Derives activateurs de ppar, procede de preparation et application en therapeutique |
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PE20080188A1 (es) | 2006-04-18 | 2008-03-10 | Janssen Pharmaceutica Nv | Derivados del acido benzoazepin-oxi-acetico como agonistas de ppar-delta usados para aumentar hdl-c, reducir ldl-c y reducir colesterol |
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CN102114076B (zh) * | 2006-10-25 | 2013-04-10 | 中国科学院上海生命科学研究院 | 肉桂提取物的制备方法、肉桂提取物、其组合物以及用途 |
EP2152663B1 (en) | 2007-06-04 | 2014-03-19 | Ben Gurion University of the Negev Research and Development Authority | Tri-aryl compounds and compositions comprising the same |
EP2240024A4 (en) * | 2008-01-15 | 2014-05-21 | Wellstat Therapeutics Corp | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS |
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JP5436941B2 (ja) * | 2009-06-03 | 2014-03-05 | あすか製薬株式会社 | ラクタム化合物又はその塩及びppar活性化剤 |
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EA201690938A1 (ru) | 2013-11-05 | 2016-11-30 | Бен-Гурион Юниверсити Оф Дзе Негев Рисерч Энд Дивелопмент Оторити | Соединения для лечения диабета и осложнений, возникающих из-за этого заболевания |
CN104945344A (zh) * | 2015-07-14 | 2015-09-30 | 佛山市赛维斯医药科技有限公司 | 一类含苯并异恶唑和末端胺基结构化合物及其用途 |
CN104961703A (zh) * | 2015-07-14 | 2015-10-07 | 佛山市赛维斯医药科技有限公司 | 一类苯并异恶唑类11β-HSD1抑制剂、制备方法及其用途 |
CN104926742A (zh) * | 2015-07-14 | 2015-09-23 | 佛山市赛维斯医药科技有限公司 | 一类含苯并异恶唑和硝基苯基类结构的化合物及其用途 |
CN104961702A (zh) * | 2015-07-14 | 2015-10-07 | 佛山市赛维斯医药科技有限公司 | 苯并异恶唑类11β-HSD1抑制剂、制备方法及其用途 |
CN105037290A (zh) * | 2015-07-14 | 2015-11-11 | 佛山市赛维斯医药科技有限公司 | 一类含苯并异恶唑和腈基苯类结构化合物及其用途 |
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CN104926743A (zh) * | 2015-07-14 | 2015-09-23 | 佛山市赛维斯医药科技有限公司 | 含苯并异恶唑和末端苄基类结构的化合物及其用途 |
CN104926746A (zh) * | 2015-07-14 | 2015-09-23 | 佛山市赛维斯医药科技有限公司 | 含苯并异恶唑和末端胺基苄基类结构的化合物及其用途 |
CN104926745A (zh) * | 2015-07-14 | 2015-09-23 | 佛山市赛维斯医药科技有限公司 | 含苯并异恶唑和末端卤代苄基类结构的化合物及其用途 |
CN105001174A (zh) * | 2015-07-14 | 2015-10-28 | 佛山市赛维斯医药科技有限公司 | 含苯并异恶唑和末端腈基苄基类结构的化合物及其用途 |
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KR100620337B1 (ko) | 1998-03-10 | 2006-09-13 | 오노 야꾸힝 고교 가부시키가이샤 | 카르복실산 유도체와 그 유도체를 유효 성분으로서함유하는 약제 |
SE9801990D0 (sv) | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl propionic acid derivatives and analogs |
SE9801992D0 (sv) | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl-2-hydroxypropionic acid derivative I |
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2003
- 2003-11-13 ZA ZA200308863A patent/ZA200308863B/en unknown
- 2003-12-03 HR HR20031001A patent/HRP20031001A2/hr not_active Application Discontinuation
- 2003-12-04 EC EC2003004877A patent/ECSP034877A/es unknown
- 2003-12-05 CO CO03107407A patent/CO5640097A2/es not_active Application Discontinuation
- 2003-12-05 NO NO20035439A patent/NO20035439D0/no not_active Application Discontinuation
-
2006
- 2006-12-11 US US11/637,223 patent/US20070276138A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2449256A1 (en) | 2002-12-19 |
CZ20033309A3 (cs) | 2004-05-12 |
NZ529351A (en) | 2006-01-27 |
PL368051A1 (en) | 2005-03-21 |
US20050020684A1 (en) | 2005-01-27 |
AR036084A1 (es) | 2004-08-11 |
JP2005509590A (ja) | 2005-04-14 |
KR20040012905A (ko) | 2004-02-11 |
EA200400010A1 (ru) | 2004-06-24 |
PE20030099A1 (es) | 2003-04-08 |
NO20035439D0 (no) | 2003-12-05 |
WO2002100813A2 (en) | 2002-12-19 |
US20070276138A1 (en) | 2007-11-29 |
EP1392637A2 (en) | 2004-03-03 |
ECSP034877A (es) | 2004-01-28 |
EE200400001A (et) | 2004-02-16 |
SK14912003A3 (sk) | 2004-09-08 |
HUP0400280A3 (en) | 2006-01-30 |
WO2002100813A3 (en) | 2003-11-27 |
CO5640097A2 (es) | 2006-05-31 |
HRP20031001A2 (en) | 2004-06-30 |
BR0210190A (pt) | 2004-04-06 |
US7192982B2 (en) | 2007-03-20 |
MXPA03011201A (es) | 2004-02-26 |
CN1543451A (zh) | 2004-11-03 |
HUP0400280A2 (hu) | 2005-01-28 |
IL158873A0 (en) | 2004-05-12 |
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